iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037445

Ensembl Protein ID

ENSFALP00000009410.1

UniProt Accession

U3K306; U3K306_FICAL

Genbank Protein ID

ENSFALP00000009410

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01011745

Gene Name

UBA7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000009022.1	ENSFALT00000009450.1	ENSFALP00000009410.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	3.70e-161	536.6	415	879

Active Site

Position(s)	Description	Evidence
596	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Q +++G++ qekl+++k+l+vGag++GcEllKn++++G+     g++ + Dmdtv +snl rq L++  d+ k+K+ vaa+a++++
   Q: 415  YDGQTAVFGANFQEKLGRQKYLVVGAGAIGCELLKNFAMMGLaagpdGELIIADMDTVALSNLHRQLLYCSADISKPKSVVAAAAVQRM 503
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqkt 170
           npdv+v++h++++ + +e  +   Ff+ +d+V++ald +ear ++ r+cl ++ pl++sgt+G+ G+v  +++ lte  +    p + t
   Q: 504  NPDVRVTPHQNQVGPATEMLYrdnFFRHLDGVASALDTIEARAYLERRCLRCHTPLLDSGTEGTQGNVLPMVPFLTEPLKPASTPRDGT 592
           *******************99***********************************************99******9999999****** PP
   S: 171  iPfctlketpnaaehtiewa.....vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsik 254
           +P+ctl+++p+ ++ht++wa      lf+  +e+ +++ e  + l+++ ++e++++v ++l++ +++++++++++a++ ++++++  i 
   Q: 593  FPLCTLRHFPRIIQHTLQWArdefeGLFQLPAEQVNQFMEDPDFLKQQRPREVLEQVWNSLRE-RPRDWQDCVRWARRRWQSCYHDAII 680
           ************************977777777777778888888888889999999777666.699********************** PP
   S: 255  qllksfecdivtkskspfwv..............................................................sfcsnae 281
           qll+  +++  t+ ++pfw                                                               + +  +e
   Q: 681  QLLHIYPPEHETSPGVPFWAgdrtcphpltfnpdndthldyvlaaahlfaqvhrvspcrdraaiqailrgvvlppfvpqeglQIPLTEE 769
           ***********************************************999999998888888888888888888777777752222222 PP
   S: 282  alqvpekvekdeevvkasap.lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiepkldddlikeiagniipai 369
            + ++  +  d + + +  + l    + l   e+ +   ++ + fekd   ++d++taa+nlrae+++i+p ++    k+iag+i+pai
   Q: 770  PA-EQAHIPTDHRQLRQITQdLVQWRQDLVGNEELQAPLMEPIHFEKDNNVHIDFITAASNLRAENYSISP-ANWLTSKRIAGRIVPAI 856
           22.333333333333333334555555566666666666889*****************************.***************** PP
   S: 370  attnavvgGlaaqEviKvvsgkf 392
            t +a+v+Gla++Ev+K+v g++
   Q: 857  ITSTAAVAGLACLEVYKLVWGCQ 879
           ******************98843 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MAPPWGGARG VRSVDAAVMA GSEEEARYSR QLYVLGGGAR RLPGAAVLVS GLRGTGAQVA 60
TALVLAGTGR VVLHDCDAAC TADRAHQFLL GESDLGQNRA EASQRALAEL NPHVVVETHS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC 60
CCCCCCCCCC CCCCCCCCCC CCCTACCCGC CCTCACCGCC ACACAGCGGC ACCGGGGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001311	Ailuropoda melanoleuca	49.80	0.00e+00	899.00
IUUC-Aca-004746	Anolis carolinensis	49.36	0.00e+00	909.00
IUUC-Ame-010933	Astyanax mexicanus	48.22	0.00e+00	838.00
IUUC-Bta-012767	Bos taurus	48.85	0.00e+00	908.00
IUUC-Cel-018260	Caenorhabditis elegans	39.27	0.00e+00	644.00
IUUC-Cja-019152	Callithrix jacchus	49.54	0.00e+00	906.00
IUUC-Cfa-020622	Canis familiaris	47.98	0.00e+00	868.00
IUUC-Cpo-022526	Cavia porcellus	49.13	0.00e+00	883.00
IUUC-Csa-023780	Chlorocebus sabaeus	49.44	0.00e+00	902.00
IUUC-Cin-025790	Ciona intestinalis	42.02	0.00e+00	797.00
IUUC-Csv-026084	Ciona savignyi	41.05	0.00e+00	768.00
IUUC-Dre-028149	Danio rerio	48.64	0.00e+00	878.00
IUUC-Dno-028884	Dasypus novemcinctus	49.14	0.00e+00	901.00
IUUC-Dor-030229	Dipodomys ordii	47.12	0.00e+00	850.00
IUUC-Dme-032045	Drosophila melanogaster	42.45	0.00e+00	781.00
IUUC-Ete-033124	Echinops telfairi	52.62	0.00e+00	632.00
IUUC-Eca-033330	Equus caballus	49.64	0.00e+00	906.00
IUUC-Eeu-034717	Erinaceus europaeus	46.05	5.00e-161	561.00
IUUC-Fca-036255	Felis catus	49.85	0.00e+00	902.00
IUUC-Gmo-039338	Gadus morhua	45.98	0.00e+00	836.00
IUUC-Gga-040365	Gallus gallus	65.78	0.00e+00	1183.00
IUUC-Gac-041773	Gasterosteus aculeatus	47.28	0.00e+00	835.00
IUUC-Ggo-045336	Gorilla gorilla	49.59	0.00e+00	887.00
IUUC-Hsa-045982	Homo sapiens	49.59	0.00e+00	885.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	49.54	0.00e+00	902.00
IUUC-Lch-050371	Latimeria chalumnae	48.43	0.00e+00	895.00
IUUC-Loc-052936	Lepisosteus oculatus	50.42	0.00e+00	914.00
IUUC-Laf-053948	Loxodonta africana	50.21	0.00e+00	900.00
IUUC-Mcc-055843	Macaca mulatta	49.24	0.00e+00	900.00
IUUC-Meu-056258	Macropus eugenii	49.34	0.00e+00	885.00
IUUC-Mga-060052	Meleagris gallopavo	66.14	0.00e+00	992.00
IUUC-Mmr-061405	Microcebus murinus	48.43	0.00e+00	867.00
IUUC-Mdo-062032	Monodelphis domestica	48.43	0.00e+00	867.00
IUUC-Mmu-063280	Mus musculus	48.90	0.00e+00	884.00
IUUC-Mpu-066409	Mustela putorius furo	49.85	0.00e+00	911.00
IUUC-Mlu-067217	Myotis lucifugus	49.33	0.00e+00	889.00
IUUC-Nle-070072	Nomascus leucogenys	47.12	0.00e+00	830.00
IUUC-Opr-070715	Ochotona princeps	44.09	0.00e+00	728.00
IUUC-Ont-071671	Oreochromis niloticus	47.70	0.00e+00	862.00
IUUC-Oan-073306	Ornithorhynchus anatinus	48.66	0.00e+00	655.00
IUUC-Ocu-074544	Oryctolagus cuniculus	49.90	0.00e+00	911.00
IUUC-Ola-087002	Oryzias latipes	48.12	0.00e+00	876.00
IUUC-Oga-088594	Otolemur garnettii	49.24	0.00e+00	879.00
IUUC-Oar-090068	Ovis aries	49.74	0.00e+00	899.00
IUUC-Ptr-090581	Pan troglodytes	45.73	0.00e+00	717.00
IUUC-Pan-092114	Papio anubis	49.34	0.00e+00	899.00
IUUC-Pma-094214	Petromyzon marinus	53.42	3.00e-38	150.00
IUUC-Pfo-097184	Poecilia formosa	46.65	0.00e+00	853.00
IUUC-Pab-097861	Pongo abelii	49.29	0.00e+00	870.00
IUUC-Pca-100347	Procavia capensis	50.82	0.00e+00	739.00
IUUC-Pva-102584	Pteropus vampyrus	49.65	0.00e+00	925.00
IUUC-Rno-105462	Rattus norvegicus	49.34	0.00e+00	887.00
IUUC-Sha-107142	Sarcophilus harrisii	50.00	0.00e+00	891.00
IUUC-Spo-108034	Schizosaccharomyces pombe	38.99	0.00e+00	675.00
IUUC-Sar-113737	Sorex araneus	48.84	0.00e+00	891.00
IUUC-Ssc-115777	Sus scrofa	49.75	0.00e+00	901.00
IUUC-Tru-118742	Takifugu rubripes	47.07	0.00e+00	839.00
IUUC-Tni-120401	Tetraodon nigroviridis	47.07	0.00e+00	837.00
IUUC-Tbe-127587	Tupaia belangeri	52.19	0.00e+00	649.00
IUUC-Ttr-128331	Tursiops truncatus	49.44	0.00e+00	889.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence