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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Mmu-064076
UUCD1 version UUC-MuM-00690
Ensembl Protein ID ENSMUSP00000108815.2
UniProt Accession Q8C0J2; Q6KAT7; Q80U97; Q80U98; Q80U99; Q80Y53; Q9DB63; A16L1_MOUSE
Genbank Protein ID BAC55090.1; BAC55091.1; BAC55092.1; BAB23866.1; BAC27201.1; BAD21370.1; AAH49122.1
Protein Name Autophagy-related protein 16-1; APG16-like 1
Genbank Nucleotide ID AB087879; AB087880; AB087881; AK005181; AK030983; AK131120; BC049122
Gene Name Atg16l1; Apg16l
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026289.15 ENSMUST00000027512.12 ENSMUSP00000027512.6
ENSMUSG00000026289.15 ENSMUST00000113186.7 ENSMUSP00000108811.1
ENSMUSG00000026289.15 ENSMUST00000113190.2 ENSMUSP00000108815.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.90e-30 104.1 422 461
UBD/Beta-Prp 3.50e-62 211.4 333 621
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvllks 38
    gH+++v + +f ++ ++vsGs+D t+k+WDlr+ v++k+
   Q: 422 GHSGKVLSAKFllDNARIVSGSHDRTLKLWDLRSKVCIKT 461
    8***********64489********************985 PP
   


   UBD/Beta-Prp

   S: 5    lkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl..lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
    ++++h++ +++v+fsp+++llatg++d+++k+w+++ k+ slsg +a++t+++f++ g +l+ +s+D + ++w ++++ htl+
   Q: 333 VFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEAFGDKCefKGSLSGSNAGITSIEFDSAGAYLLAASNDFASRIWTVDDYRLRHTLT 421
    5799***********************************9989********************************************** PP
   S: 92 ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
    gh+ +vls +f ++ ++vsGshdrt+++wdl+++ c++++++g + c + +++++++sG+ D+++r+Wd+++++++r+++
   Q: 422 GHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSS----CNDIVCTEQCVMSGHFDKKIRFWDIRSESVVREME--LL 504
    ***************************************9999988....888888889*************************6..69 PP
   S: 181 dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnght....dnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhns 265
    ++++ l+++++++el+s+s+d +k+ dl+t+ + +t+ + + ++v fsp++ +++ gs++gs+++W + +g++ k+l++++s
   Q: 505 GKITALDLNPERTELLSCSRDDLLKVIDLRTNAVKQTFSAPGfkcgSDWTRVVFSPDGSYVAAGSAEGSLYVWSVLTGKVEKVLSKQHS 593
    **********************************99999988888877777************************************** PP
   S: 266 svisvavlsfgdnvlvlgsedskvniwk 293
    s+i ++ +++ ++v++++ s++ +w+
   Q: 594 SSINAVAWAPSGLHVVSVDKGSRAVLWA 621
    **************************97 PP
   

Organism Mus musculus
Functional Description
(View)

Functional Description



     Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:18849966, PubMed:12665549, PubMed:24954904, PubMed:24553140, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (By similarity). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966).
Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:18849966, PubMed:12665549, PubMed:24954904, PubMed:24553140, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (By similarity). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966).
Protein Sequence
(Fasta)
MSSGLRAADF PRWKRHIAEE LRRRDRLQRQ AFEEIILQYT KLLEKSDLHS VLTQKLQAEK 60
HDMPNRHEIS PGHDGAWNDS QLQEMAQLRI KHQEELTELH KKRGELAQLV IDLNNQMQQK 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Mmu-064076|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAAGCCAGGG TGCCTCCCAG CGGCTGCCTC TCATCACCGA CGCTTCCGGC TTCAAGGTTG 60
CGTCATTTGA GAGCGTCCCG CGAAGTCTCG GCCGGGAGCT TGCGCGCGGC CTAGGACGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mmu-064076|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR013923--Autophagy-rel_prot_16
IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08614--ATG16
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005776--C:autophagosome
GO:0000421--C:autophagosome membrane
GO:0005930--C:axoneme
GO:0005829--C:cytosol
GO:0034045--C:pre-autophagosomal structure membrane
GO:0042802--F:identical protein binding
GO:0000045--P:autophagosome assembly
GO:0016236--P:macroautophagy
GO:0039689--P:negative stranded viral RNA replication
GO:0015031--P:protein transport

KEGG mmu:77040
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000090 Aegilops tauschii 28.57 1.00e-33 137.00
IUUC-Aml-002242 Ailuropoda melanoleuca 82.30 0.00e+00 1002.00
IUUC-Atr-003073 Amborella trichopoda 27.72 2.00e-26 113.00
IUUC-Apl-003384 Anas platyrhynchos 83.95 0.00e+00 1029.00
IUUC-Aca-004962 Anolis carolinensis 86.33 0.00e+00 1063.00
IUUC-Aly-005435 Arabidopsis lyrata 34.45 3.00e-46 179.00
IUUC-Ath-006948 Arabidopsis thaliana 34.78 2.00e-46 180.00
IUUC-Ame-010915 Astyanax mexicanus 77.23 5.00e-150 523.00
IUUC-Bta-012388 Bos taurus 92.60 0.00e+00 1151.00
IUUC-Bdi-014231 Brachypodium distachyon 30.23 3.00e-37 149.00
IUUC-Bol-016174 Brassica oleracea 35.12 9.00e-47 181.00
IUUC-Bra-017165 Brassica rapa 34.45 5.00e-46 179.00
IUUC-Cel-018131 Caenorhabditis elegans 39.33 5.00e-59 222.00
IUUC-Cja-018898 Callithrix jacchus 82.01 0.00e+00 964.00
IUUC-Cfa-020484 Canis familiaris 90.68 0.00e+00 1115.00
IUUC-Cpo-022156 Cavia porcellus 91.80 0.00e+00 1118.00
IUUC-Csa-024019 Chlorocebus sabaeus 89.39 0.00e+00 1082.00
IUUC-Cho-024311 Choloepus hoffmanni 77.69 0.00e+00 931.00
IUUC-Cin-025260 Ciona intestinalis 36.73 7.00e-97 348.00
IUUC-Csv-025836 Ciona savignyi 44.44 1.00e-47 182.00
IUUC-Dre-027702 Danio rerio 74.14 0.00e+00 887.00
IUUC-Dno-029728 Dasypus novemcinctus 91.65 0.00e+00 1157.00
IUUC-Dor-030587 Dipodomys ordii 83.11 3.00e-122 432.00
IUUC-Dme-031595 Drosophila melanogaster 38.21 8.00e-107 381.00
IUUC-Ete-032969 Echinops telfairi 71.76 0.00e+00 750.00
IUUC-Eca-034214 Equus caballus 91.14 0.00e+00 920.00
IUUC-Eeu-034537 Erinaceus europaeus 84.54 0.00e+00 874.00
IUUC-Fca-036005 Felis catus 92.71 0.00e+00 1075.00
IUUC-Fal-037593 Ficedula albicollis 85.92 0.00e+00 1013.00
IUUC-Gmo-039042 Gadus morhua 63.18 0.00e+00 674.00
IUUC-Gga-040986 Gallus gallus 86.01 0.00e+00 1069.00
IUUC-Gac-041351 Gasterosteus aculeatus 71.36 0.00e+00 888.00
IUUC-Gma-043265 Glycine max 34.11 7.00e-48 185.00
IUUC-Ggo-045427 Gorilla gorilla 93.42 0.00e+00 1140.00
IUUC-Hsa-046632 Homo sapiens 91.80 0.00e+00 1127.00
IUUC-Hvu-047655 Hordeum vulgare 29.39 7.00e-25 108.00
IUUC-Itr-048504 Ictidomys tridecemlineatus 90.24 0.00e+00 1096.00
IUUC-Lpe-051254 Leersia perrieri 30.42 4.00e-38 152.00
IUUC-Loc-052610 Lepisosteus oculatus 74.84 0.00e+00 923.00
IUUC-Laf-053936 Loxodonta africana 90.03 0.00e+00 1110.00
IUUC-Mcc-055504 Macaca mulatta 90.43 0.00e+00 1152.00
IUUC-Meu-056516 Macropus eugenii 83.63 0.00e+00 996.00
IUUC-Mtr-058062 Medicago truncatula 31.67 1.00e-43 170.00
IUUC-Mga-059777 Meleagris gallopavo 81.14 0.00e+00 1015.00
IUUC-Mmr-061298 Microcebus murinus 95.66 0.00e+00 1156.00
IUUC-Mdo-062969 Monodelphis domestica 88.75 0.00e+00 1086.00
IUUC-Mac-065022 Musa acuminata 32.33 1.00e-41 163.00
IUUC-Mpu-066196 Mustela putorius furo 93.73 0.00e+00 1131.00
IUUC-Mlu-067651 Myotis lucifugus 89.41 0.00e+00 1096.00
IUUC-Nle-069853 Nomascus leucogenys 90.35 0.00e+00 1105.00
IUUC-Opr-070350 Ochotona princeps 94.89 3.00e-121 429.00
IUUC-Ont-072489 Oreochromis niloticus 72.01 0.00e+00 879.00
IUUC-Oan-072703 Ornithorhynchus anatinus 84.22 0.00e+00 994.00
IUUC-Ocu-074205 Oryctolagus cuniculus 92.31 0.00e+00 1153.00
IUUC-Oba-075619 Oryza barthii 30.45 3.00e-37 149.00
IUUC-Obr-076632 Oryza brachyantha 30.21 7.00e-38 151.00
IUUC-Ogl-077671 Oryza glaberrima 30.45 3.00e-37 149.00
IUUC-Ogu-078052 Oryza glumaepatula 30.45 3.00e-37 149.00
IUUC-Oin-079611 Oryza indica 30.13 4.00e-35 142.00
IUUC-Olo-080408 Oryza longistaminata 30.45 7.00e-37 148.00
IUUC-Ome-081560 Oryza meridionalis 30.45 3.00e-37 149.00
IUUC-Oni-082145 Oryza nivara 30.45 3.00e-37 149.00
IUUC-Opu-083918 Oryza punctata 30.13 1.00e-36 147.00
IUUC-Oru-084858 Oryza rufipogon 30.13 6.00e-35 142.00
IUUC-Osa-086277 Oryza sativa 30.13 4.00e-35 142.00
IUUC-Ola-086816 Oryzias latipes 69.85 4.00e-99 353.00
IUUC-Olu-087622 Ostreococcus lucimarinus 33.44 1.00e-44 173.00
IUUC-Oga-088765 Otolemur garnettii 88.60 0.00e+00 1031.00
IUUC-Oar-090196 Ovis aries 89.38 0.00e+00 1006.00
IUUC-Ptr-091676 Pan troglodytes 91.96 0.00e+00 1128.00
IUUC-Pan-092068 Papio anubis 94.06 0.00e+00 1144.00
IUUC-Psi-093367 Pelodiscus sinensis 83.44 0.00e+00 1020.00
IUUC-Ppa-095699 Physcomitrella patens 33.78 8.00e-41 161.00
IUUC-Pfo-096067 Poecilia formosa 70.75 0.00e+00 862.00
IUUC-Pab-098111 Pongo abelii 93.74 0.00e+00 1144.00
IUUC-Pop-099116 Populus trichocarpa 31.44 1.00e-42 167.00
IUUC-Pca-100680 Procavia capensis 82.12 0.00e+00 938.00
IUUC-Ppe-101790 Prunus persica 31.44 5.00e-44 172.00
IUUC-Pva-102871 Pteropus vampyrus 90.58 0.00e+00 1051.00
IUUC-Rno-106088 Rattus norvegicus 97.59 0.00e+00 1180.00
IUUC-Sha-106984 Sarcophilus harrisii 85.64 0.00e+00 1043.00
IUUC-Smo-109404 Selaginella moellendorffii 31.44 3.00e-41 162.00
IUUC-Sit-110828 Setaria italica 31.58 6.00e-41 162.00
IUUC-Sly-111009 Solanum lycopersicum 31.00 3.00e-44 172.00
IUUC-Stu-112370 Solanum tuberosum 31.00 7.00e-45 174.00
IUUC-Sar-113659 Sorex araneus 58.65 9.00e-85 306.00
IUUC-Sbi-114819 Sorghum bicolor 30.62 3.00e-39 156.00
IUUC-Ssc-116241 Sus scrofa 88.40 0.00e+00 1078.00
IUUC-Tgu-116576 Taeniopygia guttata 84.08 0.00e+00 1056.00
IUUC-Tru-118336 Takifugu rubripes 64.05 0.00e+00 731.00
IUUC-Tsy-119006 Tarsius syrichta 90.19 0.00e+00 1081.00
IUUC-Tni-120300 Tetraodon nigroviridis 71.19 0.00e+00 852.00
IUUC-Tca-121002 Theobroma cacao 32.67 4.00e-45 176.00
IUUC-Tae-124868 Triticum aestivum 29.19 1.00e-34 140.00
IUUC-Tur-126463 Triticum urartu 28.57 7.00e-34 139.00
IUUC-Tbe-127631 Tupaia belangeri 92.07 0.00e+00 904.00
IUUC-Ttr-129005 Tursiops truncatus 81.68 2.00e-157 549.00
IUUC-Vpa-130246 Vicugna pacos 85.24 0.00e+00 853.00
IUUC-Vvi-130878 Vitis vinifera 33.44 6.00e-44 172.00
IUUC-Xtr-132798 Xenopus tropicalis 72.36 0.00e+00 863.00
IUUC-Xma-133264 Xiphophorus maculatus 70.00 0.00e+00 860.00
Created Date 25-Jun-2017

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