iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	17765686

Classification

Family	E-value	Score	Start	End
DUB/USP	2.70e-27	95.9	276	632

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeqqDaqEflaf 98
           G++ + N+CY++++L +++ ++++ + +l + +   + +n++e ++ l +++ + +++ +  +++++++ rell++l++++    + e++D +Efl+ 
   Q: 276  GIQGHHNSCYLDATLFSMFTFTSVFDSILYRRPGPQDIRNYSEVQKVLRDEIVNPLRKNVfVRSDRVMKLRELLDQLSSVSGL--TCEEKDPEEFLNS 371
           99****************************99999999999**************999988********************98..9************ PP
   S: 99   lldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksq.ik...clecdnvs.sreepfldlslpvpgkeetkkeslqdcL 191
           ll+q+ +        p  ++++ ++s   +   ek++k +   +++lF+ +++s+ ik   +++c  ++  r+ +++++   +  ++     +++d++
   Q: 372  LLSQIMRVE------PFLKLSSGQDSYFYQLFVEKDEKLTLPSVQQLFEQSFHSSdIKlkeVPSCFIIQmPRFGKNYKMYPRILPSQVL---DVTDII 460
           *******99......99***********************************954255444789999999*****************88...****** PP
   S: 192  esftkeeelegenk.yycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls.pfctspeekqkekkkY.eLiavvvH 286
           e+  ++++l+g+ + y+c+ c ++ +a   l+++ +++     Lk f  +++ k+ ++++kk++ p+e+++  ++++        ++ Y eL+avv+ 
   Q: 461  ENSPRQCSLCGKLAeYECRDCFGSLQAGSGLECTAFCPK---CLKTF--HSHIKRTNHVSKKIYSPKEFKIMaEHMVV-------PRLYmELFAVVCI 546
           ***********9878********************9984...56767..55556778999999999997765157777.......55565*******9 PP
   S: 287  sGslssGHYvayvknekgk...WllfdD.............skVtevke.eevleetg......................staYvlfYkr 337
           +      HYva+vk+ +g    W+ fd               ++t v+e +++l+e+g                      ++aY+++Y++
   Q: 547  ET----SHYVAFVKSGSGPdapWCFFDSmadrkgeqngyniPEITCVPElTQWLSEEGarsinetstndkvlpehakrifCDAYMCLYQS 632
           99....9********7777788*****9999999999999978888876678888777888888889999999999************96 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MNSKSDYEAE KEKKLTITNR FGDSLENYEL SNESEHKTHV YPKKIPNRKN GILKNTDANH 60
SAVDNQHLED VDLADILGTN WPKRAGPAAM ILNNKSKTDP SNSVDLILKP ASPILKIEPE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCAGAATTC ATTCCAATCG CATTCTAAAA GACACAAATT TTATAAATAC TAAACAAAAA 60
TCCAGGATAT AAACACCTTT TTATTTGTTA GTTCAATTTA TGTGTGTTTG TATTAAAACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR028889--USP_dom

PROSITE

PS50235--USP_3

Pfam

PF01302--CAP_GLY
PF00443--UCH

SMART

SM01052--CAP_GLY

Gene Ontology

GO:0005829--C:cytosol
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0055090--P:acylglycerol homeostasis
GO:0042742--P:defense response to bacterium
GO:0008340--P:determination of adult lifespan
GO:0016579--P:protein deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:1990108--P:protein linear deubiquitination
GO:0045088--P:regulation of innate immune response
GO:0006979--P:response to oxidative stress
GO:0031098--P:stress-activated protein kinase signaling cascade

KEGG

dme:Dmel_CG5603

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001298	Ailuropoda melanoleuca	46.44	2.00e-124	439.00
IUUC-Apl-003356	Anas platyrhynchos	46.34	1.00e-124	440.00
IUUC-Aca-004402	Anolis carolinensis	45.06	4.00e-120	425.00
IUUC-Ani-009301	Aspergillus nidulans	32.39	2.00e-03	35.80
IUUC-Ame-011581	Astyanax mexicanus	44.95	5.00e-111	395.00
IUUC-Bta-012359	Bos taurus	46.34	2.00e-124	439.00
IUUC-Cel-018528	Caenorhabditis elegans	36.29	4.00e-61	229.00
IUUC-Cja-018797	Callithrix jacchus	45.87	7.00e-126	444.00
IUUC-Cfa-020264	Canis familiaris	46.64	8.00e-125	440.00
IUUC-Cpo-022057	Cavia porcellus	46.44	5.00e-124	438.00
IUUC-Csa-023093	Chlorocebus sabaeus	45.68	6.00e-125	441.00
IUUC-Cho-024486	Choloepus hoffmanni	44.98	5.00e-72	265.00
IUUC-Cin-025179	Ciona intestinalis	48.06	7.00e-130	456.00
IUUC-Dre-028233	Danio rerio	45.97	5.00e-119	421.00
IUUC-Dno-029496	Dasypus novemcinctus	46.34	4.00e-124	438.00
IUUC-Dor-030919	Dipodomys ordii	46.72	9.00e-124	437.00
IUUC-Dse-031190	Dothistroma septosporum	28.28	8.00e-04	38.90
IUUC-Ete-032734	Echinops telfairi	42.97	8.00e-107	380.00
IUUC-Eca-033350	Equus caballus	46.34	2.00e-124	439.00
IUUC-Eeu-034566	Erinaceus europaeus	45.55	9.00e-43	168.00
IUUC-Fca-035632	Felis catus	42.86	1.00e-42	167.00
IUUC-Fal-037313	Ficedula albicollis	46.14	4.00e-124	438.00
IUUC-Gmo-039239	Gadus morhua	45.70	2.00e-114	405.00
IUUC-Gga-040668	Gallus gallus	46.14	1.00e-124	440.00
IUUC-Gac-042630	Gasterosteus aculeatus	45.96	1.00e-114	407.00
IUUC-Ggo-044462	Gorilla gorilla	45.68	6.00e-125	441.00
IUUC-Hsa-045846	Homo sapiens	45.68	7.00e-125	441.00
IUUC-Itr-048894	Ictidomys tridecemlineatus	45.12	2.00e-52	198.00
IUUC-Lch-049660	Latimeria chalumnae	43.56	3.00e-99	355.00
IUUC-Loc-052190	Lepisosteus oculatus	44.55	5.00e-116	411.00
IUUC-Laf-054480	Loxodonta africana	47.53	2.00e-94	339.00
IUUC-Mcc-055849	Macaca mulatta	45.68	6.00e-125	441.00
IUUC-Meu-056755	Macropus eugenii	55.41	4.00e-22	99.40
IUUC-Mla-058845	Melampsora laricipopulina	36.00	5.00e-04	37.40
IUUC-Mga-059561	Meleagris gallopavo	46.06	2.00e-123	436.00
IUUC-Mmr-060942	Microcebus murinus	46.34	2.00e-124	439.00
IUUC-Mdo-062618	Monodelphis domestica	45.45	1.00e-123	437.00
IUUC-Mmu-063843	Mus musculus	45.94	6.00e-123	434.00
IUUC-Mpu-066919	Mustela putorius furo	46.44	2.00e-124	439.00
IUUC-Mlu-066983	Myotis lucifugus	46.44	1.00e-123	436.00
IUUC-Nle-069893	Nomascus leucogenys	45.68	6.00e-125	441.00
IUUC-Opr-071181	Ochotona princeps	41.82	4.00e-86	311.00
IUUC-Ont-071697	Oreochromis niloticus	45.96	2.00e-114	406.00
IUUC-Oan-073658	Ornithorhynchus anatinus	46.14	8.00e-124	437.00
IUUC-Ocu-074954	Oryctolagus cuniculus	46.34	2.00e-124	439.00
IUUC-Osa-085438	Oryza sativa	34.15	5.20e-02	31.20
IUUC-Ola-086523	Oryzias latipes	45.96	3.00e-113	402.00
IUUC-Oga-089003	Otolemur garnettii	46.34	9.00e-125	440.00
IUUC-Oar-090376	Ovis aries	46.34	1.00e-124	440.00
IUUC-Ptr-090520	Pan troglodytes	44.04	7.00e-117	414.00
IUUC-Pan-092281	Papio anubis	45.68	6.00e-125	441.00
IUUC-Psi-093047	Pelodiscus sinensis	46.14	1.00e-123	436.00
IUUC-Pma-094575	Petromyzon marinus	42.86	6.00e-47	179.00
IUUC-Pfo-096358	Poecilia formosa	46.15	2.00e-112	399.00
IUUC-Pab-097740	Pongo abelii	45.68	7.00e-125	441.00
IUUC-Pop-100035	Populus trichocarpa	33.33	2.00e-02	33.90
IUUC-Pca-100461	Procavia capensis	40.23	8.00e-81	294.00
IUUC-Pva-102134	Pteropus vampyrus	42.72	1.00e-106	380.00
IUUC-Ptt-103760	Puccinia triticina	23.37	3.00e-03	36.60
IUUC-Rno-105807	Rattus norvegicus	45.74	5.00e-123	434.00
IUUC-Sha-107236	Sarcophilus harrisii	46.62	1.00e-117	417.00
IUUC-Sit-110232	Setaria italica	30.00	1.30e-01	32.00
IUUC-Sly-110902	Solanum lycopersicum	26.12	1.80e-02	34.30
IUUC-Stu-112312	Solanum tuberosum	25.37	5.00e-02	32.70
IUUC-Sar-113366	Sorex araneus	46.46	2.00e-114	405.00
IUUC-Tgu-117201	Taeniopygia guttata	43.44	9.00e-107	380.00
IUUC-Tru-117953	Takifugu rubripes	46.14	7.00e-114	404.00
IUUC-Tsy-119610	Tarsius syrichta	45.15	2.00e-118	419.00
IUUC-Tni-120743	Tetraodon nigroviridis	38.90	4.00e-85	308.00
IUUC-Tbe-128155	Tupaia belangeri	38.69	2.00e-49	189.00
IUUC-Ttr-128942	Tursiops truncatus	48.81	1.00e-68	254.00
IUUC-Vpa-130281	Vicugna pacos	43.75	1.00e-78	287.00
IUUC-Xtr-132627	Xenopus tropicalis	43.28	4.00e-98	352.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence