iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089686

Ensembl Protein ID

ENSOARP00000021530.1

UniProt Accession

W5QFN2; W5QFN2_SHEEP

Genbank Protein ID

ENSOARP00000021530

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01008633

Gene Name

HCLS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000020050.1	ENSOART00000021832.1	ENSOARP00000021530.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	7.20e-11	42.1	434	485

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
            +lydy+++ +de ++   dv++ i  e  degW++g    +g  GlfP+n+v+ l
   Q: 434  VALYDYQGEGSDEISFDPDDVITDI--EMVDEGWWRG--RCHGHFGLFPANYVKLL 485
           68**********************9..9*********..8*************977 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRAE HINIHLLRNK 60
VSEEHDILKK KEMESGPKAS HGYGGRFGVE KDRMDKSAVG HEYVAEVEKH SSQTDAARGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGGAAGT CTGTAGTAGG ACATGATGTA TCTGTTTCTG TGGAGACCCA GGGTGATGAC 60
TGGGACACAG ACCCTGACTT TGTGGTGAGT GTGGAAATAA CTTTACTTGG ACAAAAAGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028534--HS1
IPR003134--Hs1_Cortactin
IPR001452--SH3_domain

PROSITE

PS51090--CORTACTIN
PS50002--SH3

Pfam

PF02218--HS1_rep
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005667--C:transcription factor complex
GO:0030041--P:actin filament polymerization
GO:0071345--P:cellular response to cytokine stimulus
GO:0030218--P:erythrocyte differentiation
GO:2000107--P:negative regulation of leukocyte apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0008284--P:positive regulation of cell proliferation
GO:0030854--P:positive regulation of granulocyte differentiation
GO:0045651--P:positive regulation of macrophage differentiation
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0030833--P:regulation of actin filament polymerization
GO:0009725--P:response to hormone

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001194	Ailuropoda melanoleuca	87.24	0.00e+00	768.00
IUUC-Ame-011504	Astyanax mexicanus	43.49	4.00e-99	355.00
IUUC-Bta-012591	Bos taurus	94.90	0.00e+00	742.00
IUUC-Cja-019982	Callithrix jacchus	83.88	0.00e+00	690.00
IUUC-Cfa-020262	Canis familiaris	85.02	0.00e+00	670.00
IUUC-Cpo-021362	Cavia porcellus	83.13	0.00e+00	653.00
IUUC-Csa-023911	Chlorocebus sabaeus	85.42	0.00e+00	687.00
IUUC-Dor-030437	Dipodomys ordii	76.54	3.00e-175	607.00
IUUC-Dme-031931	Drosophila melanogaster	44.25	2.00e-71	263.00
IUUC-Ete-033160	Echinops telfairi	75.11	6.00e-154	536.00
IUUC-Eca-033269	Equus caballus	87.50	0.00e+00	742.00
IUUC-Eeu-035032	Erinaceus europaeus	72.75	8.00e-131	460.00
IUUC-Fca-035999	Felis catus	84.52	0.00e+00	763.00
IUUC-Fal-037107	Ficedula albicollis	50.84	3.00e-125	441.00
IUUC-Gga-040335	Gallus gallus	66.78	2.00e-105	375.00
IUUC-Ggo-044505	Gorilla gorilla	86.42	0.00e+00	687.00
IUUC-Hsa-046728	Homo sapiens	86.01	0.00e+00	670.00
IUUC-Itr-048592	Ictidomys tridecemlineatus	67.26	2.00e-165	575.00
IUUC-Laf-054202	Loxodonta africana	82.56	0.00e+00	686.00
IUUC-Mcc-055824	Macaca mulatta	85.42	0.00e+00	695.00
IUUC-Mmr-061281	Microcebus murinus	75.98	2.00e-169	588.00
IUUC-Mdo-062515	Monodelphis domestica	69.57	6.00e-155	540.00
IUUC-Mmu-064341	Mus musculus	82.06	0.00e+00	688.00
IUUC-Mpu-066565	Mustela putorius furo	85.19	0.00e+00	706.00
IUUC-Mlu-066942	Myotis lucifugus	82.18	0.00e+00	681.00
IUUC-Nle-069436	Nomascus leucogenys	85.60	0.00e+00	692.00
IUUC-Opr-070288	Ochotona princeps	76.23	1.00e-165	575.00
IUUC-Ocu-074686	Oryctolagus cuniculus	83.33	0.00e+00	628.00
IUUC-Ola-086894	Oryzias latipes	60.14	1.00e-94	340.00
IUUC-Oga-088585	Otolemur garnettii	77.46	0.00e+00	666.00
IUUC-Ptr-090461	Pan troglodytes	90.11	5.00e-169	587.00
IUUC-Pan-091887	Papio anubis	90.11	5.00e-170	590.00
IUUC-Psi-093785	Pelodiscus sinensis	52.82	1.00e-141	496.00
IUUC-Pab-098222	Pongo abelii	85.42	0.00e+00	685.00
IUUC-Pca-100668	Procavia capensis	82.44	0.00e+00	678.00
IUUC-Pva-102767	Pteropus vampyrus	75.31	2.00e-170	591.00
IUUC-Rno-106001	Rattus norvegicus	83.88	0.00e+00	692.00
IUUC-Sha-106912	Sarcophilus harrisii	92.02	2.00e-116	412.00
IUUC-Sar-113338	Sorex araneus	77.92	3.00e-176	611.00
IUUC-Ssc-116027	Sus scrofa	87.15	0.00e+00	747.00
IUUC-Tgu-117472	Taeniopygia guttata	57.31	5.00e-150	524.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence