iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ssc-116049

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

CU914454

Gene Name

USP18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000000774.2	ENSSSCT00000000838.2	ENSSSCP00000000822.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.20e-59	201.6	4	317

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +Gl+N+g tC +NS++Q+L++   l++ l++    ++++ + +e+  ++  +l  l+e++++s++kav+p el  +l+k++     + q
   Q: 4    VGLHNIGQTCCLNSLIQVLIMNVGLTKILKR---MTVPRGA-EEQRRNVPFQLLLLLEKMQDSRQKAVQPMELAYCLQKYNIP--MFVQ 86
           6******************************...6666554.577889********************************976..799* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +Da  +   + + +++++                          ++      ++ l+ +++k++ +clec ++ +r++++l+l+l++ +
   Q: 87   HDAAQLYLTVWNLIKDQI--------------------------TDVDLVARLQALYTIRVKETFVCLECTTEHVRNSSMLTLPLSLFD 149
           ******************..........................567788999***********************************9 PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts 267
            +++ +++l+d+L+ f+++ el g++k++ce+c +k+  ++ lkl++lP++L+lhL+Rfs   ++ + ek+  +++fp++Ldl+p +++
   Q: 150  MDSKPLKTLEDALHCFFQPRELSGRDKCFCENCGRKTCWKQVLKLSRLPQTLTLHLMRFSI--KNLRTEKVCHSLYFPQSLDLNPLLET 236
           99999******************************************************55..66899*****************9998 PP
   S: 268  peekqke....kkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg.......staYvlfYk 336
           +ee  +       +YeL+av+ H+G ++ GHY+ayv++  +gkW++f+Ds+V  v++e+++ + g       +taY+l+Y+
   Q: 237  EEEPCAAegqpGGRYELFAVIAHMGLADFGHYCAYVRSaADGKWFCFNDSNVCWVSWEDIQCTYGnhsfrwrETAYLLVYM 317
           7766655677799************************955667*******************888***************8 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MGPVGLHNIG QTCCLNSLIQ VLIMNVGLTK ILKRMTVPRG AEEQRRNVPF QLLLLLEKMQ 60
DSRQKAVQPM ELAYCLQKYN IPMFVQHDAA QLYLTVWNLI KDQITDVDLV ARLQALYTIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCGGGGCA GGGGCGGGGA CAGAGGCGGG GCGTAGGCGG GGACAGAGGT GCTGGCGCCA 60
GGCGCTCTGC GGGCAGGGCC AGAGGCGCGG GGACCGAGGC GAGGACGGAG GCATACGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0019785--F:ISG15-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0035634--P:response to stilbenoid
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001615	Ailuropoda melanoleuca	83.33	1.00e-155	542.00
IUUC-Apl-004006	Anas platyrhynchos	55.21	1.00e-102	365.00
IUUC-Aca-005088	Anolis carolinensis	53.94	8.00e-88	317.00
IUUC-Ame-010606	Astyanax mexicanus	34.70	1.00e-43	169.00
IUUC-Bta-013036	Bos taurus	83.44	2.00e-164	571.00
IUUC-Cja-019052	Callithrix jacchus	70.19	4.00e-135	473.00
IUUC-Cfa-020554	Canis familiaris	82.81	1.00e-162	565.00
IUUC-Cpo-022421	Cavia porcellus	74.61	1.00e-142	499.00
IUUC-Csa-023737	Chlorocebus sabaeus	72.28	8.00e-91	325.00
IUUC-Cho-024807	Choloepus hoffmanni	67.01	4.00e-70	258.00
IUUC-Dre-027408	Danio rerio	34.62	9.00e-47	180.00
IUUC-Dno-029813	Dasypus novemcinctus	67.19	8.00e-112	396.00
IUUC-Dor-030532	Dipodomys ordii	73.50	1.00e-139	489.00
IUUC-Ete-032254	Echinops telfairi	67.81	1.00e-134	472.00
IUUC-Eca-033482	Equus caballus	81.93	6.00e-162	562.00
IUUC-Eeu-034451	Erinaceus europaeus	69.34	5.00e-90	323.00
IUUC-Fca-036313	Felis catus	82.50	3.00e-164	570.00
IUUC-Fal-037216	Ficedula albicollis	54.89	4.00e-98	351.00
IUUC-Gmo-038649	Gadus morhua	35.46	2.00e-43	169.00
IUUC-Gga-041082	Gallus gallus	54.75	5.00e-92	330.00
IUUC-Gac-042439	Gasterosteus aculeatus	37.14	5.00e-50	191.00
IUUC-Ggo-044957	Gorilla gorilla	76.47	1.00e-128	451.00
IUUC-Hsa-046381	Homo sapiens	77.12	1.00e-152	532.00
IUUC-Itr-047918	Ictidomys tridecemlineatus	76.25	2.00e-147	514.00
IUUC-Loc-052688	Lepisosteus oculatus	32.30	2.00e-46	179.00
IUUC-Laf-054109	Loxodonta africana	75.94	4.00e-151	526.00
IUUC-Mcc-054814	Macaca mulatta	76.80	4.00e-153	533.00
IUUC-Meu-056253	Macropus eugenii	65.97	2.00e-109	388.00
IUUC-Mmr-061613	Microcebus murinus	74.06	9.00e-145	505.00
IUUC-Mdo-061890	Monodelphis domestica	63.55	8.00e-122	429.00
IUUC-Mmu-064329	Mus musculus	69.69	3.00e-131	461.00
IUUC-Mpu-066342	Mustela putorius furo	84.06	3.00e-164	570.00
IUUC-Mlu-067010	Myotis lucifugus	82.81	2.00e-162	564.00
IUUC-Nle-069148	Nomascus leucogenys	76.18	1.00e-150	525.00
IUUC-Opr-070988	Ochotona princeps	63.06	9.00e-60	223.00
IUUC-Ont-072039	Oreochromis niloticus	34.81	1.00e-48	186.00
IUUC-Oan-073740	Ornithorhynchus anatinus	56.27	2.00e-74	271.00
IUUC-Ocu-074498	Oryctolagus cuniculus	77.12	6.00e-143	499.00
IUUC-Ola-086753	Oryzias latipes	35.90	7.00e-50	190.00
IUUC-Oga-088497	Otolemur garnettii	76.47	3.00e-143	501.00
IUUC-Oar-089505	Ovis aries	81.93	4.00e-162	563.00
IUUC-Ptr-091656	Pan troglodytes	76.49	1.00e-151	528.00
IUUC-Pan-092498	Papio anubis	77.12	1.00e-153	535.00
IUUC-Psi-093409	Pelodiscus sinensis	55.21	7.00e-103	366.00
IUUC-Pfo-096507	Poecilia formosa	37.90	1.00e-50	193.00
IUUC-Pab-097828	Pongo abelii	75.78	4.00e-151	526.00
IUUC-Pca-100299	Procavia capensis	76.72	9.00e-85	306.00
IUUC-Pva-102972	Pteropus vampyrus	78.75	2.00e-154	538.00
IUUC-Rno-105738	Rattus norvegicus	68.44	5.00e-134	470.00
IUUC-Sha-107309	Sarcophilus harrisii	62.71	6.00e-115	406.00
IUUC-Sar-112983	Sorex araneus	71.43	6.00e-120	423.00
IUUC-Tgu-117115	Taeniopygia guttata	54.89	1.00e-99	355.00
IUUC-Tru-118022	Takifugu rubripes	32.81	6.00e-39	154.00
IUUC-Tsy-118986	Tarsius syrichta	79.84	8.00e-57	213.00
IUUC-Tni-120306	Tetraodon nigroviridis	33.01	1.00e-40	160.00
IUUC-Tbe-127768	Tupaia belangeri	69.80	1.00e-93	335.00
IUUC-Ttr-128686	Tursiops truncatus	82.81	7.00e-161	559.00
IUUC-Xtr-132032	Xenopus tropicalis	41.74	5.00e-68	250.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence