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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046689
Ensembl Protein ID ENSP00000444029.1
UniProt Accession P49790; B4DIK2; E7EPX5; F6QR24; Q4LE47; Q5T9I7; Q7Z743; NU153_HUMAN
Genbank Protein ID CAA80982.1; BAG58514.1; BAE06106.1; CAI12246.1; CAI12246.1; CAI12246.1; CAI16393.1; CAI16393.1; CAI16393.1; CAI40945.1; CAI40945.1; CAI40945.1; AAH52965.1
Protein Name Nuclear pore complex protein Nup153; 153 kDa nucleoporin; Nucleoporin Nup153
Genbank Nucleotide ID Z25535; AK295644; AB210024; AL138824; AL138724; AL157776; AL157776; AL138724; AL138824; AL138724; AL138824; AL157776; BC052965
Gene Name NUP153
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000124789.11 ENST00000262077.2 ENSP00000262077.2
ENSG00000124789.11 ENST00000613258.4 ENSP00000478627.1
ENSG00000124789.11 ENST00000537253.5 ENSP00000444029.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/ZnF/NZF 4.90e-20 72.4 756 781
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/NZF
   S: 4    qWaCsaCTflNePeavkCemCsrpRg 29
            W+C++C  +N+Pea+kC++C++p++
   Q: 756  TWDCDTCLVQNKPEAIKCVACETPKP 781
           5************************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC).
 Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC).
Protein Sequence
(Fasta)
MASGAGGVGG GGGGKIRTRR CHQGPIKPYQ QGRQQHQGIL SRVTESVKNI VPGWLQRYFN 60
KNEDVCSCST DTSEVPRWPE NKEDHLVYAD EESSNITDGR ITPEPAVSNT EEPSTTSTAS 120
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Protein Fasta Sequence


>IUUC-Hsa-046689|UBD,NZF|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGGCGGGCGC TGTGCGCACA GGGGAGGGGT AGGCGGGCGT CGCCAGCGGC TTCAACTGCG 60
GCAGCTACGG CTAGGGCGAC GGAAGAACTC CCACCAGTCG GCGGTCGAGT TAGGCCTCAG 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-046689|UBD,NZF|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0238--DNA-binding
KW-0325--Glycoprotein
KW-0945--Host-virus interaction
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0479--Metal-binding
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0811--Translocation
KW-0813--Transport
KW-0832--Ubl conjugation
KW-1163--Viral penetration into host nucleus
KW-1160--Virus entry into host cell
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR026054--Nucleoporin
IPR013913--Nup153_N
IPR018892--Retro-transposon_transp_CS
IPR001876--Znf_RanBP2
PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
Pfam

PF08604--Nup153
PF10599--Nup_retrotrp_bd
PF00641--zf-RanBP
SMART

SM00547--ZnF_RBZ
Gene Ontology

GO:0005829--C:cytosol
GO:0042405--C:nuclear inclusion body
GO:0031965--C:nuclear membrane
GO:0034399--C:nuclear periphery
GO:0005643--C:nuclear pore
GO:0044615--C:nuclear pore nuclear basket
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0003677--F:DNA binding
GO:0042802--F:identical protein binding
GO:0008139--F:nuclear localization sequence binding
GO:0005487--F:nucleocytoplasmic transporter activity
GO:0043495--F:protein anchor
GO:0017056--F:structural constituent of nuclear pore
GO:0008270--F:zinc ion binding
GO:0031047--P:gene silencing by RNA
GO:0075733--P:intracellular transport of virus
GO:0007077--P:mitotic nuclear envelope disassembly
GO:0006406--P:mRNA export from nucleus
GO:0046832--P:negative regulation of RNA export from nucleus
GO:0051292--P:nuclear pore complex assembly
GO:0006606--P:protein import into nucleus
GO:0016925--P:protein sumoylation
GO:1900034--P:regulation of cellular response to heat
GO:0010827--P:regulation of glucose transport
GO:0006409--P:tRNA export from nucleus
GO:0046718--P:viral entry into host cell
GO:0075732--P:viral penetration into host nucleus
GO:0016032--P:viral process
GO:0019083--P:viral transcription
KEGG hsa:9972
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001065 Aegilops tauschii 29.03 2.50e+00 27.70
IUUC-Aml-002264 Ailuropoda melanoleuca 79.38 0.00e+00 1052.00
IUUC-Aca-005186 Anolis carolinensis 56.12 0.00e+00 810.00
IUUC-Ate-010393 Aspergillus terreus 27.68 3.00e-04 39.70
IUUC-Ame-011895 Astyanax mexicanus 54.02 6.00e-93 336.00
IUUC-Bta-013564 Bos taurus 81.64 0.00e+00 1838.00
IUUC-Cja-020012 Callithrix jacchus 90.98 0.00e+00 2231.00
IUUC-Cfa-020210 Canis familiaris 83.51 0.00e+00 1805.00
IUUC-Cpo-022504 Cavia porcellus 78.05 0.00e+00 1778.00
IUUC-Csa-023330 Chlorocebus sabaeus 94.22 0.00e+00 2356.00
IUUC-Cho-025048 Choloepus hoffmanni 59.04 0.00e+00 1153.00
IUUC-Cin-025240 Ciona intestinalis 27.81 4.00e-27 117.00
IUUC-Dre-027637 Danio rerio 53.15 8.00e-93 336.00
IUUC-Dno-028993 Dasypus novemcinctus 83.77 0.00e+00 1997.00
IUUC-Dor-030413 Dipodomys ordii 80.39 0.00e+00 962.00
IUUC-Ete-032242 Echinops telfairi 69.77 7.00e-108 385.00
IUUC-Eca-033932 Equus caballus 84.16 0.00e+00 1917.00
IUUC-Eeu-034837 Erinaceus europaeus 78.97 0.00e+00 647.00
IUUC-Fca-036100 Felis catus 78.24 0.00e+00 1875.00
IUUC-Fal-037573 Ficedula albicollis 56.02 0.00e+00 959.00
IUUC-Gmo-038683 Gadus morhua 41.45 6.00e-139 489.00
IUUC-Gga-040987 Gallus gallus 58.22 0.00e+00 1052.00
IUUC-Gac-041456 Gasterosteus aculeatus 44.06 2.00e-145 510.00
IUUC-Ggo-045401 Gorilla gorilla 98.87 0.00e+00 2408.00
IUUC-Itr-048828 Ictidomys tridecemlineatus 84.26 0.00e+00 1964.00
IUUC-Lch-049785 Latimeria chalumnae 42.08 0.00e+00 706.00
IUUC-Loc-052225 Lepisosteus oculatus 49.64 0.00e+00 734.00
IUUC-Laf-053853 Loxodonta africana 82.84 0.00e+00 1871.00
IUUC-Mcc-054790 Macaca mulatta 96.08 0.00e+00 2439.00
IUUC-Meu-056865 Macropus eugenii 77.93 4.00e-153 536.00
IUUC-Mga-059887 Meleagris gallopavo 58.22 0.00e+00 1027.00
IUUC-Mmr-061334 Microcebus murinus 87.73 0.00e+00 2163.00
IUUC-Mdo-062359 Monodelphis domestica 68.54 0.00e+00 1471.00
IUUC-Mmu-064267 Mus musculus 75.67 0.00e+00 1791.00
IUUC-Mpu-066696 Mustela putorius furo 80.28 0.00e+00 1641.00
IUUC-Mlu-067812 Myotis lucifugus 83.99 0.00e+00 1975.00
IUUC-Nfi-068513 Neosartorya fischeri 28.04 2.60e-02 33.50
IUUC-Nle-069960 Nomascus leucogenys 95.22 0.00e+00 2339.00
IUUC-Opr-070987 Ochotona princeps 73.12 0.00e+00 1246.00
IUUC-Ont-072146 Oreochromis niloticus 43.79 1.00e-146 515.00
IUUC-Oan-072713 Ornithorhynchus anatinus 64.65 0.00e+00 1291.00
IUUC-Ocu-074420 Oryctolagus cuniculus 76.32 0.00e+00 1732.00
IUUC-Ola-086355 Oryzias latipes 45.52 8.00e-157 548.00
IUUC-Oga-089122 Otolemur garnettii 86.69 0.00e+00 2151.00
IUUC-Oar-089695 Ovis aries 81.82 0.00e+00 1796.00
IUUC-Ptr-091104 Pan troglodytes 99.20 0.00e+00 2419.00
IUUC-Pan-092205 Papio anubis 92.82 0.00e+00 1454.00
IUUC-Psi-093592 Pelodiscus sinensis 61.90 0.00e+00 1165.00
IUUC-Pma-094617 Petromyzon marinus 34.66 7.00e-91 328.00
IUUC-Pfo-097481 Poecilia formosa 45.16 5.00e-170 592.00
IUUC-Pab-098350 Pongo abelii 91.63 0.00e+00 2194.00
IUUC-Pca-100728 Procavia capensis 76.01 0.00e+00 754.00
IUUC-Pva-102856 Pteropus vampyrus 81.40 0.00e+00 1795.00
IUUC-Rno-105650 Rattus norvegicus 76.99 0.00e+00 1046.00
IUUC-Sha-107464 Sarcophilus harrisii 65.61 0.00e+00 1004.00
IUUC-Sar-113578 Sorex araneus 77.77 0.00e+00 993.00
IUUC-Ssc-115536 Sus scrofa 84.08 0.00e+00 1967.00
IUUC-Tgu-116947 Taeniopygia guttata 56.23 0.00e+00 1041.00
IUUC-Tru-117704 Takifugu rubripes 43.79 4.00e-166 579.00
IUUC-Tsy-119514 Tarsius syrichta 81.55 0.00e+00 1716.00
IUUC-Tni-120354 Tetraodon nigroviridis 49.57 3.00e-101 364.00
IUUC-Tbe-128064 Tupaia belangeri 70.21 0.00e+00 674.00
IUUC-Vpa-130533 Vicugna pacos 84.69 0.00e+00 2008.00
IUUC-Xtr-132016 Xenopus tropicalis 44.79 0.00e+00 909.00
Created Date 25-Jun-2017

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