iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033608

UUCD1 version

UUC-EqC-00430

Ensembl Protein ID

ENSECAP00000014213.1

UniProt Accession

F6X6S1; F6X6S1_HORSE

Protein Name

Uncharacterized protein

Gene Name

KLHL6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000016531.1	ENSECAT00000017485.1	ENSECAP00000014213.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	2.90e-19	69.3	72	135
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	7.30e-11	41.2	171	201

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkl 65
           +Dvil+v+ +ef++h++vLaa+S +F+a+f ++l+e+  ++++ ik+v++e + +ll++ Yt+k+
   Q: 72   TDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKY-EKRIIIKGVDAETMHVLLDYTYTSKA 135
           7***********************************97.***********************987 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           +eNc+gilr+Ad+++++ Lk++++++i+++F
   Q: 171  PENCVGILRLADTHSLDSLKKQVQSYIIQNF 201
           89***************************** PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MLMAGQRGTW TMSDVVEKSL EGPLAPSTDE PSQKRGELVE ILNGDKVKFD DTGLSLILQN 60
GLETLRVENS LTDVILCVDI QEFSCHRVVL AAASNYFRAM FCNDLKEKYE KRIIIKGVDA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACCTGCCTG AAACTTGGGC ACTCCTTCAG TCTGGATGTT GATGGCAGGA CAAAGGGGCA 60
CCTGGACCAT GAGCGATGTG GTAGAGAAGA GTTTGGAAGG GCCTCTGGCA CCTTCTACAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR029851--KLHL6
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0000976--F:transcription regulatory region sequence-specific DNA binding
GO:0050853--P:B cell receptor signaling pathway
GO:0002467--P:germinal center formation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

KEGG

ecb:100058733

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001509	Ailuropoda melanoleuca	97.91	0.00e+00	1274.00
IUUC-Apl-003490	Anas platyrhynchos	85.25	0.00e+00	1113.00
IUUC-Aca-005136	Anolis carolinensis	84.75	0.00e+00	1075.00
IUUC-Ame-010886	Astyanax mexicanus	66.67	0.00e+00	832.00
IUUC-Bta-013473	Bos taurus	97.26	0.00e+00	1239.00
IUUC-Cja-018888	Callithrix jacchus	95.90	0.00e+00	1230.00
IUUC-Cpo-021761	Cavia porcellus	88.18	0.00e+00	1112.00
IUUC-Csa-023206	Chlorocebus sabaeus	96.94	0.00e+00	1263.00
IUUC-Cin-025367	Ciona intestinalis	41.34	5.00e-134	471.00
IUUC-Csv-026076	Ciona savignyi	42.01	4.00e-127	448.00
IUUC-Dre-027948	Danio rerio	73.22	0.00e+00	908.00
IUUC-Dno-030045	Dasypus novemcinctus	96.45	0.00e+00	1254.00
IUUC-Dor-030839	Dipodomys ordii	88.08	0.00e+00	1120.00
IUUC-Ete-033161	Echinops telfairi	93.15	4.00e-160	558.00
IUUC-Eeu-034640	Erinaceus europaeus	94.92	0.00e+00	1217.00
IUUC-Fca-036065	Felis catus	97.10	0.00e+00	1264.00
IUUC-Fal-036949	Ficedula albicollis	86.17	0.00e+00	1101.00
IUUC-Gmo-039661	Gadus morhua	58.12	6.00e-177	613.00
IUUC-Gga-040740	Gallus gallus	84.43	0.00e+00	1104.00
IUUC-Gac-042413	Gasterosteus aculeatus	61.51	0.00e+00	787.00
IUUC-Ggo-045167	Gorilla gorilla	96.94	0.00e+00	1262.00
IUUC-Hsa-046120	Homo sapiens	96.78	0.00e+00	1260.00
IUUC-Itr-047926	Ictidomys tridecemlineatus	96.30	0.00e+00	1253.00
IUUC-Lch-049709	Latimeria chalumnae	79.15	0.00e+00	1040.00
IUUC-Loc-052239	Lepisosteus oculatus	78.03	0.00e+00	981.00
IUUC-Laf-054511	Loxodonta africana	96.07	0.00e+00	1234.00
IUUC-Mcc-055109	Macaca mulatta	96.93	0.00e+00	1259.00
IUUC-Meu-056522	Macropus eugenii	73.95	4.00e-103	368.00
IUUC-Mga-060012	Meleagris gallopavo	82.55	0.00e+00	1075.00
IUUC-Mmr-061364	Microcebus murinus	96.78	0.00e+00	1261.00
IUUC-Mdo-063033	Monodelphis domestica	82.95	0.00e+00	1018.00
IUUC-Mmu-063880	Mus musculus	94.51	0.00e+00	1196.00
IUUC-Mlu-068233	Myotis lucifugus	96.94	0.00e+00	1236.00
IUUC-Opr-070638	Ochotona princeps	95.09	0.00e+00	890.00
IUUC-Ont-071960	Oreochromis niloticus	62.23	0.00e+00	795.00
IUUC-Oan-073406	Ornithorhynchus anatinus	83.93	0.00e+00	1072.00
IUUC-Ocu-074612	Oryctolagus cuniculus	95.97	0.00e+00	1245.00
IUUC-Ola-087181	Oryzias latipes	60.16	0.00e+00	772.00
IUUC-Oga-088955	Otolemur garnettii	96.30	0.00e+00	1253.00
IUUC-Oar-089682	Ovis aries	97.26	0.00e+00	1239.00
IUUC-Ptr-090969	Pan troglodytes	96.62	0.00e+00	1258.00
IUUC-Pan-092289	Papio anubis	96.94	0.00e+00	1263.00
IUUC-Psi-093279	Pelodiscus sinensis	86.02	0.00e+00	1123.00
IUUC-Pab-097957	Pongo abelii	97.15	0.00e+00	930.00
IUUC-Pca-100619	Procavia capensis	92.90	0.00e+00	1222.00
IUUC-Pva-102533	Pteropus vampyrus	97.11	0.00e+00	758.00
IUUC-Rno-106111	Rattus norvegicus	94.51	0.00e+00	1227.00
IUUC-Sha-106716	Sarcophilus harrisii	83.93	0.00e+00	1073.00
IUUC-Tgu-116839	Taeniopygia guttata	84.43	0.00e+00	1102.00
IUUC-Tru-117792	Takifugu rubripes	60.59	0.00e+00	767.00
IUUC-Tsy-119609	Tarsius syrichta	91.75	1.00e-164	572.00
IUUC-Tni-119682	Tetraodon nigroviridis	60.26	0.00e+00	767.00
IUUC-Tme-127039	Tuber melanosporum	31.37	2.00e-12	68.20
IUUC-Tbe-127961	Tupaia belangeri	90.66	0.00e+00	1116.00
IUUC-Ttr-128917	Tursiops truncatus	97.12	0.00e+00	1060.00
IUUC-Vpa-130721	Vicugna pacos	97.87	0.00e+00	866.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence