iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091234

UUCD1 version

UUC-PaT-01064

Ensembl Protein ID

ENSPTRP00000025898.4

UniProt Accession

H2QMR4; H2QMR4_PANTR

Genbank Protein ID

JAA11237.1; JAA13014.1; JAA29602.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AACZ03025697; GABF01009131; GABD01003498

Gene Name

BAP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000014997.4	ENSPTRT00000028073.4	ENSPTRP00000025898.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	4.30e-170	565.7	3	729

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 6    kewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqv 94
           k+wleLesdPglftllvedfgvk++ qvee+y+L++++    q+pv+g+++lFk++e+r+s+rk++++++d++v+d+di++++ffa+q+
   Q: 3    KGWLELESDPGLFTLLVEDFGVKGV-QVEEIYDLQSKC----QGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQL 86
           89***********************.************....*********************************************** PP
   S: 95   igNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           i+NsCat+Allsvllnc+++  dlG+tlsr+k++tk++spe+k++a+gn+++l+++hns+ar+e+r++pe+q+++++++t+eafhfvsy
   Q: 87   IPNSCATHALLSVLLNCSNV--DLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSY 173
           ******************99..******************************************************************* PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesde....irfnllaivadrrviktlrlnvlkid......... 259
           v+i+grl+eldglk++P+d+g+++e+ee++dk+++v+  +eri+l++++e    irfnl+a+v+drr+++++rl+vlk++         
   Q: 174  VPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVI--MERIGLATAGEpyhdIRFNLMAVVPDRRIKYEARLHVLKVNrqtvlealq 260
           *************************************..************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 261  qlirvtqpeliqthksqesqlpeesksasnksplvleanrapaasegnhtdgaeeaagscaqapshsppnkpklvvkppgsslngvppn 349
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 350  ptpivqrlpafldnhnyakspmqeeedlaagvgrsrvpvrppqqysddeddyeddeeddvqntnsalrykgkgtgkpgalsgsadgqls 438
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 439  vlqpntinvlaeklkesqkdlsiplsiktssgagspavavpthsqpsptpsnestdtaseigsafnsplrspirsanptrpsspvtshi 527
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 528  skvlfgeddsllrvdcirynravrdlgpvistgllhlaedgvlsplalteggkgsspsirpiqgsqgssspvekevveatdsrektgmv 616
           ***************************************************************************************** PP
   S: 260  .............keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefgvn 335
                        keLl+Llk++e+e++++ea+l++e+ekrkkfkidd+rRt+nydefic+fi++la+eg+l++lve++is++r++gv+
   Q: 617  rpgeplsgekyspKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVS 705
           ***************************************************************************************** PP
   S: 336  egrlakqrkqgrekkirplkrkrk 359
           +grl+kqrk++r+k++rp+k+kr+
   Q: 706  IGRLHKQRKPDRRKRSRPYKAKRQ 729
           **********************97 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF KWIEERRSRR 60
KVSTLVDDTS VIDDDIVNNM FFAHQLIPNS CATHALLSVL LNCSNVDLGP TLSRMKDFTK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCGTTGTC TGTGTGTGGG ACTGAGGGGC CCCGGGGGCG GTGGGGGCTC CCGGTGGGGG 60
CAGCGGTGGG GCTGGAGGGC CTGGACATGG CGCTGAGGGG CCGCCCCGCG GGAAGATGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0035517--C:PR-DUB complex
GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0061519--P:macrophage homeostasis
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0051726--P:regulation of cell cycle
GO:0001558--P:regulation of cell growth
GO:1900015--P:regulation of cytokine production involved in inflammatory response
GO:0010035--P:response to inorganic substance
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ptr:460426

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001263	Ailuropoda melanoleuca	93.61	0.00e+00	1208.00
IUUC-Apl-003405	Anas platyrhynchos	69.79	0.00e+00	635.00
IUUC-Aca-004836	Anolis carolinensis	79.53	0.00e+00	1136.00
IUUC-Ame-011946	Astyanax mexicanus	63.32	0.00e+00	887.00
IUUC-Bta-013131	Bos taurus	91.40	0.00e+00	1078.00
IUUC-Cja-019599	Callithrix jacchus	97.81	0.00e+00	1365.00
IUUC-Cfa-021003	Canis familiaris	96.02	0.00e+00	1218.00
IUUC-Cpo-022143	Cavia porcellus	95.75	0.00e+00	1313.00
IUUC-Csa-023477	Chlorocebus sabaeus	98.63	0.00e+00	1345.00
IUUC-Cho-024734	Choloepus hoffmanni	83.40	0.00e+00	781.00
IUUC-Csv-025842	Ciona savignyi	58.95	6.00e-94	337.00
IUUC-Dre-027793	Danio rerio	64.90	0.00e+00	905.00
IUUC-Dno-029253	Dasypus novemcinctus	95.29	0.00e+00	1308.00
IUUC-Dor-030891	Dipodomys ordii	88.89	0.00e+00	1219.00
IUUC-Dme-031796	Drosophila melanogaster	61.19	1.00e-92	333.00
IUUC-Ete-032646	Echinops telfairi	85.71	6.00e-174	603.00
IUUC-Eca-033805	Equus caballus	95.06	0.00e+00	1265.00
IUUC-Eeu-035216	Erinaceus europaeus	93.54	2.00e-152	532.00
IUUC-Fca-035611	Felis catus	95.68	0.00e+00	1163.00
IUUC-Fal-037186	Ficedula albicollis	80.34	0.00e+00	992.00
IUUC-Gmo-038824	Gadus morhua	69.79	0.00e+00	633.00
IUUC-Gga-040875	Gallus gallus	81.92	0.00e+00	1122.00
IUUC-Gac-042226	Gasterosteus aculeatus	68.11	0.00e+00	936.00
IUUC-Ggo-045122	Gorilla gorilla	99.59	0.00e+00	1394.00
IUUC-Hsa-045882	Homo sapiens	99.73	0.00e+00	1394.00
IUUC-Itr-048185	Ictidomys tridecemlineatus	97.26	0.00e+00	1332.00
IUUC-Lch-049960	Latimeria chalumnae	72.55	0.00e+00	1008.00
IUUC-Loc-052408	Lepisosteus oculatus	75.11	0.00e+00	656.00
IUUC-Laf-054187	Loxodonta africana	96.30	0.00e+00	1271.00
IUUC-Mcc-055273	Macaca mulatta	97.67	0.00e+00	1341.00
IUUC-Meu-056267	Macropus eugenii	82.72	0.00e+00	1171.00
IUUC-Mga-059958	Meleagris gallopavo	87.58	1.00e-153	535.00
IUUC-Mmr-061280	Microcebus murinus	96.85	0.00e+00	1303.00
IUUC-Mdo-062625	Monodelphis domestica	89.44	0.00e+00	1280.00
IUUC-Mmu-063853	Mus musculus	93.00	0.00e+00	1276.00
IUUC-Mlu-067771	Myotis lucifugus	94.38	0.00e+00	1241.00
IUUC-Opr-070741	Ochotona princeps	93.69	0.00e+00	1290.00
IUUC-Ont-072172	Oreochromis niloticus	66.97	0.00e+00	947.00
IUUC-Oan-073167	Ornithorhynchus anatinus	80.66	0.00e+00	1150.00
IUUC-Ocu-074176	Oryctolagus cuniculus	95.19	0.00e+00	1243.00
IUUC-Ola-087203	Oryzias latipes	85.23	3.00e-135	474.00
IUUC-Oga-089153	Otolemur garnettii	96.26	0.00e+00	1314.00
IUUC-Oar-090008	Ovis aries	92.18	0.00e+00	1239.00
IUUC-Pan-092005	Papio anubis	98.63	0.00e+00	1369.00
IUUC-Psi-093995	Pelodiscus sinensis	83.68	0.00e+00	657.00
IUUC-Pma-094110	Petromyzon marinus	48.84	2.00e-119	422.00
IUUC-Pfo-097418	Poecilia formosa	66.05	0.00e+00	935.00
IUUC-Pab-098267	Pongo abelii	99.59	0.00e+00	1367.00
IUUC-Pca-101084	Procavia capensis	94.31	0.00e+00	1219.00
IUUC-Pva-102292	Pteropus vampyrus	95.53	0.00e+00	902.00
IUUC-Rno-105251	Rattus norvegicus	91.64	0.00e+00	1251.00
IUUC-Sha-107100	Sarcophilus harrisii	88.06	0.00e+00	1273.00
IUUC-Sar-113559	Sorex araneus	87.35	0.00e+00	1076.00
IUUC-Ssc-115688	Sus scrofa	94.65	0.00e+00	1297.00
IUUC-Tgu-117424	Taeniopygia guttata	80.85	0.00e+00	1120.00
IUUC-Tru-118585	Takifugu rubripes	66.49	0.00e+00	932.00
IUUC-Tsy-119299	Tarsius syrichta	85.02	0.00e+00	996.00
IUUC-Tni-120808	Tetraodon nigroviridis	66.17	0.00e+00	926.00
IUUC-Tbe-127705	Tupaia belangeri	95.70	0.00e+00	639.00
IUUC-Ttr-128225	Tursiops truncatus	94.79	0.00e+00	1248.00
IUUC-Vpa-130193	Vicugna pacos	94.58	7.00e-131	461.00
IUUC-Xtr-132449	Xenopus tropicalis	71.41	0.00e+00	948.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence