iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044721

UUCD1 version

UUC-GoG-00429

Ensembl Protein ID

ENSGGOP00000010283.2

UniProt Accession

G3R4S2; G3R4S2_GORGO

Protein Name

Uncharacterized protein

Gene Name

CUL7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000010532.2	ENSGGOT00000010586.2	ENSGGOP00000010283.2
ENSGGOG00000010532.2	ENSGGOT00000033087.1	ENSGGOP00000018719.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	2.50e-151	505.9	971	1519

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 70   nreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveL 156
            ++W+ freql++++++f      y+++           +++w+++++ed +++ll+l+++l+ a+R+++++++r+l++++++    
   Q: 971  PTFWPVFREQLCRHTRLF------YMVR-----------AQAWSQDMAED-RRSLLHLSSRLNGALRQEQNFADRFLPDDEAA---- 1035
           589***************......****...........***********.********************************.... PP
   S: 157  slnklaiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllae 242
               +a++k+++Ea++++ +q++++++++ ++   + +d+Yl+++ea +n++++  a++++++++t+Ll++ve+++++       ++
   Q: 1036 ----QALGKTCWEALVSPVVQNITSPDEDGISPLgWLLDQYLECQEAVFNPQSRGPAFFSRVRRLTHLLVHVEPCEAP-------PP 1111
           ....**************************************************************************.......** PP
   S: 243  lvallrdkktedlsrmykLlsrvln..gleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlk 327
           +va++r k++++ +++++L++r+l+  ++++l++++++++++q++++lt++++++d   +V+r++e++n lq+++se+F+++a+Fl 
   Q: 1112 VVATPRPKGRNRSHDWSSLATRGLPssIMRNLTRCWRAVVEKQVNNFLTSSWRDDD---FVPRYCEHFNILQNSSSELFGPRAAFLL 1195
           ************************999*****************************...**************************** PP
   S: 328  aldkafetfvnknsvlkaakspEllAryiDqlLrks.skglteeeleaqldkvllvfkyisekdv...FekyYkkhLakRLlsgksa 410
           al+++++ +++k ++lkaa+++E++Ar+iDq++++s ++g++e+e +aql+++l+++ ++s++++   Fe+yY++++a+RLl   ++
   Q: 1196 ALQNGCAGALLKLPFLKAAHVSEQFARHIDQQIQGSrIGGAQEMERLAQLQQCLQAVLIFSGLEIattFEHYYQHYMADRLLG--VV 1280
           ***********************************************************************************..** PP
   S: 411  sseaEesviekLkeecgaeftskL.erMfqdlkvSedlnrqFk............................................ 452
           ss++E++v+e++    g++f+++L ++M+q+l++S++l+rqF+                                            
   Q: 1281 SSWLEGAVLEQI----GPCFPNRLpQQMLQSLSTSKELQRQFHvyqlqqldqellkledtekkiqvglgasgkehksekeeeagaaa 1363
           ************....*********************************************************************** PP
   S: 453  ............eekenteesesvelsvlvLsagaWpta..set..ekvsLPaelektiekfeefY........lekhsgRkLqWqh 515
                       e+++ ++e +++e+svlvLs+++Wp+a  ++t  ++++LP++l+ t++++++fY        le++s+R+LqW++
   Q: 1364 vvdvaegeeeeeENEDLYYEGAMPEVSVLVLSRHSWPVAsiCHTlnPRTCLPSYLRGTLNRYSNFYnksqshpaLERGSQRRLQWTW 1450
           **********98889999*********************9999899***************************************** PP
   S: 516  tlgraelkaelkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk..kqvlkkep 587
            lg+ael++    g+++l+Vst+Qm++LL++n+ ++vsve+l + ++l++++L++++++L+ss+   +++++++
   Q: 1451 -LGWAELQF----GNQTLHVSTMQMWLLLYLNDLKAVSVESLLALSGLSADMLNQAIGPLTSSRgpLDLHEQKD 1519
           .********....*************************************************997777776655 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MVGELRYREF RVPLGPGLHA YPDELIRQRV GHDGHPEYQI RWLILRRGDE GDGGSGQVDC 60
KAEHILLWMS KDEIYANCHK MLDEDGQVIG PSQESVGEVG ALDKSVLEEM ETDVKSLIQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCGGCTCCG CCCCGGCGCT CTCCCAGGGC CCCTAGCTTT CCGCTGGGTC GGGCGGAAAT 60
GAGCCGTGGC TTTTGGCTGG CGGAGCCGCT GGCAGGGACC GGGCCCCACC CTGCCCCAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR004939--APC_su10/DOC_dom
IPR016024--ARM-type_fold
IPR021097--CPH_domain
IPR031223--CUL7
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR008979--Galactose-bd-like
IPR014722--Rib_L2_dom2
IPR011030--Vitellinogen_superhlx
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2
PS51284--DOC

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM01337--APC10
SM00884--Cullin_Nedd8

Gene Ontology

GO:1990393--C:3M complex
GO:0005813--C:centrosome
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0001837--P:epithelial to mesenchymal transition
GO:0000226--P:microtubule cytoskeleton organization
GO:0000281--P:mitotic cytokinesis
GO:0001890--P:placenta development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0016567--P:protein ubiquitination
GO:0007088--P:regulation of mitotic nuclear division
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0001570--P:vasculogenesis

KEGG

ggo:101146397

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002360	Ailuropoda melanoleuca	86.32	0.00e+00	2731.00
IUUC-Bta-013285	Bos taurus	84.28	0.00e+00	2719.00
IUUC-Cja-019033	Callithrix jacchus	91.17	0.00e+00	2864.00
IUUC-Cfa-020695	Canis familiaris	86.29	0.00e+00	1709.00
IUUC-Cpo-021513	Cavia porcellus	78.64	0.00e+00	2458.00
IUUC-Csa-023798	Chlorocebus sabaeus	96.82	0.00e+00	3031.00
IUUC-Dor-030234	Dipodomys ordii	83.61	0.00e+00	2719.00
IUUC-Ete-032612	Echinops telfairi	77.56	0.00e+00	875.00
IUUC-Eca-033408	Equus caballus	88.49	0.00e+00	2727.00
IUUC-Fca-035483	Felis catus	86.49	0.00e+00	2720.00
IUUC-Gac-041628	Gasterosteus aculeatus	47.53	0.00e+00	1151.00
IUUC-Hsa-046406	Homo sapiens	99.12	0.00e+00	3127.00
IUUC-Itr-048525	Ictidomys tridecemlineatus	87.46	0.00e+00	2711.00
IUUC-Lch-049956	Latimeria chalumnae	43.89	0.00e+00	1046.00
IUUC-Laf-054068	Loxodonta africana	84.98	0.00e+00	2727.00
IUUC-Mcc-055464	Macaca mulatta	96.88	0.00e+00	3004.00
IUUC-Meu-056198	Macropus eugenii	56.91	0.00e+00	1334.00
IUUC-Mmr-061464	Microcebus murinus	88.52	0.00e+00	2733.00
IUUC-Mdo-062018	Monodelphis domestica	58.86	0.00e+00	1406.00
IUUC-Mmu-063413	Mus musculus	76.56	0.00e+00	2365.00
IUUC-Mpu-066146	Mustela putorius furo	87.40	0.00e+00	2659.00
IUUC-Mlu-067036	Myotis lucifugus	84.55	0.00e+00	2701.00
IUUC-Opr-070670	Ochotona princeps	77.93	0.00e+00	2437.00
IUUC-Ocu-074155	Oryctolagus cuniculus	85.23	0.00e+00	2652.00
IUUC-Oga-089084	Otolemur garnettii	88.22	0.00e+00	2842.00
IUUC-Oar-090029	Ovis aries	85.83	0.00e+00	2725.00
IUUC-Ptr-091282	Pan troglodytes	97.51	0.00e+00	3113.00
IUUC-Pan-091883	Papio anubis	97.00	0.00e+00	3031.00
IUUC-Pab-098383	Pongo abelii	94.62	0.00e+00	2997.00
IUUC-Pca-100519	Procavia capensis	75.87	0.00e+00	828.00
IUUC-Pva-102417	Pteropus vampyrus	84.66	0.00e+00	2210.00
IUUC-Rno-105962	Rattus norvegicus	79.37	0.00e+00	2491.00
IUUC-Sar-113750	Sorex araneus	81.51	4.00e-171	596.00
IUUC-Ssc-115899	Sus scrofa	81.08	0.00e+00	2426.00
IUUC-Tsy-118860	Tarsius syrichta	85.14	0.00e+00	1120.00
IUUC-Tbe-127660	Tupaia belangeri	86.78	0.00e+00	1425.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence