iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021583

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Breast cancer type 1 susceptibility protein homolog

Genbank Nucleotide ID

AAKN02042423

Gene Name

BRCA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000013609.3	ENSCPOT00000013745.2	ENSCPOP00000012252.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.60e-07	31.7	23	64

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle +k+ p+++ C H+f++ C  k+    +++++  +CPlC+
   Q: 23   CPICLELIKE-PVSTKCDHIFCKFCMLKF---LDQKKGLSQCPLCK 64
           ********99.***************999...7889*********7 PP

Organism

Cavia porcellus

Functional Description
(View)

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator.

Protein Sequence
(Fasta)

MDVSAVRVEV QNVLNAMQKV LECPICLELI KEPVSTKCDH IFCKFCMLKF LDQKKGLSQC 60
PLCKSSITKR SLQESTRFGQ LVEELQKTIH AFELDCSSQV ENSDSLSKKQ SSSPERVKEE 120

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Nucleotide Sequence
(Fasta)

ATGGATGTAT CAGCGGTTCG AGTTGAAGTA CAAAATGTCC TTAATGCTAT GCAGAAAGTC 60
TTGGAGTGTC CAATTTGGTA AGTCTTCCTT TTGTGACTGT CTCCTAAGCA AACGAGTAGC 120

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Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR011364--BRCA1
IPR031099--BRCA1-associated
IPR025994--BRCA1_serine_dom
IPR001357--BRCT_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50172--BRCT
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00533--BRCT
PF12820--BRCT_assoc

PRINTS

PR00493--BRSTCANCERI

SMART

SM00292--BRCT
SM00184--RING

Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005737--C:cytoplasm
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0000800--C:lateral element
GO:0005886--C:plasma membrane
GO:0003684--F:damaged DNA binding
GO:0003723--F:RNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071681--P:cellular response to indole-3-methanol
GO:0071356--P:cellular response to tumor necrosis factor
GO:0007098--P:centrosome cycle
GO:0043009--P:chordate embryonic development
GO:0007059--P:chromosome segregation
GO:0006260--P:DNA replication
GO:0009048--P:dosage compensation by inactivation of X chromosome
GO:0000724--P:double-strand break repair via homologous recombination
GO:0031572--P:G2 DNA damage checkpoint
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0035067--P:negative regulation of histone acetylation
GO:0051572--P:negative regulation of histone H3-K4 methylation
GO:0051573--P:negative regulation of histone H3-K9 methylation
GO:0033147--P:negative regulation of intracellular estrogen receptor signaling pathway
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045766--P:positive regulation of angiogenesis
GO:0071158--P:positive regulation of cell cycle arrest
GO:0045739--P:positive regulation of DNA repair
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2000617--P:positive regulation of histone H3-K9 acetylation
GO:0051574--P:positive regulation of histone H3-K9 methylation
GO:2000620--P:positive regulation of histone H4-K16 acetylation
GO:0070512--P:positive regulation of histone H4-K20 methylation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010575--P:positive regulation of vascular endothelial growth factor production
GO:0006301--P:postreplication repair
GO:0051865--P:protein autoubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0044030--P:regulation of DNA methylation
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0043627--P:response to estrogen
GO:0010212--P:response to ionizing radiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002388	Ailuropoda melanoleuca	45.66	0.00e+00	1309.00
IUUC-Apl-003252	Anas platyrhynchos	38.15	2.00e-99	358.00
IUUC-Aca-004526	Anolis carolinensis	56.25	2.00e-69	256.00
IUUC-Ame-011720	Astyanax mexicanus	46.80	2.00e-51	197.00
IUUC-Bta-013433	Bos taurus	44.70	0.00e+00	1269.00
IUUC-Cel-018208	Caenorhabditis elegans	29.66	2.00e-10	60.80
IUUC-Cja-019149	Callithrix jacchus	46.72	0.00e+00	1330.00
IUUC-Cfa-020322	Canis familiaris	45.50	0.00e+00	1292.00
IUUC-Cre-022955	Chlamydomonas reinhardtii	30.87	5.00e-09	57.40
IUUC-Csa-024227	Chlorocebus sabaeus	50.74	8.00e-94	337.00
IUUC-Cho-024530	Choloepus hoffmanni	40.84	9.00e-148	518.00
IUUC-Cin-025364	Ciona intestinalis	43.42	2.00e-15	75.90
IUUC-Csv-026245	Ciona savignyi	40.70	3.00e-14	72.00
IUUC-Dno-029247	Dasypus novemcinctus	41.38	0.00e+00	867.00
IUUC-Dme-032032	Drosophila melanogaster	52.17	4.00e-10	56.20
IUUC-Ete-032472	Echinops telfairi	38.63	0.00e+00	855.00
IUUC-Eca-033446	Equus caballus	47.21	0.00e+00	1420.00
IUUC-Eeu-034858	Erinaceus europaeus	36.84	9.00e-96	345.00
IUUC-Fca-035991	Felis catus	46.49	0.00e+00	1357.00
IUUC-Fal-036803	Ficedula albicollis	54.91	3.00e-76	280.00
IUUC-Gmo-038782	Gadus morhua	44.79	6.00e-44	173.00
IUUC-Gga-040969	Gallus gallus	55.86	2.00e-75	278.00
IUUC-Gac-042296	Gasterosteus aculeatus	43.06	3.00e-47	184.00
IUUC-Ggo-044740	Gorilla gorilla	45.09	0.00e+00	1263.00
IUUC-Hsa-046086	Homo sapiens	46.83	0.00e+00	1331.00
IUUC-Itr-048512	Ictidomys tridecemlineatus	45.90	0.00e+00	1420.00
IUUC-Lch-049789	Latimeria chalumnae	55.45	2.00e-71	265.00
IUUC-Loc-051952	Lepisosteus oculatus	51.75	1.00e-63	238.00
IUUC-Laf-053648	Loxodonta africana	46.15	0.00e+00	1274.00
IUUC-Mcc-055210	Macaca mulatta	47.55	0.00e+00	1399.00
IUUC-Meu-056342	Macropus eugenii	51.23	7.00e-43	170.00
IUUC-Mga-060163	Meleagris gallopavo	55.80	3.00e-77	284.00
IUUC-Mmr-061402	Microcebus murinus	40.79	6.00e-101	361.00
IUUC-Mdo-062209	Monodelphis domestica	35.26	0.00e+00	787.00
IUUC-Mmu-064003	Mus musculus	40.65	0.00e+00	1018.00
IUUC-Mpu-065825	Mustela putorius furo	55.42	2.00e-150	525.00
IUUC-Mlu-068176	Myotis lucifugus	44.51	0.00e+00	1209.00
IUUC-Nle-069178	Nomascus leucogenys	47.25	0.00e+00	1355.00
IUUC-Opr-070574	Ochotona princeps	40.30	0.00e+00	1021.00
IUUC-Ont-072380	Oreochromis niloticus	48.06	8.00e-55	209.00
IUUC-Oan-073243	Ornithorhynchus anatinus	72.62	8.00e-30	122.00
IUUC-Ocu-074424	Oryctolagus cuniculus	43.90	0.00e+00	1238.00
IUUC-Opu-083700	Oryza punctata	37.33	1.00e-21	99.00
IUUC-Ola-086863	Oryzias latipes	45.85	2.00e-49	191.00
IUUC-Olu-087666	Ostreococcus lucimarinus	35.77	3.00e-11	63.50
IUUC-Oar-089938	Ovis aries	45.48	0.00e+00	1332.00
IUUC-Ptr-090960	Pan troglodytes	46.93	0.00e+00	1343.00
IUUC-Pan-092609	Papio anubis	44.46	0.00e+00	1079.00
IUUC-Psi-093889	Pelodiscus sinensis	25.76	9.00e-09	56.20
IUUC-Pfo-096328	Poecilia formosa	47.12	1.00e-53	205.00
IUUC-Pab-097982	Pongo abelii	47.30	0.00e+00	1365.00
IUUC-Pca-100698	Procavia capensis	50.75	6.00e-122	432.00
IUUC-Pva-102631	Pteropus vampyrus	51.33	0.00e+00	662.00
IUUC-Rno-105879	Rattus norvegicus	40.33	0.00e+00	1007.00
IUUC-Sha-106701	Sarcophilus harrisii	31.36	4.00e-105	376.00
IUUC-Spo-108335	Schizosaccharomyces pombe	36.36	1.00e-08	54.30
IUUC-Sar-113047	Sorex araneus	38.08	0.00e+00	661.00
IUUC-Ssc-115846	Sus scrofa	46.04	0.00e+00	1340.00
IUUC-Tgu-116785	Taeniopygia guttata	55.36	1.00e-74	275.00
IUUC-Tru-117895	Takifugu rubripes	44.66	5.00e-50	193.00
IUUC-Tsy-118885	Tarsius syrichta	43.90	3.00e-75	277.00
IUUC-Tni-119654	Tetraodon nigroviridis	42.23	1.00e-44	175.00
IUUC-Tbe-127421	Tupaia belangeri	44.11	1.00e-96	348.00
IUUC-Ttr-128685	Tursiops truncatus	45.63	0.00e+00	1249.00
IUUC-Vpa-130216	Vicugna pacos	55.17	9.00e-133	468.00
IUUC-Xtr-132398	Xenopus tropicalis	34.06	2.00e-58	221.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence