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Tag Content
UUCD2 ID IUUC-Cfa-020976
UUCD1 version UUC-CaF-01017
Ensembl Protein ID ENSCAFP00000021591.3
UniProt Accession F1P9P5; F1P9P5_CANLF
Genbank Protein ID ENSCAFP00000021591
Protein Name Ubiquitinyl hydrolase 1
Genbank Nucleotide ID AAEX03015272
Gene Name USP5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCAFG00000014586.3 ENSCAFT00000023250.3 ENSCAFP00000021591.3
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 7.50e-64 216.3 359 865
UBD/Alpha-Helix/UBA 7.30e-23 80.3 735 772
Active Site
Position(s) Description Evidence
368 Nucleophile {ECO:0000256|PIRSR:PIRSR016308-1}
828 Proton acceptor {ECO:0000256|PIRSR:PIRSR016308-1}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel....................wkskkkavs 69
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+++++++++kl + l                    +k+ +  ++
   Q: 359  TGIRNLGNSCYLNSVVQVLFSIPDFQRKYVD-KLEKIFQNAPTDPTQDFSTQVAKLGHGLlsgeyskpapesgdgeqvpeQKEVQDGIA 446
           7******************************.99999999********************66666666666666655443366666*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           pr++++ ++k ++efs+++qqDaqEf+ +l++ +e+++                             ++++  +++F++ ++++ikcl+
   Q: 447  PRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNC-----------------------------RSSENPNEVFRFLVEEKIKCLA 506
           **************************************.............................6788899*************** PP
   S: 159  cdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeaekk 220
            ++v+ ++   + ++lpvp++   +ke                            +++cLe++ ++e++++   ++++  ++k+ a+k+
   Q: 507  TEKVKYTQRVDYIMQLPVPMDAALNKEelleyeekkrqaeeeklplpelvraqvPFSSCLEAYGAPEQVDD---FWSTALQAKSVAVKT 592
           **********************999989*****************************************97...*************** PP
   S: 221  lklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.......................................... 267
           +++ ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s+   +                                          
   Q: 593  TRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISQLRGTglqpgeeelpdiapplvtpdepkapmldesviiqlvemgfpm 680
           *******************997.*******************98888788888888888888888888877777777777777777777 PP
   S: 268  ..........................................................peekqke........................ 274
                                                                     +     +                        
   Q: 681  dacrkavyytgnsgaeaamnwvmshmddpdfanplilpgssgpgstsaaadpppedcvS-----Tivsmgfsrdqalkalratnnsler 764
           77777777777777777777766666666666666666666666665555555555550.....0555555555555555566666666 PP
   S: 275  ...........................................kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevke 319
                                                      + kY+L+a ++H+G s+ +GHYv+++k+ +g+W+ ++D+kV ++  
   Q: 765  avdwifshiddldaeaamdisegrsaadsisesvpvgpkvrdgPGKYQLFAFISHMGtSTMCGHYVCHIKK-EGRWVIYNDQKVCAS-- 850
           6777777777777777777777777777888888888888888****************************.9***********999.. PP
   S: 320  eevleetgstaYvlfYkr 337
           e+  +   + +Y++fY+r
   Q: 851  EKPPK---DLGYIYFYQR 865
           78888...89******98 PP
   

   UBD/Alpha-Helix/UBA
   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ed +  +v+MGF+r++al+aLra+nn+le+Av++++++
   Q: 735  EDCVSTIVSMGFSRDQALKALRATNNSLERAVDWIFSH 772
           8999********************************97 PP
   
Organism Canis familiaris
Protein Sequence
(Fasta)
MRLTSSAHWT ASLGGGGLGT VGAAVCGGAA AGVMAELSEE ALLSVLPTIR VPKAGDRVHK 60
DECAFSFDTP ESEGGLYICM NTFLGFGKQY VERHFNKTGQ RVYLHLRRTR RPKEEDTTTG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cfa-020976|DUB,USP;UBD,UBA|Canis familiaris
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGCGCCTAA CGAGTAGTGC TCATTGGACG GCAAGCCTAG GGGGTGGGGG ACTGGGAACG 60
GTGGGAGCCG CTGTGTGTGG AGGAGCTGCT GCCGGTGTCA TGGCGGAGCT GAGTGAGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cfa-020976|DUB,USP;UBD,UBA|Canis familiaris
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP
SMART

SM00165--UBA
SM00290--ZnF_UBP
Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000394 Aegilops tauschii 45.45 0.00e+00 659.00
IUUC-Aml-002104 Ailuropoda melanoleuca 96.23 0.00e+00 1597.00
IUUC-Atr-002580 Amborella trichopoda 47.34 0.00e+00 742.00
IUUC-Apl-003774 Anas platyrhynchos 88.86 0.00e+00 1473.00
IUUC-Aca-005368 Anolis carolinensis 88.98 0.00e+00 1529.00
IUUC-Aly-005727 Arabidopsis lyrata 48.45 0.00e+00 741.00
IUUC-Ath-006974 Arabidopsis thaliana 48.68 0.00e+00 743.00
IUUC-Ago-007890 Ashbya gossypii 29.69 7.00e-85 308.00
IUUC-Acl-008057 Aspergillus clavatus 35.08 3.00e-127 449.00
IUUC-Afl-008547 Aspergillus flavus 37.16 6.00e-121 428.00
IUUC-Afu-008805 Aspergillus fumigatus 34.89 4.00e-117 415.00
IUUC-Ani-009441 Aspergillus nidulans 33.68 4.00e-102 365.00
IUUC-Ang-009720 Aspergillus niger 34.56 7.00e-122 431.00
IUUC-Aor-010111 Aspergillus oryzae 34.64 1.00e-130 460.00
IUUC-Ate-010531 Aspergillus terreus 32.31 8.00e-106 378.00
IUUC-Ame-011893 Astyanax mexicanus 67.89 0.00e+00 1014.00
IUUC-Bgr-012183 Blumeria graminis 34.65 3.00e-125 442.00
IUUC-Bta-013179 Bos taurus 95.87 0.00e+00 1597.00
IUUC-Bci-013858 Botrytis cinerea 35.83 2.00e-133 469.00
IUUC-Bdi-014904 Brachypodium distachyon 48.26 0.00e+00 724.00
IUUC-Bol-015296 Brassica oleracea 48.74 0.00e+00 754.00
IUUC-Bra-017939 Brassica rapa 48.98 0.00e+00 758.00
IUUC-Cel-018625 Caenorhabditis elegans 35.77 3.00e-139 489.00
IUUC-Cja-019063 Callithrix jacchus 94.47 0.00e+00 1566.00
IUUC-Cpo-022265 Cavia porcellus 98.91 0.00e+00 1613.00
IUUC-Cre-022640 Chlamydomonas reinhardtii 40.86 6.00e-115 407.00
IUUC-Csa-024177 Chlorocebus sabaeus 98.43 0.00e+00 1477.00
IUUC-Cho-024702 Choloepus hoffmanni 86.12 0.00e+00 943.00
IUUC-Cin-025411 Ciona intestinalis 51.64 0.00e+00 844.00
IUUC-Csv-026347 Ciona savignyi 47.32 0.00e+00 802.00
IUUC-Cgl-026667 Colletotrichum gloeosporioides 35.45 1.00e-116 414.00
IUUC-Cne-026831 Cryptococcus neoformans 36.34 1.00e-132 467.00
IUUC-Dre-027982 Danio rerio 65.70 0.00e+00 1083.00
IUUC-Dno-029034 Dasypus novemcinctus 95.87 0.00e+00 1611.00
IUUC-Dor-030479 Dipodomys ordii 93.32 0.00e+00 671.00
IUUC-Dse-031467 Dothistroma septosporum 37.17 6.00e-135 474.00
IUUC-Dme-032075 Drosophila melanogaster 50.59 0.00e+00 813.00
IUUC-Ete-032865 Echinops telfairi 84.97 0.00e+00 1414.00
IUUC-Eca-034059 Equus caballus 96.14 0.00e+00 1609.00
IUUC-Eeu-035304 Erinaceus europaeus 90.20 0.00e+00 1447.00
IUUC-Fca-035515 Felis catus 96.58 0.00e+00 1606.00
IUUC-Fal-037271 Ficedula albicollis 91.00 0.00e+00 1451.00
IUUC-Fox-037745 Fusarium oxysporum 36.33 4.00e-132 465.00
IUUC-Fso-038158 Fusarium solani 36.94 1.00e-132 466.00
IUUC-Gmo-039071 Gadus morhua 64.71 0.00e+00 1083.00
IUUC-Ggr-040098 Gaeumannomyces graminis 35.01 4.00e-123 435.00
IUUC-Gga-040635 Gallus gallus 88.69 0.00e+00 1544.00
IUUC-Gac-042528 Gasterosteus aculeatus 65.13 0.00e+00 1102.00
IUUC-Gma-043614 Glycine max 48.02 0.00e+00 713.00
IUUC-Ggo-044602 Gorilla gorilla 95.75 0.00e+00 1592.00
IUUC-Hsa-045959 Homo sapiens 95.75 0.00e+00 1592.00
IUUC-Hvu-047563 Hordeum vulgare 49.02 1.00e-172 599.00
IUUC-Itr-048712 Ictidomys tridecemlineatus 95.64 0.00e+00 1594.00
IUUC-Kpa-049156 Komagataella pastoris 34.08 2.00e-118 419.00
IUUC-Lch-049648 Latimeria chalumnae 84.67 0.00e+00 1394.00
IUUC-Lpe-051523 Leersia perrieri 47.69 0.00e+00 726.00
IUUC-Lma-053216 Leptosphaeria maculans 35.16 2.00e-115 411.00
IUUC-Laf-054327 Loxodonta africana 95.51 0.00e+00 1590.00
IUUC-Mcc-055443 Macaca mulatta 95.63 0.00e+00 1589.00
IUUC-Meu-056298 Macropus eugenii 94.10 0.00e+00 1075.00
IUUC-Mor-057106 Magnaporthe oryzae 36.55 3.00e-134 472.00
IUUC-Mpo-057589 Magnaporthe poae 35.85 6.00e-128 451.00
IUUC-Mtr-058680 Medicago truncatula 49.52 0.00e+00 749.00
IUUC-Mla-058903 Melampsora laricipopulina 33.18 2.00e-123 436.00
IUUC-Mga-059669 Meleagris gallopavo 87.76 0.00e+00 1461.00
IUUC-Mvi-060476 Microbotryum violaceum 35.27 1.00e-122 434.00
IUUC-Mmr-060575 Microcebus murinus 95.75 0.00e+00 1597.00
IUUC-Mdo-062183 Monodelphis domestica 92.83 0.00e+00 1546.00
IUUC-Mmu-063592 Mus musculus 95.63 0.00e+00 1593.00
IUUC-Mac-065634 Musa acuminata 43.90 0.00e+00 697.00
IUUC-Mpu-066082 Mustela putorius furo 96.32 0.00e+00 1615.00
IUUC-Mlu-067345 Myotis lucifugus 94.00 0.00e+00 1563.00
IUUC-Nfi-068558 Neosartorya fischeri 35.57 2.00e-125 443.00
IUUC-Ncr-068960 Neurospora crassa 35.70 8.00e-120 424.00
IUUC-Nle-070173 Nomascus leucogenys 98.67 0.00e+00 1608.00
IUUC-Opr-070556 Ochotona princeps 94.92 0.00e+00 1586.00
IUUC-Ont-071502 Oreochromis niloticus 67.14 0.00e+00 1108.00
IUUC-Ocu-074861 Oryctolagus cuniculus 97.81 0.00e+00 1622.00
IUUC-Oba-075109 Oryza barthii 47.65 0.00e+00 728.00
IUUC-Obr-076292 Oryza brachyantha 48.74 0.00e+00 724.00
IUUC-Ogl-077065 Oryza glaberrima 48.98 0.00e+00 757.00
IUUC-Ogu-078776 Oryza glumaepatula 47.65 0.00e+00 739.00
IUUC-Oin-080048 Oryza indica 48.50 0.00e+00 751.00
IUUC-Olo-080711 Oryza longistaminata 45.80 0.00e+00 669.00
IUUC-Ome-081506 Oryza meridionalis 46.91 0.00e+00 681.00
IUUC-Oni-082320 Oryza nivara 47.06 0.00e+00 726.00
IUUC-Opu-083801 Oryza punctata 48.13 0.00e+00 720.00
IUUC-Oru-085139 Oryza rufipogon 47.06 0.00e+00 727.00
IUUC-Osa-085713 Oryza sativa 49.10 0.00e+00 761.00
IUUC-Ola-086951 Oryzias latipes 64.60 0.00e+00 1065.00
IUUC-Olu-087822 Ostreococcus lucimarinus 41.81 1.00e-179 623.00
IUUC-Oga-088625 Otolemur garnettii 95.17 0.00e+00 1581.00
IUUC-Oar-089995 Ovis aries 94.24 0.00e+00 1560.00
IUUC-Ptr-090640 Pan troglodytes 93.15 0.00e+00 1571.00
IUUC-Pan-091974 Papio anubis 94.71 0.00e+00 1572.00
IUUC-Psi-093957 Pelodiscus sinensis 87.44 0.00e+00 1542.00
IUUC-Pma-094242 Petromyzon marinus 71.92 6.00e-166 576.00
IUUC-Pno-094835 Phaeosphaeria nodorum 35.54 8.00e-109 388.00
IUUC-Ppa-095901 Physcomitrella patens 50.41 0.00e+00 793.00
IUUC-Pfo-097148 Poecilia formosa 68.55 0.00e+00 1117.00
IUUC-Pab-098068 Pongo abelii 88.08 0.00e+00 1410.00
IUUC-Pop-098943 Populus trichocarpa 48.14 0.00e+00 729.00
IUUC-Pca-100738 Procavia capensis 94.51 0.00e+00 1079.00
IUUC-Ppe-101315 Prunus persica 48.51 0.00e+00 734.00
IUUC-Pva-102154 Pteropus vampyrus 94.57 0.00e+00 1571.00
IUUC-Pgr-103343 Puccinia graminis 34.48 6.00e-112 398.00
IUUC-Ptt-103928 Puccinia triticina 31.42 1.00e-109 390.00
IUUC-Pte-104306 Pyrenophora teres 32.67 2.00e-105 376.00
IUUC-Pyt-104696 Pyrenophora triticirepentis 33.57 2.00e-108 386.00
IUUC-Rno-105801 Rattus norvegicus 95.40 0.00e+00 1592.00
IUUC-Sce-106304 Saccharomyces cerevisiae 28.62 1.00e-74 274.00
IUUC-Sha-107635 Sarcophilus harrisii 95.27 0.00e+00 1572.00
IUUC-Sja-107678 Schizosaccharomyces japonicus 33.25 1.00e-112 400.00
IUUC-Spo-108144 Schizosaccharomyces pombe 32.74 1.00e-116 414.00
IUUC-Smo-108848 Selaginella moellendorffii 49.52 0.00e+00 747.00
IUUC-Sit-110728 Setaria italica 49.46 0.00e+00 781.00
IUUC-Sly-111523 Solanum lycopersicum 48.69 0.00e+00 770.00
IUUC-Sbi-114419 Sorghum bicolor 48.80 0.00e+00 762.00
IUUC-Sre-115225 Sporisorium reilianum 35.86 9.00e-131 461.00
IUUC-Ssc-115686 Sus scrofa 95.17 0.00e+00 1590.00
IUUC-Tgu-117346 Taeniopygia guttata 88.36 0.00e+00 1512.00
IUUC-Tru-118350 Takifugu rubripes 63.41 0.00e+00 1095.00
IUUC-Tni-120658 Tetraodon nigroviridis 64.51 0.00e+00 1080.00
IUUC-Tca-121585 Theobroma cacao 49.05 0.00e+00 732.00
IUUC-Tre-122043 Trichoderma reesei 35.43 2.00e-122 432.00
IUUC-Tvi-122303 Trichoderma virens 35.32 2.00e-128 453.00
IUUC-Tae-125686 Triticum aestivum 48.38 0.00e+00 741.00
IUUC-Tur-126732 Triticum urartu 45.84 0.00e+00 697.00
IUUC-Tme-126909 Tuber melanosporum 34.86 3.00e-120 426.00
IUUC-Tbe-127261 Tupaia belangeri 87.52 0.00e+00 979.00
IUUC-Uma-129599 Ustilago maydis 34.82 5.00e-133 468.00
IUUC-Vda-129688 Verticillium dahliae 34.77 2.00e-124 439.00
IUUC-Vvi-131116 Vitis vinifera 48.63 0.00e+00 713.00
IUUC-Xtr-131953 Xenopus tropicalis 77.52 0.00e+00 1308.00
IUUC-Xma-133837 Xiphophorus maculatus 68.53 0.00e+00 1122.00
IUUC-Yli-134510 Yarrowia lipolytica 36.08 6.00e-132 464.00
IUUC-Zma-135786 Zea mays 48.56 0.00e+00 728.00
Created Date 25-Jun-2017

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