iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mga-060070

Ensembl Protein ID

ENSMGAP00000011379.2

UniProt Accession

G1NEL0; G1NEL0_MELGA

Protein Name

E3 ubiquitin-protein ligase

Gene Name

SIAH2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000010923.2	ENSMGAT00000012254.2	ENSMGAP00000011379.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	96.11	1.00e-146	516.00	IUUC-Hsa-046179
E3 activity/RING/RING	96.09	5.00e-146	514.00	IUUC-Mmu-063206
E3 activity/RING/RING	96.09	4.00e-146	514.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Meleagris gallopavo

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

SGRSSATAPS VPRPCSRAPP PPRSPPSSSH PPGALESGGS TAQLRVLPTL RAVPILSGAG 60
GRAGRCPPQH HELTSLFECP VCFDYVLAAP SCRCQAGHLV CKQCRQKLSL CPTCRGSLTP 120

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Nucleotide Sequence
(Fasta)

TCAGGTCGAA GCTCTGCCAC CGCCCCAAGT GTGCCACGTC CCTGCAGCAG AGCAGAGGGC 60
ACTGCAGCCC CTGGTGCCCG CAGTCCCCAG GGCCACCACC ACCAGGGCGC AGCCTGCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	96.11	1.00e-147	515.00
IUUC-Ago-007904	Ashbya gossypii	42.86	1.00e-01	28.90
IUUC-Ame-011678	Astyanax mexicanus	88.58	6.00e-135	473.00
IUUC-Bta-012750	Bos taurus	96.09	2.00e-147	514.00
IUUC-Cja-019800	Callithrix jacchus	96.09	4.00e-147	513.00
IUUC-Cfa-020505	Canis familiaris	96.09	7.00e-147	512.00
IUUC-Cpo-021394	Cavia porcellus	95.70	2.00e-146	510.00
IUUC-Csa-023374	Chlorocebus sabaeus	96.09	4.00e-147	513.00
IUUC-Cho-024933	Choloepus hoffmanni	96.09	5.00e-147	512.00
IUUC-Dre-027711	Danio rerio	88.19	1.00e-134	471.00
IUUC-Dno-029260	Dasypus novemcinctus	95.93	4.00e-141	493.00
IUUC-Dor-030489	Dipodomys ordii	95.68	2.00e-107	380.00
IUUC-Ete-032946	Echinops telfairi	95.33	2.00e-147	514.00
IUUC-Eca-033546	Equus caballus	92.34	5.00e-150	522.00
IUUC-Eeu-034861	Erinaceus europaeus	92.22	7.00e-141	492.00
IUUC-Fal-037160	Ficedula albicollis	87.30	2.00e-130	457.00
IUUC-Gmo-039091	Gadus morhua	86.33	1.00e-133	468.00
IUUC-Gga-040252	Gallus gallus	97.67	3.00e-150	523.00
IUUC-Gac-041673	Gasterosteus aculeatus	86.22	4.00e-133	466.00
IUUC-Ggo-044618	Gorilla gorilla	96.09	4.00e-147	513.00
IUUC-Hsa-046179	Homo sapiens	96.09	4.00e-147	513.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	95.33	2.00e-146	510.00
IUUC-Lch-049496	Latimeria chalumnae	88.09	3.00e-143	500.00
IUUC-Loc-052107	Lepisosteus oculatus	89.24	5.00e-135	473.00
IUUC-Laf-054257	Loxodonta africana	95.72	6.00e-146	509.00
IUUC-Mcc-055023	Macaca mulatta	96.09	4.00e-147	513.00
IUUC-Meu-055922	Macropus eugenii	94.53	1.00e-143	501.00
IUUC-Mmr-061494	Microcebus murinus	96.09	4.00e-147	513.00
IUUC-Mdo-061971	Monodelphis domestica	96.09	1.00e-146	511.00
IUUC-Mmu-063206	Mus musculus	96.08	2.00e-146	511.00
IUUC-Mpu-066597	Mustela putorius furo	96.09	4.00e-147	513.00
IUUC-Mlu-067199	Myotis lucifugus	95.70	2.00e-146	511.00
IUUC-Nle-069342	Nomascus leucogenys	96.09	4.00e-147	513.00
IUUC-Opr-070341	Ochotona princeps	56.86	7.00e-51	193.00
IUUC-Ont-071906	Oreochromis niloticus	84.85	3.00e-134	470.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.85	2.00e-50	191.00
IUUC-Ocu-073950	Oryctolagus cuniculus	95.00	2.00e-147	514.00
IUUC-Oga-089154	Otolemur garnettii	96.09	4.00e-147	513.00
IUUC-Oar-089446	Ovis aries	95.04	2.00e-148	517.00
IUUC-Ptr-091088	Pan troglodytes	96.09	4.00e-147	513.00
IUUC-Psi-093079	Pelodiscus sinensis	94.72	4.00e-149	519.00
IUUC-Pfo-097007	Poecilia formosa	82.28	7.00e-127	446.00
IUUC-Pab-098092	Pongo abelii	96.09	4.00e-147	513.00
IUUC-Pca-100328	Procavia capensis	93.36	5.00e-142	496.00
IUUC-Pva-102368	Pteropus vampyrus	98.21	2.00e-63	235.00
IUUC-Rno-105477	Rattus norvegicus	96.08	2.00e-146	511.00
IUUC-Sha-107630	Sarcophilus harrisii	94.72	5.00e-149	519.00
IUUC-Ssc-116441	Sus scrofa	96.09	3.00e-147	513.00
IUUC-Tru-118004	Takifugu rubripes	83.59	7.00e-129	452.00
IUUC-Tsy-119548	Tarsius syrichta	87.97	8.00e-67	246.00
IUUC-Tni-120846	Tetraodon nigroviridis	85.43	6.00e-131	459.00
IUUC-Vpa-130799	Vicugna pacos	98.84	2.00e-103	367.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence