iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092836

Ensembl Protein ID

ENSPANP00000020037.1

UniProt Accession

A0A096P3W2; A0A096P3W2_PAPAN

Genbank Protein ID

ENSPANP00000020037

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01046597

Gene Name

NLE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000022991.1	ENSPANT00000020588.1	ENSPANP00000020037.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.40e-67	218.1	197	240
UBD/Beta-Prp	3.40e-79	266.2	106	301

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf......sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+ ++t+l++      ++ ++++s+s Dg++++WD++ g++++
   Q: 197  GHSKWITGLSWeplhvnPEcRYVASSSKDGSVRIWDTTAGRCER 240
           8***************9889**********************86 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           + +sl gh+++v +v fsp+gk+l++gs D t++ wdlst ++  t kgh + vls+s+sp+g+kl+sG +   i +wd +tg+ +  t
   Q: 106  CTSSLDGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLWDPSTGKQVGRT 194
           5789************************************************************************************* PP
   S: 133  lsghdgvvncvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+gh+++++++++     +p++++++s+s+D+ vr+Wd   g++ r ltg ht+sv++l +  +g  l s+s+d+t+k+w  + g   r
   Q: 195  LAGHSKWITGLSWeplhvNPECRYVASSSKDGSVRIWDTTAGRCERILTG-HTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCR 281
           *********98652222278899**************************9.************98.*********************** PP
   S: 217  tlnghtdnvksvrfspnderl 237
           tl+gh  +v+ +++s  d  l
   Q: 282  TLQGHGHWVNTMALS-TDYAL 301
           **************9.44444 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MAAAVADESV ARDVQRLLVQ FQDEGGQLLG SPFDVPVDIT PDRLQLVCNA LLAQEDPLPL 60
AFFVHDAEIV SSLGKTLESQ AVETEKVLDI IYQPQAVFRV RAVTRCTSSL DGHSEAVISV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTGGGTACG CAGGATGGCG GCGGCAGTGG CGGTGGGTGT GCGTGGATGG GGGCGGGGGG 60
CGTCGCGGCG CTACGGCCCG GGTCCCTGAG GCCGGAGGGA AACGAAGTGG GGCTCTTCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001826--P:inner cell mass cell differentiation
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0042273--P:ribosomal large subunit biogenesis
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000437	Aegilops tauschii	58.37	5.00e-169	587.00
IUUC-Aml-001793	Ailuropoda melanoleuca	96.19	0.00e+00	942.00
IUUC-Atr-002507	Amborella trichopoda	57.71	1.00e-167	582.00
IUUC-Apl-003964	Anas platyrhynchos	85.02	0.00e+00	815.00
IUUC-Aly-006396	Arabidopsis lyrata	55.11	2.00e-161	562.00
IUUC-Ath-007278	Arabidopsis thaliana	55.32	3.00e-161	561.00
IUUC-Ago-007951	Ashbya gossypii	47.67	7.00e-129	454.00
IUUC-Acl-008298	Aspergillus clavatus	46.86	2.00e-121	429.00
IUUC-Afl-008581	Aspergillus flavus	51.81	6.00e-109	387.00
IUUC-Afu-008906	Aspergillus fumigatus	46.14	1.00e-120	426.00
IUUC-Ani-009189	Aspergillus nidulans	43.98	1.00e-115	409.00
IUUC-Ang-009630	Aspergillus niger	46.17	9.00e-123	433.00
IUUC-Aor-010038	Aspergillus oryzae	46.56	1.00e-127	449.00
IUUC-Ate-010278	Aspergillus terreus	46.63	4.00e-122	431.00
IUUC-Ame-011890	Astyanax mexicanus	81.18	0.00e+00	824.00
IUUC-Bgr-012011	Blumeria graminis	47.48	3.00e-130	458.00
IUUC-Bta-012964	Bos taurus	95.36	0.00e+00	939.00
IUUC-Bci-013592	Botrytis cinerea	44.29	3.00e-120	425.00
IUUC-Bdi-015035	Brachypodium distachyon	58.46	2.00e-170	592.00
IUUC-Bol-015501	Brassica oleracea	55.98	1.00e-161	562.00
IUUC-Bra-017642	Brassica rapa	55.77	8.00e-161	560.00
IUUC-Cel-018430	Caenorhabditis elegans	58.58	5.00e-168	583.00
IUUC-Cja-019125	Callithrix jacchus	98.10	0.00e+00	953.00
IUUC-Cfa-021013	Canis familiaris	94.92	0.00e+00	855.00
IUUC-Cpo-021743	Cavia porcellus	95.35	0.00e+00	939.00
IUUC-Cre-022973	Chlamydomonas reinhardtii	45.47	1.00e-116	413.00
IUUC-Csa-024270	Chlorocebus sabaeus	99.16	0.00e+00	970.00
IUUC-Cin-025795	Ciona intestinalis	64.89	0.00e+00	687.00
IUUC-Csv-025953	Ciona savignyi	67.16	0.00e+00	684.00
IUUC-Cgl-026517	Colletotrichum gloeosporioides	50.93	3.00e-107	382.00
IUUC-Cne-026901	Cryptococcus neoformans	48.72	3.00e-139	488.00
IUUC-Cme-027281	Cyanidioschyzon merolae	47.23	5.00e-114	404.00
IUUC-Dre-028515	Danio rerio	77.52	0.00e+00	802.00
IUUC-Dno-029596	Dasypus novemcinctus	95.67	0.00e+00	957.00
IUUC-Dor-030494	Dipodomys ordii	94.82	0.00e+00	938.00
IUUC-Dse-031538	Dothistroma septosporum	48.03	6.00e-129	454.00
IUUC-Dme-031974	Drosophila melanogaster	58.40	1.00e-168	586.00
IUUC-Ete-032948	Echinops telfairi	96.17	5.00e-117	414.00
IUUC-Eca-033399	Equus caballus	97.24	0.00e+00	947.00
IUUC-Eeu-035013	Erinaceus europaeus	94.26	2.00e-115	409.00
IUUC-Fca-035860	Felis catus	96.41	0.00e+00	943.00
IUUC-Fal-037069	Ficedula albicollis	87.20	2.00e-131	461.00
IUUC-Fox-038059	Fusarium oxysporum	46.35	6.00e-125	441.00
IUUC-Fso-038445	Fusarium solani	46.56	2.00e-125	442.00
IUUC-Gmo-039319	Gadus morhua	75.96	0.00e+00	735.00
IUUC-Ggr-040095	Gaeumannomyces graminis	47.08	6.00e-122	431.00
IUUC-Gga-040303	Gallus gallus	85.20	9.00e-130	455.00
IUUC-Gac-042267	Gasterosteus aculeatus	78.57	0.00e+00	769.00
IUUC-Gma-043974	Glycine max	57.45	1.00e-170	592.00
IUUC-Ggo-044637	Gorilla gorilla	98.51	0.00e+00	950.00
IUUC-Hsa-046128	Homo sapiens	98.14	0.00e+00	976.00
IUUC-Hvu-047373	Hordeum vulgare	58.03	8.00e-169	586.00
IUUC-Itr-048070	Ictidomys tridecemlineatus	95.31	0.00e+00	957.00
IUUC-Kpa-049274	Komagataella pastoris	44.29	1.00e-126	446.00
IUUC-Lch-049907	Latimeria chalumnae	80.82	0.00e+00	819.00
IUUC-Lpe-050778	Leersia perrieri	53.25	4.00e-152	531.00
IUUC-Loc-051889	Lepisosteus oculatus	79.87	0.00e+00	824.00
IUUC-Lma-053041	Leptosphaeria maculans	49.77	9.00e-118	417.00
IUUC-Laf-053598	Loxodonta africana	95.85	0.00e+00	953.00
IUUC-Mcc-055660	Macaca mulatta	99.79	0.00e+00	977.00
IUUC-Meu-056197	Macropus eugenii	79.29	0.00e+00	781.00
IUUC-Mor-056949	Magnaporthe oryzae	46.38	2.00e-119	422.00
IUUC-Mpo-057571	Magnaporthe poae	44.75	3.00e-63	236.00
IUUC-Mtr-058530	Medicago truncatula	58.00	2.00e-167	582.00
IUUC-Mla-059133	Melampsora laricipopulina	46.08	3.00e-124	438.00
IUUC-Mga-059252	Meleagris gallopavo	84.38	0.00e+00	661.00
IUUC-Mvi-060522	Microbotryum violaceum	49.80	6.00e-136	477.00
IUUC-Mmr-061117	Microcebus murinus	95.83	0.00e+00	944.00
IUUC-Mdo-062892	Monodelphis domestica	88.45	0.00e+00	898.00
IUUC-Mmu-064108	Mus musculus	95.98	0.00e+00	913.00
IUUC-Mac-064430	Musa acuminata	59.10	1.00e-172	599.00
IUUC-Mpu-065882	Mustela putorius furo	95.56	0.00e+00	933.00
IUUC-Mlu-068123	Myotis lucifugus	95.99	0.00e+00	946.00
IUUC-Nfi-068484	Neosartorya fischeri	46.54	7.00e-121	427.00
IUUC-Ncr-068649	Neurospora crassa	43.67	3.00e-116	411.00
IUUC-Nle-069140	Nomascus leucogenys	98.09	0.00e+00	948.00
IUUC-Opr-070220	Ochotona princeps	88.28	0.00e+00	827.00
IUUC-Ont-072643	Oreochromis niloticus	80.46	0.00e+00	821.00
IUUC-Ocu-074007	Oryctolagus cuniculus	96.19	0.00e+00	913.00
IUUC-Oba-075904	Oryza barthii	58.89	1.00e-171	596.00
IUUC-Obr-076280	Oryza brachyantha	58.46	7.00e-171	593.00
IUUC-Ogl-077425	Oryza glaberrima	58.89	8.00e-172	596.00
IUUC-Ogu-078586	Oryza glumaepatula	58.89	8.00e-172	596.00
IUUC-Oin-079489	Oryza indica	56.75	8.00e-163	566.00
IUUC-Olo-080766	Oryza longistaminata	58.76	1.00e-171	595.00
IUUC-Ome-081905	Oryza meridionalis	58.89	6.00e-172	597.00
IUUC-Oni-083022	Oryza nivara	58.89	5.00e-172	597.00
IUUC-Opu-083615	Oryza punctata	58.89	6.00e-172	597.00
IUUC-Oru-085076	Oryza rufipogon	58.89	5.00e-172	597.00
IUUC-Osa-085516	Oryza sativa	58.89	5.00e-172	597.00
IUUC-Ola-087290	Oryzias latipes	78.36	0.00e+00	803.00
IUUC-Olu-087898	Ostreococcus lucimarinus	53.04	1.00e-143	503.00
IUUC-Oga-088980	Otolemur garnettii	95.54	0.00e+00	932.00
IUUC-Oar-089580	Ovis aries	95.61	0.00e+00	818.00
IUUC-Ptr-090845	Pan troglodytes	97.66	0.00e+00	942.00
IUUC-Psi-093965	Pelodiscus sinensis	82.46	8.00e-56	208.00
IUUC-Pno-095052	Phaeosphaeria nodorum	47.43	4.00e-123	434.00
IUUC-Ppa-095432	Physcomitrella patens	57.81	1.00e-169	589.00
IUUC-Pfo-096963	Poecilia formosa	72.27	0.00e+00	706.00
IUUC-Pab-097716	Pongo abelii	94.27	0.00e+00	902.00
IUUC-Pop-099224	Populus trichocarpa	58.72	5.00e-172	597.00
IUUC-Pca-100682	Procavia capensis	92.96	0.00e+00	681.00
IUUC-Ppe-101819	Prunus persica	58.02	1.00e-169	589.00
IUUC-Pva-102338	Pteropus vampyrus	95.07	0.00e+00	723.00
IUUC-Pgr-103583	Puccinia graminis	54.01	4.00e-131	461.00
IUUC-Ptt-103737	Puccinia triticina	44.11	4.00e-99	355.00
IUUC-Pte-104150	Pyrenophora teres	50.23	2.00e-122	432.00
IUUC-Pyt-104606	Pyrenophora triticirepentis	50.00	3.00e-122	431.00
IUUC-Rno-105987	Rattus norvegicus	95.76	0.00e+00	936.00
IUUC-Sce-106315	Saccharomyces cerevisiae	47.27	4.00e-130	457.00
IUUC-Sha-107273	Sarcophilus harrisii	89.07	0.00e+00	909.00
IUUC-Sja-107677	Schizosaccharomyces japonicus	45.27	1.00e-117	416.00
IUUC-Spo-108092	Schizosaccharomyces pombe	48.74	2.00e-123	435.00
IUUC-Ssl-108442	Sclerotinia sclerotiorum	43.94	4.00e-115	408.00
IUUC-Smo-108855	Selaginella moellendorffii	56.06	3.00e-164	571.00
IUUC-Sit-110329	Setaria italica	59.10	1.00e-171	596.00
IUUC-Sly-111830	Solanum lycopersicum	59.96	1.00e-174	606.00
IUUC-Stu-112603	Solanum tuberosum	59.96	1.00e-174	605.00
IUUC-Sar-113504	Sorex araneus	87.76	2.00e-73	269.00
IUUC-Sbi-114560	Sorghum bicolor	58.24	3.00e-169	587.00
IUUC-Sre-115133	Sporisorium reilianum	40.62	6.00e-123	434.00
IUUC-Ssc-115903	Sus scrofa	96.62	0.00e+00	943.00
IUUC-Tgu-116798	Taeniopygia guttata	85.20	0.00e+00	856.00
IUUC-Tru-118361	Takifugu rubripes	78.20	0.00e+00	805.00
IUUC-Tsy-118849	Tarsius syrichta	96.42	0.00e+00	945.00
IUUC-Tni-120094	Tetraodon nigroviridis	79.11	0.00e+00	805.00
IUUC-Tca-121634	Theobroma cacao	58.30	3.00e-168	584.00
IUUC-Tre-122051	Trichoderma reesei	45.62	1.00e-118	420.00
IUUC-Tvi-122322	Trichoderma virens	47.08	1.00e-122	433.00
IUUC-Tae-123133	Triticum aestivum	58.24	1.00e-169	589.00
IUUC-Tur-126766	Triticum urartu	52.00	6.00e-161	560.00
IUUC-Tme-127175	Tuber melanosporum	50.61	2.00e-132	465.00
IUUC-Tbe-127779	Tupaia belangeri	95.08	0.00e+00	832.00
IUUC-Ttr-128224	Tursiops truncatus	91.12	0.00e+00	808.00
IUUC-Uma-129537	Ustilago maydis	41.14	4.00e-125	441.00
IUUC-Vda-129927	Verticillium dahliae	45.40	1.00e-109	390.00
IUUC-Vpa-130658	Vicugna pacos	83.40	0.00e+00	798.00
IUUC-Vvi-131659	Vitis vinifera	58.85	1.00e-171	596.00
IUUC-Xtr-132918	Xenopus tropicalis	75.98	0.00e+00	788.00
IUUC-Xma-133700	Xiphophorus maculatus	80.46	0.00e+00	817.00
IUUC-Yli-134478	Yarrowia lipolytica	50.31	8.00e-139	486.00
IUUC-Zma-135835	Zea mays	55.78	3.00e-166	577.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence