iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000011997.1	ENSOART00000013061.1	ENSOARP00000012874.1
ENSOARG00000011997.1	ENSOART00000013074.1	ENSOARP00000012886.1
ENSOARG00000011997.1	ENSOART00000013076.1	ENSOARP00000012888.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.40e-190	634.0	414	881

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Q +++G++ qekl+ +++llvGag++GcEllK ++l+G+     g +tv Dmd+ve+snl+rqFLfr +d+ ++KAevaaea ++l
   Q: 414  YDGQTAVFGADFQEKLSHQHYLLVGAGAVGCELLKGFALMGLgaggsGGVTVADMDHVELSNLSRQFLFRSQDIHRQKAEVAAEATRRL 502
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd..dppq 168
           n d +v++ + ++++++e+i+   Ff+ +d+V++a+d +ear +v+ +c++  +pl+e+gt+G+ G + v+i+++te y+++    +++
   Q: 503  NADLQVTPLNLQLDPTTEHIFgddFFSGVDGVAAAVDTFEARDYVAARCTHFLKPLLEAGTTGTRGSAGVFIPHVTENYKAPSdaASED 591
           ***********************************************************************************777888 PP
   S: 169  ktiPfctlketpnaaehtiewa........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafaktt 249
              P+ct++  p++ eht++wa           +k+++ ++ + +  e l +++k+  ++   +++ +e+++++ +++ +a+ +++ ++
   Q: 592  APDPVCTVRYIPATTEHTVQWAkgefddlfCESAKTINSHPHALSSPEGLVKSQKQPLLQT-MRGVLTERPQTWRDCVLWALGHWQLRF 679
           8889********************9998665556666677776666666665555555554.5888899******************** PP
   S: 250  insikqllksfecdivtkskspfwv................................................sfcsnaealqvpekve 290
           +++i+qll+  ++d+v+++++pfw+                                                ++ ++ + ++ +   +
   Q: 680  HYGITQLLRTYPPDKVQEDGTPFWSgpkqcpqplefdasqdthllyvlaaanlyaqmhrlpgsqdqtalrgllNLLPLPDPQNLDRIFA 768
           **********************************************************9999999999999999999999999998888 PP
   S: 291  kdeevvkasaplylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvg 377
           ++ e  ++++  + l + l++++k ++++p  l+fekd ds  +vd+v aaa+lra++++i+  ++   +k+i+g+iipa+ tt+a+v+
   Q: 769  SELEL-DSPSGCKQLHEDLKTWSKGPSLEP--LTFEKDNDSnfHVDFVVAAASLRAQNYAIPV-ASHAETKRIVGRIIPAVVTTTAAVA 853
           88775.566568*****************9..*******************************.************************* PP
   S: 378  GlaaqEviKvvsg..kfeplknfflfda 403
           Gl+ +E++Kvv g  +  ++++ +l++a
   Q: 854  GLVGLELYKVVGGprPRHAFRHSYLHLA 881
           *************766667888888766 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MDTLETSKSL DKELYSRQLY VLGLPAMRRI QGAKVLLSGL QGLGAEVAKN LVLMGVGSLT 60
LHDPHPTCWS DLAAQFLLSE QDLGRSRAEA SQKLLAELNG AVQVSVYTGD ITEDLLLDFQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATACCC TGGAGACCTC CAAGTCGCTG GATAAGGAGC TATACTCGCG GCAGCTGTGA 60
GGCTCAGGGT GGGGAGGAGA GCAGGGTAGC CTTCTAACCC CTGATTTCCA ATTGCCTGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR000011--UBQ/SUMO-activ_enz_E1-like

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001816	Ailuropoda melanoleuca	75.22	0.00e+00	1405.00
IUUC-Bta-012665	Bos taurus	95.80	0.00e+00	1757.00
IUUC-Cja-019047	Callithrix jacchus	72.92	0.00e+00	1357.00
IUUC-Cfa-021225	Canis familiaris	75.79	0.00e+00	1429.00
IUUC-Cpo-022336	Cavia porcellus	67.16	0.00e+00	1240.00
IUUC-Csa-023462	Chlorocebus sabaeus	76.19	0.00e+00	1373.00
IUUC-Cho-024436	Choloepus hoffmanni	77.64	4.00e-101	362.00
IUUC-Dno-029347	Dasypus novemcinctus	73.02	0.00e+00	1335.00
IUUC-Dor-030997	Dipodomys ordii	68.18	0.00e+00	1239.00
IUUC-Ete-033124	Echinops telfairi	71.13	0.00e+00	912.00
IUUC-Eca-033929	Equus caballus	76.46	0.00e+00	1486.00
IUUC-Eeu-034717	Erinaceus europaeus	66.79	0.00e+00	931.00
IUUC-Fca-036564	Felis catus	76.89	0.00e+00	1422.00
IUUC-Ggo-044480	Gorilla gorilla	76.20	0.00e+00	1369.00
IUUC-Hsa-046498	Homo sapiens	75.99	0.00e+00	1349.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	71.39	0.00e+00	1307.00
IUUC-Laf-054119	Loxodonta africana	73.02	0.00e+00	1393.00
IUUC-Mcc-055597	Macaca mulatta	74.36	0.00e+00	1302.00
IUUC-Meu-056534	Macropus eugenii	51.76	0.00e+00	798.00
IUUC-Mdo-063058	Monodelphis domestica	55.75	0.00e+00	1009.00
IUUC-Mmu-063578	Mus musculus	67.17	0.00e+00	1269.00
IUUC-Mpu-066255	Mustela putorius furo	75.15	0.00e+00	1402.00
IUUC-Mlu-067814	Myotis lucifugus	73.08	0.00e+00	1286.00
IUUC-Nle-069193	Nomascus leucogenys	75.40	0.00e+00	1352.00
IUUC-Opr-070715	Ochotona princeps	66.17	0.00e+00	1198.00
IUUC-Ocu-074162	Oryctolagus cuniculus	71.97	0.00e+00	1312.00
IUUC-Oga-088895	Otolemur garnettii	73.05	0.00e+00	1299.00
IUUC-Ptr-090581	Pan troglodytes	76.33	0.00e+00	1326.00
IUUC-Pan-092458	Papio anubis	76.38	0.00e+00	1367.00
IUUC-Pab-098653	Pongo abelii	71.87	0.00e+00	1288.00
IUUC-Pca-100578	Procavia capensis	66.77	0.00e+00	772.00
IUUC-Pva-102914	Pteropus vampyrus	75.63	0.00e+00	1151.00
IUUC-Rno-106066	Rattus norvegicus	67.64	0.00e+00	1286.00
IUUC-Sha-107368	Sarcophilus harrisii	57.55	0.00e+00	1085.00
IUUC-Ssc-115743	Sus scrofa	79.84	0.00e+00	1496.00
IUUC-Tbe-127587	Tupaia belangeri	76.70	0.00e+00	1050.00
IUUC-Ttr-128422	Tursiops truncatus	80.73	0.00e+00	1425.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence