iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062176

UUCD1 version

UUC-MoD-00038

Ensembl Protein ID

ENSMODP00000002801.3

UniProt Accession

H9H604; H9H604_MONDO

Protein Name

Uncharacterized protein

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000002297.3	ENSMODT00000002857.3	ENSMODP00000002801.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.90e-119	397.8	1248	1581

Active Site

Position(s)	Description	Evidence
1549	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+++fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1248 ELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1333
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n++Vt++Nk+eY+++
   Q: 1334 AFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIER 1416
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1417 MVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHIVIRWFWAAVERFNNEQRLR 1503
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+      +f +rk  a++  lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1504 LLQFVTGTSSVPYEGFAALRgsngLLSFLYRKmGANNPPLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1581
           ********************99997889****666669*************************************985 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MLLHLCSVKN LYQNRFLGLA AMASPSRNSQ SRRRCKEPLR YSYNPDQFTN LDLRNGPRDP 60
VAMPRSTSDT DLVTSDSRST LTVSSSCYSI GHSQDLIIHW DIRRRWTPGT GSACTSSMRS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAGATGGA GCTGCGCCAA TCAGGGCGCG CGGCCTCACT GCTGGTTGGT CCCAGCTGTC 60
CCGGACCCGG AGCCGGAGCC CAAGCCGGGT AGCGTTGGGG AGGCAGAGGC ACAGGCACAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	84.91	0.00e+00	1658.00
IUUC-Apl-003299	Anas platyrhynchos	73.87	0.00e+00	2133.00
IUUC-Aca-005024	Anolis carolinensis	73.29	0.00e+00	2125.00
IUUC-Bta-012604	Bos taurus	72.95	0.00e+00	2102.00
IUUC-Cja-019880	Callithrix jacchus	74.45	0.00e+00	1940.00
IUUC-Cfa-021216	Canis familiaris	84.80	0.00e+00	1669.00
IUUC-Cpo-021466	Cavia porcellus	90.75	0.00e+00	1593.00
IUUC-Csa-023080	Chlorocebus sabaeus	76.24	0.00e+00	2182.00
IUUC-Cho-024740	Choloepus hoffmanni	89.78	0.00e+00	1096.00
IUUC-Dre-028750	Danio rerio	70.18	0.00e+00	1528.00
IUUC-Dno-030019	Dasypus novemcinctus	75.70	0.00e+00	2157.00
IUUC-Dor-031030	Dipodomys ordii	69.52	0.00e+00	1071.00
IUUC-Ete-032352	Echinops telfairi	90.94	0.00e+00	1209.00
IUUC-Eca-033948	Equus caballus	83.02	0.00e+00	1667.00
IUUC-Eeu-034474	Erinaceus europaeus	67.92	0.00e+00	794.00
IUUC-Fca-036148	Felis catus	85.52	0.00e+00	1696.00
IUUC-Fal-036957	Ficedula albicollis	75.35	0.00e+00	2171.00
IUUC-Gmo-038714	Gadus morhua	61.20	0.00e+00	972.00
IUUC-Gga-041194	Gallus gallus	74.37	0.00e+00	2147.00
IUUC-Gac-041366	Gasterosteus aculeatus	70.28	0.00e+00	1392.00
IUUC-Ggo-045442	Gorilla gorilla	75.34	0.00e+00	1507.00
IUUC-Hsa-045730	Homo sapiens	76.54	0.00e+00	2179.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	76.90	0.00e+00	2187.00
IUUC-Lch-050185	Latimeria chalumnae	73.01	0.00e+00	1343.00
IUUC-Loc-052744	Lepisosteus oculatus	68.59	0.00e+00	1948.00
IUUC-Laf-054368	Loxodonta africana	93.11	0.00e+00	1427.00
IUUC-Mcc-055487	Macaca mulatta	85.97	0.00e+00	1728.00
IUUC-Meu-056751	Macropus eugenii	87.17	0.00e+00	764.00
IUUC-Mga-059545	Meleagris gallopavo	73.76	0.00e+00	2118.00
IUUC-Mmr-061078	Microcebus murinus	83.44	0.00e+00	1654.00
IUUC-Mmu-063513	Mus musculus	84.62	0.00e+00	1665.00
IUUC-Mpu-065786	Mustela putorius furo	73.86	0.00e+00	2113.00
IUUC-Mlu-067780	Myotis lucifugus	78.53	0.00e+00	1494.00
IUUC-Nle-069213	Nomascus leucogenys	85.93	0.00e+00	1731.00
IUUC-Opr-070208	Ochotona princeps	92.16	0.00e+00	1419.00
IUUC-Ont-072132	Oreochromis niloticus	75.30	0.00e+00	1323.00
IUUC-Oan-072807	Ornithorhynchus anatinus	87.36	0.00e+00	1771.00
IUUC-Ocu-074745	Oryctolagus cuniculus	84.83	0.00e+00	1696.00
IUUC-Ola-086981	Oryzias latipes	72.80	0.00e+00	1431.00
IUUC-Oga-087965	Otolemur garnettii	85.78	0.00e+00	1667.00
IUUC-Oar-089749	Ovis aries	82.76	0.00e+00	1682.00
IUUC-Ptr-091243	Pan troglodytes	76.42	0.00e+00	2179.00
IUUC-Pan-092201	Papio anubis	86.08	0.00e+00	1730.00
IUUC-Psi-093511	Pelodiscus sinensis	85.09	0.00e+00	1680.00
IUUC-Pfo-097001	Poecilia formosa	69.66	0.00e+00	1403.00
IUUC-Pab-098728	Pongo abelii	73.34	0.00e+00	2066.00
IUUC-Pca-100129	Procavia capensis	82.97	0.00e+00	1147.00
IUUC-Pva-102250	Pteropus vampyrus	79.87	0.00e+00	1600.00
IUUC-Rno-105031	Rattus norvegicus	75.34	0.00e+00	2096.00
IUUC-Tgu-117515	Taeniopygia guttata	74.41	0.00e+00	2138.00
IUUC-Tru-117914	Takifugu rubripes	74.65	0.00e+00	1334.00
IUUC-Tsy-119379	Tarsius syrichta	76.75	0.00e+00	754.00
IUUC-Tni-120178	Tetraodon nigroviridis	74.77	0.00e+00	1356.00
IUUC-Tbe-127762	Tupaia belangeri	79.58	0.00e+00	1570.00
IUUC-Ttr-128806	Tursiops truncatus	86.18	0.00e+00	1596.00
IUUC-Xtr-132903	Xenopus tropicalis	81.83	0.00e+00	1666.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence