iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-089140

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AAQR03037363

Gene Name

UCHL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000000349.2	ENSOGAT00000000350.2	ENSOGAP00000000312.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	3.80e-97	325.7	13	360

Active Site

Position(s)	Description	Evidence
100	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
176	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktif 89
           m++++ ew+ +esdPg+ft+l++ fg+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tif
   Q: 13   MTGNAGEWCLMESDPGVFTELIKGFGCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIF 90
           788999************************.****************.********************.........899********* PP
   S: 90   fakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeaf 178
           fakqvi+N+Cat+A++svllnc+++ ++lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ +++++++    +++af
   Q: 91   FAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTSAK----EEDAF 175
           *****************************************************************************888....79*** PP
   S: 179  hfvsyvningrlyeldglkpfPldlgkkketeelkdklkvv..........................raflerikllesdeirfnllai 241
           hfvsyv++ngrlyeldgl++ P+dlg+ ++++++ ++++ v                          r+f     +++++eirfnl+ai
   Q: 176  HFVSYVPVNGRLYELDGLREGPIDLGA-CNQDDWISAVRPViekriqnylfslccstlsffkkymmsRTFRL-CLMYSEGEIRFNLMAI 262
           **************************9.78899***************************988765433332.34589999******** PP
   S: 242  vadrrviktlrlnvlkid.........keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrkl 321
           v+dr++i+++++  l+ +          +  ++l++i+se++k+++ +++e++k k++ki++irR++ny  fi++++k+la++++l  l
   Q: 263  VSDRKMIYEQKIAELQKQlaeeepmdtDQGNSMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPL 351
           ***********976665567888888744569********************************************************* PP
   S: 322  veetisevrefg 333
           ve+    + +++
   Q: 352  VEKA---KEKQN 360
           *993...33344 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

PRGGAGRRVA GAMTGNAGEW CLMESDPGVF TELIKGFGCR GAQVEEIWSL EPENFEKLKP 60
VHGLIFLFKW QPGEEPAGSV VQDSRLDTIF FAKQVINNAC ATQAIVSVLL NCTHQDVHLG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATCCGTGGT CTGTAGCAGC TGTTGTGGGG GGCGGCCGGG ACCGAGAGGT GGAGCGGGGC 60
GGCGTGTGGC CGGGGCCATG ACGGGTAATG CCGGGGAGTG GTGCCTCATG GAAAGCGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	44.29	1.00e-80	293.00
IUUC-Aml-001866	Ailuropoda melanoleuca	90.88	0.00e+00	631.00
IUUC-Atr-002966	Amborella trichopoda	43.35	9.00e-76	277.00
IUUC-Apl-003306	Anas platyrhynchos	86.59	2.00e-180	624.00
IUUC-Aca-004763	Anolis carolinensis	86.51	6.00e-174	602.00
IUUC-Aly-005581	Arabidopsis lyrata	44.51	2.00e-75	275.00
IUUC-Ath-007283	Arabidopsis thaliana	44.79	2.00e-78	285.00
IUUC-Ago-007999	Ashbya gossypii	40.29	1.00e-31	130.00
IUUC-Acl-008231	Aspergillus clavatus	38.95	5.00e-48	184.00
IUUC-Afl-008557	Aspergillus flavus	34.53	5.00e-50	191.00
IUUC-Afu-008988	Aspergillus fumigatus	40.45	8.00e-50	190.00
IUUC-Ani-009420	Aspergillus nidulans	35.26	5.00e-48	184.00
IUUC-Ang-009859	Aspergillus niger	36.76	6.00e-45	174.00
IUUC-Aor-010145	Aspergillus oryzae	34.53	5.00e-50	191.00
IUUC-Ate-010347	Aspergillus terreus	38.08	9.00e-49	187.00
IUUC-Ame-010791	Astyanax mexicanus	82.58	5.00e-176	610.00
IUUC-Bgr-012298	Blumeria graminis	34.74	1.00e-44	173.00
IUUC-Bta-013251	Bos taurus	90.00	1.00e-179	622.00
IUUC-Bci-013786	Botrytis cinerea	35.25	1.00e-53	202.00
IUUC-Bdi-014132	Brachypodium distachyon	46.00	1.00e-77	283.00
IUUC-Bol-015611	Brassica oleracea	45.63	2.00e-79	289.00
IUUC-Bra-017769	Brassica rapa	45.63	2.00e-79	289.00
IUUC-Cel-018604	Caenorhabditis elegans	43.11	1.00e-76	279.00
IUUC-Cja-019768	Callithrix jacchus	91.48	0.00e+00	656.00
IUUC-Cfa-020207	Canis familiaris	90.88	0.00e+00	631.00
IUUC-Cpo-021925	Cavia porcellus	86.76	1.00e-173	602.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	42.11	1.00e-69	256.00
IUUC-Csa-023958	Chlorocebus sabaeus	91.28	0.00e+00	634.00
IUUC-Cho-024928	Choloepus hoffmanni	100.00	2.00e-42	166.00
IUUC-Cin-025771	Ciona intestinalis	50.00	5.00e-95	340.00
IUUC-Csv-026149	Ciona savignyi	53.18	7.00e-98	350.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	34.78	7.00e-48	183.00
IUUC-Cne-026955	Cryptococcus neoformans	34.52	4.00e-50	191.00
IUUC-Cme-027104	Cyanidioschyzon merolae	32.79	1.00e-46	180.00
IUUC-Dre-027409	Danio rerio	81.74	8.00e-173	599.00
IUUC-Dno-028921	Dasypus novemcinctus	90.29	0.00e+00	627.00
IUUC-Dse-031170	Dothistroma septosporum	36.26	4.00e-54	204.00
IUUC-Dme-031677	Drosophila melanogaster	55.28	2.00e-110	391.00
IUUC-Ete-032707	Echinops telfairi	63.35	9.00e-120	422.00
IUUC-Eca-033776	Equus caballus	89.84	7.00e-166	575.00
IUUC-Eeu-035305	Erinaceus europaeus	79.08	9.00e-87	313.00
IUUC-Fca-035846	Felis catus	91.71	0.00e+00	659.00
IUUC-Fal-037597	Ficedula albicollis	86.67	2.00e-153	534.00
IUUC-Fox-037670	Fusarium oxysporum	45.35	6.00e-51	194.00
IUUC-Fso-038243	Fusarium solani	45.31	2.00e-50	192.00
IUUC-Gmo-038499	Gadus morhua	77.06	1.00e-156	545.00
IUUC-Ggr-039975	Gaeumannomyces graminis	37.36	7.00e-44	171.00
IUUC-Gga-040904	Gallus gallus	85.99	0.00e+00	625.00
IUUC-Gac-042058	Gasterosteus aculeatus	81.18	3.00e-165	573.00
IUUC-Gma-043030	Glycine max	45.21	9.00e-81	293.00
IUUC-Ggo-044699	Gorilla gorilla	85.93	2.00e-166	578.00
IUUC-Hsa-046227	Homo sapiens	91.47	0.00e+00	634.00
IUUC-Hvu-047359	Hordeum vulgare	43.45	1.00e-78	286.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	89.69	0.00e+00	654.00
IUUC-Lch-049829	Latimeria chalumnae	84.12	1.00e-168	585.00
IUUC-Lpe-050899	Leersia perrieri	45.35	3.00e-74	271.00
IUUC-Loc-052264	Lepisosteus oculatus	82.70	3.00e-167	580.00
IUUC-Lma-053110	Leptosphaeria maculans	35.56	4.00e-44	171.00
IUUC-Laf-053639	Loxodonta africana	90.88	0.00e+00	631.00
IUUC-Mcc-055506	Macaca mulatta	91.28	0.00e+00	634.00
IUUC-Mor-057001	Magnaporthe oryzae	42.05	2.00e-50	192.00
IUUC-Mpo-057608	Magnaporthe poae	41.18	3.00e-33	134.00
IUUC-Mtr-057731	Medicago truncatula	45.86	6.00e-81	293.00
IUUC-Mla-059016	Melampsora laricipopulina	43.28	1.00e-43	169.00
IUUC-Mga-060178	Meleagris gallopavo	86.40	2.00e-167	581.00
IUUC-Mvi-060353	Microbotryum violaceum	35.36	8.00e-50	190.00
IUUC-Mmr-060738	Microcebus murinus	91.47	0.00e+00	633.00
IUUC-Mdo-062266	Monodelphis domestica	97.54	2.00e-119	421.00
IUUC-Mmu-063619	Mus musculus	88.53	7.00e-179	619.00
IUUC-Mac-065301	Musa acuminata	46.51	8.00e-84	303.00
IUUC-Mpu-066058	Mustela putorius furo	90.59	0.00e+00	629.00
IUUC-Mlu-067292	Myotis lucifugus	89.41	4.00e-178	616.00
IUUC-Nfi-068275	Neosartorya fischeri	34.81	6.00e-51	194.00
IUUC-Ncr-068713	Neurospora crassa	35.94	3.00e-53	202.00
IUUC-Nle-069013	Nomascus leucogenys	90.60	0.00e+00	644.00
IUUC-Opr-070628	Ochotona princeps	86.30	1.00e-172	598.00
IUUC-Ont-072688	Oreochromis niloticus	81.87	8.00e-166	575.00
IUUC-Oan-073004	Ornithorhynchus anatinus	85.71	7.00e-136	476.00
IUUC-Ocu-074303	Oryctolagus cuniculus	90.29	0.00e+00	646.00
IUUC-Oba-075002	Oryza barthii	45.68	7.00e-78	283.00
IUUC-Obr-076392	Oryza brachyantha	45.35	3.00e-75	275.00
IUUC-Ogl-077271	Oryza glaberrima	45.68	7.00e-78	283.00
IUUC-Ogu-078493	Oryza glumaepatula	45.40	5.00e-78	284.00
IUUC-Oin-080084	Oryza indica	45.40	5.00e-78	284.00
IUUC-Olo-080803	Oryza longistaminata	45.13	1.00e-77	283.00
IUUC-Ome-081146	Oryza meridionalis	44.57	2.00e-76	279.00
IUUC-Oni-082146	Oryza nivara	45.40	5.00e-78	284.00
IUUC-Opu-083633	Oryza punctata	45.93	4.00e-74	271.00
IUUC-Oru-084789	Oryza rufipogon	45.40	5.00e-78	284.00
IUUC-Osa-086196	Oryza sativa	45.40	5.00e-78	284.00
IUUC-Ola-087126	Oryzias latipes	82.06	1.00e-162	565.00
IUUC-Olu-087665	Ostreococcus lucimarinus	38.41	2.00e-65	242.00
IUUC-Oar-090296	Ovis aries	89.71	9.00e-180	622.00
IUUC-Ptr-090566	Pan troglodytes	91.47	0.00e+00	634.00
IUUC-Pan-092052	Papio anubis	91.28	0.00e+00	634.00
IUUC-Psi-093723	Pelodiscus sinensis	86.35	7.00e-160	556.00
IUUC-Pma-094568	Petromyzon marinus	56.19	7.00e-102	363.00
IUUC-Pno-095120	Phaeosphaeria nodorum	35.87	1.00e-45	176.00
IUUC-Ppa-095761	Physcomitrella patens	43.63	9.00e-79	286.00
IUUC-Pfo-096210	Poecilia formosa	81.76	1.00e-166	578.00
IUUC-Pab-098463	Pongo abelii	91.17	0.00e+00	652.00
IUUC-Pop-099109	Populus trichocarpa	45.05	2.00e-80	292.00
IUUC-Pca-100108	Procavia capensis	87.91	5.00e-140	490.00
IUUC-Ppe-101176	Prunus persica	47.63	9.00e-82	296.00
IUUC-Pva-102629	Pteropus vampyrus	85.95	2.00e-147	514.00
IUUC-Pgr-103419	Puccinia graminis	36.71	3.00e-52	198.00
IUUC-Pte-104207	Pyrenophora teres	44.97	2.00e-33	134.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	36.45	1.00e-52	199.00
IUUC-Rno-105579	Rattus norvegicus	79.71	5.00e-158	550.00
IUUC-Sha-106894	Sarcophilus harrisii	84.49	2.00e-149	521.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	35.37	3.00e-54	204.00
IUUC-Spo-108371	Schizosaccharomyces pombe	38.79	1.00e-55	209.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	35.31	3.00e-43	168.00
IUUC-Smo-109396	Selaginella moellendorffii	46.88	4.00e-83	301.00
IUUC-Sit-110630	Setaria italica	45.76	4.00e-81	294.00
IUUC-Sly-110972	Solanum lycopersicum	46.76	2.00e-76	279.00
IUUC-Stu-112185	Solanum tuberosum	47.35	1.00e-84	306.00
IUUC-Sar-113294	Sorex araneus	80.55	5.00e-167	580.00
IUUC-Sbi-113951	Sorghum bicolor	46.05	9.00e-82	296.00
IUUC-Ssc-115501	Sus scrofa	88.89	2.00e-168	584.00
IUUC-Tgu-117152	Taeniopygia guttata	86.35	2.00e-153	534.00
IUUC-Tru-118388	Takifugu rubripes	80.88	2.00e-165	574.00
IUUC-Tsy-119109	Tarsius syrichta	91.17	0.00e+00	651.00
IUUC-Tni-120048	Tetraodon nigroviridis	80.88	5.00e-166	576.00
IUUC-Tca-121750	Theobroma cacao	45.75	4.00e-84	304.00
IUUC-Tre-122130	Trichoderma reesei	35.78	3.00e-50	192.00
IUUC-Tvi-122284	Trichoderma virens	36.28	4.00e-48	184.00
IUUC-Tae-124082	Triticum aestivum	44.29	6.00e-79	287.00
IUUC-Tur-126366	Triticum urartu	39.38	5.00e-61	228.00
IUUC-Tme-127187	Tuber melanosporum	37.58	9.00e-54	203.00
IUUC-Tbe-127619	Tupaia belangeri	81.53	2.00e-139	487.00
IUUC-Ttr-128867	Tursiops truncatus	87.35	2.00e-124	438.00
IUUC-Vda-129912	Verticillium dahliae	34.37	1.00e-48	186.00
IUUC-Vpa-130552	Vicugna pacos	78.96	8.00e-140	489.00
IUUC-Vvi-130881	Vitis vinifera	47.25	2.00e-80	292.00
IUUC-Xtr-131934	Xenopus tropicalis	78.37	4.00e-168	583.00
IUUC-Xma-133312	Xiphophorus maculatus	81.76	2.00e-166	578.00
IUUC-Yli-134487	Yarrowia lipolytica	34.56	1.00e-43	169.00
IUUC-Zma-135462	Zea mays	40.06	2.00e-67	248.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence