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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063912
Ensembl Protein ID ENSMUSP00000057320.7
UniProt Accession D3YYM4; WDR72_MOUSE
Genbank Protein ID ENSMUSP00000057320
Protein Name WD repeat-containing protein 72
Genbank Nucleotide ID AC108944
Gene Name Wdr72
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000044976.17 ENSMUST00000055879.8 ENSMUSP00000057320.7
ENSMUSG00000044976.17 ENSMUST00000215440.1 ENSMUSP00000149349.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.00e-20 73.2 60 100
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf....sd.tllvsGsdDgtikvWDlrtgvll 36
           gH++svtcla     s  +++vs++ +g + +W++++g ++
   Q: 60   GHSASVTCLARardfSKqPYVVSAAENGEMCMWNVSSGQCV 100
           8********6556665569*******************997 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Plays a major role in formation of tooth enamel (PubMed:25008349, PubMed:26247047). Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins (PubMed:25008349, PubMed:26247047). May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane (PubMed:26247047).
 Plays a major role in formation of tooth enamel (PubMed:25008349, PubMed:26247047). Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins (PubMed:25008349, PubMed:26247047). May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane (PubMed:26247047).
Protein Sequence
(Fasta)
MRGALQAVAL WGRKAPPHSI TAIMITDDQQ TIVTGSQEGQ LCLWSLSPEL KISAKELLFG 60
HSASVTCLAR ARDFSKQPYV VSAAENGEMC MWNVSSGQCV EKTSLPYRHT AICYYHCSFR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063912|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGCTTGGTT CAGCTCCGGG AAGGCGCCCA GCTCCTCCCT CTCTGGGAGT CTGAACATCC 60
GTGGGAGTGG GCTGCGGACA GCTGCATGTA GTGTCCCCAC TTTGGGTTCT GCTGGGAAAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063912|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0091--Biomineralization
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR011044--Quino_amine_DH_bsu
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
SMART

SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005768--C:endosome
GO:0070166--P:enamel mineralization
KEGG mmu:546144
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001970 Ailuropoda melanoleuca 77.19 0.00e+00 1744.00
IUUC-Apl-003551 Anas platyrhynchos 57.96 0.00e+00 1176.00
IUUC-Aca-004824 Anolis carolinensis 46.20 0.00e+00 786.00
IUUC-Bta-013152 Bos taurus 75.28 0.00e+00 1578.00
IUUC-Cja-018912 Callithrix jacchus 77.08 0.00e+00 1691.00
IUUC-Cfa-020015 Canis familiaris 76.72 0.00e+00 1692.00
IUUC-Cpo-021559 Cavia porcellus 67.84 0.00e+00 1323.00
IUUC-Csa-023543 Chlorocebus sabaeus 78.73 0.00e+00 1735.00
IUUC-Cho-024824 Choloepus hoffmanni 69.79 0.00e+00 1402.00
IUUC-Dno-029168 Dasypus novemcinctus 72.56 0.00e+00 1382.00
IUUC-Dor-030878 Dipodomys ordii 80.70 0.00e+00 1013.00
IUUC-Ete-032495 Echinops telfairi 72.69 0.00e+00 1454.00
IUUC-Eca-033815 Equus caballus 78.12 0.00e+00 1664.00
IUUC-Eeu-034851 Erinaceus europaeus 62.31 0.00e+00 1205.00
IUUC-Fca-036375 Felis catus 74.93 0.00e+00 1588.00
IUUC-Fal-037045 Ficedula albicollis 55.95 0.00e+00 1188.00
IUUC-Gga-041155 Gallus gallus 56.80 0.00e+00 1179.00
IUUC-Ggo-044617 Gorilla gorilla 74.97 0.00e+00 1266.00
IUUC-Hsa-046257 Homo sapiens 79.08 0.00e+00 1758.00
IUUC-Itr-048101 Ictidomys tridecemlineatus 80.63 0.00e+00 1835.00
IUUC-Lch-049569 Latimeria chalumnae 46.54 0.00e+00 937.00
IUUC-Loc-052632 Lepisosteus oculatus 42.38 0.00e+00 767.00
IUUC-Mcc-055089 Macaca mulatta 78.55 0.00e+00 1714.00
IUUC-Mga-059629 Meleagris gallopavo 56.83 0.00e+00 1161.00
IUUC-Mmr-061454 Microcebus murinus 71.42 0.00e+00 1595.00
IUUC-Mdo-062816 Monodelphis domestica 66.61 0.00e+00 1417.00
IUUC-Mpu-066070 Mustela putorius furo 76.54 0.00e+00 1711.00
IUUC-Mlu-067423 Myotis lucifugus 75.59 0.00e+00 1611.00
IUUC-Nle-069699 Nomascus leucogenys 78.05 0.00e+00 1755.00
IUUC-Opr-070419 Ochotona princeps 66.30 0.00e+00 924.00
IUUC-Oan-073209 Ornithorhynchus anatinus 58.55 0.00e+00 1120.00
IUUC-Ocu-074545 Oryctolagus cuniculus 76.14 0.00e+00 1682.00
IUUC-Olu-087828 Ostreococcus lucimarinus 25.79 1.00e-09 59.30
IUUC-Oga-088487 Otolemur garnettii 77.72 0.00e+00 1636.00
IUUC-Oar-090341 Ovis aries 74.48 0.00e+00 1555.00
IUUC-Ptr-091269 Pan troglodytes 78.23 0.00e+00 1721.00
IUUC-Pan-092329 Papio anubis 77.53 0.00e+00 1723.00
IUUC-Psi-093788 Pelodiscus sinensis 59.13 0.00e+00 1221.00
IUUC-Pab-098433 Pongo abelii 78.37 0.00e+00 1699.00
IUUC-Pva-102405 Pteropus vampyrus 68.93 0.00e+00 1470.00
IUUC-Rno-106031 Rattus norvegicus 93.47 0.00e+00 1725.00
IUUC-Sha-107018 Sarcophilus harrisii 67.38 0.00e+00 1387.00
IUUC-Smo-109304 Selaginella moellendorffii 23.45 4.00e-13 70.90
IUUC-Sar-113639 Sorex araneus 70.84 0.00e+00 1541.00
IUUC-Tgu-116980 Taeniopygia guttata 54.75 0.00e+00 1179.00
IUUC-Tsy-118866 Tarsius syrichta 72.61 0.00e+00 1573.00
IUUC-Tbe-127824 Tupaia belangeri 83.77 0.00e+00 812.00
IUUC-Ttr-128296 Tursiops truncatus 74.31 0.00e+00 1619.00
IUUC-Vpa-130496 Vicugna pacos 71.89 0.00e+00 1580.00
Created Date 25-Jun-2017

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