iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-072723

UUCD1 version

UUC-OrA-00833

Ensembl Protein ID

ENSOANP00000003864.1

UniProt Accession

F6ZR76; F6ZR76_ORNAN

Protein Name

Uncharacterized protein

Gene Name

USP19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000002437.4	ENSOANT00000003865.1	ENSOANP00000003864.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-114	383.4	538	1273

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l++ lwk++++a++p++l+++++ +a++f+g
   Q: 538  TGLVNLGNTCFMNSVIQSLSNTRELRDYFHDrSFEMEINYSNPLGTGGRLAIGFAGLLRTLWKGTHHAFQPSKLKAIVAGKASQFTG 624
           7******************************999***************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+++dlFqgq+ks+++c+ c +vs +++p
   Q: 625  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFVVDLFQGQYKSKLVCPVCTKVSITFDP 709
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++                                                                          
   Q: 710  FLYLPVPLPQKQKVLIVyyfakephkkpvkflvsiskenssamevldslahsvhvkpenlrlaevsknrfhriflpshsldaispsd 796
           ************87555********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 797  pllcfevlssdlakervivlqvqqrpqvpsvpitkcaacqkkqqpedeklkrctrcyrvgycnqvcqkthwpdhkglcrpeniglpf 883
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 884  lvsvpesrltyarlsqllegfarysvsvfqppfqpgrvspeqgsqtsnpekpdsliknacaastqglgdgdqdlhlpmepqasapap 970
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 971  ephpeqgsgiamrsrapldrssllspaasgfseqatsslsegslprestgekgfkpeavvpgyqqptegvgshtpqffihkidaank 1057
           *************************************************************************************** PP
   S: 186  ...........................................................slqdcLesftkeeelegenkyycekckk 213
                                                                      +l++cL+ ftk+e l  e+++yc+kck+
   Q: 1058 eqkledkgevplelsednslaliwknnerlkefvlvgskeleymedpgsaseaaraghfTLEQCLNLFTKPEVLAPEEAWYCPKCKQ 1144
           *************************************************************************************** PP
   S: 214  kqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayv 299
           ++ea+k+l+l++lP+vLi++LkRfsf++  +++ kin+ vefp + Ldls+fc+ ++++ ++  +Y+L+av++H+G++ +GHY+ay+
   Q: 1145 HREASKQLMLWRLPNVLIIQLKRFSFRSFIWRD-KINDMVEFPVRnLDLSKFCIGQKDD-HQLPTYDLYAVINHYGGMIGGHYTAYA 1229
           *****************************8886.**********9**********6665.57************************* PP
   S: 300  knekgk........WllfdDskVtevkeeevleetgstaYvlfYkrr 338
           +  ++k        W lfdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1230 RLPSDKnsqrsdvgWRLFDDSTVTTVDESQVVT---RYAYVLFYRRR 1273
           *9444444567788*******************...********996 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MSSGTGAAGQ RRASQGLEDA TNKKKQKDRA NQESKEGERP AATGPKRGRS GKAPSHFWRR 60
ETGRVFIERL LGAEESTWEE PEGAAPGRGT AALIEVMVPA DGRQWSGLFH EEIESSYSKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCAGCG GTACCGGTGC CGCAGGCCAA AGGAGGGCAT CCCAGGGGCT GGAGGACGCC 60
ACCAACAAGA AGAAGCAGAA GGATCGAGCT AACCAGGAGA GCAAGGAGGG GGAGCGGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	65.53	0.00e+00	1640.00
IUUC-Apl-003368	Anas platyrhynchos	68.95	0.00e+00	1660.00
IUUC-Aca-004267	Anolis carolinensis	66.67	0.00e+00	1687.00
IUUC-Ame-010970	Astyanax mexicanus	71.88	0.00e+00	1364.00
IUUC-Bta-012905	Bos taurus	65.41	0.00e+00	1634.00
IUUC-Cel-018257	Caenorhabditis elegans	43.56	7.00e-91	328.00
IUUC-Cja-018789	Callithrix jacchus	66.42	0.00e+00	1652.00
IUUC-Cfa-021004	Canis familiaris	76.48	0.00e+00	1554.00
IUUC-Cpo-021529	Cavia porcellus	67.27	0.00e+00	1686.00
IUUC-Csa-024035	Chlorocebus sabaeus	67.22	0.00e+00	1670.00
IUUC-Cho-025036	Choloepus hoffmanni	60.80	0.00e+00	844.00
IUUC-Cin-025451	Ciona intestinalis	41.32	5.00e-81	295.00
IUUC-Dre-028556	Danio rerio	70.23	0.00e+00	1345.00
IUUC-Dno-029240	Dasypus novemcinctus	64.76	0.00e+00	1556.00
IUUC-Dor-030495	Dipodomys ordii	73.74	0.00e+00	1026.00
IUUC-Ete-032741	Echinops telfairi	75.19	0.00e+00	1517.00
IUUC-Eca-033661	Equus caballus	66.55	0.00e+00	1707.00
IUUC-Eeu-034648	Erinaceus europaeus	75.23	0.00e+00	635.00
IUUC-Fca-035646	Felis catus	76.31	0.00e+00	1548.00
IUUC-Fal-037094	Ficedula albicollis	67.66	0.00e+00	1801.00
IUUC-Gmo-038869	Gadus morhua	68.97	0.00e+00	841.00
IUUC-Gga-041170	Gallus gallus	66.11	0.00e+00	1751.00
IUUC-Gac-041901	Gasterosteus aculeatus	65.18	0.00e+00	1352.00
IUUC-Ggo-044708	Gorilla gorilla	67.31	0.00e+00	1674.00
IUUC-Hsa-046791	Homo sapiens	73.37	0.00e+00	1590.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	65.63	0.00e+00	1630.00
IUUC-Lch-050456	Latimeria chalumnae	56.56	0.00e+00	1371.00
IUUC-Loc-052861	Lepisosteus oculatus	57.36	0.00e+00	1145.00
IUUC-Laf-053788	Loxodonta africana	66.90	0.00e+00	1706.00
IUUC-Mcc-055693	Macaca mulatta	67.64	0.00e+00	1605.00
IUUC-Meu-055921	Macropus eugenii	72.49	0.00e+00	1428.00
IUUC-Mga-059879	Meleagris gallopavo	68.55	0.00e+00	1688.00
IUUC-Mmr-060802	Microcebus murinus	65.36	0.00e+00	1691.00
IUUC-Mdo-061856	Monodelphis domestica	77.50	0.00e+00	1568.00
IUUC-Mmu-063874	Mus musculus	66.86	0.00e+00	1692.00
IUUC-Mpu-066166	Mustela putorius furo	68.26	0.00e+00	1603.00
IUUC-Nle-070161	Nomascus leucogenys	64.18	0.00e+00	1689.00
IUUC-Opr-071015	Ochotona princeps	75.44	0.00e+00	1514.00
IUUC-Ont-072308	Oreochromis niloticus	70.29	0.00e+00	1408.00
IUUC-Ocu-073938	Oryctolagus cuniculus	65.76	0.00e+00	1629.00
IUUC-Ola-086375	Oryzias latipes	60.90	0.00e+00	1406.00
IUUC-Oga-088297	Otolemur garnettii	67.51	0.00e+00	1638.00
IUUC-Oar-089675	Ovis aries	75.95	0.00e+00	1342.00
IUUC-Ptr-091621	Pan troglodytes	73.28	0.00e+00	1586.00
IUUC-Pan-092118	Papio anubis	68.03	0.00e+00	1636.00
IUUC-Pfo-097246	Poecilia formosa	61.98	0.00e+00	1002.00
IUUC-Pab-098551	Pongo abelii	72.48	0.00e+00	1561.00
IUUC-Pca-100158	Procavia capensis	65.19	0.00e+00	1647.00
IUUC-Pva-103160	Pteropus vampyrus	67.35	0.00e+00	1680.00
IUUC-Rno-105355	Rattus norvegicus	66.74	0.00e+00	1684.00
IUUC-Sha-107057	Sarcophilus harrisii	70.77	0.00e+00	1664.00
IUUC-Sar-113011	Sorex araneus	71.73	0.00e+00	1137.00
IUUC-Ssc-115761	Sus scrofa	68.42	0.00e+00	1625.00
IUUC-Tgu-116956	Taeniopygia guttata	62.42	0.00e+00	874.00
IUUC-Tru-118739	Takifugu rubripes	67.79	0.00e+00	1364.00
IUUC-Tsy-118827	Tarsius syrichta	62.88	0.00e+00	858.00
IUUC-Tni-119921	Tetraodon nigroviridis	58.80	0.00e+00	1381.00
IUUC-Tbe-128017	Tupaia belangeri	71.26	0.00e+00	1533.00
IUUC-Ttr-128869	Tursiops truncatus	66.81	0.00e+00	1691.00
IUUC-Vpa-130427	Vicugna pacos	72.54	0.00e+00	711.00
IUUC-Xtr-132734	Xenopus tropicalis	59.66	0.00e+00	1504.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence