iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-054846

Ensembl Protein ID

ENSMMUP00000048703.1

UniProt Accession

F6RME8; F6RME8_MACMU

Genbank Protein ID

AFE80253.1; AFH28793.1; AFI38380.1; EHH30595.1

Protein Name

Kelch-like protein 15

Genbank Nucleotide ID

JSUE03045087; JU471989; JV048309; CM001273

Gene Name

KLHL15; EGK_20331

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000037633.1	ENSMMUT00000062737.1	ENSMMUP00000048703.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	3.20e-18	67.0	32	96

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 2    DvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           Dv+lv+++ +f+ahk+ La++S++F+ +f+ +++e++ ++++++k++ ++ f+++l+F+Y g++++
   Q: 32   DVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERD-QDKIHLKGLTATGFSHVLQFMYYGTIEL 96
           9***********************************9.************************9876 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MAGDVEGFCS SIHDTSVSAG FRALYEEGLL LDVTLVIEDH QFQAHKALLA TQSDYFRIMF 60
TADMRERDQD KIHLKGLTAT GFSHVLQFMY YGTIELSMNT VHEILQAAMY VQLIEVVKFC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATGAGACCT TGCAATGTCA AAATAAGGAG GGGTGGGGGG CACGGTGATC ACACAATGGC 60
TATGACATCA CTCACTACAT TTATACCTGG TACACAGAGC GCAGAAACGT TTCAGCTCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030597--KLHL15
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005634--C:nucleus
GO:2000042--P:negative regulation of double-strand break repair via homologous recombination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0071630--P:ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome

KEGG

mcc:698391

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001418	Ailuropoda melanoleuca	99.01	0.00e+00	1162.00
IUUC-Apl-003970	Anas platyrhynchos	94.37	0.00e+00	1116.00
IUUC-Aca-005217	Anolis carolinensis	93.38	0.00e+00	1104.00
IUUC-Ame-011065	Astyanax mexicanus	86.59	0.00e+00	1072.00
IUUC-Bta-012443	Bos taurus	98.34	0.00e+00	1157.00
IUUC-Cja-019831	Callithrix jacchus	99.67	0.00e+00	1169.00
IUUC-Cfa-020941	Canis familiaris	99.17	0.00e+00	1165.00
IUUC-Cpo-021730	Cavia porcellus	99.34	0.00e+00	1167.00
IUUC-Csa-023247	Chlorocebus sabaeus	100.00	0.00e+00	1171.00
IUUC-Dre-028474	Danio rerio	85.43	0.00e+00	1069.00
IUUC-Dno-029411	Dasypus novemcinctus	98.34	0.00e+00	1156.00
IUUC-Dor-030576	Dipodomys ordii	99.01	0.00e+00	1163.00
IUUC-Ete-032327	Echinops telfairi	95.53	0.00e+00	1114.00
IUUC-Eca-033477	Equus caballus	98.68	0.00e+00	1160.00
IUUC-Fca-035546	Felis catus	99.01	0.00e+00	1164.00
IUUC-Fal-037370	Ficedula albicollis	94.37	0.00e+00	1116.00
IUUC-Gmo-038961	Gadus morhua	83.25	0.00e+00	985.00
IUUC-Gga-041049	Gallus gallus	94.21	0.00e+00	1116.00
IUUC-Gac-042003	Gasterosteus aculeatus	82.27	0.00e+00	988.00
IUUC-Ggo-044451	Gorilla gorilla	100.00	0.00e+00	1171.00
IUUC-Hsa-045874	Homo sapiens	99.83	0.00e+00	1170.00
IUUC-Itr-048357	Ictidomys tridecemlineatus	99.50	0.00e+00	1168.00
IUUC-Lch-049603	Latimeria chalumnae	89.17	2.00e-127	448.00
IUUC-Loc-052300	Lepisosteus oculatus	89.57	0.00e+00	1101.00
IUUC-Laf-054459	Loxodonta africana	98.18	0.00e+00	1156.00
IUUC-Meu-056797	Macropus eugenii	98.21	3.00e-115	409.00
IUUC-Mga-059446	Meleagris gallopavo	94.37	0.00e+00	1116.00
IUUC-Mmr-061125	Microcebus murinus	98.51	0.00e+00	1159.00
IUUC-Mdo-062947	Monodelphis domestica	92.72	0.00e+00	1080.00
IUUC-Mmu-063708	Mus musculus	99.50	0.00e+00	1167.00
IUUC-Mpu-066447	Mustela putorius furo	99.00	0.00e+00	1155.00
IUUC-Mlu-066999	Myotis lucifugus	94.32	0.00e+00	976.00
IUUC-Nle-069918	Nomascus leucogenys	100.00	0.00e+00	1171.00
IUUC-Ont-071446	Oreochromis niloticus	83.81	0.00e+00	979.00
IUUC-Oan-072872	Ornithorhynchus anatinus	90.40	0.00e+00	1106.00
IUUC-Ocu-073969	Oryctolagus cuniculus	98.36	0.00e+00	908.00
IUUC-Ola-087557	Oryzias latipes	83.23	2.00e-151	528.00
IUUC-Oga-088567	Otolemur garnettii	99.17	0.00e+00	1161.00
IUUC-Oar-089882	Ovis aries	98.18	0.00e+00	1157.00
IUUC-Ptr-091229	Pan troglodytes	100.00	0.00e+00	1140.00
IUUC-Pan-091977	Papio anubis	100.00	0.00e+00	1171.00
IUUC-Psi-093496	Pelodiscus sinensis	94.90	4.00e-156	544.00
IUUC-Pfo-096759	Poecilia formosa	82.90	0.00e+00	996.00
IUUC-Pab-098480	Pongo abelii	100.00	0.00e+00	1171.00
IUUC-Rno-105500	Rattus norvegicus	99.50	0.00e+00	1167.00
IUUC-Sha-106521	Sarcophilus harrisii	92.71	0.00e+00	1052.00
IUUC-Ssc-116372	Sus scrofa	99.01	0.00e+00	1164.00
IUUC-Tgu-116481	Taeniopygia guttata	94.37	0.00e+00	1116.00
IUUC-Tru-118542	Takifugu rubripes	81.13	0.00e+00	984.00
IUUC-Tsy-118848	Tarsius syrichta	100.00	1.00e-128	453.00
IUUC-Tni-119989	Tetraodon nigroviridis	81.73	0.00e+00	926.00
IUUC-Tbe-127485	Tupaia belangeri	99.67	0.00e+00	1169.00
IUUC-Ttr-129214	Tursiops truncatus	98.68	0.00e+00	1158.00
IUUC-Vpa-130261	Vicugna pacos	96.03	0.00e+00	1119.00
IUUC-Xtr-132092	Xenopus tropicalis	89.17	0.00e+00	1017.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence