iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033449

UUCD1 version

UUC-EqC-01032

Ensembl Protein ID

ENSECAP00000005331.1

UniProt Accession

F7BV54; F7BV54_HORSE

Protein Name

Uncharacterized protein

Gene Name

USP8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000006611.1	ENSECAT00000007330.1	ENSECAP00000005331.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.10e-109	364.4	776	1106

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtCYmNS+LQcL n p l++++++  ++ ++n++n  ++kge+++++  ++++lw+++ +++sp++++ +++k++ +f g
   Q: 776  TGLRNLGNTCYMNSILQCLCNAPHLADYFNRnCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAG 862
           7*****************************9899***************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeee...dkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
           y+qqD+qE+l fl+d+l+e+l+k +n ++++ee++   d+ ++ ++a++k+k+ n+s+i+ lFqgq+ks+++cl+c+++s ++e f+
   Q: 863  YSQQDSQELLLFLMDGLHEDLNKADNRKRHKEENNdhlDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 949
           *********************9855555555444411145566667***************************************** PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
           +lslp+ + +++   +lqdcL+ f+kee+l+++n++yc++c++++++ kk++++klP+vL +hLkRfs++ + ++ +k++++v+fpl
   Q: 950  YLSLPLASTSKC---TLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGR-WK-QKLQTSVDFPL 1031
           ***********9...******************************************************996.55.6********** PP
   S: 258  e.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           e Ldls++++ p+++    kkY+L++v +H+G+l++GHY+ay+kn  ++ W++fdD++V+ +  ++v++   s aY+lfY+
   Q: 1032 EnLDLSQYVIGPKNN---LKKYNLFSVSNHYGGLDGGHYTAYCKNAARQrWFKFDDHEVSDIAVSSVKS---SAAYILFYT 1106
           ***********9988...69*************************88888*******************...********8 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MPAVASVPKE LYLSSSLKDL NKKTEVKPEK ISTKSYVQSA LKIFKTAEES RLDRDEEKAY 60
VLYMKYVTVY NLIKKRPDFK QQQEYFHSIL GPTNIKKAIE EAERLSESLK LRYEEAEVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCTGCCG TGGCTTCAGT TCCTAAAGAA CTCTACCTCA GTTCCTCATT AAAAGACCTC 60
AATAAGAAGA CAGAAGTTAA ACCAGAGAAA ATAAGCACTA AGAGGTGTGT GTCCTTTGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00581--Rhodanese
PF00443--UCH
PF08969--USP8_dimer

SMART

SM00450--RHOD

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0031313--C:extrinsic component of endosome membrane
GO:0019897--C:extrinsic component of plasma membrane
GO:0030496--C:midbody
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007032--P:endosome organization
GO:0000281--P:mitotic cytokinesis
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ecb:100055443

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	93.93	0.00e+00	1949.00
IUUC-Apl-003226	Anas platyrhynchos	76.79	0.00e+00	912.00
IUUC-Aca-004936	Anolis carolinensis	66.25	0.00e+00	1297.00
IUUC-Ago-007959	Ashbya gossypii	35.62	2.00e-55	211.00
IUUC-Acl-008102	Aspergillus clavatus	31.59	7.00e-53	202.00
IUUC-Afl-008604	Aspergillus flavus	31.32	2.00e-51	197.00
IUUC-Afu-009001	Aspergillus fumigatus	31.67	5.00e-52	199.00
IUUC-Ani-009291	Aspergillus nidulans	30.49	9.00e-52	198.00
IUUC-Ang-009844	Aspergillus niger	32.22	2.00e-51	197.00
IUUC-Aor-010098	Aspergillus oryzae	31.32	1.00e-50	194.00
IUUC-Ate-010585	Aspergillus terreus	31.22	4.00e-51	196.00
IUUC-Ame-010960	Astyanax mexicanus	76.67	3.00e-85	306.00
IUUC-Bta-013008	Bos taurus	90.24	0.00e+00	1851.00
IUUC-Bol-015281	Brassica oleracea	38.21	3.00e-50	192.00
IUUC-Bra-017228	Brassica rapa	39.10	7.00e-52	198.00
IUUC-Cel-018482	Caenorhabditis elegans	33.82	2.00e-53	204.00
IUUC-Cja-019173	Callithrix jacchus	91.59	0.00e+00	1890.00
IUUC-Cfa-021243	Canis familiaris	94.18	0.00e+00	1960.00
IUUC-Cpo-021522	Cavia porcellus	85.68	0.00e+00	1747.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	44.35	1.00e-85	309.00
IUUC-Csa-023616	Chlorocebus sabaeus	92.76	0.00e+00	1628.00
IUUC-Cho-024381	Choloepus hoffmanni	77.93	0.00e+00	1569.00
IUUC-Cin-025287	Ciona intestinalis	49.87	8.00e-100	358.00
IUUC-Csv-026253	Ciona savignyi	47.79	2.00e-89	323.00
IUUC-Cne-026821	Cryptococcus neoformans	39.89	8.00e-76	279.00
IUUC-Dre-028440	Danio rerio	68.80	0.00e+00	750.00
IUUC-Dno-029039	Dasypus novemcinctus	90.70	0.00e+00	1914.00
IUUC-Dor-031043	Dipodomys ordii	96.12	6.00e-140	491.00
IUUC-Dse-031463	Dothistroma septosporum	28.07	4.00e-44	173.00
IUUC-Dme-032089	Drosophila melanogaster	44.99	2.00e-88	320.00
IUUC-Ete-033040	Echinops telfairi	82.71	0.00e+00	1542.00
IUUC-Eeu-034693	Erinaceus europaeus	95.69	1.00e-132	467.00
IUUC-Fca-035794	Felis catus	98.74	0.00e+00	935.00
IUUC-Fal-037322	Ficedula albicollis	79.83	0.00e+00	910.00
IUUC-Gmo-038584	Gadus morhua	66.46	0.00e+00	680.00
IUUC-Gga-041188	Gallus gallus	82.84	0.00e+00	935.00
IUUC-Gac-041850	Gasterosteus aculeatus	72.66	0.00e+00	753.00
IUUC-Ggo-045565	Gorilla gorilla	92.75	0.00e+00	1919.00
IUUC-Hsa-046438	Homo sapiens	92.67	0.00e+00	1916.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	89.88	0.00e+00	1855.00
IUUC-Kpa-049321	Komagataella pastoris	33.51	5.00e-51	196.00
IUUC-Lch-050485	Latimeria chalumnae	80.57	0.00e+00	867.00
IUUC-Loc-052769	Lepisosteus oculatus	73.92	0.00e+00	778.00
IUUC-Lma-053021	Leptosphaeria maculans	32.26	5.00e-56	213.00
IUUC-Laf-053432	Loxodonta africana	79.01	0.00e+00	1724.00
IUUC-Mcc-055823	Macaca mulatta	92.04	0.00e+00	1911.00
IUUC-Meu-056099	Macropus eugenii	97.40	2.00e-165	576.00
IUUC-Mla-059089	Melampsora laricipopulina	39.88	7.00e-72	266.00
IUUC-Mga-059739	Meleagris gallopavo	82.66	0.00e+00	929.00
IUUC-Mvi-060559	Microbotryum violaceum	40.11	3.00e-79	290.00
IUUC-Mmr-061158	Microcebus murinus	90.51	0.00e+00	1860.00
IUUC-Mdo-061801	Monodelphis domestica	80.98	0.00e+00	1602.00
IUUC-Mmu-063665	Mus musculus	81.20	0.00e+00	1680.00
IUUC-Mpu-066738	Mustela putorius furo	93.64	0.00e+00	1919.00
IUUC-Mlu-067307	Myotis lucifugus	89.38	0.00e+00	1864.00
IUUC-Nfi-068410	Neosartorya fischeri	31.67	2.00e-52	201.00
IUUC-Nle-069314	Nomascus leucogenys	92.58	0.00e+00	1910.00
IUUC-Opr-070378	Ochotona princeps	80.70	0.00e+00	1230.00
IUUC-Ont-071545	Oreochromis niloticus	76.22	0.00e+00	768.00
IUUC-Oan-073537	Ornithorhynchus anatinus	77.37	0.00e+00	1543.00
IUUC-Ocu-074193	Oryctolagus cuniculus	89.26	0.00e+00	1863.00
IUUC-Ola-086622	Oryzias latipes	57.41	0.00e+00	1085.00
IUUC-Oga-088271	Otolemur garnettii	88.39	0.00e+00	1825.00
IUUC-Oar-090431	Ovis aries	90.27	0.00e+00	1859.00
IUUC-Ptr-091339	Pan troglodytes	92.31	0.00e+00	1961.00
IUUC-Pan-091783	Papio anubis	87.60	0.00e+00	982.00
IUUC-Psi-093187	Pelodiscus sinensis	65.90	2.00e-156	546.00
IUUC-Pma-094626	Petromyzon marinus	58.43	2.00e-144	504.00
IUUC-Pfo-096463	Poecilia formosa	75.20	0.00e+00	763.00
IUUC-Pab-097645	Pongo abelii	92.49	0.00e+00	1915.00
IUUC-Pva-103222	Pteropus vampyrus	86.35	0.00e+00	978.00
IUUC-Pgr-103408	Puccinia graminis	35.66	1.00e-56	215.00
IUUC-Ptt-103699	Puccinia triticina	45.80	3.00e-68	254.00
IUUC-Pte-104348	Pyrenophora teres	29.13	3.00e-42	167.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	30.23	1.00e-52	201.00
IUUC-Rno-105510	Rattus norvegicus	81.38	0.00e+00	1710.00
IUUC-Sce-106166	Saccharomyces cerevisiae	35.54	3.00e-52	200.00
IUUC-Sha-106879	Sarcophilus harrisii	88.01	0.00e+00	993.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	36.29	1.00e-49	191.00
IUUC-Sar-113019	Sorex araneus	84.97	0.00e+00	1796.00
IUUC-Sre-115031	Sporisorium reilianum	37.05	1.00e-69	258.00
IUUC-Ssc-116334	Sus scrofa	90.44	0.00e+00	1896.00
IUUC-Tgu-117062	Taeniopygia guttata	80.34	0.00e+00	914.00
IUUC-Tru-117908	Takifugu rubripes	57.89	0.00e+00	1165.00
IUUC-Tsy-118867	Tarsius syrichta	87.36	0.00e+00	1088.00
IUUC-Tni-120206	Tetraodon nigroviridis	54.98	0.00e+00	1075.00
IUUC-Tme-127144	Tuber melanosporum	40.00	1.00e-79	291.00
IUUC-Tbe-127877	Tupaia belangeri	88.07	1.00e-105	377.00
IUUC-Ttr-128580	Tursiops truncatus	88.36	0.00e+00	1793.00
IUUC-Uma-129340	Ustilago maydis	35.99	2.00e-72	267.00
IUUC-Vpa-130541	Vicugna pacos	92.66	0.00e+00	1934.00
IUUC-Xtr-132161	Xenopus tropicalis	59.04	0.00e+00	1211.00
IUUC-Xma-134271	Xiphophorus maculatus	75.20	0.00e+00	761.00
IUUC-Yli-134561	Yarrowia lipolytica	35.92	3.00e-60	226.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence