iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074305

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02022571

Gene Name

HERC5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000015872.3	ENSOCUT00000015880.3	ENSOCUP00000013644.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.60e-84	283.0	617	938

Active Site

Position(s)	Description	Evidence
908	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl+k+l+v+f+gE g +  Gv  ef+++l++e+ +p++g+f+y e+ + +++p++ ++    e+ ++F f+G+l+g++l++ ++ +l
   Q: 617  NEDLRKELWVSFTGEIGYGFRGVMTEFFYCLFEEMTRPEYGMFMYPEEASFMWFPAKPKF----EEKRYF-FFGILCGLSLFNCNVANL 700
           689********************************************************9....566777.99**************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +++k+ll++k sledl+e+ p l ksl+e+++n++sd eel + +      +i  ++++ +L+p+G+ i V+++Nk++Yv++ ve
   Q: 701  SFPLALFKKLLDQKPSLEDLKELSPVLGKSLEELLDNESSDFEEL-FYIH----FNIHWDRDDIDLIPNGSCIIVNQTNKRDYVSKCVE 784
           *************************************87777777.5555....5678899**************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           ++++ ++k  +++f++Gf++v+++++++ F++ el+  i G++++d+e+++k++ y++gy++++p+i +Fwe+l+++s ee+k+fL F+
   Q: 785  HIFNISVKAIYDEFQRGFYKVCNKQIIECFRPGELKDAIVGNTDFDWETFEKNAHYEQGYNSSHPTIVMFWEALHKLSLEEKKKFLVFL 873
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg++r  +++++++k   f+++++ s+++  +++TCf +L LP+Ys++e ++e  ++Ai++++gF+
   Q: 874  TGTDRTQIKNLKNMK-ITFCCPDNLSEKDPMRAQTCFCLLYLPKYSTMERVEEAFQVAINNSRGFG 938
           ***************.7799***9****************************************96 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

ECIKLGKKMK IHSMAQGAEH VLVLSSDGKP FEYNYSIEHA NRFQSILQEK TIIQITCGDY 60
HSLALSKGGE LFAWGQNSHG QLGIGVMCPS VPTPQIVEHL AGVPLVQISA GEAHSMTLSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGTGCATTA AGTTAGGAAA AAAAATGAAG ATCCATTCCA TGGCCCAAGG CGCGGAGCAC 60
GTGCTGGTTC TATCCTCAGA TGGAAAACCA TTTGAGTACA ACTATAGCAT AGAACATGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0042296--F:ISG15 transferase activity
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0032020--P:ISG15-protein conjugation
GO:0050688--P:regulation of defense response to virus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001676	Ailuropoda melanoleuca	74.87	0.00e+00	1485.00
IUUC-Bta-012422	Bos taurus	67.59	0.00e+00	1189.00
IUUC-Cja-018751	Callithrix jacchus	72.10	0.00e+00	1368.00
IUUC-Cfa-020247	Canis familiaris	74.46	0.00e+00	1451.00
IUUC-Cpo-022346	Cavia porcellus	47.37	0.00e+00	857.00
IUUC-Csa-023204	Chlorocebus sabaeus	72.90	0.00e+00	1309.00
IUUC-Cho-025101	Choloepus hoffmanni	60.76	2.00e-173	603.00
IUUC-Dno-029795	Dasypus novemcinctus	67.64	0.00e+00	1014.00
IUUC-Dor-030862	Dipodomys ordii	64.42	0.00e+00	1169.00
IUUC-Ete-032585	Echinops telfairi	55.98	0.00e+00	768.00
IUUC-Eca-034358	Equus caballus	72.92	0.00e+00	1374.00
IUUC-Eeu-035282	Erinaceus europaeus	61.09	0.00e+00	668.00
IUUC-Fca-036505	Felis catus	74.50	0.00e+00	1461.00
IUUC-Ggo-045445	Gorilla gorilla	70.07	0.00e+00	1282.00
IUUC-Hsa-046342	Homo sapiens	72.52	0.00e+00	1345.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	69.46	0.00e+00	1310.00
IUUC-Laf-053921	Loxodonta africana	68.62	0.00e+00	1307.00
IUUC-Mcc-054850	Macaca mulatta	72.47	0.00e+00	1306.00
IUUC-Mmr-060783	Microcebus murinus	65.60	0.00e+00	1191.00
IUUC-Mdo-061839	Monodelphis domestica	45.21	0.00e+00	725.00
IUUC-Mmu-064378	Mus musculus	45.11	0.00e+00	775.00
IUUC-Mpu-066123	Mustela putorius furo	74.89	0.00e+00	1460.00
IUUC-Mlu-067914	Myotis lucifugus	72.92	0.00e+00	1362.00
IUUC-Nle-069986	Nomascus leucogenys	72.52	0.00e+00	1366.00
IUUC-Opr-070513	Ochotona princeps	78.16	0.00e+00	1092.00
IUUC-Oga-088780	Otolemur garnettii	48.28	0.00e+00	847.00
IUUC-Oar-089456	Ovis aries	74.44	0.00e+00	1375.00
IUUC-Ptr-091216	Pan troglodytes	72.25	0.00e+00	1254.00
IUUC-Pan-091706	Papio anubis	72.13	0.00e+00	1301.00
IUUC-Pca-100320	Procavia capensis	62.26	0.00e+00	1182.00
IUUC-Pva-102646	Pteropus vampyrus	74.95	0.00e+00	1448.00
IUUC-Rno-105768	Rattus norvegicus	44.46	0.00e+00	728.00
IUUC-Sha-106525	Sarcophilus harrisii	45.64	0.00e+00	806.00
IUUC-Sar-113605	Sorex araneus	72.11	5.00e-140	491.00
IUUC-Ssc-116076	Sus scrofa	75.28	5.00e-167	580.00
IUUC-Tsy-119240	Tarsius syrichta	63.46	0.00e+00	1178.00
IUUC-Tbe-127787	Tupaia belangeri	69.54	0.00e+00	1313.00
IUUC-Ttr-128191	Tursiops truncatus	73.27	0.00e+00	1371.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence