iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012400

Ensembl Protein ID

ENSBTAP00000006659.4

UniProt Accession

Q08DU6; Q08DU6_BOVIN

Genbank Protein ID

AAI23560.1

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

DAAA02021923

Gene Name

BLK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000005049.4	ENSBTAT00000006659.4	ENSBTAP00000006659.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.90e-14	53.5	56	113

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++ v +lydy+a nd +L++ kG++++++   ++ ++W+ +++  +g++G +P+nFv+++e
   Q: 56   NHFVVALYDYKAMNDRDLQMLKGEKLQIL---KETGDWWLAKSLITGREGYVPSNFVARVE 113
           57799************************...88899**********************97 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MGVVSSKRQV KEKGRSGWSP VKTSTQSKEP PPLPSLVVFN HLTPPPPDTT HPDQENHFVV 60
ALYDYKAMND RDLQMLKGEK LQILKETGDW WLAKSLITGR EGYVPSNFVA RVETLEVEKW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGATTGTTT CCGAGTCGCT GGTTGAAGCT AGGAGGCCGC TGCCCGATAA GGCGCGGCGA 60
TTTGAAGAGC TATGGTGAGC AGCCGCTGAA TACTGCCAAG GTAAGACTCA TCTTCCGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0050853--P:B cell receptor signaling pathway
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0032024--P:positive regulation of insulin secretion
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

bta:532587

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002133	Ailuropoda melanoleuca	91.74	0.00e+00	919.00
IUUC-Apl-003307	Anas platyrhynchos	76.12	0.00e+00	741.00
IUUC-Aca-004357	Anolis carolinensis	68.54	0.00e+00	669.00
IUUC-Ame-010642	Astyanax mexicanus	70.09	0.00e+00	683.00
IUUC-Cfa-021056	Canis familiaris	90.62	0.00e+00	932.00
IUUC-Cpo-021779	Cavia porcellus	85.03	0.00e+00	878.00
IUUC-Csa-023557	Chlorocebus sabaeus	89.88	0.00e+00	883.00
IUUC-Dre-027517	Danio rerio	72.61	0.00e+00	705.00
IUUC-Eca-034218	Equus caballus	91.32	0.00e+00	907.00
IUUC-Eeu-035095	Erinaceus europaeus	68.46	0.00e+00	676.00
IUUC-Fca-036015	Felis catus	89.82	0.00e+00	930.00
IUUC-Fal-036946	Ficedula albicollis	75.51	0.00e+00	728.00
IUUC-Gga-040822	Gallus gallus	75.72	0.00e+00	737.00
IUUC-Ggo-044608	Gorilla gorilla	90.61	0.00e+00	823.00
IUUC-Hsa-046719	Homo sapiens	88.84	0.00e+00	892.00
IUUC-Itr-048323	Ictidomys tridecemlineatus	88.02	0.00e+00	905.00
IUUC-Lch-050114	Latimeria chalumnae	72.77	0.00e+00	706.00
IUUC-Loc-052326	Lepisosteus oculatus	73.50	0.00e+00	707.00
IUUC-Laf-053387	Loxodonta africana	87.23	0.00e+00	901.00
IUUC-Mcc-055026	Macaca mulatta	89.67	0.00e+00	883.00
IUUC-Mga-059427	Meleagris gallopavo	75.06	0.00e+00	724.00
IUUC-Mmr-061660	Microcebus murinus	86.63	0.00e+00	902.00
IUUC-Mdo-062318	Monodelphis domestica	75.88	0.00e+00	793.00
IUUC-Mmu-063325	Mus musculus	86.43	0.00e+00	900.00
IUUC-Mpu-066582	Mustela putorius furo	91.32	0.00e+00	919.00
IUUC-Nle-069624	Nomascus leucogenys	89.86	0.00e+00	880.00
IUUC-Opr-070656	Ochotona princeps	82.24	0.00e+00	815.00
IUUC-Ont-072266	Oreochromis niloticus	71.05	0.00e+00	685.00
IUUC-Ocu-073907	Oryctolagus cuniculus	84.83	0.00e+00	874.00
IUUC-Ola-086668	Oryzias latipes	71.40	0.00e+00	671.00
IUUC-Oga-088057	Otolemur garnettii	87.43	0.00e+00	906.00
IUUC-Oar-089332	Ovis aries	93.61	0.00e+00	946.00
IUUC-Ptr-091551	Pan troglodytes	88.17	0.00e+00	858.00
IUUC-Pan-092173	Papio anubis	89.26	0.00e+00	879.00
IUUC-Psi-093895	Pelodiscus sinensis	74.55	0.00e+00	733.00
IUUC-Pfo-096608	Poecilia formosa	70.98	0.00e+00	690.00
IUUC-Pab-097598	Pongo abelii	89.67	0.00e+00	889.00
IUUC-Pva-102135	Pteropus vampyrus	91.18	0.00e+00	877.00
IUUC-Rno-104891	Rattus norvegicus	84.43	0.00e+00	860.00
IUUC-Sha-107192	Sarcophilus harrisii	78.77	0.00e+00	805.00
IUUC-Ssc-115696	Sus scrofa	94.81	0.00e+00	972.00
IUUC-Tgu-117056	Taeniopygia guttata	75.23	0.00e+00	725.00
IUUC-Tru-117621	Takifugu rubripes	68.30	0.00e+00	655.00
IUUC-Tbe-127520	Tupaia belangeri	88.95	0.00e+00	684.00
IUUC-Ttr-128457	Tursiops truncatus	93.81	0.00e+00	958.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence