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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046975
UUCD1 version UUC-HoS-00114
Ensembl Protein ID ENSP00000387365.3
UniProt Accession Q13610; A8K3R6; Q7Z3X9; PWP1_HUMAN
Genbank Protein ID AAA65201.1; BAF83370.1; EAW97802.1; AAH10921.1
Protein Name Periodic tryptophan protein 1 homolog; Keratinocyte protein IEF SSP 9502
Genbank Nucleotide ID L07758; AK290681; AC007622; BC010921
Gene Name PWP1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000136045.11 ENST00000412830.7 ENSP00000387365.3
ENSG00000136045.11 ENST00000552760.5 ENSP00000448227.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.40e-22 79.7 254 287
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf....sdtllvsGsdDgtikvWDlr 31
           gHtd v +l++      + l+s+s D+t+ +WD++
   Q: 254  GHTDAVLDLSWnkliR-NVLASASADNTVILWDMS 287
           8**********77664.689*************86 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Belongs to the WD repeat PWP1 family.
 Belongs to the WD repeat PWP1 family.
Protein Sequence
(Fasta)
MNRSRQVTCV AWVRCGVAKE TPDKVELSKE EVKRLIAEAK EKLQEEGGGS DEEETGSPSE 60
DGMQSARTQA RPREPLEDGD PEDDRTLDDD ELAEYDLDKY DEEGDPDAET LGESLLGLTV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046975|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAATGACGT CTGAAATGAG CGCCGACGCT GCCCAAACAG GAGCCTGCGC ATGCGCTCTG 60
CCCTGGCAGC GGCCCTGTGC AGATCCCTGA GCGTGTGGCA GCAGTGCGGT CGTGGTCCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046975|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005794--C:Golgi apparatus
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0034773--P:histone H4-K20 trimethylation
GO:1903262--P:negative regulation of serine phosphorylation of STAT3 protein
GO:2000738--P:positive regulation of stem cell differentiation
GO:0006351--P:transcription, DNA-templated
KEGG hsa:11137
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000884 Aegilops tauschii 35.06 2.00e-57 216.00
IUUC-Aml-001975 Ailuropoda melanoleuca 97.21 0.00e+00 877.00
IUUC-Atr-002719 Amborella trichopoda 36.25 1.00e-53 203.00
IUUC-Apl-004171 Anas platyrhynchos 75.94 3.00e-178 617.00
IUUC-Aca-005184 Anolis carolinensis 72.63 0.00e+00 652.00
IUUC-Aly-005967 Arabidopsis lyrata 34.41 2.00e-61 229.00
IUUC-Ath-006878 Arabidopsis thaliana 35.22 9.00e-54 204.00
IUUC-Ago-007922 Ashbya gossypii 37.33 1.00e-54 207.00
IUUC-Acl-008064 Aspergillus clavatus 36.56 1.00e-79 290.00
IUUC-Afl-008590 Aspergillus flavus 40.82 3.00e-75 276.00
IUUC-Afu-009081 Aspergillus fumigatus 39.22 1.00e-86 314.00
IUUC-Ani-009187 Aspergillus nidulans 38.43 3.00e-81 295.00
IUUC-Aor-010018 Aspergillus oryzae 40.97 1.00e-74 273.00
IUUC-Ate-010542 Aspergillus terreus 42.38 1.00e-57 217.00
IUUC-Ame-011810 Astyanax mexicanus 65.69 0.00e+00 632.00
IUUC-Bgr-012023 Blumeria graminis 35.28 1.00e-69 257.00
IUUC-Bta-012671 Bos taurus 96.81 0.00e+00 884.00
IUUC-Bci-013981 Botrytis cinerea 34.54 5.00e-69 255.00
IUUC-Bdi-014598 Brachypodium distachyon 38.40 5.00e-66 245.00
IUUC-Bol-016451 Brassica oleracea 33.60 8.00e-62 231.00
IUUC-Bra-017210 Brassica rapa 33.73 3.00e-61 229.00
IUUC-Cel-018525 Caenorhabditis elegans 37.13 1.00e-64 241.00
IUUC-Cja-018931 Callithrix jacchus 96.61 0.00e+00 829.00
IUUC-Cfa-020421 Canis familiaris 97.60 0.00e+00 818.00
IUUC-Cpo-022066 Cavia porcellus 90.66 0.00e+00 861.00
IUUC-Cre-022807 Chlamydomonas reinhardtii 41.75 2.00e-75 276.00
IUUC-Csa-024120 Chlorocebus sabaeus 96.81 0.00e+00 861.00
IUUC-Cho-024765 Choloepus hoffmanni 79.87 2.00e-171 595.00
IUUC-Cin-025441 Ciona intestinalis 42.15 2.00e-71 263.00
IUUC-Csv-025867 Ciona savignyi 32.21 3.00e-22 98.20
IUUC-Cgl-026678 Colletotrichum gloeosporioides 39.18 2.00e-70 259.00
IUUC-Cne-026879 Cryptococcus neoformans 32.51 5.00e-58 219.00
IUUC-Cme-027322 Cyanidioschyzon merolae 24.79 2.00e-19 90.10
IUUC-Dre-027584 Danio rerio 68.04 0.00e+00 633.00
IUUC-Dno-029634 Dasypus novemcinctus 95.41 0.00e+00 919.00
IUUC-Dor-030767 Dipodomys ordii 93.92 0.00e+00 750.00
IUUC-Dse-031449 Dothistroma septosporum 34.40 1.00e-73 271.00
IUUC-Dme-032070 Drosophila melanogaster 35.53 3.00e-72 265.00
IUUC-Ete-032857 Echinops telfairi 87.41 2.00e-138 486.00
IUUC-Eca-033871 Equus caballus 91.24 0.00e+00 814.00
IUUC-Eeu-034899 Erinaceus europaeus 92.61 0.00e+00 867.00
IUUC-Fca-036260 Felis catus 97.41 0.00e+00 817.00
IUUC-Fal-036704 Ficedula albicollis 79.62 3.00e-179 621.00
IUUC-Fox-037875 Fusarium oxysporum 45.80 1.00e-46 180.00
IUUC-Fso-038104 Fusarium solani 40.98 4.00e-70 259.00
IUUC-Gmo-038715 Gadus morhua 72.49 4.00e-159 554.00
IUUC-Ggr-040060 Gaeumannomyces graminis 34.53 2.00e-69 256.00
IUUC-Gga-040402 Gallus gallus 72.65 0.00e+00 694.00
IUUC-Gac-042618 Gasterosteus aculeatus 69.25 4.00e-177 614.00
IUUC-Gma-044165 Glycine max 37.60 4.00e-63 235.00
IUUC-Ggo-044778 Gorilla gorilla 88.12 0.00e+00 805.00
IUUC-Hvu-047774 Hordeum vulgare 35.56 8.00e-34 137.00
IUUC-Itr-048829 Ictidomys tridecemlineatus 95.61 0.00e+00 818.00
IUUC-Kpa-049194 Komagataella pastoris 31.83 9.00e-54 204.00
IUUC-Lch-049524 Latimeria chalumnae 63.88 2.00e-165 575.00
IUUC-Lpe-050918 Leersia perrieri 36.45 3.00e-61 229.00
IUUC-Loc-051947 Lepisosteus oculatus 69.67 0.00e+00 664.00
IUUC-Lma-053310 Leptosphaeria maculans 34.78 7.00e-74 271.00
IUUC-Laf-053737 Loxodonta africana 95.41 0.00e+00 885.00
IUUC-Mcc-054770 Macaca mulatta 99.20 0.00e+00 869.00
IUUC-Meu-056892 Macropus eugenii 69.54 6.00e-120 424.00
IUUC-Mor-057110 Magnaporthe oryzae 39.31 8.00e-72 264.00
IUUC-Mpo-057610 Magnaporthe poae 38.52 1.00e-42 167.00
IUUC-Mtr-058677 Medicago truncatula 35.80 1.00e-70 260.00
IUUC-Mla-059056 Melampsora laricipopulina 32.63 9.00e-68 251.00
IUUC-Mga-059434 Meleagris gallopavo 76.41 3.00e-177 614.00
IUUC-Mvi-060307 Microbotryum violaceum 38.05 1.00e-73 271.00
IUUC-Mmr-061729 Microcebus murinus 97.41 0.00e+00 856.00
IUUC-Mdo-062905 Monodelphis domestica 75.31 0.00e+00 711.00
IUUC-Mmu-063191 Mus musculus 88.84 0.00e+00 852.00
IUUC-Mac-064937 Musa acuminata 40.27 1.00e-63 237.00
IUUC-Mpu-066036 Mustela putorius furo 97.41 0.00e+00 837.00
IUUC-Mlu-068240 Myotis lucifugus 94.82 0.00e+00 862.00
IUUC-Nfi-068446 Neosartorya fischeri 38.48 2.00e-81 296.00
IUUC-Ncr-068630 Neurospora crassa 41.76 1.00e-68 254.00
IUUC-Nle-069444 Nomascus leucogenys 100.00 0.00e+00 857.00
IUUC-Opr-070284 Ochotona princeps 87.21 0.00e+00 680.00
IUUC-Ont-071946 Oreochromis niloticus 68.27 3.00e-180 624.00
IUUC-Oan-073312 Ornithorhynchus anatinus 85.48 0.00e+00 666.00
IUUC-Ocu-074548 Oryctolagus cuniculus 95.21 0.00e+00 813.00
IUUC-Oba-075486 Oryza barthii 37.97 4.00e-59 222.00
IUUC-Obr-076759 Oryza brachyantha 39.20 1.00e-63 237.00
IUUC-Ogu-078324 Oryza glumaepatula 36.04 3.00e-50 192.00
IUUC-Oin-079455 Oryza indica 39.65 3.00e-69 256.00
IUUC-Olo-080518 Oryza longistaminata 37.82 3.00e-58 219.00
IUUC-Ome-081585 Oryza meridionalis 36.36 1.00e-54 207.00
IUUC-Oni-082084 Oryza nivara 38.64 8.00e-64 238.00
IUUC-Opu-084114 Oryza punctata 38.64 1.00e-63 237.00
IUUC-Oru-084211 Oryza rufipogon 38.64 8.00e-64 238.00
IUUC-Osa-085974 Oryza sativa 39.65 3.00e-69 256.00
IUUC-Ola-087544 Oryzias latipes 65.58 0.00e+00 630.00
IUUC-Olu-087732 Ostreococcus lucimarinus 37.67 1.00e-62 234.00
IUUC-Oga-088626 Otolemur garnettii 96.01 0.00e+00 858.00
IUUC-Oar-089641 Ovis aries 94.62 0.00e+00 888.00
IUUC-Ptr-091379 Pan troglodytes 100.00 0.00e+00 857.00
IUUC-Pan-092669 Papio anubis 89.88 0.00e+00 799.00
IUUC-Psi-093753 Pelodiscus sinensis 76.83 0.00e+00 656.00
IUUC-Pma-094478 Petromyzon marinus 70.42 3.00e-114 404.00
IUUC-Pno-095033 Phaeosphaeria nodorum 38.76 7.00e-73 268.00
IUUC-Ppa-095650 Physcomitrella patens 39.18 6.00e-76 278.00
IUUC-Pfo-097516 Poecilia formosa 66.60 0.00e+00 630.00
IUUC-Pab-097912 Pongo abelii 94.92 1.00e-122 432.00
IUUC-Pop-099606 Populus trichocarpa 35.85 3.00e-69 255.00
IUUC-Pca-100653 Procavia capensis 86.40 0.00e+00 648.00
IUUC-Ppe-101910 Prunus persica 36.96 1.00e-68 254.00
IUUC-Pva-103106 Pteropus vampyrus 96.21 0.00e+00 839.00
IUUC-Pgr-103382 Puccinia graminis 35.36 6.00e-69 255.00
IUUC-Ptt-103725 Puccinia triticina 36.08 2.00e-31 130.00
IUUC-Pte-104400 Pyrenophora teres 40.16 3.00e-72 266.00
IUUC-Pyt-104707 Pyrenophora triticirepentis 35.74 9.00e-73 267.00
IUUC-Rno-105173 Rattus norvegicus 89.22 0.00e+00 834.00
IUUC-Sce-106279 Saccharomyces cerevisiae 34.22 7.00e-56 211.00
IUUC-Sha-106556 Sarcophilus harrisii 77.39 0.00e+00 714.00
IUUC-Sja-107920 Schizosaccharomyces japonicus 36.14 8.00e-60 224.00
IUUC-Spo-108023 Schizosaccharomyces pombe 35.15 2.00e-65 243.00
IUUC-Ssl-108635 Sclerotinia sclerotiorum 34.82 5.00e-70 258.00
IUUC-Smo-109124 Selaginella moellendorffii 37.89 4.00e-65 241.00
IUUC-Sit-110604 Setaria italica 38.25 6.00e-70 258.00
IUUC-Sly-111400 Solanum lycopersicum 40.25 4.00e-63 235.00
IUUC-Stu-112208 Solanum tuberosum 39.46 1.00e-42 167.00
IUUC-Sar-113458 Sorex araneus 59.72 1.00e-99 356.00
IUUC-Sbi-114069 Sorghum bicolor 37.41 7.00e-68 251.00
IUUC-Sre-115034 Sporisorium reilianum 34.96 3.00e-67 249.00
IUUC-Ssc-115281 Sus scrofa 96.21 0.00e+00 844.00
IUUC-Tgu-117052 Taeniopygia guttata 64.90 2.00e-168 585.00
IUUC-Tru-118113 Takifugu rubripes 69.25 2.00e-180 625.00
IUUC-Tsy-119546 Tarsius syrichta 83.43 0.00e+00 757.00
IUUC-Tni-120562 Tetraodon nigroviridis 68.34 0.00e+00 626.00
IUUC-Tca-121431 Theobroma cacao 38.35 1.00e-76 280.00
IUUC-Tre-122165 Trichoderma reesei 41.38 6.00e-71 261.00
IUUC-Tvi-122282 Trichoderma virens 41.38 9.00e-71 261.00
IUUC-Tae-123805 Triticum aestivum 36.84 7.00e-65 241.00
IUUC-Tur-126252 Triticum urartu 34.24 8.00e-56 211.00
IUUC-Tme-127183 Tuber melanosporum 38.70 5.00e-63 235.00
IUUC-Tbe-128052 Tupaia belangeri 82.63 0.00e+00 656.00
IUUC-Ttr-129310 Tursiops truncatus 91.82 0.00e+00 773.00
IUUC-Uma-129566 Ustilago maydis 33.78 7.00e-60 225.00
IUUC-Vda-129705 Verticillium dahliae 40.91 6.00e-69 255.00
IUUC-Vpa-130511 Vicugna pacos 89.60 0.00e+00 724.00
IUUC-Vvi-131241 Vitis vinifera 38.27 1.00e-63 237.00
IUUC-Xtr-132170 Xenopus tropicalis 69.64 0.00e+00 680.00
IUUC-Xma-133266 Xiphophorus maculatus 66.74 2.00e-179 622.00
IUUC-Yli-134585 Yarrowia lipolytica 35.27 1.00e-65 244.00
IUUC-Zma-135830 Zea mays 38.15 4.00e-69 255.00
Created Date 25-Jun-2017

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