iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059781

UUCD1 version

UUC-MeG-00840

Ensembl Protein ID

ENSMGAP00000005073.2

UniProt Accession

G1N0U1; G1N0U1_MELGA

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000005153.2	ENSMGAT00000005801.2	ENSMGAP00000005073.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.90e-111	370.4	181	712

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kNlgN+CYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++e+w k++ ++v p++l + +k ++++f+gy+
   Q: 181  TGMKNLGNSCYMNAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLVSEVWhKKRPSYVVPSSLSHGIKLVNPMFRGYA 264
           7******************************.....999999*******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk........eknkpkeeeeeedkselsde........................................ 129
           qqD+qEfl++l+dql+eelk+         +  +++e++e                                                 
   Q: 265  QQDTQEFLRCLMDQLHEELKEpivaetrdLDMGDQDEKRE--------Gdrspsedeflscdsssdrgegdgqsrttgsmgetelliqd 345
           *******************885544333322222222222........1456666779******************************* PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 346  eggrgisekermkdrkfscghrrsnseqvdedadvdttmmpmdgraspemlpaprpaspcrtpepdndafvrcssrpcspvhhemhskl 434
           ***************************************************************************************** PP
   S: 130  ..........................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke....... 185
                                      ++kk+ +++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k+       
   Q: 435  ssspprssparlgpsyvlkkaqmqasGKKKKELRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLhsaiyqs 523
           ************************9999999999*******************************************99888******* PP
   S: 186  ..........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLil 232
                                                     +l+dcL++f++++el+g+n+y+ce+ckk+++ +k +k+ +lPe+L++
   Q: 524  vpaktgacgdnyasqgwiafimeyirrfvvscipswfwgpvvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCI 612
           ***************************************************************************************** PP
   S: 233  hLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevke 319
           hLkRf  ++e + + kin++v+fple Ldl+pf+++++ +q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++Vtev+e
   Q: 613  HLKRF--RHEVMYSFKINSHVSFPLEgLDLRPFLAKECVSQ--ITTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQYVTEVHE 697
           *****..9999*************************99888..9**************************78999************** PP
   S: 320  eevleetgstaYvlfYkr 337
           + v++   ++aYvlfY++
   Q: 698  TVVQN---AEAYVLFYRK 712
           *****...********98 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

