iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132691

Ensembl Protein ID

ENSXETP00000027383.3

UniProt Accession

Q28H04; SUMO2_XENTR

Genbank Protein ID

CAJ81672.1

Protein Name

Small ubiquitin-related modifier 2

Genbank Nucleotide ID

CR761130

Gene Name

sumo2; TEgg046d06.1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000012516.3	ENSXETT00000027383.3	ENSXETP00000027383.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/SUMO	4.80e-33	113.9	14	93

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/SUMO

   S: 5    fkapvslkvagqdGsevlfklklsaqlkklmeavYvkrinldensvrfvfngqkireqetpeelevededkiellcqksGG 85
           +  +++lkvagqdGs v+fk+k++++l+klm+a Y++r++l+++++rf+f+gq+i+e++tp++le+eded+i++++q++GG
   Q: 14   NNDHINLKVAGQDGSVVQFKIKRHTPLNKLMKA-YCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGG 93
           789******************************.**********************************************9 PP

Organism

Xenopus tropicalis

Functional Description
(View)

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i, and can be promoted by an E3 ligase such as pias1-4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric sumo2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).

Protein Sequence
(Fasta)

MADDKPKEGV KTENNDHINL KVAGQDGSVV QFKIKRHTPL NKLMKAYCER QGLSMRQIRF 60
RFDGQPINET DTPAQLEMED EDTIDVFQQQ TGGSF 95

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGAACTGACA ATGGCGGACG ATAAGCCCAA GGTCCTGCTC CGGGCTGGGA GAGGGAAGGG 60
TCGCATAGCG GGCTTGGGGC CGGGGGCAGT GGGTGCGGGG CAGGAGGAGG GAGAGGCCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR022617--Rad60/SUMO-like_dom
IPR033950--Sumo
IPR027218--SUMO_2/3
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF11976--Rad60-SLD

SMART

SM00213--UBQ

Gene Ontology

GO:0005634--C:nucleus
GO:0031386--F:protein tag
GO:0016925--P:protein sumoylation

KEGG

xtr:549160

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001918	Ailuropoda melanoleuca	95.79	1.00e-51	193.00
IUUC-Apl-003372	Anas platyrhynchos	95.51	9.00e-48	180.00
IUUC-Aca-005284	Anolis carolinensis	95.79	1.00e-51	193.00
IUUC-Acl-008286	Aspergillus clavatus	50.00	4.00e-17	78.60
IUUC-Afl-008650	Aspergillus flavus	47.31	9.00e-18	80.90
IUUC-Afu-008969	Aspergillus fumigatus	46.81	6.00e-18	81.60
IUUC-Ang-009651	Aspergillus niger	51.28	5.00e-17	78.60
IUUC-Ate-010503	Aspergillus terreus	42.27	3.00e-15	73.20
IUUC-Ame-011427	Astyanax mexicanus	93.68	9.00e-51	190.00
IUUC-Bgr-012250	Blumeria graminis	46.51	4.00e-17	79.30
IUUC-Bta-013208	Bos taurus	91.58	4.00e-49	185.00
IUUC-Bci-013625	Botrytis cinerea	49.37	5.00e-18	81.60
IUUC-Cfa-020546	Canis familiaris	95.79	1.00e-51	193.00
IUUC-Cpo-021498	Cavia porcellus	95.79	1.00e-51	193.00
IUUC-Csa-023133	Chlorocebus sabaeus	95.79	1.00e-51	193.00
IUUC-Cin-025314	Ciona intestinalis	76.92	8.00e-38	147.00
IUUC-Csv-026212	Ciona savignyi	78.89	7.00e-39	151.00
IUUC-Dre-027994	Danio rerio	96.77	9.00e-51	190.00
IUUC-Dno-029390	Dasypus novemcinctus	95.79	6.00e-52	195.00
IUUC-Dor-030760	Dipodomys ordii	32.47	3.00e-06	45.80
IUUC-Dse-031390	Dothistroma septosporum	49.00	7.00e-21	91.30
IUUC-Ete-032934	Echinops telfairi	81.05	2.00e-41	159.00
IUUC-Eca-033260	Equus caballus	95.79	1.00e-51	193.00
IUUC-Fca-036393	Felis catus	90.53	6.00e-48	181.00
IUUC-Fal-037226	Ficedula albicollis	95.56	3.00e-48	182.00
IUUC-Fox-037950	Fusarium oxysporum	53.09	5.00e-20	88.60
IUUC-Fso-038430	Fusarium solani	51.85	1.00e-19	87.40
IUUC-Ggr-040015	Gaeumannomyces graminis	56.96	2.00e-21	93.60
IUUC-Gga-040145	Gallus gallus	95.79	1.00e-51	193.00
IUUC-Gac-041723	Gasterosteus aculeatus	92.47	1.00e-48	183.00
IUUC-Gma-043216	Glycine max	54.35	1.00e-21	94.00
IUUC-Ggo-045467	Gorilla gorilla	95.79	1.00e-51	193.00
IUUC-Hsa-046419	Homo sapiens	95.79	1.00e-51	193.00
IUUC-Itr-048667	Ictidomys tridecemlineatus	96.63	3.00e-48	182.00
IUUC-Lch-050572	Latimeria chalumnae	87.63	5.00e-45	171.00
IUUC-Loc-052560	Lepisosteus oculatus	94.74	4.00e-51	191.00
IUUC-Laf-054343	Loxodonta africana	96.84	9.00e-52	193.00
IUUC-Mcc-054832	Macaca mulatta	95.70	4.00e-50	189.00
IUUC-Mpo-057351	Magnaporthe poae	55.70	1.00e-20	90.90
IUUC-Mga-059768	Meleagris gallopavo	95.51	9.00e-48	180.00
IUUC-Mmr-061593	Microcebus murinus	95.70	3.00e-50	189.00
IUUC-Mdo-062678	Monodelphis domestica	95.79	2.00e-51	192.00
IUUC-Mmu-063990	Mus musculus	95.79	1.00e-51	193.00
IUUC-Mpu-065909	Mustela putorius furo	92.55	7.00e-49	184.00
IUUC-Mlu-067634	Myotis lucifugus	90.53	7.00e-48	181.00
IUUC-Nfi-068364	Neosartorya fischeri	50.00	3.00e-17	79.30
IUUC-Ncr-068663	Neurospora crassa	51.28	9.00e-19	84.30
IUUC-Nle-069631	Nomascus leucogenys	94.74	1.00e-50	190.00
IUUC-Opr-071104	Ochotona princeps	30.56	1.00e-04	41.20
IUUC-Ont-071512	Oreochromis niloticus	93.68	9.00e-50	187.00
IUUC-Ocu-074239	Oryctolagus cuniculus	94.74	3.00e-51	192.00
IUUC-Ola-086710	Oryzias latipes	96.77	3.00e-50	189.00
IUUC-Oar-089624	Ovis aries	91.58	3.00e-49	185.00
IUUC-Ptr-091082	Pan troglodytes	95.79	1.00e-51	193.00
IUUC-Pan-091791	Papio anubis	97.80	8.00e-50	188.00
IUUC-Psi-094000	Pelodiscus sinensis	95.79	1.00e-51	193.00
IUUC-Pfo-097304	Poecilia formosa	95.74	4.00e-51	191.00
IUUC-Pab-098572	Pongo abelii	95.79	1.00e-51	193.00
IUUC-Ppe-101648	Prunus persica	52.69	7.00e-22	94.70
IUUC-Rno-105391	Rattus norvegicus	94.68	3.00e-50	188.00
IUUC-Sar-113337	Sorex araneus	81.72	2.00e-41	159.00
IUUC-Ssc-115915	Sus scrofa	95.79	1.00e-51	193.00
IUUC-Tgu-116815	Taeniopygia guttata	95.56	1.00e-48	183.00
IUUC-Tre-121926	Trichoderma reesei	50.00	5.00e-21	92.00
IUUC-Tvi-122514	Trichoderma virens	52.44	7.00e-20	88.20
IUUC-Tae-125013	Triticum aestivum	52.75	9.00e-22	94.70
IUUC-Tbe-127363	Tupaia belangeri	91.40	1.00e-46	177.00
IUUC-Xma-133892	Xiphophorus maculatus	95.74	1.00e-51	193.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence