iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012646

Ensembl Protein ID

ENSBTAP00000004593.5

UniProt Accession

F1MWR6; F1MWR6_BOVIN

Genbank Protein ID

ENSBTAP00000004593

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

DAAA02023009

Gene Name

TLE4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000003532.5	ENSBTAT00000004593.5	ENSBTAP00000004593.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.40e-22	78.2	618	656
UBD/Beta-Prp	3.30e-40	138.2	486	656

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 618  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 656
           8***********999*********************998 PP

UBD/Beta-Prp

   S: 50   gheaevtavkfspdgkilvtgseDrtikvwdls...tgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.t 132
           +h + v av++s+ +   v ++  + +kvwd+s   + ++v+ l   + +++++s+++ p+g +l++G++ +t+ +wdl   +   +  
   Q: 486  NHGEVVCAVTISNPTR-HVYTGGKGCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKaE 573
           5666788889998885.555555579*******999888999988889*******************************9988766658 PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+    +   ++++pd+++++s++ D+ + +Wdl +++l+r+++g htd   +++++ +g+ l +g+ld+tv+ wdl++g+ ++
   Q: 574  LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQG-HTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 656
           88888888999*********************************9.********************************997443 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MIRDLIKMYP QTTHSAPHQP AQPFKFTISE SCDRIKEEFQ FLQAQYHSLK LECEKLASEK 60
TEMQRHYVMY YEMSYGLNIE MHKQAEIVKR LNAICAQVIP FLSQEHQQQV VQAVERAKQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGGACAATG CCCGCGGCGG GCCAGTGACG CCCGCGGGGA ATGCGGAGCG GTTCGGCCGC 60
CCGCAGCCAG GCGCCGCCGC CGCGCGTTCT TGCCGCCCGC GTCACGCGAG ACCCAGCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001746	Ailuropoda melanoleuca	84.84	0.00e+00	1127.00
IUUC-Apl-003434	Anas platyrhynchos	87.79	0.00e+00	1124.00
IUUC-Aca-005279	Anolis carolinensis	97.93	0.00e+00	1318.00
IUUC-Cel-018361	Caenorhabditis elegans	58.99	1.00e-122	433.00
IUUC-Cja-019079	Callithrix jacchus	98.58	0.00e+00	1393.00
IUUC-Cfa-020987	Canis familiaris	99.20	0.00e+00	1351.00
IUUC-Cpo-021606	Cavia porcellus	96.87	0.00e+00	1323.00
IUUC-Csa-023445	Chlorocebus sabaeus	98.97	0.00e+00	1367.00
IUUC-Cho-024590	Choloepus hoffmanni	84.97	0.00e+00	1198.00
IUUC-Cin-025282	Ciona intestinalis	75.41	2.00e-154	539.00
IUUC-Csv-026174	Ciona savignyi	57.99	3.00e-162	565.00
IUUC-Dno-028979	Dasypus novemcinctus	98.78	0.00e+00	1320.00
IUUC-Dor-030533	Dipodomys ordii	92.38	0.00e+00	1150.00
IUUC-Dme-031576	Drosophila melanogaster	86.03	0.00e+00	666.00
IUUC-Ete-032887	Echinops telfairi	88.47	0.00e+00	1218.00
IUUC-Eca-034397	Equus caballus	99.45	0.00e+00	1271.00
IUUC-Eeu-034666	Erinaceus europaeus	87.43	0.00e+00	933.00
IUUC-Fca-036030	Felis catus	99.87	0.00e+00	1382.00
IUUC-Fal-037460	Ficedula albicollis	98.68	0.00e+00	1340.00
IUUC-Gmo-038805	Gadus morhua	77.20	0.00e+00	1095.00
IUUC-Gga-040416	Gallus gallus	98.58	0.00e+00	1360.00
IUUC-Ggo-045633	Gorilla gorilla	95.20	0.00e+00	1341.00
IUUC-Hsa-046461	Homo sapiens	94.91	0.00e+00	1366.00
IUUC-Itr-048974	Ictidomys tridecemlineatus	99.10	0.00e+00	1373.00
IUUC-Lch-049943	Latimeria chalumnae	95.74	0.00e+00	1232.00
IUUC-Loc-052835	Lepisosteus oculatus	95.10	0.00e+00	1276.00
IUUC-Laf-053425	Loxodonta africana	99.47	0.00e+00	1371.00
IUUC-Mcc-055766	Macaca mulatta	95.04	0.00e+00	1367.00
IUUC-Mmr-061317	Microcebus murinus	95.51	0.00e+00	1368.00
IUUC-Mdo-062956	Monodelphis domestica	98.45	0.00e+00	1361.00
IUUC-Mmu-063576	Mus musculus	98.71	0.00e+00	1356.00
IUUC-Mpu-066410	Mustela putorius furo	99.58	0.00e+00	1273.00
IUUC-Mlu-067456	Myotis lucifugus	97.30	0.00e+00	1301.00
IUUC-Nle-069495	Nomascus leucogenys	99.34	0.00e+00	1343.00
IUUC-Ont-071419	Oreochromis niloticus	85.59	0.00e+00	1182.00
IUUC-Oan-072842	Ornithorhynchus anatinus	95.22	0.00e+00	1340.00
IUUC-Ocu-074453	Oryctolagus cuniculus	97.55	0.00e+00	1343.00
IUUC-Ola-087090	Oryzias latipes	84.94	0.00e+00	1178.00
IUUC-Oga-087939	Otolemur garnettii	98.97	0.00e+00	1372.00
IUUC-Oar-090347	Ovis aries	99.86	0.00e+00	1261.00
IUUC-Ptr-091048	Pan troglodytes	98.97	0.00e+00	1367.00
IUUC-Pan-091973	Papio anubis	94.32	0.00e+00	1312.00
IUUC-Pma-094452	Petromyzon marinus	78.35	0.00e+00	1121.00
IUUC-Pfo-097518	Poecilia formosa	84.34	0.00e+00	1137.00
IUUC-Pab-097539	Pongo abelii	95.03	0.00e+00	1245.00
IUUC-Rno-105314	Rattus norvegicus	98.65	0.00e+00	1288.00
IUUC-Sar-113267	Sorex araneus	88.67	0.00e+00	728.00
IUUC-Ssc-116408	Sus scrofa	98.84	0.00e+00	1394.00
IUUC-Tgu-117068	Taeniopygia guttata	98.40	0.00e+00	1346.00
IUUC-Tru-118782	Takifugu rubripes	81.86	0.00e+00	1123.00
IUUC-Tsy-118884	Tarsius syrichta	84.08	0.00e+00	1077.00
IUUC-Tni-120404	Tetraodon nigroviridis	83.83	0.00e+00	1182.00
IUUC-Tbe-128013	Tupaia belangeri	91.24	0.00e+00	1268.00
IUUC-Vpa-130577	Vicugna pacos	89.79	0.00e+00	702.00
IUUC-Xtr-132974	Xenopus tropicalis	97.04	0.00e+00	1289.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence