iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090845

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AACZ03108997

Gene Name

NLE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000009012.5	ENSPTRT00000016610.5	ENSPTRP00000015375.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.70e-67	218.8	197	240
UBD/Beta-Prp	5.50e-80	268.7	106	299

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf......sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+ ++t+l++      ++ ++++s+s Dg++++WD++ g++++
   Q: 197  GHSKWITGLSWeplhanPEcRYVASSSKDGSVRIWDTTAGRCER 240
           8***************9889**********************86 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           + +sl+gh+++v +v fsp+gk+l++gs D t++ wdlst ++ ++ +gh + vls+s+sp+g+kl+sG +   i +wd +tg+ +  t
   Q: 106  CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHSHARGHRHWVLSISWSPDGKKLASGCKNGQILLWDPSTGKQVGRT 194
           5799************************************************************************************* PP
   S: 133  lsghdgvvncvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+gh+++++++++     +p++++++s+s+D+ vr+Wd   g++ r ltg ht+sv++l +  +g  l s+s+d+t+k+w  + g   r
   Q: 195  LAGHSKWITGLSWeplhaNPECRYVASSSKDGSVRIWDTTAGRCERILTG-HTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCR 281
           **********9873332257889**************************9.************98.*********************** PP
   S: 217  tlnghtdnvksvrfspnde 235
           tl+gh  +v+ +++s  d 
   Q: 282  TLQGHGHWVNTMALS-TDY 299
           *************99.333 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MAAAVADEAV ARDVQRLLVQ FQDEGGQLLG SPFDVPVDIT PDRLQLVCNA LLAQEDPLPL 60
AFFVHDAEIV SSLGKTLESQ AVETEKVLDI IYQPQAIFRV RAVTRCTSSL EGHSEAVISV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTTTCTCC TCCACGTGGG GACGCAGGAT GGCGGCGGCA GTGGCGGTGG GTGTGCGTGG 60
ATGAGGGCGG GGGGCGTCGC CGCGGGGCGC TAGGGCCCGG GTCCCTGAGG CCTGAGAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005840--C:ribosome
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001826--P:inner cell mass cell differentiation
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0000027--P:ribosomal large subunit assembly
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000437	Aegilops tauschii	57.51	6.00e-166	577.00
IUUC-Aml-001793	Ailuropoda melanoleuca	96.19	0.00e+00	935.00
IUUC-Atr-002507	Amborella trichopoda	58.42	3.00e-165	574.00
IUUC-Apl-003964	Anas platyrhynchos	84.58	0.00e+00	811.00
IUUC-Aly-006396	Arabidopsis lyrata	53.83	1.00e-158	552.00
IUUC-Ath-007278	Arabidopsis thaliana	54.04	2.00e-158	551.00
IUUC-Ago-007951	Ashbya gossypii	47.95	1.00e-128	452.00
IUUC-Acl-008298	Aspergillus clavatus	47.10	2.00e-119	422.00
IUUC-Afl-008581	Aspergillus flavus	51.11	5.00e-108	384.00
IUUC-Afu-008906	Aspergillus fumigatus	46.15	8.00e-119	420.00
IUUC-Ani-009189	Aspergillus nidulans	44.62	1.00e-114	407.00
IUUC-Ang-009630	Aspergillus niger	49.64	5.00e-121	427.00
IUUC-Aor-010038	Aspergillus oryzae	46.58	8.00e-126	443.00
IUUC-Ate-010278	Aspergillus terreus	46.40	4.00e-121	428.00
IUUC-Ame-011890	Astyanax mexicanus	80.97	0.00e+00	823.00
IUUC-Bgr-012011	Blumeria graminis	48.03	3.00e-130	458.00
IUUC-Bta-012964	Bos taurus	95.36	0.00e+00	932.00
IUUC-Bci-013592	Botrytis cinerea	44.60	2.00e-118	419.00
IUUC-Bdi-015035	Brachypodium distachyon	57.39	6.00e-167	580.00
IUUC-Bol-015501	Brassica oleracea	54.70	1.00e-158	553.00
IUUC-Bra-017642	Brassica rapa	54.49	4.00e-158	550.00
IUUC-Cel-018430	Caenorhabditis elegans	58.24	5.00e-167	580.00
IUUC-Cja-019125	Callithrix jacchus	97.47	0.00e+00	946.00
IUUC-Cfa-021013	Canis familiaris	94.92	0.00e+00	848.00
IUUC-Cpo-021743	Cavia porcellus	94.71	0.00e+00	927.00
IUUC-Cre-022973	Chlamydomonas reinhardtii	46.50	7.00e-121	427.00
IUUC-Csa-024270	Chlorocebus sabaeus	98.12	0.00e+00	961.00
IUUC-Cin-025795	Ciona intestinalis	65.46	0.00e+00	675.00
IUUC-Csv-025953	Ciona savignyi	66.31	0.00e+00	674.00
IUUC-Cgl-026517	Colletotrichum gloeosporioides	50.66	1.00e-106	379.00
IUUC-Cne-026901	Cryptococcus neoformans	48.51	4.00e-136	478.00
IUUC-Cme-027281	Cyanidioschyzon merolae	47.67	2.00e-114	406.00
IUUC-Dre-028515	Danio rerio	78.01	0.00e+00	803.00
IUUC-Dno-029596	Dasypus novemcinctus	95.98	0.00e+00	934.00
IUUC-Dor-030494	Dipodomys ordii	95.34	0.00e+00	925.00
IUUC-Dse-031538	Dothistroma septosporum	47.41	2.00e-127	449.00
IUUC-Dme-031974	Drosophila melanogaster	58.95	3.00e-165	574.00
IUUC-Ete-032948	Echinops telfairi	96.17	1.00e-116	413.00
IUUC-Eca-033399	Equus caballus	97.24	0.00e+00	939.00
IUUC-Eeu-035013	Erinaceus europaeus	93.78	4.00e-115	408.00
IUUC-Fca-035860	Felis catus	95.99	0.00e+00	933.00
IUUC-Fal-037069	Ficedula albicollis	87.60	2.00e-132	464.00
IUUC-Fox-038059	Fusarium oxysporum	45.93	1.00e-122	433.00
IUUC-Fso-038445	Fusarium solani	47.39	9.00e-124	436.00
IUUC-Gmo-039319	Gadus morhua	75.74	0.00e+00	735.00
IUUC-Ggr-040095	Gaeumannomyces graminis	46.75	8.00e-121	427.00
IUUC-Gga-040303	Gallus gallus	85.60	8.00e-131	459.00
IUUC-Gac-042267	Gasterosteus aculeatus	78.69	0.00e+00	767.00
IUUC-Gma-043974	Glycine max	57.23	5.00e-168	583.00
IUUC-Ggo-044637	Gorilla gorilla	98.30	0.00e+00	946.00
IUUC-Hsa-046128	Homo sapiens	98.56	0.00e+00	975.00
IUUC-Hvu-047373	Hordeum vulgare	56.96	3.00e-165	574.00
IUUC-Itr-048070	Ictidomys tridecemlineatus	95.82	0.00e+00	935.00
IUUC-Kpa-049274	Komagataella pastoris	44.08	3.00e-125	442.00
IUUC-Lch-049907	Latimeria chalumnae	82.18	0.00e+00	819.00
IUUC-Lpe-050778	Leersia perrieri	52.61	5.00e-148	517.00
IUUC-Loc-051889	Lepisosteus oculatus	80.76	0.00e+00	825.00
IUUC-Lma-053041	Leptosphaeria maculans	49.88	3.00e-117	415.00
IUUC-Laf-053598	Loxodonta africana	96.20	0.00e+00	940.00
IUUC-Mcc-055660	Macaca mulatta	97.89	0.00e+00	949.00
IUUC-Meu-056197	Macropus eugenii	80.17	0.00e+00	777.00
IUUC-Mor-056949	Magnaporthe oryzae	45.96	6.00e-118	417.00
IUUC-Mpo-057571	Magnaporthe poae	44.75	2.00e-63	236.00
IUUC-Mtr-058530	Medicago truncatula	57.66	8.00e-164	569.00
IUUC-Mla-059133	Melampsora laricipopulina	46.75	1.00e-124	439.00
IUUC-Mga-059252	Meleagris gallopavo	84.11	0.00e+00	658.00
IUUC-Mvi-060522	Microbotryum violaceum	49.09	1.00e-134	473.00
IUUC-Mmr-061117	Microcebus murinus	95.37	0.00e+00	926.00
IUUC-Mdo-062892	Monodelphis domestica	89.43	0.00e+00	888.00
IUUC-Mmu-064108	Mus musculus	95.14	0.00e+00	902.00
IUUC-Mac-064430	Musa acuminata	58.46	2.00e-169	588.00
IUUC-Mpu-065882	Mustela putorius furo	95.56	0.00e+00	926.00
IUUC-Mlu-068123	Myotis lucifugus	95.99	0.00e+00	941.00
IUUC-Nfi-068484	Neosartorya fischeri	46.57	9.00e-119	420.00
IUUC-Ncr-068649	Neurospora crassa	43.45	1.00e-114	406.00
IUUC-Nle-069140	Nomascus leucogenys	98.73	0.00e+00	949.00
IUUC-Opr-070220	Ochotona princeps	88.11	0.00e+00	810.00
IUUC-Ont-072643	Oreochromis niloticus	80.63	0.00e+00	823.00
IUUC-Ocu-074007	Oryctolagus cuniculus	95.56	0.00e+00	903.00
IUUC-Oba-075904	Oryza barthii	57.82	4.00e-168	583.00
IUUC-Obr-076280	Oryza brachyantha	57.39	4.00e-167	580.00
IUUC-Ogl-077425	Oryza glaberrima	57.82	3.00e-168	584.00
IUUC-Ogu-078586	Oryza glumaepatula	57.82	6.00e-168	583.00
IUUC-Oin-079489	Oryza indica	55.67	5.00e-159	553.00
IUUC-Olo-080766	Oryza longistaminata	57.69	9.00e-168	583.00
IUUC-Ome-081905	Oryza meridionalis	57.82	5.00e-168	583.00
IUUC-Oni-083022	Oryza nivara	57.82	2.00e-168	584.00
IUUC-Opu-083615	Oryza punctata	57.82	3.00e-168	584.00
IUUC-Oru-085076	Oryza rufipogon	57.82	3.00e-168	584.00
IUUC-Osa-085744	Oryza sativa	58.03	7.00e-169	586.00
IUUC-Ola-087290	Oryzias latipes	78.53	0.00e+00	806.00
IUUC-Olu-087898	Ostreococcus lucimarinus	52.51	7.00e-143	500.00
IUUC-Oga-088980	Otolemur garnettii	95.33	0.00e+00	924.00
IUUC-Oar-089580	Ovis aries	95.37	0.00e+00	810.00
IUUC-Pan-092836	Papio anubis	97.68	0.00e+00	948.00
IUUC-Psi-093965	Pelodiscus sinensis	82.46	4.00e-56	209.00
IUUC-Pno-095052	Phaeosphaeria nodorum	47.52	8.00e-122	430.00
IUUC-Ppa-095432	Physcomitrella patens	58.00	7.00e-167	580.00
IUUC-Pfo-096963	Poecilia formosa	72.42	0.00e+00	709.00
IUUC-Pab-097716	Pongo abelii	95.54	0.00e+00	911.00
IUUC-Pop-099224	Populus trichocarpa	58.30	1.00e-168	586.00
IUUC-Pca-100682	Procavia capensis	91.83	0.00e+00	669.00
IUUC-Ppe-101819	Prunus persica	58.21	8.00e-167	580.00
IUUC-Pva-102338	Pteropus vampyrus	96.09	0.00e+00	712.00
IUUC-Pgr-103583	Puccinia graminis	54.88	2.00e-130	459.00
IUUC-Ptt-103737	Puccinia triticina	44.57	2.00e-98	353.00
IUUC-Pte-104150	Pyrenophora teres	50.11	4.00e-121	428.00
IUUC-Pyt-104606	Pyrenophora triticirepentis	50.11	4.00e-121	428.00
IUUC-Rno-105987	Rattus norvegicus	94.92	0.00e+00	924.00
IUUC-Sce-106315	Saccharomyces cerevisiae	46.76	3.00e-128	451.00
IUUC-Sha-107273	Sarcophilus harrisii	90.06	0.00e+00	900.00
IUUC-Sja-107677	Schizosaccharomyces japonicus	46.54	3.00e-118	418.00
IUUC-Spo-108092	Schizosaccharomyces pombe	48.97	8.00e-124	437.00
IUUC-Ssl-108442	Sclerotinia sclerotiorum	43.57	1.00e-113	402.00
IUUC-Smo-108855	Selaginella moellendorffii	55.44	1.00e-161	562.00
IUUC-Sit-110329	Setaria italica	58.24	3.00e-168	585.00
IUUC-Sly-111830	Solanum lycopersicum	59.10	3.00e-171	594.00
IUUC-Stu-112603	Solanum tuberosum	59.10	3.00e-171	594.00
IUUC-Sar-113504	Sorex araneus	92.03	4.00e-71	261.00
IUUC-Sbi-114560	Sorghum bicolor	57.39	9.00e-166	576.00
IUUC-Sre-115133	Sporisorium reilianum	41.46	6.00e-123	434.00
IUUC-Ssc-115903	Sus scrofa	95.99	0.00e+00	934.00
IUUC-Tgu-116798	Taeniopygia guttata	84.99	0.00e+00	853.00
IUUC-Tru-118361	Takifugu rubripes	78.53	0.00e+00	806.00
IUUC-Tsy-118849	Tarsius syrichta	96.60	0.00e+00	932.00
IUUC-Tni-120094	Tetraodon nigroviridis	79.11	0.00e+00	805.00
IUUC-Tca-121634	Theobroma cacao	57.45	6.00e-165	573.00
IUUC-Tre-122051	Trichoderma reesei	45.62	4.00e-117	414.00
IUUC-Tvi-122322	Trichoderma virens	46.67	4.00e-120	424.00
IUUC-Tae-125822	Triticum aestivum	57.39	5.00e-166	577.00
IUUC-Tur-126766	Triticum urartu	51.24	1.00e-157	550.00
IUUC-Tme-127175	Tuber melanosporum	50.95	2.00e-130	459.00
IUUC-Tbe-127779	Tupaia belangeri	94.85	0.00e+00	824.00
IUUC-Ttr-128224	Tursiops truncatus	91.12	0.00e+00	801.00
IUUC-Uma-129537	Ustilago maydis	41.48	9.00e-123	434.00
IUUC-Vda-129927	Verticillium dahliae	45.19	3.00e-110	392.00
IUUC-Vpa-130658	Vicugna pacos	83.65	0.00e+00	786.00
IUUC-Vvi-131659	Vitis vinifera	58.21	1.00e-168	585.00
IUUC-Xtr-132918	Xenopus tropicalis	77.47	0.00e+00	788.00
IUUC-Xma-133700	Xiphophorus maculatus	80.63	0.00e+00	820.00
IUUC-Yli-134478	Yarrowia lipolytica	49.69	3.00e-137	481.00
IUUC-Zma-135835	Zea mays	54.97	9.00e-163	566.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence