iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-134026

Ensembl Protein ID

ENSXMAP00000008339.1

UniProt Accession

M4A1J5; M4A1J5_XIPMA

Genbank Protein ID

ENSXMAP00000008339

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGAJ01033158

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000008313.1	ENSXMAT00000008350.1	ENSXMAP00000008339.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.70e-130	432.9	437	769

Active Site

Position(s)	Description	Evidence
738	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+v+f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 437  PKDLWKRLMVKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 524
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e+vdp+l++sl +i++n   di+   ld tf+v+++ +ge+ ++eLkp+G++ipV ++Nk+eYv+l+v+
   Q: 525  GFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWILDN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVSQDNKKEYVRLYVN 609
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip++ll++F+e+elel++cG  +id++d+k++t+ k+ +t+d + ++wFw+++e+f++e r+++LqFv
   Q: 610  WRFLRGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIVCGLGKIDINDWKSNTRLKH-CTPDTSIVKWFWKAVESFDEERRARLLQFV 697
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ das+++lP+++TCfn++++P+Y+++++l++kLl+Aieet gF +
   Q: 698  TGSSRVPLQGFKALQgaagPRLFTIHQiDASTNNLPKAHTCFNRIDIPPYETYDKLYDKLLTAIEETCGFAV 769
           **********************************************************************76 PP

Organism

Xiphophorus maculatus

Protein Sequence
(Fasta)

MSNQGVRRNG PVKLRLTVLC AKNLAKKDFF RLPDPFAKVV VDGSGQCHST DTVRNTLDPK 60
WNQHYDLYIG KSDSITISVW NHKKIHKKQG AGFLGCVRLL SNAINRLKDT GYQRLDLNKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCGCACAA AGCGCACAGC GATGCCGGTG TGTGAGTCAC GGTTCAGCGC CACATGTTGG 60
AGAAATGCCT GCCTCTCCCC CAGAGAGTGC TGTCGTCACC GGTCAGCTCG GGAAGCGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	89.97	0.00e+00	1398.00
IUUC-Apl-003513	Anas platyrhynchos	90.99	0.00e+00	1421.00
IUUC-Aca-005358	Anolis carolinensis	90.66	0.00e+00	1440.00
IUUC-Ame-011320	Astyanax mexicanus	89.45	0.00e+00	1434.00
IUUC-Bta-013399	Bos taurus	89.39	0.00e+00	1392.00
IUUC-Cja-019355	Callithrix jacchus	90.12	0.00e+00	1400.00
IUUC-Cpo-022200	Cavia porcellus	90.34	0.00e+00	1401.00
IUUC-Cho-024804	Choloepus hoffmanni	94.17	5.00e-180	624.00
IUUC-Cin-025126	Ciona intestinalis	64.21	0.00e+00	968.00
IUUC-Csv-026339	Ciona savignyi	63.61	0.00e+00	1005.00
IUUC-Dre-027650	Danio rerio	93.90	0.00e+00	1506.00
IUUC-Dno-029534	Dasypus novemcinctus	90.14	0.00e+00	1423.00
IUUC-Dme-031740	Drosophila melanogaster	71.50	5.00e-176	611.00
IUUC-Ete-032715	Echinops telfairi	85.92	0.00e+00	1308.00
IUUC-Eca-033580	Equus caballus	90.34	0.00e+00	1400.00
IUUC-Eeu-034945	Erinaceus europaeus	88.47	0.00e+00	1292.00
IUUC-Fal-037275	Ficedula albicollis	90.17	0.00e+00	1418.00
IUUC-Gmo-039234	Gadus morhua	86.41	0.00e+00	780.00
IUUC-Gga-041060	Gallus gallus	87.42	0.00e+00	1373.00
IUUC-Gac-041295	Gasterosteus aculeatus	94.07	0.00e+00	1486.00
IUUC-Hsa-046726	Homo sapiens	90.40	0.00e+00	1425.00
IUUC-Lch-050026	Latimeria chalumnae	90.27	0.00e+00	1431.00
IUUC-Loc-051760	Lepisosteus oculatus	90.69	0.00e+00	1429.00
IUUC-Laf-053753	Loxodonta africana	90.46	0.00e+00	1398.00
IUUC-Mcc-054815	Macaca mulatta	90.14	0.00e+00	1421.00
IUUC-Meu-056436	Macropus eugenii	69.91	0.00e+00	1040.00
IUUC-Mmr-060806	Microcebus murinus	90.08	0.00e+00	1398.00
IUUC-Mdo-062805	Monodelphis domestica	89.11	0.00e+00	1410.00
IUUC-Mmu-064034	Mus musculus	89.23	0.00e+00	1419.00
IUUC-Mpu-066762	Mustela putorius furo	89.97	0.00e+00	1400.00
IUUC-Mlu-066981	Myotis lucifugus	90.20	0.00e+00	1397.00
IUUC-Nle-069804	Nomascus leucogenys	90.48	0.00e+00	1419.00
IUUC-Opr-070591	Ochotona princeps	84.59	0.00e+00	1298.00
IUUC-Ont-071239	Oreochromis niloticus	94.90	0.00e+00	1513.00
IUUC-Oan-072699	Ornithorhynchus anatinus	90.48	0.00e+00	1437.00
IUUC-Ocu-074913	Oryctolagus cuniculus	90.27	0.00e+00	1424.00
IUUC-Ola-086597	Oryzias latipes	88.33	0.00e+00	1372.00
IUUC-Oga-089116	Otolemur garnettii	87.02	0.00e+00	1340.00
IUUC-Oar-089366	Ovis aries	89.15	0.00e+00	1394.00
IUUC-Ptr-091382	Pan troglodytes	90.40	0.00e+00	1425.00
IUUC-Psi-093298	Pelodiscus sinensis	90.99	0.00e+00	1399.00
IUUC-Pma-094354	Petromyzon marinus	72.10	0.00e+00	1134.00
IUUC-Pfo-096071	Poecilia formosa	99.22	0.00e+00	1575.00
IUUC-Pab-098682	Pongo abelii	90.40	0.00e+00	1425.00
IUUC-Pca-100516	Procavia capensis	85.76	3.00e-178	619.00
IUUC-Pva-102754	Pteropus vampyrus	89.11	0.00e+00	1360.00
IUUC-Rno-105600	Rattus norvegicus	89.07	0.00e+00	1198.00
IUUC-Sha-107144	Sarcophilus harrisii	88.64	0.00e+00	1279.00
IUUC-Sar-113122	Sorex araneus	79.81	0.00e+00	1184.00
IUUC-Tgu-117112	Taeniopygia guttata	90.14	0.00e+00	1436.00
IUUC-Tme-126897	Tuber melanosporum	38.25	6.00e-152	531.00
IUUC-Tbe-127371	Tupaia belangeri	80.08	0.00e+00	1137.00
IUUC-Ttr-129305	Tursiops truncatus	83.19	0.00e+00	1200.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence