iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106967

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01232402

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000007608.1	ENSSHAT00000008859.1	ENSSHAP00000008786.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.70e-199	662.7	336	816

Active Site

Position(s)	Description	Evidence
517	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Q++++G++ qekl+++k++lvGag++GcEllKn++++G+     g++ v+Dmdt+e+snlnrqFLfr++dv k K+++aa+a++++
   Q: 336  YDGQVAVFGSHLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLgcgdgGEVIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQM 424
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqkt 170
           np+++v++h++++ +++e+i+   Ff+ +d+V +aldn++ar++++r+c+++r+pl+esgtlG++G+v+v+i+ lte+ys+s+dpp+k+
   Q: 425  NPQMHVTSHQNRVGPDTERIYdddFFQALDGVTNALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKS 513
           ***************************************************************************************** PP
   S: 171  iPfctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafak 247
           iP+ctlk++pna+eht++wa            + +n++l ++++++e++ +l+ ++++e++++v+++l+ ++++++++++++a+ +++ 
   Q: 514  IPICTLKNFPNAIEHTLQWArdefeglfkqpaESVNQYL-TDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPRTWADCVAWACLHWHA 601
           ***************************************.999999******************************************* PP
   S: 248  ttinsikqllksfecdivtkskspfwv......................................................sfcsnaea 282
           ++ n+i+qll++f+++++t+s++pfw+                                                      +     + 
   Q: 602  QYANNIRQLLHNFPPEQLTSSGAPFWSgpkrcphpltfdvqnplhldyimaaanlfaqsyglvgsrdrtavatliqtvhvpE----FTP 686
           *****************************************************************99997777777744442....333 PP
   S: 283  lqvpekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagn 364
           ++  + +++d+e ++a+ +     l+ l+++l + ek  g k++ ++fekddd   ++d++ aa+nlrae+++i+p +d+++ k iag+
   Q: 687  KSGVKIHVSDQELQSANTSvddsrLEELKATLPSPEKLAGFKMYPIDFEKDDDNnfHMDFIVAASNLRAENYDIPP-ADRHKSKLIAGK 774
           334455555555555555566667****************************************************.************ PP
   S: 365  iipaiattnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           iipaiatt+a+v Gl+++E++Kvv+g  + e++kn fl++a+
   Q: 775  IIPAIATTTAAVVGLVCLELYKVVQGhqRLEAYKNGFLNLAL 816
           **************************988999******9875 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

FYLREEDVGK NRAEVSQPRL AELNAYVPVC SYTGPLTEDF LSNFQVVVLT NSPLEEQLRV 60
GEFCHGHGIK LVVADTRGLF GQLFCDFGEE MILTDANGEQ PLSAMVSMVT KDSPGVVTCL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCCCCCAA TCCCTTCTTC CAATAAGGAA TAAGGAAGTT ATTCATCCTT TCCCTTCTTC 60
CAAACCTTAG TTCTACCTTC GAGAAGAAGA CGTGGGCAAG AACCGGGCAG AGGTTTCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

Gene Ontology

GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0006464--P:cellular protein modification process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cho-024896	Choloepus hoffmanni	74.90	2.00e-101	363.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence