iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-105174

Ensembl Protein ID

ENSRNOP00000069961.1

UniProt Accession

A0A0G2JWP6; A0A0G2JWP6_RAT

Genbank Protein ID

ENSRNOP00000069961

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AABR07024848

Gene Name

Nwd1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000052129.1	ENSRNOT00000080387.1	ENSRNOP00000069961.1

Annotation

Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.80e-16	58.2	903	934
UBD/Beta-Prp	8.90e-42	143.7	1246	1463

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 4    dsvtcla.f.sdtllvsGsdDgtikvWDlrtg 33
           ++v+c++ f ++tl +s+s D+t+++W+l +g
   Q: 903  AEVRCVRvFaQGTLAISASKDHTLRLWSLLSG 934
           68****977988****************9877 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl..sgheaevtavkfspdgkilvtgseDrtikvwdls........tgk 85
            ++ ++c+ ++++++ll+tg  +g + v+ + + + + ++   +  ++v++++ s++++ l+  + D+++ v d+s         g+
   Q: 1246 TSNEVCCLEVAEQTKLLFTGLVSGIVLVFPLNSRQDVLCIppPEARKAVNCMSVSKSEDRLAI-AYDNIVLVLDISpgdlcpaiEGP 1331
           5678999**********************9887777777757888899*********986655.56788888899988888888888 PP
   S: 86   cvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkll 172
           +   +++  ++++ +++ + ++++v G +d  + ++d  + +++  +l+ h + v+cv+v+  ++l vsG+ D  + lWdl  + + 
   Q: 1332 TYTFYTQLPETIVRVAVLA-DYRVVYGMSDGSLFLYDCAQSKVF--PLEAHGSRVSCVEVSHREQLAVSGAEDALLCLWDL--QACR 1413
           8888889999999999999.9***********************..6**********************************..7777 PP
   S: 173  rtl....tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtl 218
           +++    ++   + v++  f+++ k++ +g +d++++ w+   g+ +  +
   Q: 1414 EKFkmsyESSYCRGVRCACFSKDDKHVFTGMEDRSIIAWSALDGTLLAVQ 1463
           7777677555889999999********************98877766555 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MDTEREALQC TAYPEVQSFC QKHGLAFEVS SLRFSSPYSL LPTSSHTPTC LTSLSACEQS 60
VVGWAFVALL GKQYGPCPVP QFERKEWETN GLSDRQPRDL ELVTRHFQKT NTIPPPTSTP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACACAG AGCGAGAAGC CCTGCAGTGC ACAGCCTACC CAGAGGTTCA GAGCTTCTGC 60
CAGAAGCACG GCTTGGCGTT CGAGGTAAGC GTCTGTGTTC ACCTGGAAAG CCACGCCACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR027417--P-loop_NTPase
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0071011--C:precatalytic spliceosome
GO:0005682--C:U5 snRNP
GO:0008380--P:RNA splicing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001525	Ailuropoda melanoleuca	70.50	0.00e+00	2141.00
IUUC-Apl-003467	Anas platyrhynchos	62.23	6.00e-85	306.00
IUUC-Ame-011400	Astyanax mexicanus	33.01	0.00e+00	775.00
IUUC-Bta-013223	Bos taurus	71.72	0.00e+00	1909.00
IUUC-Cel-018404	Caenorhabditis elegans	26.28	1.00e-65	245.00
IUUC-Cja-018773	Callithrix jacchus	67.86	0.00e+00	1292.00
IUUC-Cfa-020334	Canis familiaris	71.10	0.00e+00	2135.00
IUUC-Cpo-022316	Cavia porcellus	59.45	0.00e+00	1625.00
IUUC-Csa-023631	Chlorocebus sabaeus	70.15	0.00e+00	2099.00
IUUC-Cin-025646	Ciona intestinalis	29.05	2.00e-98	353.00
IUUC-Dre-028241	Danio rerio	33.29	0.00e+00	722.00
IUUC-Dno-029990	Dasypus novemcinctus	73.81	0.00e+00	662.00
IUUC-Dor-030869	Dipodomys ordii	55.69	4.00e-145	508.00
IUUC-Ete-033059	Echinops telfairi	75.82	0.00e+00	761.00
IUUC-Eca-033718	Equus caballus	68.20	0.00e+00	2058.00
IUUC-Fca-035748	Felis catus	69.45	0.00e+00	1906.00
IUUC-Gac-041507	Gasterosteus aculeatus	31.15	4.00e-160	559.00
IUUC-Ggo-044551	Gorilla gorilla	68.77	0.00e+00	2046.00
IUUC-Hsa-046787	Homo sapiens	69.93	0.00e+00	2113.00
IUUC-Itr-048104	Ictidomys tridecemlineatus	75.91	0.00e+00	978.00
IUUC-Lch-049578	Latimeria chalumnae	42.01	0.00e+00	1137.00
IUUC-Loc-052039	Lepisosteus oculatus	37.93	0.00e+00	992.00
IUUC-Laf-054240	Loxodonta africana	70.69	0.00e+00	2173.00
IUUC-Mcc-054657	Macaca mulatta	65.46	0.00e+00	1845.00
IUUC-Meu-056591	Macropus eugenii	56.42	0.00e+00	1003.00
IUUC-Mmr-061577	Microcebus murinus	68.04	0.00e+00	2004.00
IUUC-Mdo-062895	Monodelphis domestica	52.78	0.00e+00	1449.00
IUUC-Mmu-063866	Mus musculus	85.10	0.00e+00	2487.00
IUUC-Mpu-066510	Mustela putorius furo	70.24	0.00e+00	2140.00
IUUC-Mlu-067855	Myotis lucifugus	70.42	0.00e+00	2090.00
IUUC-Nle-069557	Nomascus leucogenys	67.56	0.00e+00	1970.00
IUUC-Opr-071196	Ochotona princeps	58.06	4.00e-150	526.00
IUUC-Ont-072070	Oreochromis niloticus	31.89	4.00e-173	602.00
IUUC-Oan-073437	Ornithorhynchus anatinus	49.67	0.00e+00	965.00
IUUC-Ola-086624	Oryzias latipes	31.65	1.00e-168	587.00
IUUC-Oga-088313	Otolemur garnettii	70.71	0.00e+00	1929.00
IUUC-Oar-090123	Ovis aries	69.84	0.00e+00	2109.00
IUUC-Ptr-090552	Pan troglodytes	74.16	0.00e+00	983.00
IUUC-Psi-093963	Pelodiscus sinensis	47.42	0.00e+00	1300.00
IUUC-Pfo-096197	Poecilia formosa	29.70	2.00e-173	603.00
IUUC-Pab-097755	Pongo abelii	70.49	0.00e+00	771.00
IUUC-Pca-100809	Procavia capensis	68.01	0.00e+00	1013.00
IUUC-Pva-102554	Pteropus vampyrus	66.48	0.00e+00	1762.00
IUUC-Sha-107304	Sarcophilus harrisii	54.20	0.00e+00	1648.00
IUUC-Sar-113168	Sorex araneus	64.53	0.00e+00	761.00
IUUC-Tru-118251	Takifugu rubripes	31.29	4.00e-136	479.00
IUUC-Tsy-119276	Tarsius syrichta	71.53	1.00e-107	385.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence