iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054280

UUCD1 version

UUC-LoA-00654

Ensembl Protein ID

ENSLAFP00000016269.2

UniProt Accession

G3TMD6; G3TMD6_LOXAF

Protein Name

Uncharacterized protein

Gene Name

TBL1XR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000021750.2	ENSLAFT00000022261.2	ENSLAFP00000016269.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.00e-53	177.2	347	385
UBD/Beta-Prp	1.50e-65	221.7	310	513

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHt++v+++++ ++ +ll+s+sdD t+k+W+++++++++
   Q: 347  GHTNEVNAIKWdPTgNLLASCSDDMTLKIWSMKQDNCVH 385
           8***********778*********************987 PP

UBD/Beta-Prp

   S: 12   vitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlsl 100
           +  +v++ ++++ +a+ s+d +i v ++ +   +++++gh++ev+a+k++p+g++l+++s+D+t+k+w++++  cvh l++h+++++++
   Q: 310  PALDVDW-QSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTI 397
           4444555.666777777777777777777777777777777777777777777777777777777777777777777777777777777 PP
   S: 101  sfsp........sg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
           ++sp        +    l+s+s d+t+r+wd++ g c++ tl++h++ v +v+++pdg++l+sGs D++v +W+ +tg l++  +g  t
   Q: 398  KWSPtgpgtsnpNAnLMLASASFDSTVRLWDVDRGICIH-TLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG--T 483
           777755554444222467777777777777777777777.7777777777777777777777777777777777777777777776..7 PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlq 210
           + +  + ++  g  + + + dg+v + dl+
   Q: 484  GGIFEVCWNAAGDKVGASASDGSVCVLDLR 513
           777777777777777777777777766665 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MSISSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GALVPPAALI SIIQKGLQYV 60
EAEVSINEGC TLFDGRPIES LSLIDAVMPD VVQTRQQAYR DKLAQQQAAA AAAAAAATNQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGTATAA GCAGTGATGA GGTCAACTTC TTGGTATATA GATACTTGCA AGAGTCAGGT 60
GAGTACTTTT ATAAATAGGC CTCAAATTAT TTTAATATTC TCAAAATAAT ACCCTTTTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0005876--C:spindle microtubule
GO:0017053--C:transcriptional repressor complex
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0060613--P:fat pad development
GO:0016042--P:lipid catabolic process
GO:0035264--P:multicellular organism growth
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030814--P:regulation of cAMP metabolic process
GO:0090207--P:regulation of triglyceride metabolic process
GO:0002021--P:response to dietary excess
GO:0050872--P:white fat cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000916	Aegilops tauschii	60.00	2.00e-54	204.00
IUUC-Aml-001717	Ailuropoda melanoleuca	98.44	0.00e+00	952.00
IUUC-Atr-002514	Amborella trichopoda	65.11	2.00e-144	505.00
IUUC-Apl-003708	Anas platyrhynchos	98.58	0.00e+00	920.00
IUUC-Aca-004611	Anolis carolinensis	98.44	0.00e+00	958.00
IUUC-Aly-005622	Arabidopsis lyrata	58.13	5.00e-119	421.00
IUUC-Ath-007137	Arabidopsis thaliana	59.23	1.00e-120	427.00
IUUC-Ago-007869	Ashbya gossypii	28.27	1.00e-32	134.00
IUUC-Ame-011601	Astyanax mexicanus	91.83	0.00e+00	899.00
IUUC-Bta-012418	Bos taurus	99.22	0.00e+00	989.00
IUUC-Bdi-014315	Brachypodium distachyon	60.16	5.00e-134	471.00
IUUC-Bol-016277	Brassica oleracea	56.99	2.00e-126	446.00
IUUC-Bra-016944	Brassica rapa	60.28	6.00e-126	444.00
IUUC-Cja-018832	Callithrix jacchus	99.03	0.00e+00	959.00
IUUC-Cfa-020029	Canis familiaris	98.64	0.00e+00	953.00
IUUC-Cpo-022080	Cavia porcellus	93.59	0.00e+00	920.00
IUUC-Csa-024075	Chlorocebus sabaeus	98.83	0.00e+00	953.00
IUUC-Cho-024872	Choloepus hoffmanni	98.29	8.00e-111	394.00
IUUC-Cme-027258	Cyanidioschyzon merolae	40.55	1.00e-106	380.00
IUUC-Dre-028075	Danio rerio	95.53	0.00e+00	924.00
IUUC-Dno-029196	Dasypus novemcinctus	99.22	0.00e+00	968.00
IUUC-Dor-030732	Dipodomys ordii	99.18	0.00e+00	733.00
IUUC-Eeu-034952	Erinaceus europaeus	88.82	0.00e+00	825.00
IUUC-Fca-035734	Felis catus	98.83	0.00e+00	965.00
IUUC-Fal-037185	Ficedula albicollis	98.64	0.00e+00	958.00
IUUC-Gmo-038870	Gadus morhua	90.08	0.00e+00	924.00
IUUC-Gga-041161	Gallus gallus	98.83	0.00e+00	961.00
IUUC-Gac-041844	Gasterosteus aculeatus	91.65	0.00e+00	947.00
IUUC-Gma-044208	Glycine max	48.15	2.00e-152	532.00
IUUC-Ggo-044882	Gorilla gorilla	98.83	0.00e+00	953.00
IUUC-Hsa-046488	Homo sapiens	98.83	0.00e+00	953.00
IUUC-Itr-047958	Ictidomys tridecemlineatus	99.73	0.00e+00	741.00
IUUC-Kpa-049338	Komagataella pastoris	28.91	8.00e-32	131.00
IUUC-Lch-050672	Latimeria chalumnae	96.12	0.00e+00	967.00
IUUC-Lpe-051084	Leersia perrieri	62.36	9.00e-136	476.00
IUUC-Loc-052030	Lepisosteus oculatus	95.56	0.00e+00	955.00
IUUC-Mcc-055203	Macaca mulatta	98.83	0.00e+00	954.00
IUUC-Meu-056563	Macropus eugenii	97.90	6.00e-135	473.00
IUUC-Mtr-058624	Medicago truncatula	60.16	4.00e-128	451.00
IUUC-Mga-059660	Meleagris gallopavo	98.83	0.00e+00	961.00
IUUC-Mvi-060557	Microbotryum violaceum	36.77	1.00e-70	261.00
IUUC-Mmr-060925	Microcebus murinus	97.41	0.00e+00	917.00
IUUC-Mdo-062078	Monodelphis domestica	98.25	0.00e+00	956.00
IUUC-Mmu-063603	Mus musculus	98.64	0.00e+00	962.00
IUUC-Mac-065508	Musa acuminata	61.42	1.00e-92	333.00
IUUC-Mpu-066741	Mustela putorius furo	98.64	0.00e+00	953.00
IUUC-Mlu-068152	Myotis lucifugus	99.03	0.00e+00	960.00
IUUC-Nle-069229	Nomascus leucogenys	98.83	0.00e+00	953.00
IUUC-Opr-070277	Ochotona princeps	88.17	0.00e+00	818.00
IUUC-Ont-072623	Oreochromis niloticus	91.84	0.00e+00	948.00
IUUC-Ocu-074280	Oryctolagus cuniculus	97.13	0.00e+00	955.00
IUUC-Oba-075618	Oryza barthii	48.47	1.00e-143	503.00
IUUC-Obr-076718	Oryza brachyantha	62.64	2.00e-136	479.00
IUUC-Ogl-077302	Oryza glaberrima	50.63	7.00e-156	543.00
IUUC-Ogu-078718	Oryza glumaepatula	50.63	7.00e-156	543.00
IUUC-Oin-079515	Oryza indica	44.12	4.00e-94	339.00
IUUC-Olo-080427	Oryza longistaminata	63.04	2.00e-131	462.00
IUUC-Ome-081696	Oryza meridionalis	49.55	2.00e-150	525.00
IUUC-Oni-082137	Oryza nivara	50.63	7.00e-156	543.00
IUUC-Oru-085276	Oryza rufipogon	50.45	4.00e-155	541.00
IUUC-Osa-085791	Oryza sativa	50.63	7.00e-156	543.00
IUUC-Ola-087365	Oryzias latipes	95.53	0.00e+00	950.00
IUUC-Olu-087589	Ostreococcus lucimarinus	51.87	8.00e-154	536.00
IUUC-Oga-088357	Otolemur garnettii	94.55	0.00e+00	901.00
IUUC-Oar-089214	Ovis aries	99.42	0.00e+00	993.00
IUUC-Ptr-091532	Pan troglodytes	98.83	0.00e+00	953.00
IUUC-Pan-091927	Papio anubis	98.83	0.00e+00	953.00
IUUC-Psi-093941	Pelodiscus sinensis	92.03	0.00e+00	936.00
IUUC-Pma-094105	Petromyzon marinus	65.87	1.00e-98	352.00
IUUC-Ppa-095868	Physcomitrella patens	66.57	3.00e-140	491.00
IUUC-Pfo-096158	Poecilia formosa	91.84	0.00e+00	947.00
IUUC-Pab-098705	Pongo abelii	98.83	0.00e+00	953.00
IUUC-Pca-100256	Procavia capensis	98.62	0.00e+00	944.00
IUUC-Ppe-101572	Prunus persica	63.41	2.00e-127	449.00
IUUC-Pva-102616	Pteropus vampyrus	98.62	0.00e+00	945.00
IUUC-Rno-105411	Rattus norvegicus	98.83	0.00e+00	965.00
IUUC-Sce-106132	Saccharomyces cerevisiae	25.27	3.00e-42	166.00
IUUC-Sha-106636	Sarcophilus harrisii	97.67	0.00e+00	949.00
IUUC-Smo-109301	Selaginella moellendorffii	63.76	3.00e-143	501.00
IUUC-Sit-110710	Setaria italica	63.43	7.00e-142	497.00
IUUC-Sly-111042	Solanum lycopersicum	50.68	6.00e-150	523.00
IUUC-Stu-112744	Solanum tuberosum	49.71	1.00e-141	496.00
IUUC-Sar-112971	Sorex araneus	90.00	0.00e+00	862.00
IUUC-Sbi-114420	Sorghum bicolor	62.91	1.00e-141	496.00
IUUC-Sre-115175	Sporisorium reilianum	37.17	7.00e-58	218.00
IUUC-Ssc-115695	Sus scrofa	97.28	0.00e+00	946.00
IUUC-Tgu-117009	Taeniopygia guttata	98.81	0.00e+00	944.00
IUUC-Tru-118581	Takifugu rubripes	94.37	0.00e+00	949.00
IUUC-Tsy-119424	Tarsius syrichta	81.66	0.00e+00	734.00
IUUC-Tni-119986	Tetraodon nigroviridis	94.76	0.00e+00	950.00
IUUC-Tca-121739	Theobroma cacao	56.59	2.00e-124	439.00
IUUC-Tur-126856	Triticum urartu	41.41	7.00e-73	267.00
IUUC-Tme-127126	Tuber melanosporum	38.71	2.00e-58	219.00
IUUC-Tbe-127665	Tupaia belangeri	83.24	0.00e+00	826.00
IUUC-Vpa-130768	Vicugna pacos	98.43	0.00e+00	939.00
IUUC-Xtr-132842	Xenopus tropicalis	91.81	0.00e+00	904.00
IUUC-Xma-134020	Xiphophorus maculatus	91.84	0.00e+00	947.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence