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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046272
UUCD1 version UUC-HoS-00442
Ensembl Protein ID ENSP00000290649.5
UniProt Accession Q9UKV5; P26442; Q8IZ70; AMFR_HUMAN
Genbank Protein ID AAD56722.1; AAH69197.1; AAA79362.1; AAA36671.1
Protein Name E3 ubiquitin-protein ligase AMFR; Autocrine motility factor receptor; RING finger protein 45; RING-type E3 ubiquitin transferase AMFR; gp78
Genbank Nucleotide ID AF124145; BC069197; L35233; M63175
Gene Name AMFR; RNF45
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000159461.14 ENST00000290649.9 ENSP00000290649.5
ENSG00000159461.14 ENST00000492830.5 ENSP00000473636.1
ENSG00000159461.14 ENST00000567738.1 ENSP00000456288.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18037895; 19103148; 19164805; 17895372; 20458442; 20133640; 19828134; 16168377
UBD/Alpha-Helix/CUE CUE 16407162; 23123110
Classification
Family E-value Score Start End
E3 activity/RING/RING 1.80e-08 36.4 341 379
UBD/Alpha-Helix/CUE 7.80e-11 43.4 456 497
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC+++++   + lpCgH+fh +Cl  w        +  +CP+Cr
   Q: 341  CAICWDSMQA-ARKLPCGHLFHNSCLRSW------LEQDTSCPTCR 379
           ********99.******************......9*********8 PP
   

   UBD/Alpha-Helix/CUE
   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +l+ +++q++e+FP+++y ++ ++L ++t s+e +++n+Leg 
   Q: 456  QLNAMAHQIQEMFPQVPYHLVLQDL-QLTRSVEITTDNILEGR 497
           5889*********************.***************95 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.
 E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.
Protein Sequence
(Fasta)
MPLLFLERFP WPSLRTYTGL SGLALLGTII SAYRALSQPE AGPGEPDQLT ASLQPEPPAP 60
ARPSAGGPRA RDVAQYLLSD SLFVWVLVNT ACCVLMLVAK LIQCIVFGPL RVSERQHLKD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046272|E3,RING;UBD,CUE|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTCTTCCGCG CCGGCAGGGG CAGCAGCGGG AGCAGCGCGG GGCGGAGCGG CGCCAGCAGC 60
CAGGAGCGGC CCGGCCCGGC CCGGCGCGGC GGCGGCGGCG GCAGCGGCAG CGGCAGCGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046272|E3,RING;UBD,CUE|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003892--CUE
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51140--CUE
PS50089--ZF_RING_2
Pfam

PF02845--CUE
PF13639--zf-RING_2
SMART

SM00546--CUE
SM00184--RING
Gene Ontology

GO:0030425--C:dendrite
GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0005794--C:Golgi apparatus
GO:0030426--C:growth cone
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:1904288--F:BAT3 complex binding
GO:0051087--F:chaperone binding
GO:0030674--F:protein binding, bridging
GO:0004872--F:receptor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0004842--F:ubiquitin-protein transferase activity
GO:1990381--F:ubiquitin-specific protease binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0007568--P:aging
GO:1904380--P:endoplasmic reticulum mannose trimming
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0036503--P:ERAD pathway
GO:0007611--P:learning or memory
GO:0006928--P:movement of cell or subcellular component
GO:0032092--P:positive regulation of protein binding
GO:0051865--P:protein autoubiquitination
GO:0006457--P:protein folding
GO:0070936--P:protein K48-linked ubiquitination
GO:0051259--P:protein oligomerization
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0007165--P:signal transduction
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:267
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001300 Ailuropoda melanoleuca 93.72 0.00e+00 1019.00
IUUC-Apl-003404 Anas platyrhynchos 88.08 0.00e+00 940.00
IUUC-Aca-004559 Anolis carolinensis 85.66 0.00e+00 875.00
IUUC-Ame-011640 Astyanax mexicanus 71.52 0.00e+00 839.00
IUUC-Bta-012980 Bos taurus 88.24 0.00e+00 1078.00
IUUC-Cel-018598 Caenorhabditis elegans 25.29 6.00e-35 142.00
IUUC-Cja-019577 Callithrix jacchus 97.51 0.00e+00 1221.00
IUUC-Cfa-020793 Canis familiaris 94.46 0.00e+00 1010.00
IUUC-Cpo-022387 Cavia porcellus 95.49 0.00e+00 1186.00
IUUC-Csa-023168 Chlorocebus sabaeus 99.38 0.00e+00 1244.00
IUUC-Cho-024433 Choloepus hoffmanni 96.69 0.00e+00 840.00
IUUC-Cin-025215 Ciona intestinalis 44.77 5.00e-149 521.00
IUUC-Csv-026133 Ciona savignyi 47.35 6.00e-132 464.00
IUUC-Dre-027594 Danio rerio 68.83 0.00e+00 791.00
IUUC-Dno-029407 Dasypus novemcinctus 96.95 0.00e+00 1021.00
IUUC-Dor-030961 Dipodomys ordii 96.59 0.00e+00 1040.00
IUUC-Ete-032962 Echinops telfairi 87.10 0.00e+00 868.00
IUUC-Eca-033683 Equus caballus 89.44 0.00e+00 1070.00
IUUC-Eeu-034515 Erinaceus europaeus 99.26 5.00e-80 291.00
IUUC-Fca-035398 Felis catus 95.70 0.00e+00 979.00
IUUC-Fal-036758 Ficedula albicollis 81.61 0.00e+00 882.00
IUUC-Gmo-039014 Gadus morhua 69.00 0.00e+00 778.00
IUUC-Gga-040575 Gallus gallus 85.07 0.00e+00 1016.00
IUUC-Gac-041414 Gasterosteus aculeatus 68.41 0.00e+00 759.00
IUUC-Itr-047956 Ictidomys tridecemlineatus 95.73 0.00e+00 1031.00
IUUC-Lch-050491 Latimeria chalumnae 76.20 0.00e+00 869.00
IUUC-Loc-052758 Lepisosteus oculatus 76.07 0.00e+00 843.00
IUUC-Laf-053452 Loxodonta africana 96.79 0.00e+00 1032.00
IUUC-Mcc-055820 Macaca mulatta 99.27 0.00e+00 1050.00
IUUC-Meu-056726 Macropus eugenii 85.77 0.00e+00 865.00
IUUC-Mga-059937 Meleagris gallopavo 86.64 0.00e+00 959.00
IUUC-Mmr-060730 Microcebus murinus 93.00 0.00e+00 1144.00
IUUC-Mdo-062771 Monodelphis domestica 89.06 0.00e+00 1071.00
IUUC-Mmu-064219 Mus musculus 94.38 0.00e+00 1176.00
IUUC-Mpu-066796 Mustela putorius furo 95.44 0.00e+00 1014.00
IUUC-Mlu-068189 Myotis lucifugus 93.88 0.00e+00 1008.00
IUUC-Nle-069239 Nomascus leucogenys 99.03 0.00e+00 1189.00
IUUC-Opr-070702 Ochotona princeps 90.58 4.00e-141 495.00
IUUC-Ont-072033 Oreochromis niloticus 71.29 0.00e+00 821.00
IUUC-Oan-073717 Ornithorhynchus anatinus 85.52 0.00e+00 869.00
IUUC-Ocu-074145 Oryctolagus cuniculus 93.47 0.00e+00 1155.00
IUUC-Ogl-077929 Oryza glaberrima 53.49 1.00e-11 62.80
IUUC-Ola-087152 Oryzias latipes 69.22 0.00e+00 799.00
IUUC-Oga-088486 Otolemur garnettii 97.16 0.00e+00 1046.00
IUUC-Oar-089310 Ovis aries 95.18 0.00e+00 1040.00
IUUC-Ptr-090649 Pan troglodytes 100.00 0.00e+00 1080.00
IUUC-Pan-091692 Papio anubis 95.33 0.00e+00 1137.00
IUUC-Psi-093064 Pelodiscus sinensis 94.72 0.00e+00 779.00
IUUC-Pma-094763 Petromyzon marinus 77.46 1.00e-97 349.00
IUUC-Ppa-095969 Physcomitrella patens 29.91 5.00e-36 145.00
IUUC-Pfo-096810 Poecilia formosa 70.18 0.00e+00 807.00
IUUC-Pab-097859 Pongo abelii 99.27 0.00e+00 1053.00
IUUC-Pop-099576 Populus trichocarpa 27.06 1.00e-28 121.00
IUUC-Pca-100344 Procavia capensis 92.71 0.00e+00 1101.00
IUUC-Pva-103114 Pteropus vampyrus 68.47 0.00e+00 731.00
IUUC-Rno-105880 Rattus norvegicus 92.45 0.00e+00 1127.00
IUUC-Sha-107015 Sarcophilus harrisii 93.35 0.00e+00 988.00
IUUC-Smo-109664 Selaginella moellendorffii 31.35 5.00e-33 135.00
IUUC-Sar-113397 Sorex araneus 98.38 0.00e+00 766.00
IUUC-Ssc-115988 Sus scrofa 92.36 8.00e-143 499.00
IUUC-Tgu-116717 Taeniopygia guttata 89.42 0.00e+00 948.00
IUUC-Tru-117805 Takifugu rubripes 69.04 0.00e+00 829.00
IUUC-Tsy-119442 Tarsius syrichta 90.50 0.00e+00 945.00
IUUC-Tni-119777 Tetraodon nigroviridis 71.56 2.00e-171 595.00
IUUC-Tbe-127322 Tupaia belangeri 68.37 2.00e-114 406.00
IUUC-Ttr-128181 Tursiops truncatus 94.98 0.00e+00 1040.00
IUUC-Vpa-130483 Vicugna pacos 85.24 0.00e+00 662.00
IUUC-Xtr-132614 Xenopus tropicalis 77.27 0.00e+00 801.00
Created Date 25-Jun-2017

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