iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091299

UUCD1 version

UUC-PaT-01097

Ensembl Protein ID

ENSPTRP00000022085.3

UniProt Accession

H2QJF0; H2QJF0_PANTR

Genbank Protein ID

JAA16892.1; JAA36075.1

Protein Name

Ubiquitin specific peptidase 37

Genbank Nucleotide ID

AACZ03018877; GABE01008664

Gene Name

USP37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000012920.4	ENSPTRT00000023951.3	ENSPTRP00000022085.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.50e-88	297.2	341	950

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +G++NlgNtCYmN++LQ+L+++++++++ll+   + ++++  k p ++l++ +++l+ +    +s++k+   +++++a++++ae+fsgy
   Q: 341  QGFSNLGNTCYMNAILQSLFSLQSFANDLLK---QGIPWK--KIPLNALIRRFAHLLVKKDicNSETKKDLLKKVKNAISATAERFSGY 424
           69*****************************...*****9..679999999999999776567************************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
           +q+Da+Efl+++ldql+e+++k  nk++++e  + +++++d+   + ++ +++++ ++++++++++i+c++c+++  ++e+f+dls+++
   Q: 425  MQNDAHEFLSQCLDQLKEDMEK-LNKTWKTEPVSGEENSPDI---SATRAYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDL 509
           ********************55.9999999999999999999...7999**************************************** PP
   S: 177  pgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           p++++  ++ s+qd+L+ f+++eele    y+cekc +k+ a  ++k+++lP+vLilhLkR+sf+ + + ++ki ++v +p+ L+ls++
   Q: 510  PRRKKPLPPrSIQDSLDLFFRAEELE----YSCEKCGGKC-ALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSH 593
           *999886545***************9....*********9.89999******************************************* PP
   S: 265  cts...................................................................................... 267
           ct+                                                                                      
   Q: 594  CTEntkppftlgwsahmaisrplkasqmvnscitspstpskkftfksksslalcldsdsedelkrsvalsqrlcemlgneqqqedlekd 682
           ***99****************99999999999999999999999999999999999999999999999999999999999888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 683  sklcpiepdkselensgfdrmseeellaavleiskrdaspslshedddkptsspdtgfaeddiqempenpdtmetekprtiteldpasf 771
           88888888888888888888888888888888888888888877777777777777777777777777777777777777777777777 PP
   S: 268  ...............peekqke................................................................... 274
                          p     e                                                                   
   Q: 772  teitkdcdenkenktP-----Egsqgevdwlqqydmerereeqelqqalaqslqeqeaweqkedddlkratelslqefnnsfvdalgsd 855
           7766666655555550.....05555555555555555555555666666666666677777777777777777777888888888888 PP
   S: 275  ..............................kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaY 331
                                         +++Y+Li+vv+H G ++ssGHY+++v++ k++ W++++D +V++++e+ v++++++++Y
   Q: 856  edsgnedvfdmeyteaeaeelkrnaetgnlPHSYRLISVVSHIGsTSSSGHYISDVYDIKKQaWFTYNDLEVSKIQEAAVQSDRDRSGY 944
           888888888888888888888899999999****************************99999************************** PP
   S: 332  vlfYkr 337
           ++fY++
   Q: 945  IFFYMH 950
           ****98 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MSPLKIHGPI RIRSMQTGIT KWKEGSFEIV EKENKVSLVV HYNTGGIPRI FQLSHNIKNV 60
VLRPSGAKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD AVHQNRLPAA MKPSQGSGSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTCCTC TGAAGATACA TGGTCCTATC AGAATTCGAA GTATGCAGAC TGGGATTACA 60
AAGTGGAAAG AAGGATCCTT TGAAATTGTA GAAAAAGAGA ATAAAGTCAG CCTAGTAGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0006275--P:regulation of DNA replication
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ptr:459944

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001400	Ailuropoda melanoleuca	95.31	0.00e+00	1741.00
IUUC-Apl-004033	Anas platyrhynchos	77.43	0.00e+00	1432.00
IUUC-Aca-005370	Anolis carolinensis	70.05	0.00e+00	1314.00
IUUC-Ame-011884	Astyanax mexicanus	57.45	0.00e+00	984.00
IUUC-Bta-012725	Bos taurus	94.50	0.00e+00	1712.00
IUUC-Cja-019939	Callithrix jacchus	96.84	0.00e+00	1712.00
IUUC-Cfa-020835	Canis familiaris	95.51	0.00e+00	1793.00
IUUC-Cpo-022067	Cavia porcellus	93.43	0.00e+00	1558.00
IUUC-Cre-022867	Chlamydomonas reinhardtii	29.63	2.00e-24	107.00
IUUC-Csa-023085	Chlorocebus sabaeus	98.67	0.00e+00	1819.00
IUUC-Cho-024390	Choloepus hoffmanni	86.83	2.00e-165	576.00
IUUC-Cin-025496	Ciona intestinalis	37.25	1.00e-42	168.00
IUUC-Csv-025812	Ciona savignyi	36.22	6.00e-42	165.00
IUUC-Dre-028255	Danio rerio	57.27	0.00e+00	944.00
IUUC-Dno-028986	Dasypus novemcinctus	94.19	0.00e+00	1694.00
IUUC-Dor-031062	Dipodomys ordii	80.17	0.00e+00	889.00
IUUC-Ete-032359	Echinops telfairi	82.56	0.00e+00	815.00
IUUC-Eca-033964	Equus caballus	94.09	0.00e+00	1733.00
IUUC-Eeu-034492	Erinaceus europaeus	86.05	0.00e+00	825.00
IUUC-Fca-036359	Felis catus	94.69	0.00e+00	1732.00
IUUC-Fal-037640	Ficedula albicollis	77.53	0.00e+00	1402.00
IUUC-Gmo-039600	Gadus morhua	54.52	0.00e+00	931.00
IUUC-Gga-040126	Gallus gallus	77.33	0.00e+00	1364.00
IUUC-Gac-041557	Gasterosteus aculeatus	53.92	0.00e+00	911.00
IUUC-Ggo-045571	Gorilla gorilla	95.47	0.00e+00	1608.00
IUUC-Hsa-046043	Homo sapiens	99.80	0.00e+00	1799.00
IUUC-Itr-048207	Ictidomys tridecemlineatus	94.59	0.00e+00	1700.00
IUUC-Lch-050357	Latimeria chalumnae	64.06	0.00e+00	1038.00
IUUC-Loc-052849	Lepisosteus oculatus	61.39	0.00e+00	1004.00
IUUC-Laf-054570	Loxodonta africana	92.17	0.00e+00	1643.00
IUUC-Mcc-054989	Macaca mulatta	98.54	0.00e+00	1680.00
IUUC-Meu-056273	Macropus eugenii	64.73	8.00e-171	594.00
IUUC-Mga-059814	Meleagris gallopavo	75.71	0.00e+00	1371.00
IUUC-Mmr-061726	Microcebus murinus	94.90	0.00e+00	1743.00
IUUC-Mdo-062974	Monodelphis domestica	85.11	0.00e+00	1570.00
IUUC-Mmu-064069	Mus musculus	90.21	0.00e+00	1619.00
IUUC-Mpu-066008	Mustela putorius furo	94.69	0.00e+00	1698.00
IUUC-Mlu-068224	Myotis lucifugus	41.95	4.00e-169	588.00
IUUC-Nle-069259	Nomascus leucogenys	99.08	0.00e+00	1786.00
IUUC-Opr-070882	Ochotona princeps	78.42	9.00e-141	494.00
IUUC-Ont-072441	Oreochromis niloticus	54.66	0.00e+00	926.00
IUUC-Oan-073151	Ornithorhynchus anatinus	76.26	4.00e-119	421.00
IUUC-Ocu-074879	Oryctolagus cuniculus	93.37	0.00e+00	1714.00
IUUC-Ola-087007	Oryzias latipes	53.35	0.00e+00	884.00
IUUC-Oga-088385	Otolemur garnettii	93.61	0.00e+00	1727.00
IUUC-Oar-090305	Ovis aries	92.56	0.00e+00	1736.00
IUUC-Pan-091996	Papio anubis	98.64	0.00e+00	1761.00
IUUC-Psi-093176	Pelodiscus sinensis	78.08	0.00e+00	1433.00
IUUC-Pma-094331	Petromyzon marinus	48.62	0.00e+00	768.00
IUUC-Ppa-095732	Physcomitrella patens	31.09	8.00e-25	108.00
IUUC-Pfo-096503	Poecilia formosa	56.29	0.00e+00	928.00
IUUC-Pab-098543	Pongo abelii	97.82	0.00e+00	957.00
IUUC-Pca-101099	Procavia capensis	86.98	0.00e+00	1298.00
IUUC-Pva-103163	Pteropus vampyrus	87.97	0.00e+00	1602.00
IUUC-Rno-105766	Rattus norvegicus	91.23	0.00e+00	1636.00
IUUC-Sha-106610	Sarcophilus harrisii	81.25	0.00e+00	1471.00
IUUC-Sar-113256	Sorex araneus	88.79	2.00e-109	390.00
IUUC-Ssc-116353	Sus scrofa	94.40	0.00e+00	1689.00
IUUC-Tgu-116971	Taeniopygia guttata	77.33	0.00e+00	1368.00
IUUC-Tru-117932	Takifugu rubripes	45.08	0.00e+00	664.00
IUUC-Tsy-119185	Tarsius syrichta	90.34	0.00e+00	1129.00
IUUC-Tni-119842	Tetraodon nigroviridis	60.13	1.00e-110	393.00
IUUC-Tbe-127281	Tupaia belangeri	83.45	0.00e+00	657.00
IUUC-Ttr-128177	Tursiops truncatus	94.68	0.00e+00	1342.00
IUUC-Vpa-130031	Vicugna pacos	94.70	0.00e+00	1769.00
IUUC-Xtr-132949	Xenopus tropicalis	65.22	0.00e+00	1160.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence