iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048076

Ensembl Protein ID

ENSSTOP00000003937.2

UniProt Accession

I3M453; I3M453_ICTTR

Genbank Protein ID

ENSSTOP00000003937

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01011566

Gene Name

WDR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000004366.2	ENSSTOT00000004388.2	ENSSTOP00000003937.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.90e-40	134.5	233	263
UBD/Beta-Prp	2.50e-61	207.4	56	275

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H+++++++++ +d t+l+s+s+D+t k+WD+
   Q: 233  HEGGIYAISWsPDsTHLLSASGDKTSKIWDV 263
           9**********999****************7 PP

UBD/Beta-Prp

   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl..sgheaevtavkfspdgkilvtgseD..rtikvwdlstgkcvhtlkg 92
           +h +++ + k++p++ ++a+g  +g++++wd+t++  l ++  +   ++++++ + +d+k ++ ++e   ++  v+  ++g+ v  ++g
   Q: 56   EHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYeyQPFAGKIKDIAWTEDSKRIAVVGEGreKFGAVFLWDSGSSVGEITG 144
           556666678*************************998777742334567***********99999999887777777789********* PP
   S: 93   hedsvlslsfspsg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl..tgg 178
           h++ + s+++ +s+ ++lv+Gs+d+ +  ++ +  +    t   h+++vncv+++pdgn ++++s+D+++ ++d ktg+ +  l   ++
   Q: 145  HNKVINSVDIKQSRpYRLVTGSDDNCAAFFEGPPFKFKF-TIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALgeGKA 232
           ************999*****************9999998.99******************************************99556 PP
   S: 179  htdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlngh 221
           h++ +y +s+++++++l+s+s d+t k+wd+  +++v t+   
   Q: 233  HEGGIYAISWSPDSTHLLSASGDKTSKIWDVGVNSVVSTFPMG 275
           **********************************999999754 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

XRVSTEKVFA SLPQVERGVS KILGGDPKGN NFLYTNGKCV ILRNIDNPAV ADIYTEHAHQ 60
VVVAKYAPSG FYIASGDVSG KLRIWDTTQK EHLLKYEYQP FAGKIKDIAW TEDSKRIAVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NTTCGTGTCT CCACAGAGAA GGTGTTCGCC AGCCTCCCCC AGGTGGAGAG GGGCGTTTCC 60
AAAATCCTCG GCGGCGACCC TAAGGGCAAC AATTTTCTGT ACACCAATGG CAAGTGTGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR011045--N2O_reductase_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0030043--P:actin filament fragmentation
GO:0043297--P:apical junction assembly
GO:0030865--P:cortical cytoskeleton organization
GO:0042247--P:establishment of planar polarity of follicular epithelium
GO:0045199--P:maintenance of epithelial cell apical/basal polarity
GO:0002446--P:neutrophil mediated immunity
GO:1990266--P:neutrophil migration
GO:0030220--P:platelet formation
GO:0030836--P:positive regulation of actin filament depolymerization
GO:0008360--P:regulation of cell shape
GO:0060307--P:regulation of ventricular cardiac muscle cell membrane repolarization
GO:0045214--P:sarcomere organization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000457	Aegilops tauschii	35.67	1.00e-82	300.00
IUUC-Aml-002368	Ailuropoda melanoleuca	96.69	0.00e+00	1187.00
IUUC-Atr-003160	Amborella trichopoda	37.32	4.00e-115	408.00
IUUC-Apl-004012	Anas platyrhynchos	88.02	0.00e+00	1070.00
IUUC-Aca-004707	Anolis carolinensis	83.36	0.00e+00	1045.00
IUUC-Aly-006465	Arabidopsis lyrata	37.75	3.00e-110	392.00
IUUC-Ath-006740	Arabidopsis thaliana	37.58	1.00e-108	387.00
IUUC-Ago-007920	Ashbya gossypii	28.43	1.00e-74	273.00
IUUC-Acl-008262	Aspergillus clavatus	37.40	1.00e-109	390.00
IUUC-Afl-008471	Aspergillus flavus	30.50	3.00e-69	256.00
IUUC-Afu-008989	Aspergillus fumigatus	38.78	7.00e-99	354.00
IUUC-Ani-009167	Aspergillus nidulans	38.20	7.00e-118	417.00
IUUC-Ang-009595	Aspergillus niger	38.36	3.00e-106	378.00
IUUC-Aor-009908	Aspergillus oryzae	37.33	7.00e-106	377.00
IUUC-Ate-010580	Aspergillus terreus	38.03	2.00e-111	397.00
IUUC-Ame-011269	Astyanax mexicanus	61.40	6.00e-136	477.00
IUUC-Bgr-011996	Blumeria graminis	34.59	4.00e-108	385.00
IUUC-Bta-013278	Bos taurus	95.01	0.00e+00	1189.00
IUUC-Bci-013925	Botrytis cinerea	35.95	6.00e-109	387.00
IUUC-Bdi-014659	Brachypodium distachyon	36.18	1.00e-104	373.00
IUUC-Bol-016043	Brassica oleracea	35.47	1.00e-105	377.00
IUUC-Bra-017139	Brassica rapa	36.53	4.00e-109	388.00
IUUC-Cel-018417	Caenorhabditis elegans	41.12	4.00e-125	441.00
IUUC-Cja-019952	Callithrix jacchus	95.67	0.00e+00	1150.00
IUUC-Cfa-020225	Canis familiaris	96.17	0.00e+00	1177.00
IUUC-Cpo-021900	Cavia porcellus	95.17	0.00e+00	1176.00
IUUC-Csa-023028	Chlorocebus sabaeus	96.34	0.00e+00	1156.00
IUUC-Cho-025030	Choloepus hoffmanni	68.17	0.00e+00	753.00
IUUC-Cin-025152	Ciona intestinalis	55.86	2.00e-83	301.00
IUUC-Csv-025986	Ciona savignyi	37.42	4.00e-93	335.00
IUUC-Cgl-026597	Colletotrichum gloeosporioides	39.22	5.00e-114	404.00
IUUC-Cne-026814	Cryptococcus neoformans	33.88	1.00e-95	343.00
IUUC-Dre-027498	Danio rerio	81.58	3.00e-94	337.00
IUUC-Dno-029383	Dasypus novemcinctus	94.68	0.00e+00	1133.00
IUUC-Dor-030633	Dipodomys ordii	94.65	0.00e+00	1093.00
IUUC-Dse-031526	Dothistroma septosporum	39.00	3.00e-120	425.00
IUUC-Dme-031597	Drosophila melanogaster	48.17	3.00e-168	584.00
IUUC-Ete-032780	Echinops telfairi	85.02	0.00e+00	1025.00
IUUC-Eca-034306	Equus caballus	94.51	0.00e+00	1145.00
IUUC-Eeu-034531	Erinaceus europaeus	73.52	7.00e-136	477.00
IUUC-Fca-036301	Felis catus	96.51	0.00e+00	1205.00
IUUC-Fal-037361	Ficedula albicollis	88.08	0.00e+00	1126.00
IUUC-Fox-037924	Fusarium oxysporum	35.39	2.00e-103	369.00
IUUC-Fso-038199	Fusarium solani	35.33	1.00e-100	360.00
IUUC-Gmo-039238	Gadus morhua	71.97	0.00e+00	889.00
IUUC-Ggr-039830	Gaeumannomyces graminis	35.77	2.00e-97	349.00
IUUC-Gga-040235	Gallus gallus	88.85	0.00e+00	1097.00
IUUC-Gac-042363	Gasterosteus aculeatus	72.33	0.00e+00	922.00
IUUC-Gma-044189	Glycine max	36.93	3.00e-112	399.00
IUUC-Ggo-044632	Gorilla gorilla	94.35	0.00e+00	1127.00
IUUC-Hsa-045792	Homo sapiens	96.34	0.00e+00	1181.00
IUUC-Hvu-047517	Hordeum vulgare	35.63	6.00e-108	384.00
IUUC-Kpa-049183	Komagataella pastoris	33.06	5.00e-86	311.00
IUUC-Lch-050428	Latimeria chalumnae	76.91	0.00e+00	997.00
IUUC-Lpe-051306	Leersia perrieri	36.56	1.00e-109	390.00
IUUC-Loc-052096	Lepisosteus oculatus	71.96	0.00e+00	897.00
IUUC-Lma-053313	Leptosphaeria maculans	39.55	6.00e-120	426.00
IUUC-Laf-054060	Loxodonta africana	93.01	0.00e+00	1126.00
IUUC-Mcc-055619	Macaca mulatta	94.87	0.00e+00	1138.00
IUUC-Meu-056689	Macropus eugenii	77.10	3.00e-178	618.00
IUUC-Mor-056940	Magnaporthe oryzae	35.12	5.00e-99	355.00
IUUC-Mpo-057557	Magnaporthe poae	29.26	2.00e-60	226.00
IUUC-Mtr-058478	Medicago truncatula	36.29	2.00e-110	392.00
IUUC-Mla-059103	Melampsora laricipopulina	33.86	1.00e-77	283.00
IUUC-Mga-060150	Meleagris gallopavo	89.35	0.00e+00	1098.00
IUUC-Mvi-060448	Microbotryum violaceum	31.18	4.00e-75	275.00
IUUC-Mmr-061226	Microcebus murinus	94.68	0.00e+00	1148.00
IUUC-Mdo-062674	Monodelphis domestica	91.51	0.00e+00	1135.00
IUUC-Mmu-064170	Mus musculus	96.34	0.00e+00	1180.00
IUUC-Mac-065124	Musa acuminata	38.16	1.00e-114	406.00
IUUC-Mpu-066001	Mustela putorius furo	92.95	0.00e+00	1162.00
IUUC-Mlu-067253	Myotis lucifugus	94.84	0.00e+00	1175.00
IUUC-Nfi-068550	Neosartorya fischeri	38.57	9.00e-113	400.00
IUUC-Ncr-068948	Neurospora crassa	37.58	3.00e-115	408.00
IUUC-Nle-070115	Nomascus leucogenys	92.52	0.00e+00	1072.00
IUUC-Opr-070254	Ochotona princeps	93.50	0.00e+00	1115.00
IUUC-Ont-071666	Oreochromis niloticus	75.37	0.00e+00	948.00
IUUC-Oan-073594	Ornithorhynchus anatinus	92.49	9.00e-169	585.00
IUUC-Ocu-074824	Oryctolagus cuniculus	95.34	0.00e+00	1139.00
IUUC-Oba-075010	Oryza barthii	37.01	3.00e-111	395.00
IUUC-Obr-076364	Oryza brachyantha	37.48	8.00e-112	397.00
IUUC-Ogl-077019	Oryza glaberrima	37.01	3.00e-111	395.00
IUUC-Ogu-078496	Oryza glumaepatula	37.01	3.00e-111	395.00
IUUC-Oin-080116	Oryza indica	37.17	1.00e-111	396.00
IUUC-Olo-080290	Oryza longistaminata	37.01	6.00e-111	394.00
IUUC-Ome-081969	Oryza meridionalis	37.01	4.00e-111	395.00
IUUC-Oni-082075	Oryza nivara	37.01	3.00e-111	395.00
IUUC-Opu-083959	Oryza punctata	37.05	4.00e-111	394.00
IUUC-Oru-084711	Oryza rufipogon	37.01	3.00e-111	395.00
IUUC-Osa-085958	Oryza sativa	37.17	1.00e-111	396.00
IUUC-Ola-086968	Oryzias latipes	76.79	0.00e+00	963.00
IUUC-Oga-089108	Otolemur garnettii	95.71	0.00e+00	1204.00
IUUC-Oar-089986	Ovis aries	89.72	0.00e+00	1116.00
IUUC-Ptr-091281	Pan troglodytes	96.67	0.00e+00	1183.00
IUUC-Pan-092585	Papio anubis	96.51	0.00e+00	1159.00
IUUC-Psi-093811	Pelodiscus sinensis	87.35	0.00e+00	1119.00
IUUC-Pma-094542	Petromyzon marinus	69.62	0.00e+00	887.00
IUUC-Pno-095086	Phaeosphaeria nodorum	37.60	6.00e-111	394.00
IUUC-Ppa-095876	Physcomitrella patens	37.13	1.00e-112	400.00
IUUC-Pfo-096973	Poecilia formosa	75.63	0.00e+00	982.00
IUUC-Pab-098391	Pongo abelii	96.17	0.00e+00	1160.00
IUUC-Pop-098850	Populus trichocarpa	37.01	1.00e-112	400.00
IUUC-Pca-100257	Procavia capensis	60.26	4.00e-91	328.00
IUUC-Ppe-101578	Prunus persica	38.26	2.00e-115	409.00
IUUC-Pva-102872	Pteropus vampyrus	90.03	0.00e+00	1119.00
IUUC-Pgr-103593	Puccinia graminis	32.72	1.00e-79	290.00
IUUC-Pte-104365	Pyrenophora teres	40.07	5.00e-114	404.00
IUUC-Pyt-104689	Pyrenophora triticirepentis	39.74	1.00e-116	413.00
IUUC-Rno-105737	Rattus norvegicus	96.51	0.00e+00	1206.00
IUUC-Sce-106383	Saccharomyces cerevisiae	29.39	9.00e-70	257.00
IUUC-Sha-107084	Sarcophilus harrisii	90.37	0.00e+00	1013.00
IUUC-Sja-107688	Schizosaccharomyces japonicus	36.27	6.00e-113	400.00
IUUC-Spo-108309	Schizosaccharomyces pombe	33.61	3.00e-95	342.00
IUUC-Ssl-108408	Sclerotinia sclerotiorum	36.12	3.00e-109	388.00
IUUC-Smo-109255	Selaginella moellendorffii	34.26	5.00e-99	354.00
IUUC-Sit-109962	Setaria italica	38.16	7.00e-114	404.00
IUUC-Sly-110897	Solanum lycopersicum	38.10	5.00e-115	408.00
IUUC-Stu-111971	Solanum tuberosum	37.93	3.00e-114	405.00
IUUC-Sar-113415	Sorex araneus	71.59	4.00e-108	385.00
IUUC-Sbi-114857	Sorghum bicolor	37.60	2.00e-111	395.00
IUUC-Sre-114900	Sporisorium reilianum	34.00	7.00e-92	331.00
IUUC-Tgu-117256	Taeniopygia guttata	87.85	0.00e+00	1122.00
IUUC-Tru-117871	Takifugu rubripes	70.55	0.00e+00	887.00
IUUC-Tsy-119172	Tarsius syrichta	96.67	8.00e-139	486.00
IUUC-Tni-120339	Tetraodon nigroviridis	70.55	0.00e+00	922.00
IUUC-Tca-121609	Theobroma cacao	36.72	3.00e-112	399.00
IUUC-Tre-122076	Trichoderma reesei	36.63	1.00e-97	350.00
IUUC-Tvi-122528	Trichoderma virens	35.19	9.00e-100	357.00
IUUC-Tae-123530	Triticum aestivum	35.84	4.00e-109	388.00
IUUC-Tur-126845	Triticum urartu	35.45	4.00e-81	295.00
IUUC-Tme-127217	Tuber melanosporum	35.43	6.00e-105	374.00
IUUC-Tbe-127526	Tupaia belangeri	93.36	0.00e+00	1152.00
IUUC-Ttr-128898	Tursiops truncatus	87.54	0.00e+00	1080.00
IUUC-Uma-129631	Ustilago maydis	32.41	1.00e-94	340.00
IUUC-Vda-129732	Verticillium dahliae	35.77	4.00e-94	338.00
IUUC-Vvi-131217	Vitis vinifera	38.26	5.00e-113	401.00
IUUC-Xtr-132860	Xenopus tropicalis	74.18	0.00e+00	935.00
IUUC-Xma-133830	Xiphophorus maculatus	75.63	0.00e+00	982.00
IUUC-Yli-134335	Yarrowia lipolytica	33.61	4.00e-78	285.00
IUUC-Zma-135907	Zea mays	37.77	6.00e-112	397.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence