iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132302

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Kelch-like protein 25; Ectoderm-neural cortex protein 2

Genbank Nucleotide ID

BC122041

Gene Name

klhl25; enc2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000007622.2	ENSXETT00000016578.2	ENSXETP00000016578.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	3.00e-19	69.3	46	114

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgkldene 69
           +Dv+l  g++ f++h++vLaa+S++F+a+f+++l+es   ++v+++d + pev++ ll+F Y++k+ +ne
   Q: 46   TDVTLWAGNRSFPCHRAVLAACSQYFEAMFSNGLRESL-DNTVNFHDsLHPEVLELLLDFAYSSKIIINE 114
           7************************************9.*******99*****************99987 PP

Organism

Xenopus tropicalis

Functional Description
(View)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated eif4ebp1 (4E-BP1) (By similarity).

Protein Sequence
(Fasta)

MSVTVHENRK SRTSTGSMNI SLYHKLSHSD CVLNHLNTMR KQRLFTDVTL WAGNRSFPCH 60
RAVLAACSQY FEAMFSNGLR ESLDNTVNFH DSLHPEVLEL LLDFAYSSKI IINEENAESL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAGCGGCC TGCGGTACTT GGCACAGTCA CACATGCCAG GGTAAGTGGG TTTTACAAAG 60
AGGGAAAGAA TAGCGGCTCT GCGCAACCCC TGTGTGTGTG CGACTGACTC CGGCTTGTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0810--Translation regulation
KW-0833--Ubl conjugation pathway

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030565--KLHL25
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006446--P:regulation of translational initiation

KEGG

xtr:779996

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002373	Ailuropoda melanoleuca	84.89	0.00e+00	1066.00
IUUC-Apl-003543	Anas platyrhynchos	87.46	0.00e+00	1058.00
IUUC-Aca-004729	Anolis carolinensis	86.25	0.00e+00	1052.00
IUUC-Ame-011020	Astyanax mexicanus	85.91	0.00e+00	1043.00
IUUC-Bta-012955	Bos taurus	83.87	0.00e+00	1060.00
IUUC-Cja-018839	Callithrix jacchus	84.55	0.00e+00	1061.00
IUUC-Cfa-020224	Canis familiaris	85.40	0.00e+00	1075.00
IUUC-Cpo-021593	Cavia porcellus	82.68	0.00e+00	1003.00
IUUC-Csa-023276	Chlorocebus sabaeus	84.89	0.00e+00	1065.00
IUUC-Dre-028053	Danio rerio	86.59	0.00e+00	1027.00
IUUC-Dno-029287	Dasypus novemcinctus	83.19	0.00e+00	1052.00
IUUC-Fca-035897	Felis catus	85.23	0.00e+00	1068.00
IUUC-Fal-037036	Ficedula albicollis	87.61	0.00e+00	1066.00
IUUC-Gmo-039345	Gadus morhua	84.38	0.00e+00	994.00
IUUC-Gga-040404	Gallus gallus	87.44	0.00e+00	1065.00
IUUC-Gac-042447	Gasterosteus aculeatus	84.55	0.00e+00	1008.00
IUUC-Ggo-045060	Gorilla gorilla	84.89	0.00e+00	1064.00
IUUC-Hsa-046494	Homo sapiens	85.06	0.00e+00	1066.00
IUUC-Itr-047993	Ictidomys tridecemlineatus	85.74	0.00e+00	1074.00
IUUC-Lch-050211	Latimeria chalumnae	84.35	0.00e+00	1030.00
IUUC-Loc-052578	Lepisosteus oculatus	85.40	0.00e+00	1040.00
IUUC-Laf-053498	Loxodonta africana	85.40	0.00e+00	1030.00
IUUC-Mcc-055033	Macaca mulatta	84.89	0.00e+00	1064.00
IUUC-Meu-056893	Macropus eugenii	87.78	0.00e+00	1095.00
IUUC-Mga-060025	Meleagris gallopavo	87.61	0.00e+00	1065.00
IUUC-Mmr-060658	Microcebus murinus	84.38	0.00e+00	1061.00
IUUC-Mdo-062667	Monodelphis domestica	87.95	0.00e+00	1099.00
IUUC-Mmu-063125	Mus musculus	83.36	0.00e+00	1015.00
IUUC-Mpu-066209	Mustela putorius furo	84.72	0.00e+00	1065.00
IUUC-Mlu-068237	Myotis lucifugus	82.51	0.00e+00	1013.00
IUUC-Nle-069454	Nomascus leucogenys	84.73	0.00e+00	1050.00
IUUC-Ont-072138	Oreochromis niloticus	85.23	0.00e+00	998.00
IUUC-Oan-073320	Ornithorhynchus anatinus	80.31	0.00e+00	1015.00
IUUC-Ocu-073765	Oryctolagus cuniculus	80.48	0.00e+00	994.00
IUUC-Oga-088002	Otolemur garnettii	84.72	0.00e+00	1068.00
IUUC-Oar-089481	Ovis aries	83.53	0.00e+00	1057.00
IUUC-Ptr-091200	Pan troglodytes	84.89	0.00e+00	1061.00
IUUC-Psi-093884	Pelodiscus sinensis	87.95	0.00e+00	1062.00
IUUC-Pva-102321	Pteropus vampyrus	84.04	0.00e+00	1059.00
IUUC-Pyt-104594	Pyrenophora triticirepentis	46.51	6.00e-04	39.70
IUUC-Rno-104835	Rattus norvegicus	83.36	0.00e+00	1014.00
IUUC-Sha-107528	Sarcophilus harrisii	87.61	0.00e+00	1094.00
IUUC-Ssc-116161	Sus scrofa	84.72	0.00e+00	1062.00
IUUC-Tgu-116569	Taeniopygia guttata	87.78	0.00e+00	1070.00
IUUC-Tni-120525	Tetraodon nigroviridis	76.99	0.00e+00	899.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence