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Tag Content
UUCD2 ID IUUC-Cfa-020264
UUCD1 version UUC-CaF-01030
Ensembl Protein ID ENSCAFP00000014406.3
UniProt Accession E2RIB3; E2RIB3_CANLF
Genbank Protein ID ENSCAFP00000014406
Protein Name Uncharacterized protein
Genbank Nucleotide ID AAEX03001616
Gene Name CYLD
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCAFG00000009802.3 ENSCAFT00000015568.3 ENSCAFP00000014406.3
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.80e-24 86.9 590 946
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           G++ + N+CY++S+L cL++++++ + +l + kek +   ++e+++ l +++ + ++     + +k ++ r++l+++++++    ++e+
   Q: 590  GIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRPKEKNDVGYYSETQELLRTEIVNPLRIYGyVCATKIMKLRKILEKVEAASGF--TSEE 676
           999***************************889998888889999999999*99999887899**************988875..899* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksq.ik...clecdnvs.sreepfldls 173
           +D +Efl++l++q+ +       k ++  ++ +++   ++  ek++k +  +i++l+++++ ++ +k    ++c  ++  r+ + ++l 
   Q: 677  KDPEEFLNILFHQILRVE--PLLKIRSAGQKVQDCYFYQIFMEKNEKVGVPTIQQLLEWSFINSnLKfaeAPSCLIIQmPRFGKDFKLF 763
           ****************99..88999999999999**************************9854144444799****99********** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenk.yycekckkkqeaekklklkklPe....vLilhLkRfsfseeqksrekinkkvefpl 257
            ++  + e    +++d+Le+  ++++++g  + y+c++c+++ + +    +k++++      +lh kR   +       +  + v++p+
   Q: 764  KKIFPSLEL---NITDLLEDTPRQCRICGGLAmYECRECYDDPDISAG-NIKQFCKtcntQVHLHPKRL--N-------HKYNPVSLPK 839
           ****99998...***************987655********9985554.66666663334688999999..2.......3356788886 PP
   S: 258  eL...dlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk..WllfdD.............skVtevke.eevleetg 327
            L   d ++ c+        ++k eL+av++ +      HYva+vk  k++  Wl fd               +Vt+++e  e l+++ 
   Q: 840  DLpdwDWRHGCIP-------CQKMELFAVLCIET----SHYVAFVKYGKDDsaWLFFDSmadrdggqngfniPQVTPCPEvGEYLKMSP 917
           6511144444554.......9**********999....9********777778****99999999999999988888876577777666 PP
   S: 328  ...................staYvlfYkr 337
                              ++aY+++Y++
   Q: 918  edlhsldsrriqgcarrllCDAYMCMYQS 946
           8888888999999999***********85 PP
   
Organism Canis familiaris
Protein Sequence
(Fasta)
MSSGLWSQEK VTSPYWEERI FYLLLQECSV TDKQTQKLLK VPKGSIGQYI QDRSVGHSRI 60
PSAKGKKNQI GLKILEQPHA VLFVDEKDVV EINEKFTELL LAITNCEERF SLFKNKNRLS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cfa-020264|DUB,USP|Canis familiaris
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCCGGGGCGG TTCGGAGGCG GGGCAGGTGG GGGCGGGCCC AGGTAGCAGG TTCGGTTGCG 60
CCGCGGCCGC GCGTCGGAGG TAAATATTAA GGCGGTGGGT GTGGGGCGCT GGGGCCGGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cfa-020264|DUB,USP|Canis familiaris
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00845--CAP_GLY_1
PS50245--CAP_GLY_2
PS00972--USP_1
PS50235--USP_3
Pfam

PF01302--CAP_GLY
PF00443--UCH
SMART

SM01052--CAP_GLY
Gene Ontology

GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0097542--C:ciliary tip
GO:0005881--C:cytoplasmic microtubule
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0030496--C:midbody
GO:0005819--C:spindle
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043369--P:CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0048872--P:homeostasis of number of cells
GO:0045087--P:innate immune response
GO:0070266--P:necroptotic process
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045581--P:negative regulation of T cell differentiation
GO:1903829--P:positive regulation of cellular protein localization
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0045582--P:positive regulation of T cell differentiation
GO:0050862--P:positive regulation of T cell receptor signaling pathway
GO:1990108--P:protein linear deubiquitination
GO:0045577--P:regulation of B cell differentiation
GO:1902017--P:regulation of cilium assembly
GO:2001242--P:regulation of intrinsic apoptotic signaling pathway
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:0007346--P:regulation of mitotic cell cycle
GO:0043393--P:regulation of protein binding
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:1901026--P:ripoptosome assembly involved in necroptotic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001298 Ailuropoda melanoleuca 98.95 0.00e+00 1955.00
IUUC-Apl-003356 Anas platyrhynchos 87.42 0.00e+00 1692.00
IUUC-Aca-004402 Anolis carolinensis 81.04 0.00e+00 1517.00
IUUC-Ame-011581 Astyanax mexicanus 67.49 0.00e+00 1236.00
IUUC-Bta-012359 Bos taurus 97.27 0.00e+00 1917.00
IUUC-Cel-018528 Caenorhabditis elegans 34.11 7.00e-56 213.00
IUUC-Cja-018797 Callithrix jacchus 96.03 0.00e+00 1899.00
IUUC-Cpo-022057 Cavia porcellus 96.55 0.00e+00 1918.00
IUUC-Csa-023093 Chlorocebus sabaeus 97.06 0.00e+00 1913.00
IUUC-Cho-024486 Choloepus hoffmanni 82.85 1.00e-178 620.00
IUUC-Cin-025179 Ciona intestinalis 43.48 3.00e-115 408.00
IUUC-Dre-028233 Danio rerio 67.11 0.00e+00 1260.00
IUUC-Dno-029496 Dasypus novemcinctus 96.96 0.00e+00 1919.00
IUUC-Dor-030919 Dipodomys ordii 90.17 0.00e+00 1758.00
IUUC-Dme-032159 Drosophila melanogaster 46.64 1.00e-124 440.00
IUUC-Ete-032734 Echinops telfairi 90.69 0.00e+00 1777.00
IUUC-Eca-033350 Equus caballus 98.11 0.00e+00 1940.00
IUUC-Eeu-034566 Erinaceus europaeus 97.85 1.00e-113 404.00
IUUC-Fca-035632 Felis catus 98.67 0.00e+00 1367.00
IUUC-Fal-037313 Ficedula albicollis 82.60 0.00e+00 1581.00
IUUC-Gmo-039239 Gadus morhua 67.26 0.00e+00 1215.00
IUUC-Gga-040668 Gallus gallus 87.63 0.00e+00 1694.00
IUUC-Gac-042630 Gasterosteus aculeatus 67.53 0.00e+00 1203.00
IUUC-Ggo-044462 Gorilla gorilla 96.86 0.00e+00 1912.00
IUUC-Hsa-045846 Homo sapiens 96.86 0.00e+00 1912.00
IUUC-Itr-048894 Ictidomys tridecemlineatus 95.82 0.00e+00 855.00
IUUC-Lch-050303 Latimeria chalumnae 70.64 0.00e+00 1305.00
IUUC-Loc-052190 Lepisosteus oculatus 69.72 0.00e+00 1286.00
IUUC-Laf-054480 Loxodonta africana 91.73 0.00e+00 752.00
IUUC-Mcc-055849 Macaca mulatta 96.76 0.00e+00 1910.00
IUUC-Meu-056755 Macropus eugenii 83.33 0.00e+00 890.00
IUUC-Mga-059561 Meleagris gallopavo 87.25 0.00e+00 1686.00
IUUC-Mmr-060942 Microcebus murinus 97.07 0.00e+00 1906.00
IUUC-Mdo-062618 Monodelphis domestica 92.78 0.00e+00 1846.00
IUUC-Mmu-063843 Mus musculus 94.77 0.00e+00 1826.00
IUUC-Mpu-066919 Mustela putorius furo 99.27 0.00e+00 1959.00
IUUC-Mlu-066983 Myotis lucifugus 91.40 0.00e+00 1793.00
IUUC-Nle-069893 Nomascus leucogenys 96.97 0.00e+00 1914.00
IUUC-Opr-071181 Ochotona princeps 88.38 0.00e+00 1607.00
IUUC-Ont-071697 Oreochromis niloticus 66.80 0.00e+00 1199.00
IUUC-Oan-073658 Ornithorhynchus anatinus 90.98 0.00e+00 1788.00
IUUC-Ocu-074954 Oryctolagus cuniculus 97.07 0.00e+00 1920.00
IUUC-Ola-086523 Oryzias latipes 65.92 0.00e+00 1188.00
IUUC-Oga-089003 Otolemur garnettii 97.18 0.00e+00 1927.00
IUUC-Oar-090376 Ovis aries 96.88 0.00e+00 1920.00
IUUC-Ptr-090520 Pan troglodytes 95.19 0.00e+00 1865.00
IUUC-Pan-092281 Papio anubis 97.06 0.00e+00 1913.00
IUUC-Psi-093047 Pelodiscus sinensis 88.59 0.00e+00 1614.00
IUUC-Pma-094575 Petromyzon marinus 55.50 2.00e-66 245.00
IUUC-Pfo-096358 Poecilia formosa 66.32 0.00e+00 1148.00
IUUC-Pab-097740 Pongo abelii 96.65 0.00e+00 1907.00
IUUC-Pca-100461 Procavia capensis 86.26 0.00e+00 1525.00
IUUC-Pva-102134 Pteropus vampyrus 86.92 0.00e+00 1692.00
IUUC-Rno-105807 Rattus norvegicus 93.28 0.00e+00 1793.00
IUUC-Sha-107236 Sarcophilus harrisii 93.59 0.00e+00 1802.00
IUUC-Sar-113366 Sorex araneus 97.78 0.00e+00 930.00
IUUC-Tgu-117201 Taeniopygia guttata 84.52 0.00e+00 1622.00
IUUC-Tru-117953 Takifugu rubripes 67.64 0.00e+00 1198.00
IUUC-Tsy-119610 Tarsius syrichta 94.98 0.00e+00 1874.00
IUUC-Tni-120743 Tetraodon nigroviridis 40.49 1.00e-164 573.00
IUUC-Tbe-128155 Tupaia belangeri 79.77 0.00e+00 764.00
IUUC-Ttr-128942 Tursiops truncatus 92.36 0.00e+00 1805.00
IUUC-Vpa-130281 Vicugna pacos 86.72 0.00e+00 1662.00
IUUC-Xtr-132627 Xenopus tropicalis 76.76 0.00e+00 1413.00
Created Date 25-Jun-2017

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