iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-136455

Ensembl Protein ID

ENSDARP00000116319.1

UniProt Accession

A3KQS4; MINY1_DANRE

Genbank Protein ID

BX927401

Protein Name

Ubiquitin carboxyl-terminal hydrolase MINDY-1;Deubiquitinating enzyme MINDY-1;Protein FAM63A

Genbank Nucleotide ID

CAM56381.1

Gene Name

mindy1;fam63a;si:ch211-210h11.5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000004866.9	ENSDART00000147491.2	ENSDARP00000116319.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/MINDY	3.90e-60	202.3	196	318

Active Site

Position(s)	Description	Evidence
189	Nucleophile	{ECO:0000250\|UniProtKB:Q8N5J2}
371	Proton acceptor	{ECO:0000250\|UniProtKB:Q8N5J2}

Domain Profile

DUB/MINDY

   S: 1    nilllswkvklvpkkevitleelievlgdilldvkdkekseiselnyeqnvddalsllpklaeGldvnvrftGvrsfeytkecsvfdll 89
           nilll wkvk++ ++ev+t+eel+++lg+++l++k++ek+e+ eln++qn++da+++lpkl +GldvnvrftGv++feyt+ec+vfdll
   Q: 196  NILLLRWKVKFPAQTEVVTTEELMAHLGECVLSIKPREKAEGMELNFQQNMSDAMAVLPKLSTGLDVNVRFTGVSDFEYTPECIVFDLL 284
           9**************************************************************************************** PP
   S: 90   didlyhGWlvdsqideavkavgklsyeqlveril 123
           di+lyhGWlvd+q++e+v avgklsy+qlve+i+
   Q: 285  DIPLYHGWLVDPQSPEVVSAVGKLSYNQLVEKII 318
           *********************************8 PP

Organism

Danio rerio

Functional Description
(View)

Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. May play a regulatory role at the level of protein turnover.

Protein Sequence
(Fasta)

MADSCADTVD GEIKGFSEGQ QLNITKNEDL EQTKPQKEAI ANTEESSACV SQIKQDLAPC 60
KDPPTTTTAS LEDDAKATSS ASVTSKSQDE SEVINSQSYT PSQSEATPSF SMASLEFSEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAAGTGAGA CAGGCAAAAA CAAGATTACG GAAAGAGTGG CGAGAAAGAG AGAGCGAGAG 60
AGAAAGAGAG AGAGAGAGAC GTGTGTCTGT ATCAGCAGCA CAGAGACAGC AAAAACCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR007518--MINDY
IPR033979--MINDY_domain

Pfam

PF04424--MINDY_DUB

Gene Ontology

GO:0036435--F:K48-linked polyubiquitin binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity

KEGG

dre:563470

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-136378	Aegilops tauschii	43.85	7.00e-28	119.00
IUUC-Aml-136381	Ailuropoda melanoleuca	74.64	5.00e-126	444.00
IUUC-Atr-136384	Amborella trichopoda	39.89	2.00e-32	134.00
IUUC-Apl-136388	Anas platyrhynchos	75.68	2.00e-131	462.00
IUUC-Ago-136399	Ashbya gossypii	31.25	7.00e-32	131.00
IUUC-Afl-136401	Aspergillus flavus	41.98	5.00e-11	63.90
IUUC-Aor-136405	Aspergillus oryzae	30.93	3.00e-26	113.00
IUUC-Ame-136409	Astyanax mexicanus	71.77	5.00e-172	597.00
IUUC-Bta-136413	Bos taurus	64.69	2.00e-128	452.00
IUUC-Bdi-136417	Brachypodium distachyon	42.58	2.00e-34	140.00
IUUC-Cja-136426	Callithrix jacchus	69.17	4.00e-130	458.00
IUUC-Cfa-136431	Canis familiaris	70.30	3.00e-126	444.00
IUUC-Cpo-136435	Cavia porcellus	67.97	5.00e-126	444.00
IUUC-Csa-136440	Chlorocebus sabaeus	68.61	3.00e-125	442.00
IUUC-Cme-136451	Cyanidioschyzon merolae	34.57	8.00e-24	105.00
IUUC-Dno-136458	Dasypus novemcinctus	69.55	6.00e-135	474.00
IUUC-Eca-136474	Equus caballus	64.53	5.00e-132	464.00
IUUC-Eeu-136475	Erinaceus europaeus	68.90	1.00e-99	356.00
IUUC-Fca-136480	Felis catus	63.43	6.00e-131	460.00
IUUC-Gga-136494	Gallus gallus	74.26	2.00e-130	459.00
IUUC-Gac-136498	Gasterosteus aculeatus	76.19	3.00e-145	507.00
IUUC-Ggo-136504	Gorilla gorilla	68.66	4.00e-128	451.00
IUUC-Hsa-136506	Homo sapiens	68.89	6.00e-127	447.00
IUUC-Hvu-136509	Hordeum vulgare	42.58	2.00e-36	147.00
IUUC-Itr-136512	Ictidomys tridecemlineatus	64.27	2.00e-128	452.00
IUUC-Kpa-136513	Komagataella pastoris	28.16	7.00e-22	98.60
IUUC-Lch-136516	Latimeria chalumnae	73.21	5.00e-127	447.00
IUUC-Lpe-136519	Leersia perrieri	41.67	5.00e-36	146.00
IUUC-Loc-136523	Lepisosteus oculatus	78.96	2.00e-152	532.00
IUUC-Laf-136529	Loxodonta africana	61.94	5.00e-132	464.00
IUUC-Mcc-136533	Macaca mulatta	77.91	9.00e-125	440.00
IUUC-Meu-136536	Macropus eugenii	79.30	9.00e-126	443.00
IUUC-Mtr-136539	Medicago truncatula	45.10	5.00e-37	149.00
IUUC-Mvi-136546	Microbotryum violaceum	28.81	4.00e-34	140.00
IUUC-Mmr-136550	Microcebus murinus	69.75	1.00e-128	453.00
IUUC-Mdo-136554	Monodelphis domestica	70.25	4.00e-133	468.00
IUUC-Mmu-136557	Mus musculus	77.73	1.00e-124	439.00
IUUC-Mac-136560	Musa acuminata	41.77	6.00e-32	132.00
IUUC-Mpu-136564	Mustela putorius furo	54.64	5.00e-130	457.00
IUUC-Mlu-136567	Myotis lucifugus	64.43	2.00e-127	449.00
IUUC-Nle-136574	Nomascus leucogenys	66.49	3.00e-129	455.00
IUUC-Opr-136578	Ochotona princeps	68.82	5.00e-127	447.00
IUUC-Ont-136581	Oreochromis niloticus	78.79	7.00e-155	540.00
IUUC-Ocu-136587	Oryctolagus cuniculus	78.74	3.00e-124	438.00
IUUC-Oba-136590	Oryza barthii	40.00	1.00e-34	142.00
IUUC-Obr-136591	Oryza brachyantha	41.29	5.00e-35	142.00
IUUC-Ogl-136594	Oryza glaberrima	39.74	1.00e-34	141.00
IUUC-Ogu-136596	Oryza glumaepatula	39.74	1.00e-34	141.00
IUUC-Oin-136598	Oryza indica	39.74	1.00e-34	142.00
IUUC-Olo-136600	Oryza longistaminata	40.00	2.00e-34	140.00
IUUC-Ome-136601	Oryza meridionalis	39.74	1.00e-34	141.00
IUUC-Oni-136603	Oryza nivara	39.74	1.00e-34	141.00
IUUC-Opu-136605	Oryza punctata	39.74	9.00e-35	142.00
IUUC-Oru-136607	Oryza rufipogon	40.00	1.00e-34	141.00
IUUC-Osa-136609	Oryza sativa	39.74	1.00e-34	142.00
IUUC-Ola-136612	Oryzias latipes	75.46	7.00e-143	499.00
IUUC-Oga-136618	Otolemur garnettii	68.35	7.00e-129	454.00
IUUC-Oar-136621	Ovis aries	67.48	8.00e-130	457.00
IUUC-Ptr-136625	Pan troglodytes	68.39	1.00e-127	449.00
IUUC-Pan-136630	Papio anubis	77.91	1.00e-124	439.00
IUUC-Psi-136634	Pelodiscus sinensis	65.94	5.00e-139	488.00
IUUC-Ppa-136640	Physcomitrella patens	43.67	2.00e-37	150.00
IUUC-Pfo-136643	Poecilia formosa	76.31	9.00e-158	549.00
IUUC-Pab-136648	Pongo abelii	65.94	1.00e-131	463.00
IUUC-Pop-136649	Populus trichocarpa	45.52	3.00e-29	121.00
IUUC-Pca-136654	Procavia capensis	72.09	8.00e-94	337.00
IUUC-Ppe-136657	Prunus persica	42.31	3.00e-33	137.00
IUUC-Pva-136661	Pteropus vampyrus	69.36	5.00e-133	468.00
IUUC-Rno-136668	Rattus norvegicus	69.19	1.00e-128	453.00
IUUC-Sha-136673	Sarcophilus harrisii	69.66	2.00e-128	452.00
IUUC-Spo-136676	Schizosaccharomyces pombe	29.20	6.00e-19	88.60
IUUC-Smo-136679	Selaginella moellendorffii	47.13	3.00e-38	153.00
IUUC-Sit-136681	Setaria italica	42.58	1.00e-30	128.00
IUUC-Sar-136687	Sorex araneus	75.23	6.00e-95	341.00
IUUC-Sbi-136689	Sorghum bicolor	41.77	4.00e-36	146.00
IUUC-Sre-136690	Sporisorium reilianum	28.66	1.00e-30	128.00
IUUC-Ssc-136693	Sus scrofa	69.27	6.00e-131	461.00
IUUC-Tru-136701	Takifugu rubripes	86.08	5.00e-158	550.00
IUUC-Tni-136708	Tetraodon nigroviridis	79.29	3.00e-144	504.00
IUUC-Tca-136710	Theobroma cacao	45.16	1.00e-30	128.00
IUUC-Tae-136715	Triticum aestivum	42.58	3.00e-36	147.00
IUUC-Tur-136717	Triticum urartu	43.08	1.00e-27	118.00
IUUC-Ttr-136725	Tursiops truncatus	62.32	7.00e-132	464.00
IUUC-Uma-136726	Ustilago maydis	30.28	7.00e-30	126.00
IUUC-Vvi-136733	Vitis vinifera	44.74	9.00e-33	135.00
IUUC-Xtr-136737	Xenopus tropicalis	74.59	6.00e-132	464.00
IUUC-Xma-136740	Xiphophorus maculatus	76.54	3.00e-155	541.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence