iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059660

UUCD1 version

UUC-MeG-00450

Ensembl Protein ID

ENSMGAP00000010252.2

UniProt Accession

G1NC30; G1NC30_MELGA

Protein Name

Uncharacterized protein

Gene Name

TBL1XR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000009892.2	ENSMGAT00000011100.2	ENSMGAP00000010252.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.10e-54	176.8	346	384
UBD/Beta-Prp	9.90e-66	221.6	310	512

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHt++v+++++ ++ +ll+s+sdD t+k+W+++++ +++
   Q: 346  GHTNEVNAIKWdPTgNLLASCSDDMTLKIWSMKQDSCVH 384
           8***********778********************9986 PP

UBD/Beta-Prp

   S: 13   itcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlsls 101
             +v++ ++++ +a+ s+d +i v ++ +   +++++gh++ev+a+k++p+g++l+++s+D+t+k+w++++ +cvh l++h++++++++
   Q: 310  ALDVDW-QSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDSCVHDLQAHNKEIYTIK 397
           444555.6667777777777777777777777777777777777777777777777777777777777777777777777777777777 PP
   S: 102  fsp........sg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           +sp        +    l+s+s d+t+r+wd++ g c++ tl++h++ v +v+++pdg++l+sGs D++v +W+ +tg l++  +g  t+
   Q: 398  WSPtgpgtnnpNAnLMLASASFDSTVRLWDVDRGICIH-TLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG--TG 483
           77755555443222457777777777777777777777.7777777777777777777777777777777777777777777776..77 PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlq 210
            +  + ++  g  + + + dg+v + dl+
   Q: 484  GIFEVCWNAAGDKVGASASDGSVCVLDLR 512
           77777777777777777777777666665 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MSISSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GALVPPAALI SIIQKGLQYV 60
EAEVSINEDG TLFDGRPIES LSLIDAVMPD VVQTRQQAYR DKLAQQQAAA AAAAAATNQQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGTATAA GCAGTGATGA GGTTAACTTC CTGGTTTATA GATACTTACA AGAGTCAGGT 60
GAGTTTTTTC AATTATGGTT GTTTTAACCA TGTTTAATTT ATTTGGTTTT CATCTGCAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0005876--C:spindle microtubule
GO:0017053--C:transcriptional repressor complex
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0060613--P:fat pad development
GO:0016042--P:lipid catabolic process
GO:0035264--P:multicellular organism growth
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030814--P:regulation of cAMP metabolic process
GO:0090207--P:regulation of triglyceride metabolic process
GO:0002021--P:response to dietary excess
GO:0050872--P:white fat cell differentiation

KEGG

mgp:100547429

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000916	Aegilops tauschii	60.71	5.00e-55	206.00
IUUC-Aml-001717	Ailuropoda melanoleuca	95.53	0.00e+00	956.00
IUUC-Atr-002514	Amborella trichopoda	65.38	3.00e-145	508.00
IUUC-Apl-003708	Anas platyrhynchos	99.80	0.00e+00	932.00
IUUC-Aca-004611	Anolis carolinensis	99.22	0.00e+00	967.00
IUUC-Aly-005622	Arabidopsis lyrata	58.40	6.00e-120	424.00
IUUC-Ath-007137	Arabidopsis thaliana	59.50	1.00e-121	430.00
IUUC-Ame-011601	Astyanax mexicanus	90.06	0.00e+00	906.00
IUUC-Bta-012418	Bos taurus	99.22	0.00e+00	989.00
IUUC-Bdi-014315	Brachypodium distachyon	60.42	9.00e-135	473.00
IUUC-Bol-016277	Brassica oleracea	56.99	1.00e-126	446.00
IUUC-Bra-016944	Brassica rapa	60.28	4.00e-126	444.00
IUUC-Cja-018832	Callithrix jacchus	99.03	0.00e+00	958.00
IUUC-Cfa-020029	Canis familiaris	95.33	0.00e+00	954.00
IUUC-Cpo-022080	Cavia porcellus	94.36	0.00e+00	924.00
IUUC-Csa-024075	Chlorocebus sabaeus	95.91	0.00e+00	954.00
IUUC-Cho-024872	Choloepus hoffmanni	98.29	2.00e-111	395.00
IUUC-Cme-027258	Cyanidioschyzon merolae	40.17	9.00e-107	380.00
IUUC-Dre-028075	Danio rerio	96.49	0.00e+00	935.00
IUUC-Dno-029196	Dasypus novemcinctus	99.61	0.00e+00	968.00
IUUC-Dor-030732	Dipodomys ordii	99.18	0.00e+00	731.00
IUUC-Eeu-034952	Erinaceus europaeus	88.82	0.00e+00	825.00
IUUC-Fca-035734	Felis catus	99.03	0.00e+00	965.00
IUUC-Fal-037185	Ficedula albicollis	99.81	0.00e+00	970.00
IUUC-Gmo-038870	Gadus morhua	90.64	0.00e+00	932.00
IUUC-Gga-041161	Gallus gallus	100.00	0.00e+00	974.00
IUUC-Gac-041844	Gasterosteus aculeatus	92.43	0.00e+00	957.00
IUUC-Ggo-044882	Gorilla gorilla	95.91	0.00e+00	954.00
IUUC-Hsa-046488	Homo sapiens	95.91	0.00e+00	954.00
IUUC-Itr-047958	Ictidomys tridecemlineatus	99.73	0.00e+00	739.00
IUUC-Lch-050672	Latimeria chalumnae	96.12	0.00e+00	972.00
IUUC-Lpe-051084	Leersia perrieri	62.64	1.00e-136	479.00
IUUC-Loc-052030	Lepisosteus oculatus	95.37	0.00e+00	966.00
IUUC-Laf-054280	Loxodonta africana	98.83	0.00e+00	988.00
IUUC-Mcc-055203	Macaca mulatta	95.91	0.00e+00	954.00
IUUC-Meu-056563	Macropus eugenii	98.74	1.00e-135	475.00
IUUC-Mtr-058624	Medicago truncatula	60.44	5.00e-129	454.00
IUUC-Mmr-060925	Microcebus murinus	97.60	0.00e+00	917.00
IUUC-Mdo-062078	Monodelphis domestica	98.83	0.00e+00	964.00
IUUC-Mmu-063603	Mus musculus	99.03	0.00e+00	962.00
IUUC-Mac-065508	Musa acuminata	61.80	2.00e-93	335.00
IUUC-Mpu-066741	Mustela putorius furo	95.33	0.00e+00	954.00
IUUC-Mlu-068152	Myotis lucifugus	99.42	0.00e+00	960.00
IUUC-Nle-069229	Nomascus leucogenys	95.91	0.00e+00	954.00
IUUC-Opr-070277	Ochotona princeps	88.56	0.00e+00	817.00
IUUC-Ont-072623	Oreochromis niloticus	92.43	0.00e+00	958.00
IUUC-Ocu-074280	Oryctolagus cuniculus	97.51	0.00e+00	956.00
IUUC-Oba-075618	Oryza barthii	48.65	8.00e-145	506.00
IUUC-Obr-076718	Oryza brachyantha	62.91	3.00e-137	481.00
IUUC-Ogl-077302	Oryza glaberrima	50.81	6.00e-157	546.00
IUUC-Ogu-078718	Oryza glumaepatula	50.81	7.00e-157	546.00
IUUC-Oin-079515	Oryza indica	44.12	1.00e-94	340.00
IUUC-Olo-080427	Oryza longistaminata	63.32	3.00e-132	465.00
IUUC-Ome-081696	Oryza meridionalis	49.73	1.00e-151	529.00
IUUC-Oni-082137	Oryza nivara	50.81	7.00e-157	546.00
IUUC-Opu-083505	Oryza punctata	48.39	1.00e-143	503.00
IUUC-Oru-085276	Oryza rufipogon	50.63	2.00e-156	545.00
IUUC-Osa-085791	Oryza sativa	50.81	7.00e-157	546.00
IUUC-Ola-087365	Oryzias latipes	95.34	0.00e+00	955.00
IUUC-Olu-087589	Ostreococcus lucimarinus	52.52	6.00e-156	543.00
IUUC-Oga-088357	Otolemur garnettii	95.32	0.00e+00	905.00
IUUC-Oar-089214	Ovis aries	99.42	0.00e+00	992.00
IUUC-Ptr-091532	Pan troglodytes	95.91	0.00e+00	954.00
IUUC-Pan-091927	Papio anubis	95.91	0.00e+00	954.00
IUUC-Psi-093941	Pelodiscus sinensis	92.60	0.00e+00	939.00
IUUC-Pma-094105	Petromyzon marinus	63.49	5.00e-101	360.00
IUUC-Ppa-095868	Physcomitrella patens	66.57	4.00e-140	491.00
IUUC-Pfo-096158	Poecilia formosa	92.23	0.00e+00	958.00
IUUC-Pab-098705	Pongo abelii	95.91	0.00e+00	954.00
IUUC-Pca-100256	Procavia capensis	98.23	0.00e+00	944.00
IUUC-Ppe-101572	Prunus persica	63.69	3.00e-128	451.00
IUUC-Pva-102616	Pteropus vampyrus	99.01	0.00e+00	946.00
IUUC-Rno-105411	Rattus norvegicus	99.22	0.00e+00	966.00
IUUC-Sce-106132	Saccharomyces cerevisiae	25.49	2.00e-42	166.00
IUUC-Sha-106636	Sarcophilus harrisii	98.45	0.00e+00	956.00
IUUC-Smo-109301	Selaginella moellendorffii	63.49	6.00e-143	500.00
IUUC-Sit-110710	Setaria italica	63.71	9.00e-143	499.00
IUUC-Sly-111042	Solanum lycopersicum	50.78	6.00e-151	526.00
IUUC-Stu-112786	Solanum tuberosum	48.37	5.00e-143	500.00
IUUC-Sar-112971	Sorex araneus	86.86	0.00e+00	865.00
IUUC-Sbi-114420	Sorghum bicolor	63.19	2.00e-142	499.00
IUUC-Sre-115175	Sporisorium reilianum	37.17	4.00e-58	219.00
IUUC-Ssc-115695	Sus scrofa	97.67	0.00e+00	945.00
IUUC-Tgu-117009	Taeniopygia guttata	100.00	0.00e+00	957.00
IUUC-Tru-118581	Takifugu rubripes	95.53	0.00e+00	959.00
IUUC-Tsy-119424	Tarsius syrichta	82.05	0.00e+00	734.00
IUUC-Tni-119986	Tetraodon nigroviridis	95.73	0.00e+00	962.00
IUUC-Tca-121739	Theobroma cacao	56.87	3.00e-125	441.00
IUUC-Tur-126856	Triticum urartu	60.61	6.00e-62	231.00
IUUC-Tme-127126	Tuber melanosporum	38.42	2.00e-58	219.00
IUUC-Tbe-127665	Tupaia belangeri	83.79	0.00e+00	827.00
IUUC-Vpa-130768	Vicugna pacos	95.48	0.00e+00	939.00
IUUC-Xtr-132842	Xenopus tropicalis	92.38	0.00e+00	912.00
IUUC-Xma-134020	Xiphophorus maculatus	92.23	0.00e+00	958.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence