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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063143
Ensembl Protein ID ENSMUSP00000027056.5
UniProt Accession Q3LAC4; E9QMG3; Q3UQI2; Q3UU18; Q9CXD5; PREX2_MOUSE
Genbank Protein ID CAJ33348.1; BAB31066.1; BAE23811.1; BAE25059.1
Protein Name Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein; DEP domain-containing protein 2
Genbank Nucleotide ID AM109952; AC102481; AK138884; AK142414
Gene Name Prex2; Depdc2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000048960.13 ENSMUST00000027056.11 ENSMUSP00000027056.5
ENSMUSG00000048960.13 ENSMUST00000188189.6 ENSMUSP00000140621.1
ENSMUSG00000048960.13 ENSMUST00000187745.6 ENSMUSP00000140788.1
ENSMUSG00000048960.13 ENSMUST00000189385.6 ENSMUSP00000140863.1
ENSMUSG00000048960.13 ENSMUST00000188154.1 ENSMUSP00000140580.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
miRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
PHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UFD/PB1 28.96 4.00e-19 92.80 IUUC-Sce-106197
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase (By similarity).
 Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase (By similarity).
Protein Sequence
(Fasta)
MSDESAREVD KQLRLRVCVL SELQKTERDY VGTLEFLVSA FLHRMNQCAA AKVDKNVTEE 60
TVKMLFSNIE EILIVHKEFL KVVEECLYPE PSAQQEVGAC FLHFKDKFRI YDEYCSNHEK 120
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Protein Fasta Sequence


>IUUC-Mmu-063143|ULD,PB1|Mus musculus
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Nucleotide Sequence
(Fasta)
ATTTGATTGA TGTCCAAGTC ACCGCTGTGG CTGGAGCCGC CTCCCCTCGG GCTGGAGCCG 60
CGTGAGGCCG GAGCAGCGGG CCGGGCTGGG TTCCCGCTCT CCGGGGACTG TCCCGTTCTG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063143|ULD,PB1|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR000591--DEP_dom
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR001478--PDZ
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS50186--DEP
PS00741--DH_1
PS50010--DH_2
PS50106--PDZ
PS50003--PH_DOMAIN
Pfam

PF00610--DEP
PF00169--PH
PF00621--RhoGEF
SMART

SM00049--DEP
SM00228--PDZ
SM00233--PH
SM00325--RhoGEF
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0005096--F:GTPase activator activity
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0008344--P:adult locomotory behavior
GO:0048813--P:dendrite morphogenesis
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006469--P:negative regulation of protein kinase activity
GO:0032007--P:negative regulation of TOR signaling
GO:0014065--P:phosphatidylinositol 3-kinase signaling
GO:0035023--P:regulation of Rho protein signal transduction
KEGG mmu:109294
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002073 Ailuropoda melanoleuca 35.42 2.00e-53 204.00
IUUC-Apl-004117 Anas platyrhynchos 36.54 6.00e-54 205.00
IUUC-Aca-004793 Anolis carolinensis 36.83 2.00e-52 201.00
IUUC-Ago-008003 Ashbya gossypii 28.03 6.00e-17 82.80
IUUC-Acl-008142 Aspergillus clavatus 28.79 7.00e-18 86.30
IUUC-Afl-008481 Aspergillus flavus 28.78 1.00e-17 85.90
IUUC-Afu-009099 Aspergillus fumigatus 28.68 5.00e-18 87.00
IUUC-Ani-009276 Aspergillus nidulans 28.10 9.00e-19 89.40
IUUC-Aor-010216 Aspergillus oryzae 28.78 1.00e-17 85.90
IUUC-Ate-010338 Aspergillus terreus 28.28 7.00e-19 89.70
IUUC-Ame-010682 Astyanax mexicanus 35.08 3.00e-54 207.00
IUUC-Bgr-012058 Blumeria graminis 26.15 2.00e-15 78.20
IUUC-Bta-013253 Bos taurus 34.81 2.00e-55 210.00
IUUC-Bci-013634 Botrytis cinerea 24.66 2.00e-16 81.60
IUUC-Cja-019555 Callithrix jacchus 35.09 3.00e-50 193.00
IUUC-Cfa-020578 Canis familiaris 35.66 4.00e-51 197.00
IUUC-Csa-023331 Chlorocebus sabaeus 33.42 1.00e-56 214.00
IUUC-Cho-025069 Choloepus hoffmanni 95.15 0.00e+00 1048.00
IUUC-Cin-025453 Ciona intestinalis 32.57 5.00e-46 179.00
IUUC-Csv-025922 Ciona savignyi 33.43 2.00e-46 181.00
IUUC-Cne-027023 Cryptococcus neoformans 24.80 3.00e-18 87.80
IUUC-Dre-028197 Danio rerio 37.21 1.00e-53 206.00
IUUC-Dno-029679 Dasypus novemcinctus 35.28 5.00e-49 190.00
IUUC-Dor-030739 Dipodomys ordii 35.19 2.00e-56 213.00
IUUC-Dse-031545 Dothistroma septosporum 27.34 1.00e-13 72.80
IUUC-Dme-031672 Drosophila melanogaster 29.72 3.00e-24 107.00
IUUC-Ete-032545 Echinops telfairi 48.56 4.00e-112 400.00
IUUC-Eca-034299 Equus caballus 35.42 2.00e-51 197.00
IUUC-Eeu-034720 Erinaceus europaeus 85.52 0.00e+00 1952.00
IUUC-Fca-036416 Felis catus 34.69 4.00e-50 192.00
IUUC-Fal-037035 Ficedula albicollis 36.83 3.00e-55 211.00
IUUC-Gmo-039587 Gadus morhua 35.79 5.00e-57 215.00
IUUC-Ggr-039728 Gaeumannomyces graminis 26.90 8.00e-14 73.20
IUUC-Gga-040841 Gallus gallus 37.16 5.00e-58 219.00
IUUC-Gac-042498 Gasterosteus aculeatus 37.72 2.00e-57 216.00
IUUC-Ggo-044700 Gorilla gorilla 93.42 0.00e+00 3030.00
IUUC-Hsa-045681 Homo sapiens 34.09 3.00e-55 210.00
IUUC-Itr-048380 Ictidomys tridecemlineatus 36.24 2.00e-49 190.00
IUUC-Kpa-049278 Komagataella pastoris 28.32 8.00e-25 109.00
IUUC-Lch-049639 Latimeria chalumnae 37.28 2.00e-56 213.00
IUUC-Loc-051994 Lepisosteus oculatus 37.83 2.00e-58 220.00
IUUC-Laf-054307 Loxodonta africana 35.29 2.00e-53 204.00
IUUC-Mcc-055305 Macaca mulatta 38.02 7.00e-41 161.00
IUUC-Meu-056376 Macropus eugenii 35.98 2.00e-60 227.00
IUUC-Mor-057139 Magnaporthe oryzae 25.98 7.00e-11 63.50
IUUC-Mpo-057433 Magnaporthe poae 27.72 9.00e-11 62.80
IUUC-Mla-059044 Melampsora laricipopulina 24.62 2.00e-20 95.10
IUUC-Mga-059644 Meleagris gallopavo 36.83 7.00e-55 209.00
IUUC-Mvi-060486 Microbotryum violaceum 28.24 5.00e-25 110.00
IUUC-Mmr-061664 Microcebus murinus 35.56 2.00e-51 198.00
IUUC-Mdo-062404 Monodelphis domestica 91.39 0.00e+00 2971.00
IUUC-Mpu-066851 Mustela putorius furo 35.42 6.00e-48 186.00
IUUC-Mlu-066956 Myotis lucifugus 35.42 4.00e-50 193.00
IUUC-Nfi-068331 Neosartorya fischeri 29.06 7.00e-19 89.70
IUUC-Ncr-068819 Neurospora crassa 31.18 3.00e-11 64.30
IUUC-Nle-069174 Nomascus leucogenys 70.98 1.00e-93 336.00
IUUC-Opr-070209 Ochotona princeps 36.39 2.00e-50 193.00
IUUC-Ont-072637 Oreochromis niloticus 36.89 1.00e-57 218.00
IUUC-Oan-073722 Ornithorhynchus anatinus 35.42 7.00e-50 191.00
IUUC-Ocu-074885 Oryctolagus cuniculus 36.34 3.00e-51 197.00
IUUC-Ola-087155 Oryzias latipes 70.22 0.00e+00 2256.00
IUUC-Oga-088758 Otolemur garnettii 35.29 9.00e-55 209.00
IUUC-Oar-089923 Ovis aries 34.81 2.00e-55 210.00
IUUC-Ptr-091555 Pan troglodytes 35.29 1.00e-53 204.00
IUUC-Pan-092037 Papio anubis 35.56 2.00e-54 208.00
IUUC-Psi-093865 Pelodiscus sinensis 36.26 7.00e-55 209.00
IUUC-Pma-094503 Petromyzon marinus 32.65 2.00e-24 107.00
IUUC-Pfo-096918 Poecilia formosa 76.18 0.00e+00 2494.00
IUUC-Pab-097910 Pongo abelii 35.56 2.00e-54 208.00
IUUC-Pca-100891 Procavia capensis 84.72 0.00e+00 967.00
IUUC-Pva-102967 Pteropus vampyrus 38.64 1.00e-47 184.00
IUUC-Pgr-103400 Puccinia graminis 24.08 4.00e-23 104.00
IUUC-Rno-105479 Rattus norvegicus 56.26 0.00e+00 1797.00
IUUC-Sce-106197 Saccharomyces cerevisiae 28.79 9.00e-20 92.40
IUUC-Sha-107592 Sarcophilus harrisii 36.22 1.00e-52 202.00
IUUC-Sja-107728 Schizosaccharomyces japonicus 24.25 2.00e-15 78.20
IUUC-Spo-108284 Schizosaccharomyces pombe 24.40 2.00e-20 95.10
IUUC-Ssl-108541 Sclerotinia sclerotiorum 24.40 2.00e-15 78.60
IUUC-Sly-111026 Solanum lycopersicum 31.94 1.60e-01 30.80
IUUC-Stu-111937 Solanum tuberosum 31.94 1.90e-01 30.80
IUUC-Sar-113369 Sorex araneus 36.49 2.00e-36 146.00
IUUC-Sre-115126 Sporisorium reilianum 30.86 4.00e-29 124.00
IUUC-Tgu-117088 Taeniopygia guttata 37.70 4.00e-58 219.00
IUUC-Tru-118716 Takifugu rubripes 55.42 0.00e+00 1765.00
IUUC-Tsy-118846 Tarsius syrichta 37.22 2.00e-46 179.00
IUUC-Tni-120887 Tetraodon nigroviridis 75.39 0.00e+00 2471.00
IUUC-Tre-121935 Trichoderma reesei 25.99 1.00e-18 89.00
IUUC-Tme-127216 Tuber melanosporum 26.99 1.00e-25 112.00
IUUC-Tbe-127248 Tupaia belangeri 80.43 0.00e+00 876.00
IUUC-Uma-129594 Ustilago maydis 29.62 4.00e-26 114.00
IUUC-Vda-129831 Verticillium dahliae 31.74 1.00e-12 68.90
IUUC-Vpa-130750 Vicugna pacos 94.85 0.00e+00 1680.00
IUUC-Xtr-132676 Xenopus tropicalis 37.57 7.00e-60 224.00
IUUC-Xma-133871 Xiphophorus maculatus 75.77 0.00e+00 2428.00
IUUC-Yli-134423 Yarrowia lipolytica 27.67 8.00e-25 108.00
Created Date 25-Jun-2017

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