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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063160
Ensembl Protein ID ENSMUSP00000034745.7
UniProt Accession E9Q634; Q80X36; Q91ZI4; MYO1E_MOUSE
Genbank Protein ID AAH51391.1; AAL26545.1
Protein Name Unconventional myosin-Ie; Unconventional myosin 1E
Genbank Nucleotide ID AC157086; AF426465
Gene Name Myo1e; Myr3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000032220.10 ENSMUST00000214042.1 ENSMUSP00000150376.1
ENSMUSG00000032220.10 ENSMUST00000034745.8 ENSMUSP00000034745.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexHINT
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
PHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 9.40e-16 58.6 1054 1107
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           ++++ly y+aq++deL++++ d++++i  +e   gW+ g   l+gk+GlfP+n+v+k+
   Q: 1054 QCKALYAYDAQDTDELSFNANDIIDII--KEDPSGWWTG--RLRGKQGLFPNNYVTKI 1107
           79*************************..88889*****..9*************986 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain (By similarity). Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14 (By similarity).
 Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain (By similarity). Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14 (By similarity).
Protein Sequence
(Fasta)
MGSKGAYRYH WQSHNVKHSG VDDMVLLSKI TESSIVENLK KRYMDDYIFT YIGSVLISVN 60
PFKQMPYFGE KEVEMYQGAA QYENPPHIYA LADSMYRNMI IDRENQCVII SGESGAGKTV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063160|UBD,SH3|Mus musculus
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Nucleotide Sequence
(Fasta)
AGCCTGAGCC AGAGAAGAGT TCGGATTAAG TGTTAAGAGA AAGCGGGTCC AGGCAAAGCA 60
GTTGGACAAG CAATCCCGCA GAGCGCATCA GGGTGCATCT CTAGACAGTT GGGGATCGCC 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063160|UBD,SH3|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0009--Actin-binding
KW-0067--ATP-binding
KW-0112--Calmodulin-binding
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0446--Lipid-binding
KW-0505--Motor protein
KW-0518--Myosin
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR000048--IQ_motif_EF-hand-BS
IPR001609--Myosin_head_motor_dom
IPR010926--Myosin_TH1
IPR027417--P-loop_NTPase
IPR001452--SH3_domain
PROSITE

PS50096--IQ
PS51456--MYOSIN_MOTOR
PS50002--SH3
PS51757--TH1
Pfam

PF00063--Myosin_head
PF06017--Myosin_TH1
PF00018--SH3_1
PRINTS

PR00193--MYOSINHEAVY
PR00452--SH3DOMAIN
SMART

SM00242--MYSc
SM00326--SH3
Gene Ontology

GO:0005912--C:adherens junction
GO:0005903--C:brush border
GO:0005911--C:cell-cell junction
GO:0045334--C:clathrin-coated endocytic vesicle
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0070062--C:extracellular exosome
GO:0016459--C:myosin complex
GO:0051015--F:actin filament binding
GO:0005524--F:ATP binding
GO:0042623--F:ATPase activity, coupled
GO:0005516--F:calmodulin binding
GO:0003774--F:motor activity
GO:0035091--F:phosphatidylinositol binding
GO:0006897--P:endocytosis
GO:0032836--P:glomerular basement membrane development
GO:0003094--P:glomerular filtration
GO:0072015--P:glomerular visceral epithelial cell development
GO:0030097--P:hemopoiesis
GO:0001701--P:in utero embryonic development
GO:0001822--P:kidney development
GO:0006807--P:nitrogen compound metabolic process
GO:0048008--P:platelet-derived growth factor receptor signaling pathway
GO:0035166--P:post-embryonic hemopoiesis
GO:0001570--P:vasculogenesis
KEGG mmu:71602
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002000 Ailuropoda melanoleuca 96.30 0.00e+00 2144.00
IUUC-Apl-003276 Anas platyrhynchos 90.53 0.00e+00 1969.00
IUUC-Aca-004926 Anolis carolinensis 87.50 0.00e+00 1937.00
IUUC-Ame-011036 Astyanax mexicanus 75.83 0.00e+00 1722.00
IUUC-Bta-013102 Bos taurus 95.04 0.00e+00 2093.00
IUUC-Cja-019330 Callithrix jacchus 96.03 0.00e+00 2147.00
IUUC-Cfa-020843 Canis familiaris 96.84 0.00e+00 2164.00
IUUC-Cpo-022167 Cavia porcellus 95.03 0.00e+00 2115.00
IUUC-Csa-023357 Chlorocebus sabaeus 96.48 0.00e+00 2152.00
IUUC-Cin-025743 Ciona intestinalis 66.00 2.00e-17 79.70
IUUC-Dre-028794 Danio rerio 79.66 0.00e+00 1829.00
IUUC-Dno-029858 Dasypus novemcinctus 95.76 0.00e+00 2140.00
IUUC-Dor-030253 Dipodomys ordii 83.08 0.00e+00 1503.00
IUUC-Eca-034303 Equus caballus 94.95 0.00e+00 2072.00
IUUC-Eeu-034561 Erinaceus europaeus 72.85 1.00e-121 431.00
IUUC-Gmo-038566 Gadus morhua 82.09 0.00e+00 1554.00
IUUC-Gga-040272 Gallus gallus 91.25 0.00e+00 1979.00
IUUC-Gac-042415 Gasterosteus aculeatus 80.86 0.00e+00 1793.00
IUUC-Ggo-044547 Gorilla gorilla 96.39 0.00e+00 2151.00
IUUC-Hsa-046285 Homo sapiens 96.12 0.00e+00 2145.00
IUUC-Kpa-049352 Komagataella pastoris 56.86 4.00e-13 69.70
IUUC-Lch-050042 Latimeria chalumnae 75.00 0.00e+00 1663.00
IUUC-Laf-054148 Loxodonta africana 95.84 0.00e+00 2143.00
IUUC-Mcc-055355 Macaca mulatta 96.21 0.00e+00 2149.00
IUUC-Meu-056504 Macropus eugenii 75.81 0.00e+00 1518.00
IUUC-Mga-059294 Meleagris gallopavo 84.51 0.00e+00 660.00
IUUC-Mvi-060271 Microbotryum violaceum 44.83 3.00e-09 56.60
IUUC-Mdo-062463 Monodelphis domestica 91.55 0.00e+00 2028.00
IUUC-Nle-070144 Nomascus leucogenys 96.30 0.00e+00 2145.00
IUUC-Ont-071404 Oreochromis niloticus 81.69 0.00e+00 1807.00
IUUC-Ocu-074845 Oryctolagus cuniculus 93.01 0.00e+00 2014.00
IUUC-Ola-086687 Oryzias latipes 80.49 0.00e+00 1781.00
IUUC-Oga-088019 Otolemur garnettii 96.48 0.00e+00 2123.00
IUUC-Oar-089527 Ovis aries 95.13 0.00e+00 2095.00
IUUC-Ptr-090485 Pan troglodytes 96.21 0.00e+00 2147.00
IUUC-Pan-092820 Papio anubis 96.21 0.00e+00 2148.00
IUUC-Pma-094458 Petromyzon marinus 74.15 0.00e+00 1670.00
IUUC-Pfo-096486 Poecilia formosa 78.53 0.00e+00 1780.00
IUUC-Pab-098517 Pongo abelii 93.87 0.00e+00 2081.00
IUUC-Pca-100128 Procavia capensis 67.79 0.00e+00 884.00
IUUC-Pva-102994 Pteropus vampyrus 93.86 0.00e+00 2080.00
IUUC-Ptt-103726 Puccinia triticina 40.74 9.00e-09 53.90
IUUC-Rno-104993 Rattus norvegicus 92.89 0.00e+00 1798.00
IUUC-Sha-107065 Sarcophilus harrisii 93.25 0.00e+00 2022.00
IUUC-Ssc-115601 Sus scrofa 96.03 0.00e+00 2145.00
IUUC-Tgu-116572 Taeniopygia guttata 89.00 0.00e+00 1907.00
IUUC-Tru-117568 Takifugu rubripes 81.00 0.00e+00 1818.00
IUUC-Tni-120636 Tetraodon nigroviridis 80.85 0.00e+00 1814.00
IUUC-Tbe-127462 Tupaia belangeri 87.31 0.00e+00 1380.00
IUUC-Ttr-128783 Tursiops truncatus 95.30 0.00e+00 2126.00
IUUC-Xma-133052 Xiphophorus maculatus 80.36 0.00e+00 1776.00
Created Date 25-Jun-2017

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