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Tag Content
UUCD2 ID IUUC-Ggo-044462
UUCD1 version UUC-GoG-01144
Ensembl Protein ID ENSGGOP00000024034.1
UniProt Accession G3S7H6; G3S7H6_GORGO
Protein Name Uncharacterized protein
Gene Name CYLD
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSGGOG00000008448.2 ENSGGOT00000031947.1 ENSGGOP00000024034.1
ENSGGOG00000008448.2 ENSGGOT00000008490.2 ENSGGOP00000008261.2
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.50e-24 87.2 593 949
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           G++ + N+CY++S+L cL++++++ + +l + kek + e ++e+++ l +++ + ++     + +k ++ r++l+++++++    ++e+
   Q: 593  GIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGyVCATKIMKLRKILEKVEAASGF--TSEE 679
           999***************************99999999999999999999****999887899**************988875..899* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksq.ik...clecdnvs.sreepfldls 173
           +D +Efl++l++++ +       k ++  ++ +++   ++  ek++k +  +i++l+++++ ++ +k    ++c  ++  r+ + ++l 
   Q: 680  KDPEEFLNILFHHILRVE--PLLKIRSAGQKVQDCYFYQIFMEKNEKVGVPTIQQLLEWSFINSnLKfaeAPSCLIIQmPRFGKDFKLF 766
           ****************99..88999999999999**************************9854144444799****99********** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenk.yycekckkkqeaekklklkklPe....vLilhLkRfsfseeqksrekinkkvefpl 257
            ++  + e    +++d+Le+  ++++++g  + y+c++c+++ + +   k+k++++      +lh kR   +       +  + v++p+
   Q: 767  KKIFPSLEL---NITDLLEDTPRQCRICGGLAmYECRECYDDPDISAG-KIKQFCKtcntQVHLHPKRL--N-------HKYNPVSLPK 842
           ****99998...***************987655********9984433.55555553334688999999..2.......3356788886 PP
   S: 258  eL...dlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk..WllfdD.............skVtevke.eevleetg 327
            L   d ++ c+        +++ eL+av++ +      HYva+vk  k++  Wl fd               +Vt+++e  e l+++ 
   Q: 843  DLpdwDWRHGCIP-------CQNMELFAVLCIET----SHYVAFVKYGKDDsaWLFFDSmadrdggqngfniPQVTPCPEvGEYLKMSL 920
           6511144444554.......99*********999....9********777788*****9999*******99999999976678888776 PP
   S: 328  ...................staYvlfYkr 337
                              ++aY+++Y++
   Q: 921  edlhsldsrriqgcarrllCDAYMCMYQS 949
           899999999999999************85 PP
   
Organism Gorilla gorilla
Protein Sequence
(Fasta)
MSSGLWSQEK VTSPYWEERI FYLLLQECSV TDKQTQKLLK VPKGSIGQYI QDRSVGHSRI 60
PSAKGKKNQI GLKILEQPHA VLFVDEKDVV EINEKFTELL LAITNCEERF SLFKNRNRLS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ggo-044462|DUB,USP|Gorilla gorilla
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGCGGTTCG GAGGCGGGGC AGGTGGGGGC GGGCCCAGGT AGCAGGTTTG GCTGCGCGGG 60
GGCCGCGCGT CGGAGGTAAA TACTAGGGCG GTGGGTGTGG GGAGCCGGGG CCGGCCCGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ggo-044462|DUB,USP|Gorilla gorilla
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00845--CAP_GLY_1
PS50245--CAP_GLY_2
PS00972--USP_1
PS50235--USP_3
Pfam

PF01302--CAP_GLY
PF00443--UCH
SMART

SM01052--CAP_GLY
Gene Ontology

GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0097542--C:ciliary tip
GO:0005881--C:cytoplasmic microtubule
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0030496--C:midbody
GO:0005819--C:spindle
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043369--P:CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0048872--P:homeostasis of number of cells
GO:0045087--P:innate immune response
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045581--P:negative regulation of T cell differentiation
GO:1903829--P:positive regulation of cellular protein localization
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0045582--P:positive regulation of T cell differentiation
GO:0050862--P:positive regulation of T cell receptor signaling pathway
GO:1990108--P:protein linear deubiquitination
GO:0045577--P:regulation of B cell differentiation
GO:1902017--P:regulation of cilium assembly
GO:2001242--P:regulation of intrinsic apoptotic signaling pathway
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:0007346--P:regulation of mitotic cell cycle
GO:0043393--P:regulation of protein binding
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:1901026--P:ripoptosome assembly involved in necroptotic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001298 Ailuropoda melanoleuca 97.07 0.00e+00 1925.00
IUUC-Apl-003356 Anas platyrhynchos 87.25 0.00e+00 1693.00
IUUC-Aca-004402 Anolis carolinensis 80.89 0.00e+00 1518.00
IUUC-Ame-011581 Astyanax mexicanus 67.85 0.00e+00 1225.00
IUUC-Bta-012359 Bos taurus 96.55 0.00e+00 1898.00
IUUC-Cel-018528 Caenorhabditis elegans 34.72 3.00e-55 211.00
IUUC-Cja-018797 Callithrix jacchus 98.85 0.00e+00 1962.00
IUUC-Cfa-020264 Canis familiaris 96.86 0.00e+00 1912.00
IUUC-Cpo-022057 Cavia porcellus 96.23 0.00e+00 1907.00
IUUC-Csa-023093 Chlorocebus sabaeus 99.16 0.00e+00 1957.00
IUUC-Cho-024486 Choloepus hoffmanni 83.38 2.00e-180 625.00
IUUC-Cin-025179 Ciona intestinalis 43.89 9.00e-116 410.00
IUUC-Dre-028233 Danio rerio 67.25 0.00e+00 1260.00
IUUC-Dno-029496 Dasypus novemcinctus 95.82 0.00e+00 1894.00
IUUC-Dor-030919 Dipodomys ordii 90.38 0.00e+00 1763.00
IUUC-Dme-032159 Drosophila melanogaster 45.68 9.00e-125 440.00
IUUC-Ete-032734 Echinops telfairi 90.06 0.00e+00 1771.00
IUUC-Eca-033350 Equus caballus 96.76 0.00e+00 1912.00
IUUC-Eeu-034566 Erinaceus europaeus 98.39 1.00e-114 407.00
IUUC-Fca-035632 Felis catus 95.74 0.00e+00 1331.00
IUUC-Fal-037313 Ficedula albicollis 82.24 0.00e+00 1575.00
IUUC-Gmo-039239 Gadus morhua 67.15 0.00e+00 1205.00
IUUC-Gga-040668 Gallus gallus 87.57 0.00e+00 1694.00
IUUC-Gac-042630 Gasterosteus aculeatus 67.43 0.00e+00 1196.00
IUUC-Hsa-045846 Homo sapiens 99.90 0.00e+00 1975.00
IUUC-Itr-048894 Ictidomys tridecemlineatus 93.55 0.00e+00 836.00
IUUC-Lch-050303 Latimeria chalumnae 70.64 0.00e+00 1312.00
IUUC-Loc-052190 Lepisosteus oculatus 69.71 0.00e+00 1276.00
IUUC-Laf-054480 Loxodonta africana 92.48 0.00e+00 761.00
IUUC-Mcc-055849 Macaca mulatta 99.37 0.00e+00 1967.00
IUUC-Meu-056755 Macropus eugenii 82.96 0.00e+00 882.00
IUUC-Mga-059561 Meleagris gallopavo 87.08 0.00e+00 1683.00
IUUC-Mmr-060942 Microcebus murinus 97.38 0.00e+00 1911.00
IUUC-Mdo-062618 Monodelphis domestica 92.89 0.00e+00 1853.00
IUUC-Mmu-063843 Mus musculus 94.67 0.00e+00 1826.00
IUUC-Mpu-066919 Mustela putorius furo 96.76 0.00e+00 1914.00
IUUC-Mlu-066983 Myotis lucifugus 90.27 0.00e+00 1766.00
IUUC-Nle-069893 Nomascus leucogenys 99.90 0.00e+00 1977.00
IUUC-Opr-071181 Ochotona princeps 87.60 0.00e+00 1594.00
IUUC-Ont-071697 Oreochromis niloticus 66.60 0.00e+00 1188.00
IUUC-Oan-073658 Ornithorhynchus anatinus 90.59 0.00e+00 1783.00
IUUC-Ocu-074954 Oryctolagus cuniculus 96.65 0.00e+00 1910.00
IUUC-Ola-086523 Oryzias latipes 66.12 0.00e+00 1181.00
IUUC-Oga-089003 Otolemur garnettii 97.28 0.00e+00 1924.00
IUUC-Oar-090376 Ovis aries 96.67 0.00e+00 1912.00
IUUC-Ptr-090520 Pan troglodytes 98.22 0.00e+00 1928.00
IUUC-Pan-092281 Papio anubis 99.16 0.00e+00 1957.00
IUUC-Psi-093047 Pelodiscus sinensis 88.63 0.00e+00 1617.00
IUUC-Pma-094575 Petromyzon marinus 55.50 8.00e-67 246.00
IUUC-Pfo-096358 Poecilia formosa 66.33 0.00e+00 1137.00
IUUC-Pab-097740 Pongo abelii 99.16 0.00e+00 1963.00
IUUC-Pca-100461 Procavia capensis 86.26 0.00e+00 1534.00
IUUC-Pva-102134 Pteropus vampyrus 85.88 0.00e+00 1676.00
IUUC-Rno-105807 Rattus norvegicus 92.78 0.00e+00 1781.00
IUUC-Sha-107236 Sarcophilus harrisii 93.50 0.00e+00 1794.00
IUUC-Sar-113366 Sorex araneus 98.44 0.00e+00 938.00
IUUC-Tgu-117201 Taeniopygia guttata 84.25 0.00e+00 1617.00
IUUC-Tru-117953 Takifugu rubripes 67.95 0.00e+00 1187.00
IUUC-Tsy-119610 Tarsius syrichta 95.19 0.00e+00 1878.00
IUUC-Tni-120743 Tetraodon nigroviridis 40.96 1.00e-166 580.00
IUUC-Tbe-128155 Tupaia belangeri 78.40 0.00e+00 753.00
IUUC-Ttr-128942 Tursiops truncatus 91.74 0.00e+00 1796.00
IUUC-Vpa-130281 Vicugna pacos 86.09 0.00e+00 1658.00
IUUC-Xtr-132627 Xenopus tropicalis 76.32 0.00e+00 1404.00
Created Date 25-Jun-2017

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