YSPTASDLNQ VVLEILFNEM GKQQRVEVRM EDTRDICPHL DSIGEVTRDD LLLKSKGTCQ 60
SCGAVGPNLW ACLQIGCPYV GCGESYADHS TLHAQAKKHN LTVNLTTFRV WCYACEKEVF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TACTCTCCTA CTGCCAGTGA TTTGAATCAG GTAGTACTGG AAATTCTTTT TAATGAAATG 60
GGAAAACAGC AGAGAGTAGA GGCTGTGCTC CTGGAGTTAT TAACTTTCTA AGTTCATCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0005813--C:centrosome
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	83.23	0.00e+00	1515.00
IUUC-Apl-003351	Anas platyrhynchos	95.77	0.00e+00	1768.00
IUUC-Aca-005077	Anolis carolinensis	79.26	0.00e+00	1135.00
IUUC-Ame-011777	Astyanax mexicanus	76.32	0.00e+00	1351.00
IUUC-Bta-013063	Bos taurus	84.47	0.00e+00	1515.00
IUUC-Cja-019868	Callithrix jacchus	84.83	0.00e+00	1545.00
IUUC-Cfa-020761	Canis familiaris	83.95	0.00e+00	1535.00
IUUC-Cpo-022267	Cavia porcellus	79.98	0.00e+00	1431.00
IUUC-Csa-024251	Chlorocebus sabaeus	85.78	0.00e+00	1563.00
IUUC-Cho-024483	Choloepus hoffmanni	94.34	5.00e-122	431.00
IUUC-Dre-028061	Danio rerio	75.70	0.00e+00	1222.00
IUUC-Dno-029423	Dasypus novemcinctus	85.78	0.00e+00	1546.00
IUUC-Dor-030877	Dipodomys ordii	84.33	0.00e+00	999.00
IUUC-Dme-031837	Drosophila melanogaster	49.57	9.00e-138	484.00
IUUC-Ete-032802	Echinops telfairi	73.80	2.00e-131	462.00
IUUC-Eca-034283	Equus caballus	83.97	0.00e+00	1530.00
IUUC-Eeu-034620	Erinaceus europaeus	82.78	0.00e+00	1078.00
IUUC-Fca-036357	Felis catus	84.82	0.00e+00	1516.00
IUUC-Fal-037411	Ficedula albicollis	94.55	0.00e+00	1731.00
IUUC-Gmo-038944	Gadus morhua	59.04	0.00e+00	1043.00
IUUC-Gga-041101	Gallus gallus	96.94	0.00e+00	1786.00
IUUC-Gac-041315	Gasterosteus aculeatus	73.80	0.00e+00	1326.00
IUUC-Ggo-045600	Gorilla gorilla	85.13	0.00e+00	1518.00
IUUC-Hsa-045825	Homo sapiens	85.78	0.00e+00	1532.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	73.35	0.00e+00	1268.00
IUUC-Lch-050002	Latimeria chalumnae	77.03	0.00e+00	1355.00
IUUC-Loc-052574	Lepisosteus oculatus	77.91	0.00e+00	1401.00
IUUC-Laf-054428	Loxodonta africana	85.05	0.00e+00	1531.00
IUUC-Mcc-055736	Macaca mulatta	85.56	0.00e+00	1557.00
IUUC-Mdo-063048	Monodelphis domestica	88.78	0.00e+00	1550.00
IUUC-Mmu-064079	Mus musculus	82.23	0.00e+00	1502.00
IUUC-Mpu-066616	Mustela putorius furo	83.12	0.00e+00	1561.00
IUUC-Mlu-067294	Myotis lucifugus	84.26	0.00e+00	1477.00
IUUC-Nle-070015	Nomascus leucogenys	85.78	0.00e+00	1520.00
IUUC-Opr-070328	Ochotona princeps	84.60	0.00e+00	1536.00
IUUC-Ont-071464	Oreochromis niloticus	76.91	0.00e+00	1320.00
IUUC-Oan-073259	Ornithorhynchus anatinus	80.24	0.00e+00	1361.00
IUUC-Ocu-074630	Oryctolagus cuniculus	82.23	0.00e+00	1470.00
IUUC-Ola-087240	Oryzias latipes	75.14	0.00e+00	1293.00
IUUC-Oga-088761	Otolemur garnettii	84.13	0.00e+00	1542.00
IUUC-Oar-089490	Ovis aries	80.22	0.00e+00	1381.00
IUUC-Ptr-091662	Pan troglodytes	85.67	0.00e+00	1529.00
IUUC-Pan-092199	Papio anubis	85.48	0.00e+00	1551.00
IUUC-Psi-093726	Pelodiscus sinensis	91.92	0.00e+00	1690.00
IUUC-Pma-094389	Petromyzon marinus	64.38	6.00e-100	356.00
IUUC-Pfo-097415	Poecilia formosa	62.43	0.00e+00	1081.00
IUUC-Pab-098632	Pongo abelii	85.45	0.00e+00	1520.00
IUUC-Pca-100614	Procavia capensis	78.91	0.00e+00	1187.00
IUUC-Rno-105215	Rattus norvegicus	82.10	0.00e+00	1500.00
IUUC-Sce-106176	Saccharomyces cerevisiae	30.50	8.00e-26	112.00
IUUC-Sha-106601	Sarcophilus harrisii	88.02	0.00e+00	1536.00
IUUC-Ssc-115533	Sus scrofa	83.98	0.00e+00	1506.00
IUUC-Tgu-117364	Taeniopygia guttata	94.21	0.00e+00	1691.00
IUUC-Tru-117770	Takifugu rubripes	74.30	0.00e+00	1300.00
IUUC-Tni-120001	Tetraodon nigroviridis	74.06	0.00e+00	1278.00
IUUC-Ttr-128732	Tursiops truncatus	84.92	0.00e+00	1527.00
IUUC-Xtr-132157	Xenopus tropicalis	77.44	0.00e+00	1378.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence