iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-091883

Ensembl Protein ID

ENSPANP00000012693.1

UniProt Accession

A0A096NI95; A0A096NI95_PAPAN

Genbank Protein ID

ENSPANP00000012693

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01197242

Gene Name

CUL7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000020449.1	ENSPANT00000017607.1	ENSPANP00000012693.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	9.30e-151	503.6	970	1518

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 70   nreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveL 156
            ++W+ freql++++++f      y+++           +++w+++++ed +++ll+l+++l+ a+R+++++++r+l++++++    
   Q: 970  PTFWPVFREQLCRHTRLF------YMVR-----------AQAWSQDMAED-RRSLLHLSSRLNGALRQEQNFADRFLPDDEAA---- 1034
           589***************......****...........***********.********************************.... PP
   S: 157  slnklaiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllae 242
               +a++k+++Ea++++ +q++++++++ ++   + +++Yl+++ea +n++++  a++++++++t+Ll++ve+++++       ++
   Q: 1035 ----QALGKTCWEALVSPVVQNITSPDEDGVSPLgWLLEQYLECQEAVFNPQSRGPAFFSRVRRLTHLLVHVEPCEAP-------PP 1110
           ....**************************************************************************.......** PP
   S: 243  lvallrdkktedlsrmykLlsrvln..gleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlk 327
           + a++r k++++ +++++L++r+l+  ++++l++++++++++q++++lt++++++d   +V+r++e +n lq+++se+F+++a+Fl 
   Q: 1111 VAATPRPKGRNRSHDWSSLATRGLPssIMRNLTRCWQAVVEKQVNNFLTSSWRDDD---FVPRYCEQFNILQNSSSELFGPRAAFLL 1194
           ************************999*****************************...**************************** PP
   S: 328  aldkafetfvnknsvlkaakspEllAryiDqlLrks.skglteeeleaqldkvllvfkyisekdv...FekyYkkhLakRLlsgksa 410
           al+++++ +++k ++lkaa+++E++Ar+iDq++++s ++g++e+e +aql+++l+++ ++s++++   Fe+yY++++a+RLl   ++
   Q: 1195 ALQNGCAGALLKLPFLKAAHVSEQFARHIDQQIQGSrIGGAQEMERLAQLQQCLQAVLIFSGLEIattFEHYYQHYMADRLLG--VV 1279
           ***********************************************************************************..** PP
   S: 411  sseaEesviekLkeecgaeftskL.erMfqdlkvSedlnrqFk............................................ 452
           ss++E++v+e++    g++f+++L ++M+q+l++S++l+rqF+                                            
   Q: 1280 SSWLEGAVLEQI----GPCFPNRLpQQMLQSLSTSKELQRQFHvyqlqrldqellkledtekkiqvghrasgkeyksekeegagaaa 1362
           ************....*********************************************************************** PP
   S: 453  ............eekenteesesvelsvlvLsagaWpta..set..ekvsLPaelektiekfeefY........lekhsgRkLqWqh 515
                       e+++ ++e +++e+svlvLs+++Wp+a  ++t  ++++LP++l+ t++++++fY        le++s+R+LqW++
   Q: 1363 avdvtegeeeeeENEDLYYEGAMPEVSVLVLSRHCWPVAsiCHTlnPRTCLPSYLRGTLNRYSNFYnksqshpaLEQGSQRRLQWTW 1449
           **********98889999*********************9999899***************************************** PP
   S: 516  tlgraelkaelkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk..kqvlkkep 587
            lg+ael++    g+++l+Vst+Qm++LL++n+ ++vsve+l + ++l++++L+ ++++L+ss+   +++++++
   Q: 1450 -LGWAELQF----GNQTLHVSTVQMWLLLYLNDLKAVSVESLLALSGLSADMLNEAIGPLTSSRgpLDLHEQKD 1518
           .********....*************************************************997777776655 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MVGELRYREF RVPLGPGLHA YPDELIRQRV GHDGHPEYQI RWLILRRGDE GDGGSGQVDC 60
KAEHILLWMS KDEIYANCHK MLGEDGQVIG PSQESAGEVG ALDKSVLEEM ETDVKSLIQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGACGTGTGG TGTGCTACTG CGGAAGGTGA ATGGCACAGC CATTATCCAG CTGCCGTCTA 60
AGAGGCAGAT GCAGGTGTGT ATGGGTATGG CTGGGAGGGG TCAGCAAAGG AGGAATTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR004939--APC_su10/DOC_dom
IPR016024--ARM-type_fold
IPR021097--CPH_domain
IPR031223--CUL7
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR008979--Galactose-bd-like
IPR014722--Rib_L2_dom2
IPR011030--Vitellinogen_superhlx
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2
PS51284--DOC

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM01337--APC10
SM00884--Cullin_Nedd8

Gene Ontology

GO:1990393--C:3M complex
GO:0005813--C:centrosome
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0001837--P:epithelial to mesenchymal transition
GO:0000226--P:microtubule cytoskeleton organization
GO:0000281--P:mitotic cytokinesis
GO:0001890--P:placenta development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0016567--P:protein ubiquitination
GO:0007088--P:regulation of mitotic nuclear division
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0001570--P:vasculogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002360	Ailuropoda melanoleuca	86.19	0.00e+00	2752.00
IUUC-Ame-010611	Astyanax mexicanus	47.56	0.00e+00	913.00
IUUC-Bta-013285	Bos taurus	84.16	0.00e+00	2747.00
IUUC-Cja-019033	Callithrix jacchus	91.69	0.00e+00	2927.00
IUUC-Cfa-020695	Canis familiaris	85.46	0.00e+00	1739.00
IUUC-Cpo-021513	Cavia porcellus	78.87	0.00e+00	2476.00
IUUC-Csa-023798	Chlorocebus sabaeus	99.06	0.00e+00	3132.00
IUUC-Cin-025402	Ciona intestinalis	34.63	2.00e-103	371.00
IUUC-Dno-029587	Dasypus novemcinctus	80.93	0.00e+00	1474.00
IUUC-Dor-030234	Dipodomys ordii	83.48	0.00e+00	2766.00
IUUC-Ete-032612	Echinops telfairi	77.39	0.00e+00	900.00
IUUC-Eca-033408	Equus caballus	88.43	0.00e+00	2766.00
IUUC-Eeu-035166	Erinaceus europaeus	62.93	0.00e+00	937.00
IUUC-Fca-035483	Felis catus	86.03	0.00e+00	2764.00
IUUC-Gmo-038795	Gadus morhua	53.41	0.00e+00	682.00
IUUC-Gac-041628	Gasterosteus aculeatus	46.65	0.00e+00	1335.00
IUUC-Ggo-044721	Gorilla gorilla	97.11	0.00e+00	3022.00
IUUC-Hsa-046406	Homo sapiens	97.29	0.00e+00	3071.00
IUUC-Itr-048525	Ictidomys tridecemlineatus	87.10	0.00e+00	2744.00
IUUC-Lch-049956	Latimeria chalumnae	43.95	0.00e+00	1065.00
IUUC-Laf-054068	Loxodonta africana	84.74	0.00e+00	2755.00
IUUC-Mcc-055464	Macaca mulatta	99.41	0.00e+00	3127.00
IUUC-Meu-056198	Macropus eugenii	55.75	0.00e+00	1585.00
IUUC-Mmr-061464	Microcebus murinus	88.18	0.00e+00	2771.00
IUUC-Mdo-062018	Monodelphis domestica	59.47	0.00e+00	1393.00
IUUC-Mmu-063413	Mus musculus	76.73	0.00e+00	2376.00
IUUC-Mpu-066146	Mustela putorius furo	87.15	0.00e+00	2681.00
IUUC-Mlu-067036	Myotis lucifugus	84.78	0.00e+00	2753.00
IUUC-Opr-070670	Ochotona princeps	78.09	0.00e+00	2463.00
IUUC-Oan-073451	Ornithorhynchus anatinus	50.73	0.00e+00	1164.00
IUUC-Ocu-074155	Oryctolagus cuniculus	85.04	0.00e+00	2674.00
IUUC-Ola-087072	Oryzias latipes	48.64	0.00e+00	960.00
IUUC-Oga-089084	Otolemur garnettii	88.05	0.00e+00	2868.00
IUUC-Oar-090029	Ovis aries	85.88	0.00e+00	2758.00
IUUC-Ptr-091282	Pan troglodytes	95.66	0.00e+00	3058.00
IUUC-Pab-098383	Pongo abelii	93.46	0.00e+00	2982.00
IUUC-Pca-100519	Procavia capensis	76.03	0.00e+00	837.00
IUUC-Pva-102417	Pteropus vampyrus	84.58	0.00e+00	2241.00
IUUC-Rno-105962	Rattus norvegicus	79.13	0.00e+00	2493.00
IUUC-Sar-113750	Sorex araneus	81.51	1.00e-173	604.00
IUUC-Ssc-115899	Sus scrofa	80.16	0.00e+00	2426.00
IUUC-Tgu-116915	Taeniopygia guttata	57.78	6.00e-132	463.00
IUUC-Tru-118013	Takifugu rubripes	55.54	0.00e+00	723.00
IUUC-Tsy-118860	Tarsius syrichta	84.87	0.00e+00	1135.00
IUUC-Tbe-127660	Tupaia belangeri	86.57	0.00e+00	1436.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence