iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089428

Ensembl Protein ID

ENSOARP00000012263.1

UniProt Accession

W5PP87; W5PP87_SHEEP

Genbank Protein ID

ENSOARP00000012263

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01106632

Gene Name

HACE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000011435.1	ENSOART00000012439.1	ENSOARP00000012263.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.20e-113	378.0	576	895

Active Site

Position(s)	Description	Evidence
876	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s+ d +t+qpn++s + np+hl++F+f+G++lg+al +++l+++ 
   Q: 576  AKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIVNPDYALFTQSA-DGTTFQPNSNSSV-NPDHLNYFRFAGQILGLALNHRQLVNIY 661
           679999*************.**********************6666.67788*******9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +++sfyk++lg +++++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG +i Vt++Nk eYv+lv+e+
   Q: 662  FTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTEL 747
           **********************************99...************************************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+++ i+ q++af +Gf+  ip++l++lF+e elell++G++eidv+d+ k+t+y++gy++++p+iqwFwev+e+++ eer  +LqFvT
   Q: 748  RMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITPEERVLLLQFVT 836
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekL 323
           gssr+P+gGfa+++     + f+i     +++ lP+s+TC+n+LkLPeY+skei +++L
   Q: 837  GSSRVPHGGFANIMggsgLQNFTIAAvPYTPNLLPTSSTCINMLKLPEYPSKEIQHRQL 895
           ******************8888888868888**********************988877 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MERAMEQLNR LTRSLRRART VELPDDNETA VYTLMPMVMA DQHRSVSELL SNSKFDVNYA 60
FGRVKRSLLH IAANCGSVEC LVLLLKKGAN PNYQDISGCT PLHLAARNGQ KKCMSKLLEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGAGAG CGATGGAGCA GCTCAATCGC CTGACGCGCT CGCTGCGCCG CGCGCGCACC 60
GTGGAGCTGC CCGATGGTGA GCGGGCCGCG GGGCTGGGGC CGCCGGGGGC TGGGCTCAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT

Pfam

PF12796--Ank_2
PF00632--HECT

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0000139--C:Golgi membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030334--P:regulation of cell migration

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001490	Ailuropoda melanoleuca	98.11	0.00e+00	1835.00
IUUC-Apl-003400	Anas platyrhynchos	86.98	0.00e+00	1117.00
IUUC-Aca-005375	Anolis carolinensis	90.75	0.00e+00	1702.00
IUUC-Ame-011847	Astyanax mexicanus	84.01	0.00e+00	1604.00
IUUC-Bta-012831	Bos taurus	98.97	0.00e+00	1803.00
IUUC-Cja-019160	Callithrix jacchus	97.99	0.00e+00	1831.00
IUUC-Cfa-020346	Canis familiaris	98.44	0.00e+00	1846.00
IUUC-Cpo-021766	Cavia porcellus	96.54	0.00e+00	1812.00
IUUC-Csa-023768	Chlorocebus sabaeus	97.77	0.00e+00	1832.00
IUUC-Cho-024688	Choloepus hoffmanni	92.70	0.00e+00	1134.00
IUUC-Cin-025417	Ciona intestinalis	50.11	2.00e-133	469.00
IUUC-Csv-025993	Ciona savignyi	43.35	0.00e+00	737.00
IUUC-Dre-027819	Danio rerio	84.66	0.00e+00	1592.00
IUUC-Dno-029027	Dasypus novemcinctus	96.56	0.00e+00	1801.00
IUUC-Dor-030327	Dipodomys ordii	89.43	0.00e+00	1590.00
IUUC-Ete-032966	Echinops telfairi	89.52	0.00e+00	1660.00
IUUC-Eca-034339	Equus caballus	98.33	0.00e+00	1841.00
IUUC-Eeu-034544	Erinaceus europaeus	70.31	0.00e+00	693.00
IUUC-Fca-035617	Felis catus	98.11	0.00e+00	1306.00
IUUC-Fal-036687	Ficedula albicollis	90.53	0.00e+00	1725.00
IUUC-Gmo-039508	Gadus morhua	86.62	0.00e+00	794.00
IUUC-Gga-040845	Gallus gallus	90.85	0.00e+00	1747.00
IUUC-Gac-041894	Gasterosteus aculeatus	84.25	0.00e+00	1552.00
IUUC-Ggo-044465	Gorilla gorilla	93.88	0.00e+00	1751.00
IUUC-Hsa-045731	Homo sapiens	97.88	0.00e+00	1835.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	97.77	0.00e+00	1827.00
IUUC-Lch-050436	Latimeria chalumnae	89.02	0.00e+00	1658.00
IUUC-Loc-052287	Lepisosteus oculatus	84.36	0.00e+00	1626.00
IUUC-Laf-053846	Loxodonta africana	97.88	0.00e+00	1830.00
IUUC-Mcc-055845	Macaca mulatta	97.77	0.00e+00	1833.00
IUUC-Meu-056060	Macropus eugenii	97.69	0.00e+00	704.00
IUUC-Mga-059935	Meleagris gallopavo	93.35	0.00e+00	1724.00
IUUC-Mmr-060960	Microcebus murinus	98.21	0.00e+00	1840.00
IUUC-Mdo-061851	Monodelphis domestica	92.25	0.00e+00	1771.00
IUUC-Mmu-063657	Mus musculus	95.87	0.00e+00	1801.00
IUUC-Mpu-066161	Mustela putorius furo	97.92	0.00e+00	792.00
IUUC-Mlu-067354	Myotis lucifugus	95.97	0.00e+00	1756.00
IUUC-Nle-069112	Nomascus leucogenys	97.77	0.00e+00	1832.00
IUUC-Opr-070686	Ochotona princeps	87.32	0.00e+00	769.00
IUUC-Ont-072398	Oreochromis niloticus	83.87	0.00e+00	1549.00
IUUC-Oan-073194	Ornithorhynchus anatinus	94.21	0.00e+00	1692.00
IUUC-Ocu-074397	Oryctolagus cuniculus	85.24	0.00e+00	1531.00
IUUC-Ola-086777	Oryzias latipes	80.24	0.00e+00	1527.00
IUUC-Oga-088684	Otolemur garnettii	97.88	0.00e+00	1831.00
IUUC-Ptr-090529	Pan troglodytes	97.77	0.00e+00	1833.00
IUUC-Pan-091702	Papio anubis	97.66	0.00e+00	1831.00
IUUC-Psi-093969	Pelodiscus sinensis	90.50	0.00e+00	1675.00
IUUC-Pfo-097364	Poecilia formosa	85.76	0.00e+00	1574.00
IUUC-Pab-098574	Pongo abelii	97.88	0.00e+00	1835.00
IUUC-Pca-100525	Procavia capensis	86.31	4.00e-178	618.00
IUUC-Pva-102365	Pteropus vampyrus	86.50	0.00e+00	1570.00
IUUC-Rno-105153	Rattus norvegicus	95.76	0.00e+00	1803.00
IUUC-Sha-107319	Sarcophilus harrisii	92.25	0.00e+00	1766.00
IUUC-Sar-113449	Sorex araneus	82.37	3.00e-179	622.00
IUUC-Ssc-115865	Sus scrofa	98.44	0.00e+00	1843.00
IUUC-Tgu-117225	Taeniopygia guttata	90.53	0.00e+00	1739.00
IUUC-Tru-118026	Takifugu rubripes	81.51	0.00e+00	1527.00
IUUC-Tsy-119407	Tarsius syrichta	84.82	0.00e+00	1536.00
IUUC-Tni-120234	Tetraodon nigroviridis	83.97	0.00e+00	1273.00
IUUC-Tbe-127708	Tupaia belangeri	88.45	0.00e+00	879.00
IUUC-Ttr-128667	Tursiops truncatus	98.21	0.00e+00	1840.00
IUUC-Vpa-130200	Vicugna pacos	98.28	0.00e+00	1781.00
IUUC-Xtr-132176	Xenopus tropicalis	86.57	0.00e+00	1661.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence