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Tag Content
UUCD2 ID IUUC-Ptr-090520
UUCD1 version UUC-PaT-01134
Ensembl Protein ID ENSPTRP00000013840.4
UniProt Accession H2QB33; H2QB33_PANTR
Genbank Protein ID ENSPTRP00000013840
Protein Name Uncharacterized protein
Genbank Nucleotide ID AACZ03103057
Gene Name CYLD
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPTRG00000008107.5 ENSPTRT00000014947.4 ENSPTRP00000013840.4
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 2.40e-18 66.4 593 933
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
    G++ + N+CY++S+L cL++++++ + +l + kek + e ++e+++ l +++ + ++ + +k ++ r++l+++++++ ++e+
   Q: 593 GIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGyVCATKIMKLRKILEKVEAASGF--TSEE 679
    999***************************99999999999999999999****999887899**************988875..899* PP
   S: 90 qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksq.ik...clecdnvs.sreepfldls 173
    +D +E+ +++++ ++ ek++k + +i++l+++++ ++ +k ++c ++ r+ + ++l
   Q: 680 KDPEELNFSAGQKVQDCY------------------FYQIFMEKNEKVGVPTIQQLLEWSFINSnLKfaeAPSCLIIQmPRFGKDFKLF 750
    *****9999999999888..................67889999****************9854144444799****99********** PP
   S: 174 lpvpgkeetkkeslqdcLesftkeeelegenk.yycekckkkqeaekklklkklPe....vLilhLkRfsfseeqksrekinkkvefpl 257
    ++ + e +++d+Le+ ++++++g + y+c++c+++ + + k+k++++ +lh kR + + + v++p+
   Q: 751 KKIFPSLEL---NITDLLEDTPRQCRICGGLAmYECRECYDDPDISAG-KIKQFCKtcntQVHLHPKRL--N-------HKYNPVSLPK 826
    ****99998...***************987655********9984433.55555553334688999999..2.......3356788886 PP
   S: 258 eL...dlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk..WllfdD.............skVtevke.eevleetg 327
    L d ++ c+ +++ eL+av++ + HYva+vk k++ Wl fd +Vt+++e e l+++
   Q: 827 DLpdwDWRHGCIP-------CQNMELFAVLCIET----SHYVAFVKYGKDDsaWLFFDSmadrdggqngfniPQVTPCPEvGEYLKMSL 904
    6511144444554.......99*********999....9********777788*****9999*******99999999976678888776 PP
   S: 328 ...................staYvlfYkr 337
    ++aY+++Y++
   Q: 905 edlhsldsrriqgcarrllCDAYMCMYQS 933
    899999999999999************85 PP
   

Organism Pan troglodytes
Protein Sequence
(Fasta)
MSSGLWSQEK VTSPYWEERI FYLLLQECSV TDKQTQKLLK VPKGSIGQYI QDRSVGHSRI 60
PSAKGKKNQI GLKILEQPHA VLFVDEKDVV EINEKFTELL LAITNCEERF SLFKNRNRLS 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Ptr-090520|DUB,USP|Pan troglodytes
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGTGGGGGC GGGCCCAGGT AGCAGGTTTG GCTGCGCGGG GGCCGCGCGT CGGAGGTAAA 60
TACTAGGGCG GTGGGTGTGG GGAGCCGGGG CCGGCCCGGG ACGCGGGCTG GGGAGCCGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Ptr-090520|DUB,USP|Pan troglodytes
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00845--CAP_GLY_1
PS50245--CAP_GLY_2
PS00972--USP_1
PS50235--USP_3

Pfam

PF01302--CAP_GLY
PF00443--UCH

SMART

SM01052--CAP_GLY

Gene Ontology

GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0097542--C:ciliary tip
GO:0005881--C:cytoplasmic microtubule
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0030496--C:midbody
GO:0005819--C:spindle
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043369--P:CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0048872--P:homeostasis of number of cells
GO:0045087--P:innate immune response
GO:0070266--P:necroptotic process
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045581--P:negative regulation of T cell differentiation
GO:1903829--P:positive regulation of cellular protein localization
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0045582--P:positive regulation of T cell differentiation
GO:0050862--P:positive regulation of T cell receptor signaling pathway
GO:1990108--P:protein linear deubiquitination
GO:0045577--P:regulation of B cell differentiation
GO:1902017--P:regulation of cilium assembly
GO:2001242--P:regulation of intrinsic apoptotic signaling pathway
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:0007346--P:regulation of mitotic cell cycle
GO:0043393--P:regulation of protein binding
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:1901026--P:ripoptosome assembly involved in necroptotic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001298 Ailuropoda melanoleuca 95.29 0.00e+00 1875.00
IUUC-Apl-003356 Anas platyrhynchos 85.48 0.00e+00 1642.00
IUUC-Aca-004402 Anolis carolinensis 79.13 0.00e+00 1469.00
IUUC-Ame-011581 Astyanax mexicanus 66.29 0.00e+00 1177.00
IUUC-Bta-012359 Bos taurus 94.77 0.00e+00 1847.00
IUUC-Cel-018528 Caenorhabditis elegans 34.03 1.00e-49 192.00
IUUC-Cja-018797 Callithrix jacchus 97.07 0.00e+00 1911.00
IUUC-Cfa-020264 Canis familiaris 95.19 0.00e+00 1865.00
IUUC-Cpo-022057 Cavia porcellus 94.46 0.00e+00 1857.00
IUUC-Csa-023093 Chlorocebus sabaeus 97.38 0.00e+00 1905.00
IUUC-Cho-024486 Choloepus hoffmanni 83.38 2.00e-180 626.00
IUUC-Cin-025179 Ciona intestinalis 43.06 2.00e-107 382.00
IUUC-Dre-028233 Danio rerio 65.81 0.00e+00 1212.00
IUUC-Dno-029496 Dasypus novemcinctus 94.04 0.00e+00 1845.00
IUUC-Dor-030919 Dipodomys ordii 88.60 0.00e+00 1714.00
IUUC-Dme-032159 Drosophila melanogaster 44.04 1.00e-116 413.00
IUUC-Ete-032734 Echinops telfairi 88.28 0.00e+00 1721.00
IUUC-Eca-033350 Equus caballus 94.98 0.00e+00 1860.00
IUUC-Eeu-034566 Erinaceus europaeus 98.39 9.00e-115 407.00
IUUC-Fca-035632 Felis catus 95.74 0.00e+00 1332.00
IUUC-Fal-037313 Ficedula albicollis 80.46 0.00e+00 1526.00
IUUC-Gmo-039239 Gadus morhua 65.60 0.00e+00 1157.00
IUUC-Gga-040668 Gallus gallus 85.79 0.00e+00 1643.00
IUUC-Gac-042630 Gasterosteus aculeatus 65.87 0.00e+00 1149.00
IUUC-Ggo-044462 Gorilla gorilla 98.22 0.00e+00 1928.00
IUUC-Hsa-045846 Homo sapiens 98.12 0.00e+00 1927.00
IUUC-Itr-048894 Ictidomys tridecemlineatus 93.05 0.00e+00 798.00
IUUC-Lch-050303 Latimeria chalumnae 68.88 0.00e+00 1262.00
IUUC-Loc-052190 Lepisosteus oculatus 68.15 0.00e+00 1232.00
IUUC-Laf-054480 Loxodonta africana 88.22 0.00e+00 711.00
IUUC-Mcc-055849 Macaca mulatta 97.59 0.00e+00 1917.00
IUUC-Meu-056755 Macropus eugenii 82.96 0.00e+00 881.00
IUUC-Mga-059561 Meleagris gallopavo 85.31 0.00e+00 1633.00
IUUC-Mmr-060942 Microcebus murinus 95.61 0.00e+00 1861.00
IUUC-Mdo-062618 Monodelphis domestica 91.11 0.00e+00 1802.00
IUUC-Mmu-063843 Mus musculus 92.99 0.00e+00 1780.00
IUUC-Mpu-066919 Mustela putorius furo 94.98 0.00e+00 1862.00
IUUC-Mlu-066983 Myotis lucifugus 88.49 0.00e+00 1716.00
IUUC-Nle-069893 Nomascus leucogenys 98.12 0.00e+00 1926.00
IUUC-Opr-071181 Ochotona princeps 85.70 0.00e+00 1543.00
IUUC-Ont-071697 Oreochromis niloticus 65.07 0.00e+00 1141.00
IUUC-Oan-073658 Ornithorhynchus anatinus 88.81 0.00e+00 1734.00
IUUC-Ocu-074954 Oryctolagus cuniculus 94.87 0.00e+00 1862.00
IUUC-Ola-086523 Oryzias latipes 64.49 0.00e+00 1136.00
IUUC-Oga-089003 Otolemur garnettii 95.50 0.00e+00 1876.00
IUUC-Oar-090376 Ovis aries 94.90 0.00e+00 1862.00
IUUC-Pan-092281 Papio anubis 97.38 0.00e+00 1905.00
IUUC-Psi-093047 Pelodiscus sinensis 86.71 0.00e+00 1567.00
IUUC-Pma-094575 Petromyzon marinus 55.50 9.00e-67 246.00
IUUC-Pfo-096358 Poecilia formosa 64.79 0.00e+00 1090.00
IUUC-Pab-097740 Pongo abelii 97.38 0.00e+00 1914.00
IUUC-Pca-100461 Procavia capensis 89.20 0.00e+00 1196.00
IUUC-Pva-102134 Pteropus vampyrus 84.10 0.00e+00 1627.00
IUUC-Rno-105807 Rattus norvegicus 91.11 0.00e+00 1738.00
IUUC-Sha-107236 Sarcophilus harrisii 91.69 0.00e+00 1745.00
IUUC-Sar-113366 Sorex araneus 94.67 0.00e+00 889.00
IUUC-Tgu-117201 Taeniopygia guttata 82.48 0.00e+00 1566.00
IUUC-Tru-117953 Takifugu rubripes 66.39 0.00e+00 1139.00
IUUC-Tsy-119610 Tarsius syrichta 93.41 0.00e+00 1828.00
IUUC-Tni-120743 Tetraodon nigroviridis 39.44 7.00e-158 551.00
IUUC-Tbe-128155 Tupaia belangeri 83.89 0.00e+00 660.00
IUUC-Ttr-128942 Tursiops truncatus 91.74 0.00e+00 1793.00
IUUC-Vpa-130281 Vicugna pacos 84.31 0.00e+00 1609.00
IUUC-Xtr-132627 Xenopus tropicalis 75.23 0.00e+00 1365.00
Created Date 25-Jun-2017

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