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Tag Content
UUCD2 ID IUUC-Ocu-074620
UUCD1 version UUC-OrC-01024
Ensembl Protein ID ENSOCUP00000012707.2
UniProt Accession G1T835; G1T835_RABIT
Genbank Protein ID ENSOCUP00000012707
Protein Name Ubiquitinyl hydrolase 1
Genbank Nucleotide ID AAGW02025072
Gene Name USP3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOCUG00000014775.3 ENSOCUT00000014775.3 ENSOCUP00000012707.2
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 2.50e-100 336.0 159 509
UBD/ZnF/ZnF_UBP 4.70e-27 94.1 27 104
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             +++ + +++ +++ +l+++++k + +lw+++++a+sp++l+ +++
   Q: 159  TGLRNLGNTCFMNAILQSLSNIEQFCCYFKElpavelrngktAGRRTYHTRSQGDTSVSLVEEFRKTLCALWQGSQTAFSPESLFYVIW 247
           7******************************888888777775555555556688999******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l+ el+   n    ++  ++ +++ + +++   +  +++++ +F+g l++++ cl c+++s +++
   Q: 248  KIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAVLQE-NSTLSASSKCCVNGASTVVTAIFGGILQNEVNCLICGTESRKFD 335
           *****************************664444444444444.3444445788889999**************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         sl+dcL+sft  eel++ + y c kckkkq+++kk++++klP+vL+lhLkRf+++   + r+
   Q: 336  PFLDLSLDIPSQFRSKRSknqengpvcSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTA--YLRN 422
           **********77655555678899999****************************************************7755..799* PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           k++++vefpl+ Ld++ ++ +pe+++ e++ Y+L avvvH+G +++sGHY+ay+ + +g+W++f+Ds+Vt ++ee+v +   ++aY+lf
   Q: 423  KVDTYVEFPLRgLDMKCYLLEPENSDPENCLYDLAAVVVHHGsGVGSGHYTAYATH-EGRWFHFNDSTVTLTDEETVGK---AKAYILF 507
           ********************************************************.9*********************...******* PP
   S: 335  Yk 336
           Y 
   Q: 508  YV 509
           *6 PP
   

   UBD/ZnF/ZnF_UBP
   S: 1    kkcsvcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhpl................vlslstlsvycYacddyvhr 62
           ++csvc++++++W+cLtc+sv+CGRyv+gHa+kHye++q pl                ++++s++s+ycY+cdd+v++
   Q: 27   WCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQIPLtnhkksekqekiqhtvCMDCSSYSTYCYRCDDFVVN 104
           9***************************************************************************85 PP
   
Organism Oryctolagus cuniculus
Protein Sequence
(Fasta)
MECPHLSSSV CIAPDSAKFP NGSPSSWCCS VCRSNKSPWV CLTCSSVHCG RYVNGHAKKH 60
YEDAQIPLTN HKKSEKQEKI QHTVCMDCSS YSTYCYRCDD FVVNDTKLGL VQKVREHLQN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ocu-074620|DUB,USP;UBD,ZnF_UBP|Oryctolagus cuniculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGAGTGTC CGCACCTCAG CTCCAGCGTC TGCATCGCTC CGGACTCAGC CAAGTTTCCC 60
AACGGGTCCC CGTCGTCCTG GTGCTGCAGC GGTGAGTGCG GCCCCGGCCC GGCCCGGCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ocu-074620|DUB,USP;UBD,ZnF_UBP|Oryctolagus cuniculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
SMART

SM00290--ZnF_UBP
Gene Ontology

GO:0070938--C:contractile ring
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016578--P:histone deubiquitination
GO:0000278--P:mitotic cell cycle
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG ocu:100345783
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001537 Ailuropoda melanoleuca 96.35 0.00e+00 942.00
IUUC-Apl-003358 Anas platyrhynchos 94.08 0.00e+00 887.00
IUUC-Aca-004454 Anolis carolinensis 91.60 0.00e+00 825.00
IUUC-Ame-011544 Astyanax mexicanus 77.37 0.00e+00 741.00
IUUC-Bta-012738 Bos taurus 95.97 0.00e+00 919.00
IUUC-Cel-018186 Caenorhabditis elegans 37.05 4.00e-55 209.00
IUUC-Cja-018893 Callithrix jacchus 95.96 0.00e+00 935.00
IUUC-Cfa-020607 Canis familiaris 96.54 0.00e+00 925.00
IUUC-Cpo-021828 Cavia porcellus 94.81 0.00e+00 910.00
IUUC-Csa-023884 Chlorocebus sabaeus 96.47 0.00e+00 764.00
IUUC-Cho-024863 Choloepus hoffmanni 85.96 0.00e+00 796.00
IUUC-Dre-028452 Danio rerio 75.05 0.00e+00 757.00
IUUC-Dno-029531 Dasypus novemcinctus 94.90 0.00e+00 852.00
IUUC-Dor-030913 Dipodomys ordii 88.02 2.00e-175 608.00
IUUC-Ete-032611 Echinops telfairi 89.62 0.00e+00 864.00
IUUC-Eca-033622 Equus caballus 96.12 0.00e+00 859.00
IUUC-Eeu-035268 Erinaceus europaeus 91.62 0.00e+00 790.00
IUUC-Fca-035801 Felis catus 95.10 0.00e+00 886.00
IUUC-Fal-036749 Ficedula albicollis 93.48 0.00e+00 845.00
IUUC-Gmo-039598 Gadus morhua 77.10 0.00e+00 773.00
IUUC-Gga-040883 Gallus gallus 94.29 0.00e+00 852.00
IUUC-Gac-042235 Gasterosteus aculeatus 76.39 0.00e+00 746.00
IUUC-Ggo-044767 Gorilla gorilla 91.04 0.00e+00 831.00
IUUC-Hsa-046581 Homo sapiens 96.54 0.00e+00 965.00
IUUC-Itr-047898 Ictidomys tridecemlineatus 96.73 0.00e+00 927.00
IUUC-Lch-049732 Latimeria chalumnae 89.23 0.00e+00 903.00
IUUC-Loc-052371 Lepisosteus oculatus 88.65 0.00e+00 896.00
IUUC-Laf-054565 Loxodonta africana 95.96 0.00e+00 922.00
IUUC-Mcc-055522 Macaca mulatta 96.35 0.00e+00 961.00
IUUC-Meu-056754 Macropus eugenii 84.66 2.00e-175 608.00
IUUC-Mga-060095 Meleagris gallopavo 93.47 0.00e+00 635.00
IUUC-Mmr-060839 Microcebus murinus 96.73 0.00e+00 927.00
IUUC-Mdo-062339 Monodelphis domestica 95.63 0.00e+00 744.00
IUUC-Mmu-063638 Mus musculus 96.15 0.00e+00 904.00
IUUC-Mpu-066647 Mustela putorius furo 96.32 0.00e+00 747.00
IUUC-Mlu-067921 Myotis lucifugus 94.69 0.00e+00 873.00
IUUC-Nle-069752 Nomascus leucogenys 96.73 0.00e+00 963.00
IUUC-Opr-070636 Ochotona princeps 83.65 0.00e+00 744.00
IUUC-Ont-071638 Oreochromis niloticus 76.63 0.00e+00 696.00
IUUC-Oan-073417 Ornithorhynchus anatinus 88.65 0.00e+00 877.00
IUUC-Ola-087281 Oryzias latipes 78.57 2.00e-180 624.00
IUUC-Olu-087697 Ostreococcus lucimarinus 39.16 5.00e-48 184.00
IUUC-Oga-088448 Otolemur garnettii 96.15 0.00e+00 957.00
IUUC-Oar-090132 Ovis aries 95.77 0.00e+00 923.00
IUUC-Ptr-090696 Pan troglodytes 96.33 0.00e+00 901.00
IUUC-Pan-092124 Papio anubis 95.96 0.00e+00 956.00
IUUC-Psi-093801 Pelodiscus sinensis 93.79 0.00e+00 732.00
IUUC-Pma-094472 Petromyzon marinus 71.49 3.00e-94 337.00
IUUC-Pfo-096330 Poecilia formosa 79.34 0.00e+00 779.00
IUUC-Pab-098191 Pongo abelii 96.54 0.00e+00 962.00
IUUC-Pca-100341 Procavia capensis 94.30 0.00e+00 714.00
IUUC-Pva-103177 Pteropus vampyrus 95.58 0.00e+00 909.00
IUUC-Rno-105048 Rattus norvegicus 94.83 0.00e+00 889.00
IUUC-Sha-107429 Sarcophilus harrisii 94.77 0.00e+00 858.00
IUUC-Sar-113024 Sorex araneus 94.88 0.00e+00 802.00
IUUC-Ssc-115749 Sus scrofa 93.95 5.00e-149 520.00
IUUC-Tgu-117277 Taeniopygia guttata 93.67 0.00e+00 882.00
IUUC-Tru-117844 Takifugu rubripes 78.50 0.00e+00 775.00
IUUC-Tsy-119456 Tarsius syrichta 94.07 0.00e+00 856.00
IUUC-Tni-120251 Tetraodon nigroviridis 74.90 0.00e+00 792.00
IUUC-Tbe-127423 Tupaia belangeri 90.96 0.00e+00 845.00
IUUC-Ttr-128401 Tursiops truncatus 89.16 0.00e+00 776.00
IUUC-Vpa-130549 Vicugna pacos 86.23 2.00e-161 561.00
IUUC-Xtr-131892 Xenopus tropicalis 81.85 0.00e+00 790.00
Created Date 25-Jun-2017

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