iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-097007

Ensembl Protein ID

ENSPFOP00000001878.2

UniProt Accession

A0A087X7X5; A0A087X7X5_POEFO

Genbank Protein ID

ENSPFOP00000001878

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AYCK01019597

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000001984.2	ENSPFOT00000001882.2	ENSPFOP00000001878.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	85.38	8.00e-132	467.00	IUUC-Hsa-046179
E3 activity/RING/RING	85.38	5.00e-132	468.00	IUUC-Mmu-063206
E3 activity/RING/RING	85.38	3.00e-132	468.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Poecilia formosa

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MSRPSSAGGG GLGAGKAGGG KHGGSGGTAS AAAAAAAAAA AAVAATAGVG SVPGSGSAAA 60
SSAGSLPHAA ALPGQSPELT ALFECPVCFD YVLPPILQCQ AGHLVCNPCR QKLSCCPTCR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCAAACTA ATACAAACTA ACCGCCGCCA TGTTGTGTCT CCGCGGCCCG GAGGGACGTC 60
CGGTCGTAAA TAGTAAATGA CGGTACCGCC CGCTGGGCCG CTGACTGGAC CGGACCACAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	85.38	3.00e-133	468.00
IUUC-Ame-011678	Astyanax mexicanus	90.55	1.00e-140	493.00
IUUC-Bta-012750	Bos taurus	84.98	4.00e-133	467.00
IUUC-Cja-019800	Callithrix jacchus	85.38	2.00e-133	468.00
IUUC-Cfa-020505	Canis familiaris	85.77	1.00e-133	469.00
IUUC-Cpo-021394	Cavia porcellus	85.38	3.00e-133	467.00
IUUC-Csa-023374	Chlorocebus sabaeus	85.38	2.00e-133	468.00
IUUC-Cho-024933	Choloepus hoffmanni	85.38	2.00e-133	468.00
IUUC-Dre-027711	Danio rerio	91.34	7.00e-142	496.00
IUUC-Dno-029260	Dasypus novemcinctus	86.01	3.00e-129	454.00
IUUC-Dor-030489	Dipodomys ordii	84.70	8.00e-95	339.00
IUUC-Ete-032946	Echinops telfairi	84.98	8.00e-133	466.00
IUUC-Eca-033546	Equus caballus	84.17	3.00e-134	471.00
IUUC-Eeu-034861	Erinaceus europaeus	83.00	6.00e-129	453.00
IUUC-Gmo-039091	Gadus morhua	91.86	4.00e-143	500.00
IUUC-Gga-040252	Gallus gallus	84.58	3.00e-131	461.00
IUUC-Gac-041673	Gasterosteus aculeatus	93.68	5.00e-143	500.00
IUUC-Ggo-044618	Gorilla gorilla	85.38	2.00e-133	468.00
IUUC-Hsa-046179	Homo sapiens	85.38	2.00e-133	468.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	84.98	9.00e-133	465.00
IUUC-Lch-049496	Latimeria chalumnae	84.98	7.00e-134	469.00
IUUC-Loc-052107	Lepisosteus oculatus	90.80	2.00e-139	488.00
IUUC-Laf-054257	Loxodonta africana	84.98	2.00e-131	461.00
IUUC-Mcc-055023	Macaca mulatta	85.38	2.00e-133	468.00
IUUC-Meu-055922	Macropus eugenii	85.38	1.00e-132	465.00
IUUC-Mga-060070	Meleagris gallopavo	81.15	6.00e-128	450.00
IUUC-Mmr-061494	Microcebus murinus	85.38	2.00e-133	468.00
IUUC-Mdo-061971	Monodelphis domestica	86.17	8.00e-134	469.00
IUUC-Mmu-063206	Mus musculus	85.38	1.00e-133	469.00
IUUC-Mpu-066597	Mustela putorius furo	85.38	2.00e-133	468.00
IUUC-Mlu-067199	Myotis lucifugus	84.98	1.00e-132	466.00
IUUC-Nle-069342	Nomascus leucogenys	85.38	2.00e-133	468.00
IUUC-Ont-071906	Oreochromis niloticus	91.89	3.00e-144	504.00
IUUC-Ocu-073950	Oryctolagus cuniculus	84.98	6.00e-133	466.00
IUUC-Oga-089154	Otolemur garnettii	85.38	2.00e-133	468.00
IUUC-Oar-089446	Ovis aries	84.98	5.00e-133	466.00
IUUC-Ptr-091088	Pan troglodytes	85.38	2.00e-133	468.00
IUUC-Psi-093079	Pelodiscus sinensis	85.38	4.00e-133	467.00
IUUC-Pab-098092	Pongo abelii	85.38	2.00e-133	468.00
IUUC-Pca-100328	Procavia capensis	83.00	3.00e-129	454.00
IUUC-Pva-102368	Pteropus vampyrus	91.82	9.00e-59	220.00
IUUC-Rno-105477	Rattus norvegicus	85.38	1.00e-133	469.00
IUUC-Sha-107630	Sarcophilus harrisii	85.77	2.00e-133	468.00
IUUC-Ssc-116441	Sus scrofa	84.98	5.00e-133	467.00
IUUC-Tru-118004	Takifugu rubripes	91.41	1.00e-141	495.00
IUUC-Tsy-119548	Tarsius syrichta	81.82	5.00e-62	230.00
IUUC-Tni-120846	Tetraodon nigroviridis	91.70	1.00e-141	495.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence