iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	circBase	microRNA	TRANSFAC
RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.10e-30	104.6	330	367
UBD/Beta-Prp	7.90e-46	157.7	279	448

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd..tllvsGsdDgtikvWDlrtgvll 36
           gH+  v++++f++  t ++s+++D  +k+WD+ tg ++
   Q: 330  GHSKAVRDICFNTagTQFLSAAYDRYLKLWDTETGQCI 367
           8**********444699******************996 PP

UBD/Beta-Prp

   S: 85   kcvhtlkghedsvlslsfsp.sgdklvsGshdrtirvwdlet.gqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkl 171
           k++h+++gh++ v +++++p sg+ l+s s d  i++w++   + cl+ t+ gh+++v+ ++++  g  + s+++Dr ++lWd +tg++
   Q: 279  KQIHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVYGdRRCLR-TFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQC 366
           899*****************999****************975156776.**************************************** PP
   S: 172  lrtltgghtdsvyslsfdsng...kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW..d 250
           + ++t  + +  y+++f+++    + +v+g  d+++  wd+++ge+v+++  h   v+ + f +++ r+vs+s+D+s+r+W  d
   Q: 367  ISRFT--NRKVPYCVKFNPDEdkqNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWewD 448
           ****8..588889***999988889*******************************************************9444 PP

Organism

Mus musculus

Functional Description
(View)

Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing.

Protein Sequence
(Fasta)

MSAAIAALAA SYGSGSGSES DSDSEGSRCP LPAADSLMHL TKSPSAKLSL TVAVDSAPEV 60
AVKEDLETGV HLDPAVKEVQ YNPTYETMFA PEFGPENPFR TQQMAAPRNM LSGYAEPAHI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCAACGAGG TCCTGAAAGT TACAAATAGT TGTAATCCCT TGTGCTTCTT TAGATAAATG 60
TTTGTGAATC TCAAGTTTTG ATACAGTTAT CTCAATAATA AAGTTTTTTT CGAGAAGTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0853--WD repeat

Interpro

IPR032847--PRPF17
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005634--C:nucleus
GO:0003723--F:RNA binding
GO:0000398--P:mRNA splicing, via spliceosome

KEGG

mmu:71713

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000473	Aegilops tauschii	50.00	4.00e-144	504.00
IUUC-Aml-002243	Ailuropoda melanoleuca	98.10	0.00e+00	806.00
IUUC-Atr-002502	Amborella trichopoda	51.13	8.00e-154	536.00
IUUC-Apl-003885	Anas platyrhynchos	94.26	0.00e+00	1021.00
IUUC-Aca-004854	Anolis carolinensis	69.60	0.00e+00	748.00
IUUC-Aly-006158	Arabidopsis lyrata	50.94	1.00e-154	540.00
IUUC-Ath-007474	Arabidopsis thaliana	52.25	2.00e-155	542.00
IUUC-Ago-007726	Ashbya gossypii	37.08	2.00e-70	259.00
IUUC-Acl-008220	Aspergillus clavatus	43.57	7.00e-133	467.00
IUUC-Afl-008473	Aspergillus flavus	42.51	8.00e-130	457.00
IUUC-Afu-008773	Aspergillus fumigatus	43.50	2.00e-131	462.00
IUUC-Ani-009323	Aspergillus nidulans	43.42	6.00e-118	417.00
IUUC-Ang-009851	Aspergillus niger	43.26	1.00e-130	459.00
IUUC-Aor-009950	Aspergillus oryzae	42.51	8.00e-130	457.00
IUUC-Ate-010372	Aspergillus terreus	44.80	4.00e-133	468.00
IUUC-Ame-011660	Astyanax mexicanus	85.74	0.00e+00	982.00
IUUC-Bgr-012230	Blumeria graminis	44.44	1.00e-125	442.00
IUUC-Bta-012568	Bos taurus	98.55	0.00e+00	1087.00
IUUC-Bci-013646	Botrytis cinerea	45.26	1.00e-122	433.00
IUUC-Bdi-014199	Brachypodium distachyon	50.48	3.00e-145	508.00
IUUC-Bol-015695	Brassica oleracea	51.98	7.00e-162	563.00
IUUC-Bra-017923	Brassica rapa	52.27	4.00e-162	564.00
IUUC-Cel-018535	Caenorhabditis elegans	51.72	2.00e-178	618.00
IUUC-Cja-019071	Callithrix jacchus	98.91	0.00e+00	1091.00
IUUC-Cfa-020559	Canis familiaris	98.55	0.00e+00	1085.00
IUUC-Cpo-022356	Cavia porcellus	99.09	0.00e+00	1093.00
IUUC-Cre-022594	Chlamydomonas reinhardtii	44.02	3.00e-77	281.00
IUUC-Csa-023125	Chlorocebus sabaeus	99.09	0.00e+00	1092.00
IUUC-Cho-024676	Choloepus hoffmanni	90.70	0.00e+00	953.00
IUUC-Cin-025229	Ciona intestinalis	71.23	0.00e+00	770.00
IUUC-Csv-025868	Ciona savignyi	70.53	2.00e-40	155.00
IUUC-Cgl-026739	Colletotrichum gloeosporioides	41.07	1.00e-107	383.00
IUUC-Cne-026885	Cryptococcus neoformans	51.66	1.00e-152	533.00
IUUC-Dre-027631	Danio rerio	85.16	0.00e+00	988.00
IUUC-Dno-029815	Dasypus novemcinctus	87.97	0.00e+00	1001.00
IUUC-Dor-031143	Dipodomys ordii	84.06	0.00e+00	915.00
IUUC-Dse-031520	Dothistroma septosporum	46.09	2.00e-96	346.00
IUUC-Dme-032050	Drosophila melanogaster	62.59	0.00e+00	749.00
IUUC-Ete-032866	Echinops telfairi	96.01	0.00e+00	1058.00
IUUC-Eca-033384	Equus caballus	98.91	0.00e+00	1088.00
IUUC-Eeu-034471	Erinaceus europaeus	84.24	0.00e+00	852.00
IUUC-Fca-035727	Felis catus	98.55	0.00e+00	1088.00
IUUC-Fal-036774	Ficedula albicollis	94.83	0.00e+00	1032.00
IUUC-Fox-037951	Fusarium oxysporum	42.33	4.00e-127	448.00
IUUC-Fso-038287	Fusarium solani	43.33	8.00e-125	440.00
IUUC-Gmo-039670	Gadus morhua	81.68	0.00e+00	949.00
IUUC-Ggr-039764	Gaeumannomyces graminis	40.22	1.00e-116	413.00
IUUC-Gga-040293	Gallus gallus	95.16	0.00e+00	1033.00
IUUC-Gac-042159	Gasterosteus aculeatus	84.49	0.00e+00	983.00
IUUC-Gma-044299	Glycine max	50.38	1.00e-145	509.00
IUUC-Ggo-044864	Gorilla gorilla	98.91	0.00e+00	1092.00
IUUC-Hsa-046602	Homo sapiens	98.91	0.00e+00	1092.00
IUUC-Itr-047985	Ictidomys tridecemlineatus	99.52	0.00e+00	818.00
IUUC-Kpa-049318	Komagataella pastoris	45.85	2.00e-96	345.00
IUUC-Lch-049796	Latimeria chalumnae	76.01	0.00e+00	848.00
IUUC-Lpe-051153	Leersia perrieri	51.15	2.00e-146	512.00
IUUC-Loc-052467	Lepisosteus oculatus	87.36	0.00e+00	996.00
IUUC-Lma-053107	Leptosphaeria maculans	48.16	4.00e-113	401.00
IUUC-Laf-053787	Loxodonta africana	98.38	0.00e+00	1117.00
IUUC-Mcc-055706	Macaca mulatta	99.28	0.00e+00	1095.00
IUUC-Meu-056757	Macropus eugenii	80.92	0.00e+00	637.00
IUUC-Mor-057079	Magnaporthe oryzae	38.86	3.00e-115	409.00
IUUC-Mpo-057533	Magnaporthe poae	50.71	2.00e-112	399.00
IUUC-Mtr-057950	Medicago truncatula	62.39	1.00e-135	476.00
IUUC-Mla-058910	Melampsora laricipopulina	47.05	1.00e-148	520.00
IUUC-Mga-059366	Meleagris gallopavo	94.08	0.00e+00	1030.00
IUUC-Mvi-060349	Microbotryum violaceum	58.69	9.00e-137	480.00
IUUC-Mmr-061209	Microcebus murinus	99.09	0.00e+00	1130.00
IUUC-Mdo-062118	Monodelphis domestica	96.01	0.00e+00	1106.00
IUUC-Mac-065080	Musa acuminata	51.66	9.00e-153	533.00
IUUC-Mpu-066659	Mustela putorius furo	98.37	0.00e+00	1086.00
IUUC-Mlu-067029	Myotis lucifugus	98.55	0.00e+00	1066.00
IUUC-Nfi-068334	Neosartorya fischeri	45.05	2.00e-132	466.00
IUUC-Ncr-068675	Neurospora crassa	38.79	1.00e-103	370.00
IUUC-Nle-070113	Nomascus leucogenys	98.55	0.00e+00	1091.00
IUUC-Opr-070685	Ochotona princeps	90.76	0.00e+00	1038.00
IUUC-Ont-071680	Oreochromis niloticus	84.83	0.00e+00	979.00
IUUC-Oan-073573	Ornithorhynchus anatinus	96.88	0.00e+00	963.00
IUUC-Ocu-074074	Oryctolagus cuniculus	98.91	0.00e+00	1126.00
IUUC-Oba-075625	Oryza barthii	51.81	3.00e-147	514.00
IUUC-Obr-076510	Oryza brachyantha	51.33	2.00e-147	515.00
IUUC-Ogl-077275	Oryza glaberrima	51.81	3.00e-147	514.00
IUUC-Ogu-078563	Oryza glumaepatula	51.81	3.00e-147	514.00
IUUC-Oin-079898	Oryza indica	63.45	2.00e-134	472.00
IUUC-Olo-081080	Oryza longistaminata	52.02	2.00e-141	495.00
IUUC-Oni-083121	Oryza nivara	51.81	4.00e-147	514.00
IUUC-Opu-083329	Oryza punctata	51.34	1.00e-146	513.00
IUUC-Oru-084807	Oryza rufipogon	51.36	1.00e-128	453.00
IUUC-Osa-086039	Oryza sativa	51.90	8.00e-148	517.00
IUUC-Ola-087149	Oryzias latipes	83.91	0.00e+00	972.00
IUUC-Olu-087627	Ostreococcus lucimarinus	43.35	6.00e-121	427.00
IUUC-Oga-088359	Otolemur garnettii	99.28	0.00e+00	1097.00
IUUC-Oar-089390	Ovis aries	98.55	0.00e+00	1083.00
IUUC-Ptr-090894	Pan troglodytes	98.91	0.00e+00	1092.00
IUUC-Pan-092476	Papio anubis	99.28	0.00e+00	1095.00
IUUC-Psi-093527	Pelodiscus sinensis	92.53	0.00e+00	984.00
IUUC-Pno-094771	Phaeosphaeria nodorum	48.19	1.00e-112	399.00
IUUC-Ppa-095386	Physcomitrella patens	50.47	2.00e-155	542.00
IUUC-Pfo-096139	Poecilia formosa	85.71	0.00e+00	989.00
IUUC-Pab-097838	Pongo abelii	98.99	0.00e+00	969.00
IUUC-Pop-098945	Populus trichocarpa	51.50	7.00e-153	534.00
IUUC-Pca-100876	Procavia capensis	83.15	0.00e+00	934.00
IUUC-Ppe-101777	Prunus persica	50.85	3.00e-151	528.00
IUUC-Pva-102418	Pteropus vampyrus	98.19	0.00e+00	1084.00
IUUC-Pgr-103456	Puccinia graminis	50.37	5.00e-159	554.00
IUUC-Ptt-103731	Puccinia triticina	46.11	2.00e-145	509.00
IUUC-Pte-104386	Pyrenophora teres	49.51	3.00e-114	405.00
IUUC-Pyt-104560	Pyrenophora triticirepentis	50.49	2.00e-114	405.00
IUUC-Rno-105694	Rattus norvegicus	95.11	0.00e+00	1026.00
IUUC-Sce-106339	Saccharomyces cerevisiae	37.89	1.00e-75	276.00
IUUC-Sha-106709	Sarcophilus harrisii	96.20	0.00e+00	1105.00
IUUC-Sja-107817	Schizosaccharomyces japonicus	40.54	8.00e-125	441.00
IUUC-Spo-108331	Schizosaccharomyces pombe	42.34	8.00e-123	434.00
IUUC-Ssl-108530	Sclerotinia sclerotiorum	47.31	6.00e-117	414.00
IUUC-Smo-108778	Selaginella moellendorffii	45.30	5.00e-127	447.00
IUUC-Sit-110446	Setaria italica	48.80	3.00e-145	508.00
IUUC-Sly-111330	Solanum lycopersicum	49.46	3.00e-151	528.00
IUUC-Stu-112610	Solanum tuberosum	49.12	2.00e-151	528.00
IUUC-Sar-113065	Sorex araneus	78.00	2.00e-126	445.00
IUUC-Sbi-114005	Sorghum bicolor	49.71	5.00e-143	501.00
IUUC-Sre-114988	Sporisorium reilianum	50.19	3.00e-158	551.00
IUUC-Ssc-115760	Sus scrofa	98.91	0.00e+00	1092.00
IUUC-Tgu-116493	Taeniopygia guttata	95.36	0.00e+00	1039.00
IUUC-Tru-118489	Takifugu rubripes	81.87	0.00e+00	951.00
IUUC-Tsy-119332	Tarsius syrichta	98.55	0.00e+00	1125.00
IUUC-Tni-120202	Tetraodon nigroviridis	78.32	0.00e+00	882.00
IUUC-Tca-121429	Theobroma cacao	49.72	1.00e-150	526.00
IUUC-Tre-122162	Trichoderma reesei	43.38	3.00e-125	442.00
IUUC-Tvi-122500	Trichoderma virens	42.94	2.00e-122	432.00
IUUC-Tae-125557	Triticum aestivum	49.71	8.00e-144	503.00
IUUC-Tur-126554	Triticum urartu	49.61	8.00e-142	497.00
IUUC-Tme-126919	Tuber melanosporum	45.31	4.00e-139	488.00
IUUC-Tbe-127968	Tupaia belangeri	93.48	0.00e+00	1048.00
IUUC-Ttr-129215	Tursiops truncatus	98.37	0.00e+00	1081.00
IUUC-Uma-129622	Ustilago maydis	49.46	2.00e-160	559.00
IUUC-Vda-129750	Verticillium dahliae	44.23	3.00e-124	438.00
IUUC-Vpa-130617	Vicugna pacos	96.51	0.00e+00	981.00
IUUC-Vvi-131238	Vitis vinifera	61.81	3.00e-134	472.00
IUUC-Xtr-131865	Xenopus tropicalis	90.07	0.00e+00	1012.00
IUUC-Xma-133627	Xiphophorus maculatus	85.90	0.00e+00	991.00
IUUC-Yli-134390	Yarrowia lipolytica	45.76	8.00e-116	410.00
IUUC-Zma-135925	Zea mays	51.24	7.00e-141	494.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence