iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012886

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase RNF34; RING finger protein 34; RING-type E3 ubiquitin transferase RNF34

Genbank Nucleotide ID

BT020924

Gene Name

RNF34

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000002315.4	ENSBTAT00000002986.2	ENSBTAP00000002986.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	92.00	9.00e-174	607.00	IUUC-Hsa-046299
E3 activity/RING/RING	85.83	6.00e-163	570.00	IUUC-Rno-105481

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells. Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation.

Protein Sequence
(Fasta)

MKAGATSMWA SCCGLLNEVM GTGAVRGQQS GFAGGTGPFR FTPNSDFSAY PPASAEGPNI 60
VCKACGLSFS VFRKKHVCCD CKKDFCSVCS VLQENLRRCS TCHLLQETAF QRPQLMRLKV 120

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Nucleotide Sequence
(Fasta)

AAGGGAGGAG GGCGGTTGTG CTAGAAGCTG CTATGGTGCT GAGTTCCCTG GCAGAGCCGA 60
CCCAGACGCG GCGGTCGCGG CCATGAAGGT GAGGGGCCGG TGGGGCCGGG CAGTCCCTCC 120

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Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003034--SAP_dom
IPR011011--Znf_FYVE_PHD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0012505--C:endomembrane system
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:1901981--F:phosphatidylinositol phosphate binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0070417--P:cellular response to cold
GO:2001271--P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1901797--P:negative regulation of signal transduction by p53 class mediator
GO:0035872--P:nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000374--P:regulation of oxygen metabolic process

KEGG

bta:506764

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002341	Ailuropoda melanoleuca	93.87	3.00e-177	613.00
IUUC-Apl-003398	Anas platyrhynchos	74.01	4.00e-142	497.00
IUUC-Aca-005050	Anolis carolinensis	71.07	2.00e-78	285.00
IUUC-Cja-019045	Callithrix jacchus	90.40	7.00e-173	599.00
IUUC-Cfa-020037	Canis familiaris	91.85	1.00e-164	572.00
IUUC-Cpo-021618	Cavia porcellus	78.95	1.00e-142	499.00
IUUC-Csa-023303	Chlorocebus sabaeus	90.93	7.00e-173	599.00
IUUC-Cho-024671	Choloepus hoffmanni	83.69	3.00e-172	597.00
IUUC-Dre-027887	Danio rerio	60.62	1.00e-101	363.00
IUUC-Dno-029136	Dasypus novemcinctus	92.27	0.00e+00	635.00
IUUC-Dor-030596	Dipodomys ordii	85.29	5.00e-159	553.00
IUUC-Ete-032684	Echinops telfairi	86.86	7.00e-147	513.00
IUUC-Eca-033598	Equus caballus	94.97	0.00e+00	634.00
IUUC-Eeu-034878	Erinaceus europaeus	91.71	4.00e-175	607.00
IUUC-Fca-036370	Felis catus	92.67	7.00e-178	616.00
IUUC-Fal-036937	Ficedula albicollis	73.14	6.00e-139	486.00
IUUC-Gga-040411	Gallus gallus	72.97	1.00e-126	446.00
IUUC-Gac-042281	Gasterosteus aculeatus	62.23	2.00e-114	405.00
IUUC-Ggo-044752	Gorilla gorilla	91.71	4.00e-172	597.00
IUUC-Hsa-046299	Homo sapiens	92.00	2.00e-173	601.00
IUUC-Itr-047907	Ictidomys tridecemlineatus	91.51	4.00e-178	617.00
IUUC-Lch-049616	Latimeria chalumnae	65.37	2.00e-108	385.00
IUUC-Loc-052099	Lepisosteus oculatus	60.60	7.00e-121	426.00
IUUC-Laf-054103	Loxodonta africana	86.70	3.00e-165	574.00
IUUC-Mcc-055295	Macaca mulatta	90.96	2.00e-173	601.00
IUUC-Mga-059584	Meleagris gallopavo	72.70	7.00e-133	466.00
IUUC-Mmr-061766	Microcebus murinus	91.32	3.00e-179	620.00
IUUC-Mdo-062738	Monodelphis domestica	75.26	1.00e-137	482.00
IUUC-Mmu-064403	Mus musculus	88.03	2.00e-157	548.00
IUUC-Mpu-066021	Mustela putorius furo	94.13	0.00e+00	639.00
IUUC-Mlu-067144	Myotis lucifugus	91.76	4.00e-170	590.00
IUUC-Nle-070133	Nomascus leucogenys	92.11	1.00e-162	565.00
IUUC-Opr-070683	Ochotona princeps	82.57	2.00e-159	555.00
IUUC-Ont-072065	Oreochromis niloticus	61.19	9.00e-112	396.00
IUUC-Oan-073504	Ornithorhynchus anatinus	80.95	2.00e-144	505.00
IUUC-Ocu-074382	Oryctolagus cuniculus	88.00	7.00e-172	596.00
IUUC-Ola-087022	Oryzias latipes	61.98	3.00e-117	415.00
IUUC-Oga-087963	Otolemur garnettii	90.55	0.00e+00	633.00
IUUC-Oar-089439	Ovis aries	98.67	0.00e+00	656.00
IUUC-Ptr-091616	Pan troglodytes	90.93	1.00e-169	588.00
IUUC-Pan-092754	Papio anubis	91.18	3.00e-174	604.00
IUUC-Psi-093217	Pelodiscus sinensis	69.84	2.00e-124	438.00
IUUC-Pab-098124	Pongo abelii	91.44	1.00e-171	595.00
IUUC-Pca-100954	Procavia capensis	90.43	6.00e-179	619.00
IUUC-Pva-102588	Pteropus vampyrus	92.25	3.00e-175	607.00
IUUC-Rno-105481	Rattus norvegicus	85.83	2.00e-158	551.00
IUUC-Sha-106640	Sarcophilus harrisii	80.80	5.00e-145	507.00
IUUC-Sit-110649	Setaria italica	39.66	1.00e-08	52.00
IUUC-Sar-113331	Sorex araneus	94.91	0.00e+00	631.00
IUUC-Tgu-117252	Taeniopygia guttata	73.28	2.00e-135	474.00
IUUC-Tru-118556	Takifugu rubripes	60.96	3.00e-113	401.00
IUUC-Tsy-118891	Tarsius syrichta	65.40	5.00e-65	241.00
IUUC-Tni-119741	Tetraodon nigroviridis	58.38	2.00e-113	402.00
IUUC-Tbe-127380	Tupaia belangeri	91.42	0.00e+00	627.00
IUUC-Ttr-128999	Tursiops truncatus	94.12	1.00e-180	625.00
IUUC-Vpa-130168	Vicugna pacos	80.91	8.00e-93	332.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence