iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cin-025771

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

EAAA01001187

Gene Name

LOC100175935

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCING00000000924.3	ENSCINT00000001676.3	ENSCINP00000001676.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	1.40e-69	234.8	3	322

Active Site

Position(s)	Description	Evidence
87	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
162	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 4    qvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffak 92
            + ew+ +esdPg+f  l++dfgv +  qvee+ sLd+++++ + +pv+gl++lFk+ ++ +++           + d+   + iffak
   Q: 3    SAGEWCLIESDPGVFSALIKDFGVLGI-QVEEICSLDSDSFKDL-KPVHGLIFLFKYDQDMKTEG---------TILDQTTQSDIFFAK 80
           5679**********************9.****************.**************999999.........5789999999***** PP
   S: 93   qvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfv 181
           qvi+N+Cat+A++  lln ++k + lG+tl+ ++++t+ +++ +++lal+n++v++++hns+ r++ ++ +e+       + ++ +hfv
   Q: 81   QVISNACATQAIINILLNTKHKDVVLGSTLEDFRNFTQCFDASMRGLALSNSKVIQQVHNSFSRQQVFEYDEKAT-----KSEDSYHFV 164
           **********************************************************************99883.....36899**** PP
   S: 182  syvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid........... 259
            yv++ngr+ eldglk  P+d+g+  e +++ + ++ ++    ri+ ++sdei fnl+a+v d++++ +++++ l +            
   Q: 165  GYVQVNGRVLELDGLKSGPVDHGP-VEGDDWIETVRPII--QRRIQRYTSDEIHFNLMAVVGDKKMMLEKKIEKLTTLidgyndameee 250
           ************************.78899*********..****************************99987765466998888864 PP
   S: 260  keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevref 332
           +     l  +    e+ +  l+de +kr++  +++irR++ny  fi++ i+ la e  l  l e+   +v+ +
   Q: 251  E-QRVPLAILMESLEQCKCLLNDETQKRQRNQVENIRRKHNYLPFIIEMIRILAAEEKLLPLIEHAKEKVKPQ 322
           2.222233333344678889************************************99999988766666555 PP

Organism

Ciona intestinalis

Protein Sequence
(Fasta)

MSSAGEWCLI ESDPGVFSAL IKDFGVLGIQ VEEICSLDSD SFKDLKPVHG LIFLFKYDQD 60
MKTEGTILDQ TTQSDIFFAK QVISNACATQ AIINILLNTK HKDVVLGSTL EDFRNFTQCF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGAGTTCT GTCTCAAATA CTTACTGTAA TTTAAGTTAA CTAAATTTTG CAAATGTAAA 60
ATGAGCTCCG CTGGGGAATG GTGTCTTATC GAAAGCGACC CCGGAGTTTT TTCTGCCCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

cin:100175935

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	42.55	2.00e-71	261.00
IUUC-Aml-001866	Ailuropoda melanoleuca	54.17	3.00e-102	363.00
IUUC-Atr-002966	Amborella trichopoda	39.38	7.00e-59	219.00
IUUC-Apl-003306	Anas platyrhynchos	48.30	4.00e-94	336.00
IUUC-Aca-004763	Anolis carolinensis	55.13	2.00e-103	367.00
IUUC-Aly-005581	Arabidopsis lyrata	44.17	2.00e-66	244.00
IUUC-Ath-007283	Arabidopsis thaliana	44.79	1.00e-68	251.00
IUUC-Ago-007999	Ashbya gossypii	36.36	4.00e-33	133.00
IUUC-Acl-008231	Aspergillus clavatus	42.15	3.00e-52	197.00
IUUC-Afl-008557	Aspergillus flavus	45.27	3.00e-56	210.00
IUUC-Afu-008988	Aspergillus fumigatus	42.15	3.00e-51	194.00
IUUC-Ani-009420	Aspergillus nidulans	37.30	4.00e-54	203.00
IUUC-Ang-009859	Aspergillus niger	39.11	3.00e-48	184.00
IUUC-Aor-010145	Aspergillus oryzae	45.27	3.00e-56	210.00
IUUC-Ate-010347	Aspergillus terreus	41.25	5.00e-52	196.00
IUUC-Ame-010791	Astyanax mexicanus	54.01	3.00e-105	373.00
IUUC-Bgr-012298	Blumeria graminis	37.42	1.00e-49	188.00
IUUC-Bta-013251	Bos taurus	54.49	2.00e-102	363.00
IUUC-Bci-013786	Botrytis cinerea	36.45	6.00e-58	216.00
IUUC-Bdi-014132	Brachypodium distachyon	41.77	4.00e-70	256.00
IUUC-Bol-015611	Brassica oleracea	43.38	3.00e-68	250.00
IUUC-Bra-017769	Brassica rapa	43.38	4.00e-68	250.00
IUUC-Cel-018604	Caenorhabditis elegans	46.42	2.00e-76	277.00
IUUC-Cja-019768	Callithrix jacchus	49.41	7.00e-97	345.00
IUUC-Cfa-020207	Canis familiaris	54.17	3.00e-102	363.00
IUUC-Cpo-021925	Cavia porcellus	51.60	7.00e-96	342.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	42.32	9.00e-67	245.00
IUUC-Csa-023958	Chlorocebus sabaeus	54.17	5.00e-102	362.00
IUUC-Cho-024928	Choloepus hoffmanni	55.84	3.00e-22	97.40
IUUC-Csv-026149	Ciona savignyi	83.65	7.00e-154	534.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	33.99	1.00e-46	178.00
IUUC-Cne-026955	Cryptococcus neoformans	36.14	8.00e-54	202.00
IUUC-Cme-027104	Cyanidioschyzon merolae	34.14	2.00e-46	177.00
IUUC-Dre-027409	Danio rerio	54.63	2.00e-105	374.00
IUUC-Dno-028921	Dasypus novemcinctus	54.17	7.00e-102	362.00
IUUC-Dor-030891	Dipodomys ordii	34.15	6.00e-36	144.00
IUUC-Dse-031170	Dothistroma septosporum	39.06	6.00e-55	206.00
IUUC-Dme-031677	Drosophila melanogaster	50.31	6.00e-95	338.00
IUUC-Ete-032707	Echinops telfairi	39.75	2.00e-61	228.00
IUUC-Eca-033776	Equus caballus	52.60	3.00e-90	323.00
IUUC-Eeu-035305	Erinaceus europaeus	53.51	4.00e-53	199.00
IUUC-Fca-035846	Felis catus	49.85	3.00e-97	347.00
IUUC-Fal-037597	Ficedula albicollis	51.90	4.00e-89	319.00
IUUC-Fox-037670	Fusarium oxysporum	46.29	1.00e-50	192.00
IUUC-Fso-038243	Fusarium solani	45.85	3.00e-50	190.00
IUUC-Gmo-038499	Gadus morhua	52.24	3.00e-97	347.00
IUUC-Ggr-039975	Gaeumannomyces graminis	40.49	1.00e-48	185.00
IUUC-Gga-040904	Gallus gallus	54.32	8.00e-107	378.00
IUUC-Gac-042058	Gasterosteus aculeatus	54.17	7.00e-103	365.00
IUUC-Gma-043030	Glycine max	42.56	7.00e-67	245.00
IUUC-Ggo-044699	Gorilla gorilla	50.49	9.00e-89	318.00
IUUC-Hsa-046227	Homo sapiens	54.17	3.00e-102	363.00
IUUC-Hvu-047359	Hordeum vulgare	42.33	1.00e-69	255.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	49.56	2.00e-97	347.00
IUUC-Lch-049829	Latimeria chalumnae	53.53	2.00e-100	357.00
IUUC-Lpe-050899	Leersia perrieri	41.96	2.00e-67	247.00
IUUC-Loc-052264	Lepisosteus oculatus	54.31	5.00e-100	356.00
IUUC-Lma-053110	Leptosphaeria maculans	41.74	2.00e-45	175.00
IUUC-Laf-053639	Loxodonta africana	54.17	3.00e-102	363.00
IUUC-Mcc-055506	Macaca mulatta	54.17	5.00e-102	363.00
IUUC-Meu-056267	Macropus eugenii	37.75	2.00e-42	166.00
IUUC-Mor-057001	Magnaporthe oryzae	44.96	5.00e-55	206.00
IUUC-Mpo-057608	Magnaporthe poae	41.85	1.00e-33	134.00
IUUC-Mtr-057731	Medicago truncatula	41.09	1.00e-68	251.00
IUUC-Mla-059016	Melampsora laricipopulina	42.79	8.00e-43	165.00
IUUC-Mga-060178	Meleagris gallopavo	51.83	1.00e-93	334.00
IUUC-Mvi-060353	Microbotryum violaceum	33.13	7.00e-47	179.00
IUUC-Mmr-060738	Microcebus murinus	54.17	2.00e-102	363.00
IUUC-Mdo-062266	Monodelphis domestica	60.29	3.00e-74	269.00
IUUC-Mmu-063619	Mus musculus	54.81	4.00e-103	366.00
IUUC-Mac-065301	Musa acuminata	42.24	7.00e-71	258.00
IUUC-Mpu-066058	Mustela putorius furo	54.17	4.00e-102	363.00
IUUC-Mlu-067292	Myotis lucifugus	55.13	8.00e-103	365.00
IUUC-Nfi-068275	Neosartorya fischeri	35.45	2.00e-53	201.00
IUUC-Ncr-068713	Neurospora crassa	36.83	1.00e-52	198.00
IUUC-Nle-069013	Nomascus leucogenys	53.85	2.00e-101	360.00
IUUC-Opr-070628	Ochotona princeps	46.90	1.00e-87	315.00
IUUC-Ont-072688	Oreochromis niloticus	54.63	2.00e-102	363.00
IUUC-Oan-073004	Ornithorhynchus anatinus	57.99	2.00e-75	274.00
IUUC-Ocu-074303	Oryctolagus cuniculus	54.17	6.00e-102	363.00
IUUC-Oba-075002	Oryza barthii	41.93	3.00e-67	247.00
IUUC-Obr-076392	Oryza brachyantha	41.96	1.00e-67	248.00
IUUC-Ogl-077271	Oryza glaberrima	41.93	3.00e-67	247.00
IUUC-Ogu-078493	Oryza glumaepatula	42.24	2.00e-68	251.00
IUUC-Oin-080084	Oryza indica	42.24	2.00e-68	251.00
IUUC-Olo-080803	Oryza longistaminata	41.93	5.00e-68	249.00
IUUC-Ome-081146	Oryza meridionalis	41.93	3.00e-68	250.00
IUUC-Oni-082146	Oryza nivara	42.24	2.00e-68	251.00
IUUC-Opu-083633	Oryza punctata	42.27	2.00e-66	244.00
IUUC-Oru-084789	Oryza rufipogon	42.24	2.00e-68	251.00
IUUC-Osa-086196	Oryza sativa	42.24	2.00e-68	251.00
IUUC-Ola-087126	Oryzias latipes	54.81	3.00e-103	366.00
IUUC-Olu-087665	Ostreococcus lucimarinus	40.83	9.00e-63	232.00
IUUC-Oga-089140	Otolemur garnettii	49.85	4.00e-97	346.00
IUUC-Oar-090296	Ovis aries	53.85	2.00e-100	357.00
IUUC-Ptr-090566	Pan troglodytes	54.17	3.00e-102	363.00
IUUC-Pan-092052	Papio anubis	54.17	6.00e-102	362.00
IUUC-Psi-093723	Pelodiscus sinensis	52.25	3.00e-90	323.00
IUUC-Pma-094568	Petromyzon marinus	46.71	5.00e-76	276.00
IUUC-Pno-095120	Phaeosphaeria nodorum	42.42	9.00e-47	179.00
IUUC-Ppa-095761	Physcomitrella patens	40.23	4.00e-65	240.00
IUUC-Pfo-096210	Poecilia formosa	54.81	3.00e-103	367.00
IUUC-Pab-098463	Pongo abelii	54.17	4.00e-102	363.00
IUUC-Pop-099423	Populus trichocarpa	42.35	3.00e-66	243.00
IUUC-Pca-100108	Procavia capensis	59.66	4.00e-84	303.00
IUUC-Ppe-101176	Prunus persica	42.47	9.00e-65	239.00
IUUC-Pva-102629	Pteropus vampyrus	61.02	1.00e-85	308.00
IUUC-Pgr-103419	Puccinia graminis	44.72	5.00e-57	213.00
IUUC-Pte-104207	Pyrenophora teres	40.83	1.00e-28	117.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	35.06	5.00e-51	192.00
IUUC-Rno-105579	Rattus norvegicus	46.91	3.00e-85	306.00
IUUC-Sha-106894	Sarcophilus harrisii	51.67	7.00e-84	302.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	35.35	1.00e-52	198.00
IUUC-Spo-108371	Schizosaccharomyces pombe	36.73	2.00e-55	207.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	35.64	6.00e-46	176.00
IUUC-Smo-109396	Selaginella moellendorffii	42.07	4.00e-63	233.00
IUUC-Sit-110630	Setaria italica	42.06	6.00e-71	259.00
IUUC-Sly-110972	Solanum lycopersicum	41.67	4.00e-64	236.00
IUUC-Stu-112185	Solanum tuberosum	42.60	2.00e-72	264.00
IUUC-Sar-113294	Sorex araneus	45.95	6.00e-84	302.00
IUUC-Sbi-113951	Sorghum bicolor	42.68	6.00e-71	259.00
IUUC-Ssc-115501	Sus scrofa	52.68	8.00e-93	332.00
IUUC-Tgu-117152	Taeniopygia guttata	51.90	4.00e-89	319.00
IUUC-Tru-118388	Takifugu rubripes	54.81	3.00e-103	366.00
IUUC-Tsy-119109	Tarsius syrichta	54.17	3.00e-102	363.00
IUUC-Tni-120048	Tetraodon nigroviridis	54.81	1.00e-103	367.00
IUUC-Tca-121750	Theobroma cacao	44.01	2.00e-70	257.00
IUUC-Tre-122130	Trichoderma reesei	37.33	1.00e-52	198.00
IUUC-Tvi-122284	Trichoderma virens	37.79	2.00e-49	187.00
IUUC-Tae-124082	Triticum aestivum	42.64	8.00e-70	255.00
IUUC-Tur-126366	Triticum urartu	34.05	4.00e-50	190.00
IUUC-Tme-127187	Tuber melanosporum	38.23	9.00e-56	208.00
IUUC-Tbe-127619	Tupaia belangeri	45.26	4.00e-68	249.00
IUUC-Ttr-128867	Tursiops truncatus	52.74	1.00e-69	255.00
IUUC-Vda-129912	Verticillium dahliae	33.90	3.00e-49	187.00
IUUC-Vpa-130552	Vicugna pacos	61.35	3.00e-76	277.00
IUUC-Vvi-130881	Vitis vinifera	42.26	2.00e-64	237.00
IUUC-Xtr-131934	Xenopus tropicalis	55.03	5.00e-105	372.00
IUUC-Xma-133312	Xiphophorus maculatus	55.13	2.00e-104	370.00
IUUC-Yli-134487	Yarrowia lipolytica	38.31	4.00e-46	176.00
IUUC-Zma-135639	Zea mays	37.71	8.00e-60	222.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence