iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003686

Ensembl Protein ID

ENSAPLP00000013904.1

UniProt Accession

U3J327; U3J327_ANAPL

Genbank Protein ID

ENSAPLP00000013904

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01087484

Gene Name

PRPF19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000014044.1	ENSAPLT00000014671.1	ENSAPLP00000013904.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.80e-21	74.5	218	256
UBD/Beta-Prp	7.30e-43	146.5	187	408

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+ +vt++ f ++  l+ s+s D ti++W++    +++
   Q: 218  GHSKKVTSVVFhPSqELVFSASPDATIRIWSVPNASCVQ 256
           8***********777****************99888876 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgd 107
             d++ ++tg++d+ ++v+d ++++ l++l+gh+++vt+v f+p++++  ++s D+ti++w++ + +cv+++++he sv+ ls++++gd
   Q: 187  PSDTNKILTGGADKNVIVFDKSSEQILATLKGHSKKVTSVVFHPSQELVFSASPDATIRIWSVPNASCVQVVRAHEGSVTGLSLHATGD 275
           568899*********************************************************************************** PP
   S: 108  klvsGshdrtirvwdletgqclee.tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkel 195
           +l+s s+d++    d++tg +l + t++    + +c+++hpdg ++ +G+ D+++++Wdlk  + +  + g h ++++s++f++ng   
   Q: 276  YLLSSSDDQYWAFSDIQTGRVLTKvTDESSGCALTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPG-HSGPITSIAFSENG--- 360
           **********************997777777799************************************9.************87... PP
   S: 196  vsgsldgtvklwdlqtgecvrtlnghtd.nvksvrfspnderlvsgssDgsiri 248
                  +vklwdl++ +  +tl+  ++  vks+ f++ +++l+ g+ D +i+i
   Q: 361  ------XSVKLWDLRKLKNFKTLQLDNNfEVKSLIFDQSGTYLALGGTDVQIYI 408
           ......89*******999999999866527*******************99988 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

PPSATSIPAI LKALQDEWGN GAERACVCVS ERAPSRQDAV MLHSFTLRQQ LQTTRQELSH 60
ALYQHDAACR VIARLTKEVT ASEVTAAREE AEASGLIVPQ TVPSSQPNVA GAGESMDLGE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCCGTCCG CCACCAGCAT CCCGGCCATC CTGAAGGCGC TGCAGGATGA GTGGGTGAGT 60
GGCAGCCCCC GGATGGGAGC GGGGGCCGGT AACGGGGCTG AGCGTGCGTG TGTGTGTGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR013915--Pre-mRNA_splic_Prp19
IPR000772--Ricin_B_lectin
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50231--RICIN_B_LECTIN
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08606--Prp19
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005737--C:cytoplasm
GO:0005662--C:DNA replication factor A complex
GO:0005811--C:lipid particle
GO:0016020--C:membrane
GO:0016607--C:nuclear speck
GO:0000974--C:Prp19 complex
GO:0035861--C:site of double-strand break
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0034613--P:cellular protein localization
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0008610--P:lipid biosynthetic process
GO:0045665--P:negative regulation of neuron differentiation
GO:0048711--P:positive regulation of astrocyte differentiation
GO:0048026--P:positive regulation of mRNA splicing, via spliceosome
GO:0010498--P:proteasomal protein catabolic process
GO:0070534--P:protein K63-linked ubiquitination
GO:0072422--P:signal transduction involved in DNA damage checkpoint
GO:0000245--P:spliceosomal complex assembly
GO:0000244--P:spliceosomal tri-snRNP complex assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000488	Aegilops tauschii	39.34	5.00e-80	292.00
IUUC-Aml-001230	Ailuropoda melanoleuca	84.42	0.00e+00	693.00
IUUC-Atr-002594	Amborella trichopoda	42.66	4.00e-90	325.00
IUUC-Aca-005272	Anolis carolinensis	87.15	0.00e+00	729.00
IUUC-Aly-005586	Arabidopsis lyrata	41.78	3.00e-87	315.00
IUUC-Ath-007693	Arabidopsis thaliana	41.46	9.00e-85	306.00
IUUC-Acl-008335	Aspergillus clavatus	32.18	1.00e-44	174.00
IUUC-Afl-008527	Aspergillus flavus	33.56	2.00e-43	169.00
IUUC-Afu-008957	Aspergillus fumigatus	33.56	1.00e-47	183.00
IUUC-Ani-009280	Aspergillus nidulans	33.87	1.00e-35	143.00
IUUC-Ang-009746	Aspergillus niger	31.71	3.00e-36	145.00
IUUC-Aor-009905	Aspergillus oryzae	33.33	5.00e-47	181.00
IUUC-Ate-010412	Aspergillus terreus	32.64	7.00e-34	137.00
IUUC-Ame-011561	Astyanax mexicanus	71.94	2.00e-61	228.00
IUUC-Bgr-012283	Blumeria graminis	29.26	3.00e-33	135.00
IUUC-Bta-013242	Bos taurus	88.08	0.00e+00	734.00
IUUC-Bci-013901	Botrytis cinerea	31.16	2.00e-38	152.00
IUUC-Bdi-014277	Brachypodium distachyon	42.13	8.00e-92	330.00
IUUC-Bol-016207	Brassica oleracea	42.73	3.00e-85	308.00
IUUC-Bra-017902	Brassica rapa	41.78	2.00e-86	312.00
IUUC-Cel-018271	Caenorhabditis elegans	47.31	3.00e-108	385.00
IUUC-Cja-019879	Callithrix jacchus	87.62	0.00e+00	730.00
IUUC-Cfa-020175	Canis familiaris	88.08	0.00e+00	734.00
IUUC-Cpo-022379	Cavia porcellus	87.85	0.00e+00	732.00
IUUC-Cre-022993	Chlamydomonas reinhardtii	37.35	2.00e-67	249.00
IUUC-Csa-023500	Chlorocebus sabaeus	87.85	0.00e+00	732.00
IUUC-Cho-025065	Choloepus hoffmanni	71.91	2.00e-93	335.00
IUUC-Cin-025699	Ciona intestinalis	60.55	2.00e-139	488.00
IUUC-Csv-026128	Ciona savignyi	57.72	4.00e-147	514.00
IUUC-Cgl-026507	Colletotrichum gloeosporioides	29.77	2.00e-36	146.00
IUUC-Cne-026860	Cryptococcus neoformans	32.35	7.00e-61	227.00
IUUC-Dre-028187	Danio rerio	73.54	3.00e-177	614.00
IUUC-Dno-029453	Dasypus novemcinctus	87.62	0.00e+00	730.00
IUUC-Dor-030150	Dipodomys ordii	91.21	3.00e-117	415.00
IUUC-Dse-031220	Dothistroma septosporum	27.65	5.00e-30	125.00
IUUC-Dme-031906	Drosophila melanogaster	60.42	1.00e-143	502.00
IUUC-Ete-033035	Echinops telfairi	73.13	9.00e-167	579.00
IUUC-Eca-033478	Equus caballus	88.08	0.00e+00	733.00
IUUC-Eeu-034974	Erinaceus europaeus	94.61	1.00e-167	582.00
IUUC-Fca-036194	Felis catus	88.08	0.00e+00	734.00
IUUC-Fal-037417	Ficedula albicollis	89.49	0.00e+00	744.00
IUUC-Fox-037922	Fusarium oxysporum	31.88	9.00e-39	154.00
IUUC-Fso-038256	Fusarium solani	30.25	3.00e-39	155.00
IUUC-Gmo-038713	Gadus morhua	75.64	0.00e+00	635.00
IUUC-Ggr-039854	Gaeumannomyces graminis	29.48	1.00e-32	134.00
IUUC-Gga-041143	Gallus gallus	90.19	0.00e+00	748.00
IUUC-Gac-042129	Gasterosteus aculeatus	77.80	0.00e+00	657.00
IUUC-Gma-044273	Glycine max	42.44	1.00e-87	317.00
IUUC-Ggo-045262	Gorilla gorilla	87.85	0.00e+00	732.00
IUUC-Hsa-046036	Homo sapiens	87.85	0.00e+00	732.00
IUUC-Hvu-047442	Hordeum vulgare	41.13	9.00e-49	186.00
IUUC-Itr-048169	Ictidomys tridecemlineatus	87.62	0.00e+00	695.00
IUUC-Lch-050105	Latimeria chalumnae	80.37	0.00e+00	683.00
IUUC-Lpe-050976	Leersia perrieri	42.92	3.00e-89	322.00
IUUC-Loc-052042	Lepisosteus oculatus	65.60	7.00e-146	509.00
IUUC-Lma-053143	Leptosphaeria maculans	31.95	2.00e-41	164.00
IUUC-Laf-053451	Loxodonta africana	88.08	0.00e+00	735.00
IUUC-Mcc-055786	Macaca mulatta	87.85	0.00e+00	732.00
IUUC-Meu-056161	Macropus eugenii	96.68	7.00e-139	486.00
IUUC-Mor-057215	Magnaporthe oryzae	28.95	1.00e-28	120.00
IUUC-Mpo-057419	Magnaporthe poae	28.34	4.00e-30	125.00
IUUC-Mtr-057756	Medicago truncatula	42.96	2.00e-86	312.00
IUUC-Mla-059085	Melampsora laricipopulina	35.82	8.00e-62	231.00
IUUC-Mga-060158	Meleagris gallopavo	90.19	0.00e+00	749.00
IUUC-Mvi-060441	Microbotryum violaceum	33.03	2.00e-48	186.00
IUUC-Mmr-061085	Microcebus murinus	87.85	0.00e+00	732.00
IUUC-Mdo-061804	Monodelphis domestica	88.08	0.00e+00	734.00
IUUC-Mmu-063608	Mus musculus	88.55	0.00e+00	739.00
IUUC-Mac-064754	Musa acuminata	42.22	2.00e-80	293.00
IUUC-Mpu-065700	Mustela putorius furo	88.08	0.00e+00	734.00
IUUC-Mlu-068223	Myotis lucifugus	88.32	0.00e+00	737.00
IUUC-Nfi-068504	Neosartorya fischeri	32.87	4.00e-47	181.00
IUUC-Ncr-068729	Neurospora crassa	32.72	6.00e-37	148.00
IUUC-Nle-069754	Nomascus leucogenys	87.85	0.00e+00	732.00
IUUC-Opr-070621	Ochotona princeps	87.85	0.00e+00	733.00
IUUC-Ont-071377	Oreochromis niloticus	74.71	0.00e+00	630.00
IUUC-Oan-073498	Ornithorhynchus anatinus	92.86	3.00e-96	344.00
IUUC-Ocu-074182	Oryctolagus cuniculus	88.60	0.00e+00	740.00
IUUC-Oba-075509	Oryza barthii	42.59	1.00e-90	327.00
IUUC-Obr-076480	Oryza brachyantha	42.99	3.00e-91	328.00
IUUC-Ogl-077052	Oryza glaberrima	42.59	1.00e-90	327.00
IUUC-Ogu-078919	Oryza glumaepatula	42.59	1.00e-90	327.00
IUUC-Oin-079357	Oryza indica	41.71	1.00e-83	303.00
IUUC-Olo-080376	Oryza longistaminata	42.82	7.00e-91	327.00
IUUC-Ome-081973	Oryza meridionalis	42.59	8.00e-91	327.00
IUUC-Oni-082849	Oryza nivara	42.82	3.00e-91	328.00
IUUC-Opu-083243	Oryza punctata	42.59	2.00e-90	326.00
IUUC-Oru-084613	Oryza rufipogon	42.92	1.00e-90	327.00
IUUC-Osa-085407	Oryza sativa	42.59	1.00e-90	327.00
IUUC-Ola-086566	Oryzias latipes	74.19	2.00e-180	624.00
IUUC-Olu-087757	Ostreococcus lucimarinus	36.82	3.00e-69	255.00
IUUC-Oga-089010	Otolemur garnettii	83.37	0.00e+00	689.00
IUUC-Oar-089638	Ovis aries	88.08	0.00e+00	734.00
IUUC-Ptr-091141	Pan troglodytes	87.85	0.00e+00	732.00
IUUC-Pan-092662	Papio anubis	87.85	0.00e+00	732.00
IUUC-Psi-093777	Pelodiscus sinensis	91.75	0.00e+00	703.00
IUUC-Pno-095115	Phaeosphaeria nodorum	32.26	8.00e-42	164.00
IUUC-Ppa-095841	Physcomitrella patens	42.18	2.00e-88	319.00
IUUC-Pfo-096390	Poecilia formosa	75.18	0.00e+00	633.00
IUUC-Pab-098250	Pongo abelii	87.85	0.00e+00	730.00
IUUC-Pop-099854	Populus trichocarpa	43.50	6.00e-88	317.00
IUUC-Pca-100553	Procavia capensis	87.15	0.00e+00	723.00
IUUC-Ppe-101383	Prunus persica	40.88	1.00e-79	290.00
IUUC-Pva-102189	Pteropus vampyrus	88.32	0.00e+00	735.00
IUUC-Pgr-103304	Puccinia graminis	33.26	6.00e-60	224.00
IUUC-Ptt-103984	Puccinia triticina	34.52	7.00e-62	231.00
IUUC-Pte-104385	Pyrenophora teres	29.63	2.00e-44	173.00
IUUC-Pyt-104697	Pyrenophora triticirepentis	30.00	1.00e-45	176.00
IUUC-Rno-105581	Rattus norvegicus	87.62	0.00e+00	731.00
IUUC-Sha-107071	Sarcophilus harrisii	88.86	0.00e+00	746.00
IUUC-Spo-108315	Schizosaccharomyces pombe	25.43	3.00e-19	89.40
IUUC-Ssl-108628	Sclerotinia sclerotiorum	31.23	3.00e-39	155.00
IUUC-Smo-109648	Selaginella moellendorffii	41.27	1.00e-88	320.00
IUUC-Sit-109873	Setaria italica	41.98	7.00e-89	321.00
IUUC-Sly-111673	Solanum lycopersicum	42.14	8.00e-83	300.00
IUUC-Stu-112125	Solanum tuberosum	41.91	6.00e-82	297.00
IUUC-Sbi-114696	Sorghum bicolor	40.23	4.00e-78	285.00
IUUC-Sre-115134	Sporisorium reilianum	27.29	5.00e-43	168.00
IUUC-Ssc-116260	Sus scrofa	88.08	0.00e+00	734.00
IUUC-Tgu-116533	Taeniopygia guttata	89.49	0.00e+00	745.00
IUUC-Tru-117800	Takifugu rubripes	76.17	0.00e+00	650.00
IUUC-Tsy-118980	Tarsius syrichta	91.05	0.00e+00	705.00
IUUC-Tni-120334	Tetraodon nigroviridis	80.46	5.00e-151	526.00
IUUC-Tca-121807	Theobroma cacao	41.36	2.00e-88	318.00
IUUC-Tre-121920	Trichoderma reesei	30.02	9.00e-41	160.00
IUUC-Tvi-122294	Trichoderma virens	29.65	3.00e-37	149.00
IUUC-Tae-125713	Triticum aestivum	43.06	2.00e-93	336.00
IUUC-Tur-126664	Triticum urartu	38.43	7.00e-86	311.00
IUUC-Tme-127026	Tuber melanosporum	29.95	1.00e-40	160.00
IUUC-Tbe-127582	Tupaia belangeri	94.28	1.00e-166	579.00
IUUC-Ttr-128313	Tursiops truncatus	87.85	0.00e+00	726.00
IUUC-Uma-129626	Ustilago maydis	29.19	9.00e-44	171.00
IUUC-Vda-129699	Verticillium dahliae	32.26	5.00e-43	168.00
IUUC-Vpa-130593	Vicugna pacos	87.05	0.00e+00	702.00
IUUC-Vvi-131668	Vitis vinifera	41.50	2.00e-87	316.00
IUUC-Xtr-132186	Xenopus tropicalis	77.47	2.00e-171	595.00
IUUC-Xma-133212	Xiphophorus maculatus	75.18	0.00e+00	632.00
IUUC-Zma-135662	Zea mays	43.16	1.00e-91	330.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence